Effects of successful percutaneous coronary intervention of chronic total occlusions on myocardial perfusion and left ventricular function

Item does not contain fulltextAIMS: The aim of the present study was to investigate the effects of successful PCI CTO on absolute myocardial blood flow (MBF) and functional recovery. METHODS AND RESULTS: Patients with a documented CTO were prospectively examined for ischaemia and viability with [15O]H2O positron emission tomography (PET) and late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR). Sixty-nine consecutive patients, in whom PCI was successful, underwent follow-up PET and CMR after approximately 12 weeks to evaluate potential improvement of MBF as well as systolic function. After PCI, stress MBF in the CTO area increased from 1.22+/-0.36 to 2.40+/-0.90 mL.min-1.g-1 (p<0.001), whilst stress MBF in the remote area also increased significantly between baseline and follow-up PET (2.58+/-0.68 to 2.77+/-0.77 mL.min-1.g-1, p=0.01). The ratio of stress MBF between CTO and remote area was 0.49+/-0.13 at baseline and increased to 0.87+/-0.24 at follow-up (p<0.001). The MBF defect size of the CTO area decreased from 5.12+/-1.69 to 1.91+/-1.75 myocardial segments after PCI (p<0.001). Left ventricular ejection fraction (LVEF) increased significantly (46.4+/-11.0 vs. 47.5+/-11.4%, p=0.01) at follow-up. CONCLUSIONS: The vast majority of CTO patients with documented ischaemia and viability showed significant improvement in stress MBF and a reduction of ischaemic burden after successful percutaneous revascularisation with only minimal effect on LVEF

Effect of dietary levels of methionine + cystine on performance of broiler breeders Efeito dos níveis dietéticos de metionina + cistina no desempenho de matrizes pesadas

The objective of this experiment was to evaluate levels of methionine + cystine levels for broiler breeders from 40 to 60 weeks of age. It was used 288 Cobb broiler breeders, distributed in a randomized experimental design with six levels of methionine+ cystine in the diets (0.39; 0.47; 0.55; 0.63; 0.71 and 0.79%), eight repetitions and six breeders per experimental unit. The diets were isocaloric and isoprotein (2,850 kcal ME/kg and 12.58% CP) and oferred at a fixed amount (155 g) per bird. For the entire studied period, by using polynomial analysis, it was observed a quadratic effect of methionine + cystine levels on the percentage of egg production, on number of eggs per hen housed, on number of eggs per hen and egg weight. There was also a linear effect on shell weight when it was calculated in relation to egg weight. The total methionine + cystine requirement for broiler breeders was calculated at 0.521% for percentage of egg production and number of eggs per hen, which corresponds to a daily intake of 808 mg of methionine + cystine/day. The digestible methionine + cystine requirement for broiler breeders was estimated at 727 mg for laying percentage and number of eggs per hen.<br>Com o objetivo de avaliar níveis de metionina + cistina para matrizes pesadas de 40 a 60 semanas de idade, conduziu-se um experimento com 288 matrizes da linhagem Cobb-500, distribuídas em delineamento inteiramente casualizado, com seis níveis de metionina + cistina nas dietas (0,39; 0,47; 0,55; 0,63; 0,71 e 0,79%), oito repetições e seis matrizes por unidade experimental. As rações foram isocalóricas e isoproteicas (2.850 kcal EM/kg e 12,58% PB) e fornecidas em quantidade fixa (155 g) por ave. No período total estudado, por meio de análise polinomial, foi observado efeito quadrático dos níveis de metionina + cistina sobre o percentual de produção de ovos, o número de ovos por ave alojada, o número de ovos por ave e o peso dos ovos. Houve também efeito linear sobre o peso da casca quando calculado em relação ao peso dos ovos. A exigência de metionina + cistina total para matrizes pesadas foi estimada em 0,521% para percentual de produção de ovos e número de ovos por ave, o que corresponde a uma ingestão diária de 808 mg de metionina + cistina total. A exigência de metionina + cistina digestível para matrizes pesadas é de 727 mg para percentual de postura e número de ovos por ave