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Reduced global plant respiration due to the acclimation of leaf dark respiration coupled to photosynthesis
Leaf dark respiration (Rd) acclimates to environmental changes. However, the magnitude, controls and time scales of acclimation remain unclear and are inconsistently treated in ecosystem models. We hypothesized that Rd and Rubisco carboxylation capacity (Vcmax) at 25°C (Rd,25, Vcmax,25) are coordinated so that Rd,25 variations support Vcmax,25 at a level allowing full light use, with Vcmax,25 reflecting daytime conditions (for photosynthesis), and Rd,25/Vcmax,25 reflecting night-time conditions (for starch degradation and sucrose export). We tested this hypothesis temporally using a 5-yr warming experiment, and spatially using an extensive field-measurement data set. We compared the results to three published alternatives: Rd,25 declines linearly with daily average prior temperature; Rd at average prior night temperatures tends towards a constant value; and Rd,25/Vcmax,25 is constant. Our hypothesis accounted for more variation in observed Rd,25 over time (R2 = 0.74) and space (R2 = 0.68) than the alternatives. Night-time temperature dominated the seasonal time-course of Rd, with an apparent response time scale of c. 2 wk. Vcmax dominated the spatial patterns. Our acclimation hypothesis results in a smaller increase in global Rd in response to rising CO2 and warming than is projected by the two of three alternative hypotheses, and by current models
Electronic correlations in the iron pnictides
In correlated metals derived from Mott insulators, the motion of an electron
is impeded by Coulomb repulsion due to other electrons. This phenomenon causes
a substantial reduction in the electron's kinetic energy leading to remarkable
experimental manifestations in optical spectroscopy. The high-Tc
superconducting cuprates are perhaps the most studied examples of such
correlated metals. The occurrence of high-Tc superconductivity in the iron
pnictides puts a spotlight on the relevance of correlation effects in these
materials. Here we present an infrared and optical study on single crystals of
the iron pnictide superconductor LaFePO. We find clear evidence of electronic
correlations in metallic LaFePO with the kinetic energy of the electrons
reduced to half of that predicted by band theory of nearly free electrons.
Hallmarks of strong electronic many-body effects reported here are important
because the iron pnictides expose a new pathway towards a correlated electron
state that does not explicitly involve the Mott transition.Comment: 10 page
High-mass star formation in the nearby region G352.630-1.067. I. parallax
Young or forming high-mass stars that are nearby and not within a cluster environment have the potential to provide fundamental insights into star formation. In this paper we report such a candidate (G352.630-1.067), for which we have measured the distance through very long baseline interferometry parallax observations of the associated 6.7 GHz class II methanol maser. We determine the distance to the source to be 0.69+0.10-0.08 kpc, which makes it the second nearest high-mass star formation region (HMSFR) known, with only the Orion Nebula being closer. This may place this source, not within a Galactic spiral arm, but in the region between the Local and Sagittarius arms, indicating that molecular clouds in interarm regions may also generate high-mass stars. Kinematic association between this source and the Sagittarius Arm suggests that it may be located in a spur extending outward from this arm. Comparison with the known, nearby HMSFRs (distances less than 1 kpc), reveal that G352.630-1.067 is in a more isolated environment than others, hence providing an excellent candidate for investigations of the processes that form individual high-mass stars. We find a good spatial correlation between the 6.7 GHz methanol maser and high angular resolution images of the infrared outflow, suggesting that the class II methanol masers are closely associated with a jet/outflow in this source
Emergence of scale-free leadership structure in social recommender systems
The study of the organization of social networks is important for
understanding of opinion formation, rumor spreading, and the emergence of
trends and fashion. This paper reports empirical analysis of networks extracted
from four leading sites with social functionality (Delicious, Flickr, Twitter
and YouTube) and shows that they all display a scale-free leadership structure.
To reproduce this feature, we propose an adaptive network model driven by
social recommending. Artificial agent-based simulations of this model highlight
a "good get richer" mechanism where users with broad interests and good
judgments are likely to become popular leaders for the others. Simulations also
indicate that the studied social recommendation mechanism can gradually improve
the user experience by adapting to tastes of its users. Finally we outline
implications for real online resource-sharing systems
The influence of HLA genotype on the development of metal hypersensitivity following joint replacement
\ua9 2022, The Author(s). Background: Over five million joint replacements are performed across the world each year. Cobalt chrome (CoCr) components are used in most of these procedures. Some patients develop delayed-type hypersensitivity (DTH) responses to CoCr implants, resulting in tissue damage and revision surgery. DTH is unpredictable and genetic links have yet to be definitively established. Methods: At a single site, we carried out an initial investigation to identify HLA alleles associated with development of DTH following metal-on-metal hip arthroplasty. We then recruited patients from other centres to train and validate an algorithm incorporating patient age, gender, HLA genotype, and blood metal concentrations to predict the development of DTH. Accuracy of the modelling was assessed using performance metrics including time-dependent receiver operator curves. Results: Using next-generation sequencing, here we determine the HLA genotypes of 606 patients. 176 of these patients had experienced failure of their prostheses; the remaining 430 remain asymptomatic at a mean follow up of twelve years. We demonstrate that the development of DTH is associated with patient age, gender, the magnitude of metal exposure, and the presence of certain HLA class II alleles. We show that the predictive algorithm developed from this investigation performs to an accuracy suitable for clinical use, with weighted mean survival probability errors of 1.8% and 3.1% for pre-operative and post-operative models respectively. Conclusions: The development of DTH following joint replacement appears to be determined by the interaction between implant wear and a patient’s genotype. The algorithm described in this paper may improve implant selection and help direct patient surveillance following surgery. Further consideration should be given towards understanding patient-specific responses to different biomaterials
Gene expression and splicing alterations analyzed by high throughput RNA sequencing of chronic lymphocytic leukemia specimens.
BackgroundTo determine differentially expressed and spliced RNA transcripts in chronic lymphocytic leukemia specimens a high throughput RNA-sequencing (HTS RNA-seq) analysis was performed.MethodsTen CLL specimens and five normal peripheral blood CD19+ B cells were analyzed by HTS RNA-seq. The library preparation was performed with Illumina TrueSeq RNA kit and analyzed by Illumina HiSeq 2000 sequencing system.ResultsAn average of 48.5 million reads for B cells, and 50.6 million reads for CLL specimens were obtained with 10396 and 10448 assembled transcripts for normal B cells and primary CLL specimens respectively. With the Cuffdiff analysis, 2091 differentially expressed genes (DEG) between B cells and CLL specimens based on FPKM (fragments per kilobase of transcript per million reads and false discovery rate, FDR q < 0.05, fold change >2) were identified. Expression of selected DEGs (n = 32) with up regulated and down regulated expression in CLL from RNA-seq data were also analyzed by qRT-PCR in a test cohort of CLL specimens. Even though there was a variation in fold expression of DEG genes between RNA-seq and qRT-PCR; more than 90 % of analyzed genes were validated by qRT-PCR analysis. Analysis of RNA-seq data for splicing alterations in CLL and B cells was performed by Multivariate Analysis of Transcript Splicing (MATS analysis). Skipped exon was the most frequent splicing alteration in CLL specimens with 128 significant events (P-value <0.05, minimum inclusion level difference >0.1).ConclusionThe RNA-seq analysis of CLL specimens identifies novel DEG and alternatively spliced genes that are potential prognostic markers and therapeutic targets. High level of validation by qRT-PCR for a number of DEG genes supports the accuracy of this analysis. Global comparison of transcriptomes of B cells, IGVH non-mutated CLL (U-CLL) and mutated CLL specimens (M-CLL) with multidimensional scaling analysis was able to segregate CLL and B cell transcriptomes but the M-CLL and U-CLL transcriptomes were indistinguishable. The analysis of HTS RNA-seq data to identify alternative splicing events and other genetic abnormalities specific to CLL is an added advantage of RNA-seq that is not feasible with other genome wide analysis
Superconductivity above 30 K in alkali-metal-doped hydrocarbon
The recent discovery of superconductivity with a transition temperature (Tc) at 18 K in Kxpicene has extended the possibility of high-Tc superconductors in organic materials. Previous experience based on similar hydrocarbons, like alkali-metal doped phenanthrene, suggested that even higher transition temperatures might be achieved in alkali-metals or alkali-earth-metals doped such polycyclic-aromatic-hydrocarbons (PAHs), a large family of molecules composed of fused benzene rings. Here we report the discovery of high-Tc superconductivity at 33 K in K-doped 1,2:8,9-dibenzopentacene (C30H18). To our best knowledge, it is higher than any Tc reported previously for an organic superconductor under ambient pressure. This finding provides an indication that superconductivity at much higher temperature may be possible in such PAHs system and is worthy of further exploration
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