Correlacionando tipos de cultura organizacional com estratégias de remuneração utilizando a tipologia de Charles Handy

Este estudo identificou as correlações entre as estratégias de remuneração e a tipologia de cultura organizacional proposta por Handy (2003) baseada nas dimensões do grau de formalização e centralização que identifica a cultura: Zeus (poder), Apolo (papéis), Atena (tarefa), e Dionísio (pessoa). A pesquisa foi aplicada a gestores de remuneração de 76 empresas associadas ao Grupo de Permuta de Informações Salariais (Grupisa), e os questionários com um construto composto por doze componentes da remuneração organizacional foram analisados utilizando Correlação de Pearson e Regressão Múltipla. Concluímos que as variáveis de remuneração se correlacionam de forma diferente com cada um dos tipos de cultura: (i) organizações "Zeus" devem enfatizar os fatores comportamentais em todas as esferas do sistema de remuneração; (ii) para as organizações "Apolo" a ênfase deve ser aplicada nas oportunidades de crescimento e desenvolvimento, (iii) nas organizações "Atena" o foco deve ser nas recompensas financeiras, e, (iv) organizações "Dionísio" devem dar ênfase à qualidade da remuneração

Widening of the genetic and clinical spectrum of Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency

Purpose Lamb-Shaffer syndrome (LAMSHF) is a neurodevelopmental disorder described in just over two dozen patients with heterozygous genetic alterations involving SOX5, a gene encoding a transcription factor regulating cell fate and differentiation in neurogenesis and other discrete developmental processes. The genetic alterations described so far are mainly microdeletions. The present study was aimed at increasing our understanding of LAMSHF, its clinical and genetic spectrum, and the pathophysiological mechanisms involved. Methods Clinical and genetic data were collected through GeneMatcher and clinical or genetic networks for 41 novel patients harboring various types ofSOX5 alterations. Functional consequences of selected substitutions were investigated. Results Microdeletions and truncating variants occurred throughout SOX5. In contrast, most missense variants clustered in the pivotal SOX-specific high-mobility-group domain. The latter variants prevented SOX5 from binding DNA and promoting transactivation in vitro, whereas missense variants located outside the high-mobility-group domain did not. Clinical manifestations and severity varied among patients. No clear genotype-phenotype correlations were found, except that missense variants outside the high-mobility-group domain were generally better tolerated. Conclusions This study extends the clinical and genetic spectrum associated with LAMSHF and consolidates evidence that SOX5 haploinsufficiency leads to variable degrees of intellectual disability, language delay, and other clinical features.Genetics of disease, diagnosis and treatmen

Cluster in nuclei: Experimental perspectives

This lecture notes treat some experimental aspects of nuclear cluster states studies, ranging from traditional techniques to some of the most recent developments and emerging methods. Experimental investigations, in the field of nuclear clusters are discussed in terms of detection techniques and associated electronics. Recent developments in accelerator technology and targetry are also presented in the scope of new opportunities in cluster studies. The nature of cluster states makes exclusive measurements crucial. It requires the simultaneous detection of nucleons, light, intermediate-mass and heavy fragments, and possibly -rays together with timing information. Precise measurements of angular correlations and energy distributions between emitted particles are needed for kinematic reconstruction in order to achieve a detailed study of the decay modes and the underlying dynamics. Within this scope, highly segmented and high-efficiency detection systems are depicted. Developments in digital signal processing have made possible major advances in experimental nuclear physics. The combination of large numbers of channels with fast data acquisition systems is one of the key aspects of this modern technology. Nuclear reactions play a key role in the study of the structure of nuclear clusters. Therefore, aspects of acceleration, including high-intensity, low-energy stable and radioactive beams are presented. Targetry has received a renewed interest with the advent of active targets (ACTAR). The combination of radioactive beams and active targets for the study of nuclear clustering is certainly opening new horizons in this field of physics. A number of current experimental setups and computer codes are cited to illustrate some of the techniques described but this list is by no means exhaustive. © 2012 Springer-Verlag Berlin Heidelberg