High-precision physics-based radiation force models for the Galileo spacecraft

We present two new high-precision physics-based radiation force models for the In-Orbit Validation (IOV) and Full Operational Capability (FOC) spacecraft (s/c) of the Galileo Global Navigation Satellite System (GNSS). In both cases, the s/c bus surfaces are covered in material types, i.e., Laser Retro-reflector Array (LRA), Optical Surface Reflector (OSR) and Single-Layer Insulation (SLI) coverings, that were either not encountered or not specifically dealt with in earlier work. To address this, a number of modelling enhancements were proposed and tested, including: a specific model to account for the direct and reflected solar radiation force for LRA surfaces; a design update of the bus model computation process to allow for more than one insulation material; a specific thermal force model for OSR surfaces; a thermal force model for the Navigation Antenna (NAVANT) surface that includes a temperature model derived from on-orbit temperature measurements; and force models to account for thermal emissions from radiator panels on the +X and \pm Y surfaces for both IOV and FOC, and on the -Z surface for FOC only. In the UCL2+ model each of these effects are accounted for. The theoretical impact of each modelling concept introduced is assessed, individually, by considering the magnitude of its effect in acceleration-space. The impact on orbit accuracy is confirmed through a rigorous set of Precise Orbit Determination (POD) validation tests, in which observations from all active Galileo s/c over two full years, 2017 and 2018, including during eclipsing periods, are included in the analysis. The UCL2+ approach results in day boundary discontinuities of 22 mm, 17 mm and 27 mm in the radial, across-track and along-track components, respectively. Analysis of the one-way Satellite Laser Ranging (SLR) residuals suggests that radial accuracy at better than 1 cm (3.7 mm mean residuals) and precision at better than 2 cm (17 mm root mean square (rms) error) is achievable with the UCL2+ model

Mapping the Design Process for Urban Ecology Researchers

The integration of research into the design process is an opportunity to build ecologically informed urban design solutions. To date, designers have traditionally relied on environmental consultants to provide the best available science; however, serious gaps in our understanding of urban ecosystems remain. To evaluate ecosystem processes and services for sustainable urban design and to further advance our understanding of social-ecological processes within the urban context, we need to integrate primary research into the urban design process. In this article, we develop a road map for such a synthesis. Supporting our proposals by case studies, we identify strategic entry points at which urban ecology researchers can integrate their work into the design process

Coulomb Engineering of two-dimensional Mott materials

Two-dimensional materials can be strongly influenced by their surroundings. A dielectric environment screens and reduces the Coulomb interaction between electrons in the two-dimensional material. Since the Coulomb interaction is responsible for the insulating state of Mott materials, dielectric screening provides direct access to the Mottness. Our many-body calculations reveal the spectroscopic fingerprints of Coulomb engineering. We demonstrate eV-scale changes to the position of the Hubbard bands and show a Coulomb engineered insulator-to-metal transition. Based on this theoretical analysis, we discuss prerequisites for an effective experimental realization of Coulomb engineering.Comment: 5+4 page

The Grizzly, October 3, 2000

Marathon Painter to Update \u27Athens\u27 • GOP Senator Tilghman Speaks in Olin • Red & Gold Recruits Experience Ursinus • S.T.A.R. to Take Back the Night Oct. 27th • Men and Women Unite to Break Stereotypes • Jessicas Clean House in Special Soph. Elections • State of New Jersey may be Built Out by 2030 • Gore Talks to Youth at Michigan Town Hall Forum on MTV • Opinions: Food Services Getting Bad Wrap; Student Supervisor says Zack\u27s Attack Lacks Facts; Can one Person Make a Difference?; Gore on Guns; Social or Socialist Security?; Honesty Best Policy; Zack\u27s Customer Speaks out in Favor of Student Eatery • Collegeville Police Chief Ready to Assist UC • UC Homecoming 2000 • UC Grad\u27s A16 Captures Terror, Passion of WTO Riots • Summer with Blink 182, Bad Religion • Bears\u27 Volleyball Serves Cabrini a Shutout • X-C Runs Sub Par • Field Hockey Struggles to Go the Distance • Soccer Downs Swat with Wilkes\u27 Hat-Trick • Lady Bears Soccer Fall to .500 Record • Out of Africa: West Nile Virus Appears in Pa. • Depression: Who\u27s at Risk? What are the Signs? • Bears Beat Back Garnet Tide in 34-13 Victoryhttps://digitalcommons.ursinus.edu/grizzlynews/1474/thumbnail.jp

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships

Lysyl oxidase (LOX) is a secreted copper-dependent amine oxidase that crosslinks collagens and elastin in the extracellular matrix (ECM) and is a critical mediator of tumor growth and metastatic spread. LOX is a target for cancer therapy and thus the search for therapeutic agents against LOX has been widely sought. We report herein the medicinal chemistry discovery of a series of LOX inhibitors bearing an aminomethylenethiophene (AMT) scaffold. High throughput screening (HTS) provided the initial hits. Structure-activity relationship (SAR) studies led to the discovery of AMT inhibitors with sub-micromolar half maximal inhibitory concentrations (IC50) in a LOX enzyme activity assay. Further SAR optimisation yielded the orally bioavailable LOX inhibitor CCT365623 with good anti-LOX potency, selectivity, pharmacokinetic properties, as well as anti-metastatic efficacy

The Grizzly, September 26, 2000

Family Day 2000 • Taking a Seat: Prized Furniture Borrowed from Pfahler Hall • UC on the Internet: How Slow Can it Go • A.L.M.A. Takes Part in Annual Puerto Rican Day Parade • Construction of WWII Memorial Scheduled to Start on Veteran\u27s Day • Opinions: 2 Thumbs Up for Theater Prof\u27s Fringe Work; Students Fed Up with Slow Internet Service; Are UC Students for the Dems or GOP?; Premature Closings Leave Students Hungering for More; Order Forms Subverting the Sandwich Experience; Yugoslav Elections Spotlight Lack of Foreign Policy Debate; UC International Students Sound Off on American Politics; Are Reimert Residents Overcharged for Damages?; UC Swimming Pool: Drowning in Dust • Students Have Splash at Philly College Fair • Virtual Grad School Fair and Greater Philadelphia Techlink: Connecting Students to Their Future • Philly Fringe Festival\u27s UC Debut a Smashing Success • Chinese Watercolors at Berman Through October • Phirst Phish Show Thrills UC Phreshman • Volleyball Spikes to .500 Overall Record • Field Hockey Grabs First League Win • Cross Country Steps Up at Messiah Invite • Lacrosse\u27s Fall Ball to Prepare Squad for Rigors of Spring • Soccer Blown Away by Blue Jays, 7-1 • Women\u27s Squad Falls at Feet of Diplomats • The Agony of Ecstasy: Illegal Drug Popular Among Young Adults • Cyrsky\u27s Guide to Eating Right at UC • Green Terror Spooks Grizzlies with Field Goal in Final Secondshttps://digitalcommons.ursinus.edu/grizzlynews/1473/thumbnail.jp

Serum neurofilament light in atrial fibrillation: clinical, neuroimaging and cognitive correlates

Emerging evidence suggests that atrial fibrillation is associated with cognitive dysfunction independently of stroke, but the underlying mechanisms remain unclear. In this cross-sectional analysis from the Swiss-atrial fibrillation Study (NCT02105844), we investigated the association of serum neurofilament light protein, a neuronal injury biomarker, with (i) the CHA; 2; DS; 2; -VASc score (congestive heart failure, hypertension, age 65-74 or >75 years, diabetes mellitus, stroke or transient ischaemic attack, vascular disease, sex), clinical and neuroimaging parameters and (ii) cognitive measures in atrial fibrillation patients. We measured neurofilament light in serum using an ultrasensitive single-molecule array assay in a sample of 1379 atrial fibrillation patients (mean age, 72 years; female, 27%). Ischaemic infarcts, small vessel disease markers and normalized brain volume were assessed on brain MRI. Cognitive testing included the Montreal cognitive assessment, trail-making test, semantic verbal fluency and digit symbol substitution test, which were summarized using principal component analysis. Results were analysed using univariable and multivariable linear regression. Neurofilament light was associated with the CHA; 2; DS; 2; -VASc score, with an average 19.2% [95% confidence interval (17.2%, 21.3%)] higher neurofilament per unit CHA; 2; DS; 2; -VASc increase. This association persisted after adjustment for age and MRI characteristics. In multivariable analyses, clinical parameters associated with neurofilament light were higher age [32.5% (27.2%, 38%) neurofilament increase per 10 years], diabetes mellitus, heart failure and peripheral artery disease [26.8% (16.8%, 37.6%), 15.7% (8.1%, 23.9%) and 19.5% (6.8%, 33.7%) higher neurofilament, respectively]. Mean arterial pressure showed a curvilinear association with neurofilament, with evidence for both an inverse linear and a U-shaped association. MRI characteristics associated with neurofilament were white matter lesion volume and volume of large non-cortical or cortical infarcts [4.3% (1.8%, 6.8%) and 5.5% (2.5%, 8.7%) neurofilament increase per unit increase in log-volume of the respective lesion], as well as normalized brain volume [4.9% (1.7%, 8.1%) higher neurofilament per 100 cm; 3; smaller brain volume]. Neurofilament light was inversely associated with all cognitive measures in univariable analyses. The effect sizes diminished after adjusting for clinical and MRI variables, but the association with the first principal component was still evident. Our results suggest that in atrial fibrillation patients, neuronal loss measured by serum neurofilament light is associated with age, diabetes mellitus, heart failure, blood pressure and vascular brain lesions, and inversely correlates with normalized brain volume and cognitive function