207 research outputs found
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Associations between inattention and impulsivity ADHD symptoms and disordered eating risk in a community sample of young adults.
BACKGROUND: Symptoms of attention deficit hyperactivity disorder (ADHD) and trait impulsivity have been associated with disordered eating but are seldom assessed in community studies, or longitudinally and little is known about the mediating mechanisms. METHODS: We tested associations between ADHD symptoms and disordered eating cross-sectionally and between trait impulsivity and disordered eating longitudinally. We utilised data from a normative cohort of young adults (642 participants: 65% female, Mage = 23 years). Participants were classified as high risk or low risk for disordered eating using the SCOFF instrument. In the first two steps of both cross-sectional and longitudinal hierarchical logistic regression models, demographics and covariates were entered. For the cross-sectional regression, Adult ADHD self-report scale (ASRS) scores, separated into inattentive and hyperactive/impulsive symptoms, were entered in the third step. In a separate longitudinal model, Barratt impulsivity scale subscales (attentional, motor and non-planning impulsivity) were entered in the third step. Depression, as assessed by the moods and feelings questionnaire (MFQ), was examined as a mediator. RESULTS: Cross-sectionally, sex, MFQ score and inattentive symptoms predicted disordered eating risk (model R2 = 20%). Longitudinally, sex, MFQ score and attentional impulsivity predicted disordered eating risk (model R2 = 16%). The relationship between inattentive symptoms and the disordered eating risk was partially mediated by MFQ score, whereas the relationship between attentional impulsivity and the disordered eating risk was fully mediated by MFQ scores. CONCLUSIONS: These data highlight (1) a specific role for inattentive symptoms of ADHD and (2) the importance of both depression and impulsivity in predicting eating disorder risk
Hydrodynamic Propulsion of Liposomes Electrostatically Attracted to a Lipid Membrane Reveals Size-Dependent Conformational Changes
The efficiency of lipid nanoparticle uptake across cellular membranes is
strongly dependent on the very first interaction step. Detailed understanding of this
step is in part hampered by the large heterogeneity in the physicochemical properties
of lipid nanoparticles, such as liposomes, making conventional ensemble-averaging
methods too blunt to address details of this complex process. Here, we contribute a
means to explore whether individual liposomes become deformed upon binding to
fluid cell-membrane mimics. This was accomplished by using hydrodynamic forces to
control the propulsion of nanoscale liposomes electrostatically attracted to a
supported lipid bilayer. In this way, the size of individual liposomes could be
determined by simultaneously measuring both their individual drift velocity and diffusivity, revealing that for a radius of
∼45 nm, a close agreement with dynamic light scattering data was observed, while larger liposomes (radius ∼75 nm)
displayed a significant deformation unless composed of a gel-phase lipid. The relevance of being able to extract this type of
information is discussed in the context of membrane fusion and cellular uptake
Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours
Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a transdiagnostic 'disinhibition' phenotype. In a cohort of 117 individuals, recruited as part of the Neuroscience in Psychiatry Network (NSPN), we examined how brain functional connectome and network properties relate to disinhibition. Reduced functional connectivity within a subnetwork of frontal (especially right inferior frontal gyrus), occipital and parietal regions was linked to disinhibition. Findings provide insights into neurobiological pathways underlying the emergence of impulsive and compulsive disorders
A microscopic theory of gauge mediation
We construct models of indirect gauge mediation where the dynamics
responsible for breaking supersymmetry simultaneously generates a weakly
coupled subsector of messengers. This provides a microscopic realization of
messenger gauge mediation where the messenger and hidden sector fields are
unified into a single sector. The UV theory is SQCD with massless and massive
quarks plus singlets, and at low energies it flows to a weakly coupled quiver
gauge theory. One node provides the primary source of supersymmetry breaking,
which is then transmitted to the node giving rise to the messenger fields.
These models break R-symmetry spontaneously, produce realistic gaugino and
sfermion masses, and give a heavy gravitino.Comment: 24 pages, 2 figures, accepted to JHEP for publicatio
Collective Quartics from Simple Groups
This article classifies Little Higgs models that have collective quartic
couplings. There are two classes of collective quartics: Special Cosets and
Special Quartics. After taking into account dangerous singlets, the smallest
Special Coset models are SU(5)/SO(5) and SU(6)/Sp(6). The smallest Special
Quartic model is SU(5)/SU(3) x SU(2) x U(1) and has not previously been
considered as a candidate Little Higgs model.Comment: 22 pages, 2 figure
UV friendly T-parity in the SU(6)/Sp(6) little Higgs model
Electroweak precision tests put stringent constraints on the parameter space
of little Higgs models. Tree-level exchange of TeV scale particles in a generic
little Higgs model produce higher dimensional operators that make contributions
to electroweak observables that are typically too large. To avoid this problem
a discrete symmetry dubbed T-parity can be introduced to forbid the dangerous
couplings. However, it was realized that in simple group models such as the
littlest Higgs model, the implementation of T-parity in a UV completion could
present some challenges. The situation is analogous to the one in QCD where the
pion can easily be defined as being odd under a new symmetry in the
chiral Lagrangian, but this is not a symmetry of the quark Lagrangian. In
this paper we examine the possibility of implementing a T-parity in the low
energy model that might be easier to realize in the UV. In our
model, the T-parity acts on the low energy non-linear sigma model field in way
which is different to what was originally proposed for the Littlest Higgs, and
lead to a different low energy theory. In particular, the Higgs sector of this
model is a inert two Higgs doublets model with an approximate custodial
symmetry. We examine the contributions of the various sectors of the model to
electroweak precision data, and to the dark matter abundance.Comment: 21 pages,4 figures. Clarifications added, typos corrected and
references added. Published in JHE
T-parity, its problems and their solution
We point out a basic difficulty in the construction of little-Higgs models
with T-parity which is overlooked by large part of the present literature.
Almost all models proposed so far fail to achieve their goal: they either
suffer from sizable electroweak corrections or from a breakdown of collective
breaking. We provide a model building recipe to bypass the above problem and
apply it to build the simplest T-invariant extension of the Littlest Higgs. Our
model predicts additional T-odd pseudo-Goldstone bosons with weak scale masses.Comment: 25 pages, 2 appendice
A Systematic Review of Online Sex Addiction and Clinical Treatments Using CONSORT Evaluation
Researchers have suggested that the advances of the Internet over the past two decades have gradually eliminated traditional offline methods of obtaining sexual material. Additionally, research on cybersex and/or online sex addictions has increased alongside the development of online technology. The present study extended the findings from Griffiths’ (2012) systematic empirical review of online sex addiction by additionally investigating empirical studies that implemented and/or documented clinical treatments for online sex addiction in adults. A total of nine studies were identified and then each underwent a CONSORT evaluation. The main findings of the present review provide some evidence to suggest that some treatments (both psychological and/or pharmacological) provide positive outcomes among those experiencing difficulties with online sex addiction. Similar to Griffiths’ original review, this study recommends that further research is warranted to establish the efficacy of empirically driven treatments for online sex addiction
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Culture and Subjectivity in Neoliberal and postfeminist times
My aim in this paper is to think through a number of issues concerning the relationship between culture and subjectivity. It seems to me that exploring the relationship of changing forms of political organisation, social relations and cultural practices to changing modes and experiences of subjecthood and subjectivity are among the most important and urgent tasks for critical intellectual work. These questions go to the heart of understanding power, ideology and agency and they require research that is interdisciplinary, psychosocial and intersectional. My particular focus in this short article is on the interrelations between changing representational practices in visual culture and changing subjectivity/ies. I argue that neoliberalism and postfeminism are central to understanding contemporary media culture, and I put the case for research which does not retreat from exploring how these broader social/political/economic/cultural discourses and formations may relate to subjectivity
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