11 year retrospective study of tubal reanastomosis by microsurgical technique

Background: Tubal reanastomosis is a procedure to anastomose the cut ends of the fallopian tube. Laparotomy is the most frequently used microsurgical technique for this reversal, with results showing intrauterine pregnancies ranging from 50 to 80% and a rate of ectopic pregnancy less than 5% in these series. The objective of this study was to determine the pregnancy rate and live birth rate achieved through laparotomy tubal reanastomosis.Methods: Data from 152 consecutive laparotomy tubal reanastomosis procedures done between January 2004 and December 2014 were retrospectively analyzed. All procedures were performed by the same surgeon by laparotomy using microsurgical instruments. The main outcome measures were: total pregnancy rate and live birth rate.Results: Out of 152 women, who were willing for reversal operation, 4 had fimbriectomy, 8 had residual tube length <4 cm. Remaining 140 patients underwent tubal reanastomosis. 2 patients died, 2 patient’s husband died, 22 patients were lost to follow-up, and 9 are still in follow up period. Hence 105 patients were analyzed. Total pregnancy rate was 82.8% and live birth rate 73.3%.Conclusions: Tubal reanastomosis by laparotomy with microsurgical instruments results in a satisfactory pregnancy rate

Delivery of a fetus with undiagnosed sacro coccygeal teratoma

Sacrococcygeal teratoma is the most common tumour of the fetus and neonate with an incidence of 1 in 40000 births. Here we describe the management of an undiagnosed sacrococcygeal teratoma, which is rare in this era

In vitro propagation of Hoya wightii ssp. palniensis K.T. Mathew, a highly vulnerable and endemic species of Western Ghats of Tamil Nadu, India

In vitro propagation of Hoya wightii ssp. palniensis (Asclepiadaceae), a highly vulnerable and endemic plant species of Western Ghats, Tamil Nadu, India was carried out. Shoot tip explants were cultured on MS medium fortified with cytokinins (KN, BA, 2-iP and TDZ) in various concentrations and in combination with auxins (IBA, IAA and NAA). High frequency of shoot bud proliferation and multiplication was observed on KN (4.65 &#236;M) + IBA (1.47 &#236;M). Multiple shoot induction efficiency was increased on ascorbic acid (100 mg/l) supplemented medium along with KN (4.65 &#236;M) +IBA (1.47 &#236;M). Rhizogenesis was observed on MS medium supplemented with IBA (0.98 &#236;M), plantlets produced through micropropagation were hardened with the survival success of 56%. The efficient plantlet regeneration protocol developed would aid ex situ conservation of this vulnerable species

Stringy effects in black hole decay

We compute the low energy decay rates of near-extremal three(four) charge black holes in five(four) dimensional N=4 string theory to sub-leading order in the large charge approximation. This involves studying stringy corrections to scattering amplitudes of a scalar field off a black hole. We adapt and use recently developed techniques to compute such amplitudes as near-horizon quantities. We then compare this with the corresponding calculation in the microscopic configuration carrying the same charges as the black hole. We find perfect agreement between the microscopic and macroscopic calculations; in the cases we study, the zero energy limit of the scattering cross section is equal to four times the Wald entropy of the black hole.Comment: 32 page

Discrete Information from CHL Black Holes

AdS_2/CFT_1 correspondence predicts that the logarithm of a Z_N twisted index over states carrying a fixed set of charges grows as 1/N times the entropy of the black hole carrying the same set of charges. In this paper we verify this explicitly by calculating the microscopic Z_N twisted index for a class of states in the CHL models. This demonstrates that black holes carry more information about the microstates than just the total degeneracy.Comment: LaTeX file, 24 pages; v2: references adde

A Twist in the Dyon Partition Function

In four dimensional string theories with N=4 and N=8 supersymmetries one can often define twisted index in a subspace of the moduli space which captures additional information on the partition function than the ones contained in the usual helicity trace index. We compute several such indices in type IIB string theory on K3 x T^2 and T^6, and find that they share many properties with the usual helicity trace index that captures the spectrum of quarter BPS states in N=4 supersymmetric string theories. In particular the partition function is a modular form of a subgroup of Sp(2,Z) and the jumps across the walls of marginal stability are controlled by the residues at the poles of the partition function. However for large charges the logarithm of this index grows as 1/n times the entropy of a black hole carrying the same charges where n is the order of the symmetry generator that is used to define the twisted index. We provide a macroscopic explanation of this phenomenon using quantum entropy function formalism. The leading saddle point corresponding to the attractor geometry fails to contribute to the twisted index, but a Z_n orbifold of the attractor geometry produces the desired contribution.Comment: LaTeX file, 35 pages; v2: references adde

Trends in Compulsory Licensing of Pharmaceuticals Since the Doha Declaration: A Database Analysis

Reed Beall and Randall Kuhn describe their findings from an analysis of use of compulsory licenses for pharmaceutical products by World Trade Organization members since 1995

Optical Magnetometry

Some of the most sensitive methods of measuring magnetic fields utilize interactions of resonant light with atomic vapor. Recent developments in this vibrant field are improving magnetometers in many traditional areas such as measurement of geomagnetic anomalies and magnetic fields in space, and are opening the door to new ones, including, dynamical measurements of bio-magnetic fields, detection of nuclear magnetic resonance (NMR), magnetic-resonance imaging (MRI), inertial-rotation sensing, magnetic microscopy with cold atoms, and tests of fundamental symmetries of Nature.Comment: 11 pages; 4 figures; submitted to Nature Physic

Competing risk and heterogeneity of treatment effect in clinical trials

It has been demonstrated that patients enrolled in clinical trials frequently have a large degree of variation in their baseline risk for the outcome of interest. Thus, some have suggested that clinical trial results should routinely be stratified by outcome risk using risk models, since the summary results may otherwise be misleading. However, variation in competing risk is another dimension of risk heterogeneity that may also underlie treatment effect heterogeneity. Understanding the effects of competing risk heterogeneity may be especially important for pragmatic comparative effectiveness trials, which seek to include traditionally excluded patients, such as the elderly or complex patients with multiple comorbidities. Indeed, the observed effect of an intervention is dependent on the ratio of outcome risk to competing risk, and these risks – which may or may not be correlated – may vary considerably in patients enrolled in a trial. Further, the effects of competing risk on treatment effect heterogeneity can be amplified by even a small degree of treatment related harm. Stratification of trial results along both the competing and the outcome risk dimensions may be necessary if pragmatic comparative effectiveness trials are to provide the clinically useful information their advocates intend