19 research outputs found
The potential role of adiponectin- and resistin-like peptides in the regulation of lipid levels in the hemolymph of over-wintering adult females of Osmia bicornis
Factors influencing mothers’ health care seeking behaviour for their children: evidence from 31 countries in sub-Saharan Africa
Electroconvulsive Therapy: a Video-Based Educational Resource Using Standardized Patients
Therapeutic drug monitoring of monoclonal antibodies in inflammatory and malignant disease: translating TNF-É‘ experience to oncology
Lack of response to monoclonal antibodies (mAbs) has been associated with inadequate mAb serum concentrations. Therapeutic drug monitoring (TDM) of mAbs has the potential to guide to more effective dosing in individual patients. This review discusses the mechanisms responsible for interpatient variability of mAb pharmacokinetics, summarizes exposure-response data of mAbs used in inflammatory and malignant disease, presents current evidence of mAb-TDM in inflammatory disease, and provides hurdles and required future steps for further implementing mAb-TDM