Long-term, low-dose lead exposure alters the gonadotropin-releasing hormone system in the male rat.

Lead is a male reproductive toxicant. Data suggest that rats dosed with relatively high levels of lead acetate for short periods of time induced changes in the hypothalamic gonadotropin-releasing hormone (GnRH) at the molecular level, but these changes were attenuated with increased concentration of exposure. The current study evaluated whether exposure to low levels of lead acetate over longer periods of time would produce a similar pattern of adaptation to toxicity at the molecular and biologic levels. Adult 100-day-old Sprague-Dawley male rats were dosed with 0, 0.025, 0.05, 0.1, and 0.3% lead acetate in water. Animals were killed after 1, 4, 8, and 16 weeks of treatment. Luteinzing hormone (LH) and GnRH levels were measured in serum, and lead levels were quantified in whole blood. Hypothalamic GnRH mRNA levels were also quantified. We found no significant differences in serum LH and GnRH among the groups of animals treated within each time period. A significant dose-related increase of GnRH mRNA concentrations with lead dosing occurred in animals treated for 1 week. Animals treated for more than 1 week also exhibited a significant increase in GnRH mRNA, but with an attenuation of the increase at the higher concentrations of lead with increased duration of exposure. We conclude that the signals within and between the hypothalamus and pituitary gland appear to be disrupted by long-term, low-dose lead exposure

Arbitrary Q-factor Dielectric Resonator

New circuit component, active resonator, is proposed for use in microwave and millimetrewave circuits. It consists of a common resonator and an amplifier, compensating for losses in the resonator. Properly designed, such an arrangement behaves as a (passive) resonator with dramatically increased quality factor. High quality factors can be achieved even at millimetrewave frequencies, where common resonators suffer from losses due to small skin depths. Viability of the component is experimentally verified at microwave region using a TE01 dielectric resonator and an oscillator

Connections of Trapezoidal Sheets under Fire

This paper describes two different experiments on connections of trapezoidal sheets under elevated temperatures. The first experiments were tensile tests carried out on four sets of tests with screwed connections under ambient and elevated temperatures. One diameter of self-drilling screws and three different thicknesses of trapezoidal sheets were used. The applied screws were without washers, or with sealed or steel washers. The second experiment was performed in a laboratory furnace to check the catenary action of a thin-walled trapezoidal sheet. The basic theory tested in this experiment was that in the first phase of the fire the sheet behaves as a simply supported beam, while in the second phase the load bearing is transferred by a tension membrane. These experiments will be used to develop a design model of connections at high temperatures. High fire resistance of the trapezoidal sheet, dependent on suitable design of the screwed connection to the bearing structure, was confirmed. The experiment with the simple beam also confirmed catenary action.

An Information Extraction Approach to Reorganizing and Summarizing Specifications

Materials and Process Specifications are complex semi-structured documents containing numeric data, text, and images. This article describes a coarse-grain extraction technique to automatically reorganize and summarize spec content. Specifically, a strategy for semantic-markup, to capture content within a semantic ontology, relevant to semi-automatic extraction, has been developed and experimented with. The working prototypes were built in the context of Cohesia\u27s existing software infrastructure, and use techniques from Information Extraction, XML technology, etc

International Advisees\u27 Perspectives on the Advising Relationship in Counseling Psychology Doctoral Programs

Ten international students in U.S.-based counseling psychology doctoral programs were interviewed regarding their experiences as doctoral students, especially their advising relationship. Data were analyzed using consensual qualitative research (CQR). Participants reported more challenges than benefits of being international students, and more often described their doctoral programs as not culturally receptive than receptive to international students. Despite this assessment of the overall doctoral program, they described their own advising relationships as predominantly positive. Many international students discussed with their advisor their difficulties adjusting to a new environment and being away from home, and identified unique personal and professional needs as international students. Participants recommended that international students openly communicate with and seek a good relationship with their advisors, and also recommended that advisors of international students seek to understand and attend to international students\u27 culture and the challenges of being an international student. Implications for training and research are addressed

Extreme Peripheral Blood Plasmacytosis Mimicking Plasma Cell Leukemia as a Presenting Feature of Angioimmunoblastic T-Cell Lymphoma (AITL).

Angioimmunoblastic T-cell lymphoma (AITL) is one of four major subtypes of nodal peripheral T cell lymphoma, characterized by its cell of origin, the follicular helper T-cell (TFH). Patients typically present with prominent constitutional (B) symptoms, generalized lymphadenopathy, hepatosplenomegaly, cytopenias, and rash. Here we present a case of a 62-year-old male with progressive cervical adenopathy, fevers and weight loss presenting with extreme polyclonal plasmacytosis and high plasma EBV viral load. While the initial presentation appeared to mimic plasma cell leukemia or severe infection, lymph node biopsy and bone marrow biopsy confirmed a diagnosis of AITL. This case highlights the heterogeneity of the clinical presentation of AITL to enable physicians to more promptly recognize, diagnose and initiate treatment

Inequalities of harmonic univalent functions with connections of hypergeometric functions

Let SH be the class of functions f = h + (g) over bar that are harmonic univalent and sense-preserving in the open unit disk U = {z : vertical bar z vertical bar < 1} for which f(0) = f'(0) - 1 = 0. In this paper, we introduce and study a subclass H(alpha, beta)of the class SH and the subclass NH(alpha, beta) with negative coefficients. We obtain basic results involving sufficient coefficient conditions for a function in the subclass H(alpha, beta) and we show that these conditions are also necessary for negative coefficients, distortion bounds, extreme points, convolution and convex combinations. In this paper an attempt has also been made to discuss some results that uncover some of the connections of hypergeometric functions with a subclass of harmonic univalent functions

Structure-activity relationships of hierarchical three-dimensional electrodes with photosystem II for semi-artifcial photosynthesis

Semi-artificial photosynthesis integrates photosynthetic enzymes with artificial electronics, which is an emerging approach to reroute the natural photoelectrogenetic pathways for sustainable fuel and chemical synthesis. However, the reduced catalytic activity of enzymes in bioelectrodes limits the overall performance and further applications in fuel production. Here, we show new insights into factors that govern the photoelectrogenesis in a model system consisting of photosystem II and three-dimensional indium tin oxide and graphene electrodes. Fluorescence microscopy and in situ surface-sensitive infrared spectroscopy are employed to probe the enzyme distribution and penetration within electrode scaffolds of different structures, which is further correlated with protein film-photoelectrochemistry to establish relationships between the electrode structure and enzyme activity. We find that the hierarchical 1 structure of electrodes mainly affects the protein integration, but not the enzyme activity. Photoactivity is more limited by light intensity and electronic communication at the biointerface. This study provides guidelines for maximizing the performance of semi-artificial photosynthesis and also presents a set of methodologies to probe the photoactive biofilms in three-dimensional electrodes.CSC-Cambridge PhD Scholarship, EPSRC PhD studentship, Newton-Mosharafa Research Fellowship, ERC Consolidator Grant 'MatEnSAP

Overcoming the compensation of acceptors in GaN:Mg by defect complex formation

In GaN:Mg, the MgGa acceptor is compensated extensively by the formation of nitrogen vacancies (VN) and Mg interstitials (Mgi). However, we show that such compensation can be overcome by forming two kinds of Mg-rich complexes: one that contains VN and the other that contains only MgGa and Mgi. Such complexing not only neutralizes VN and Mgi but also forms better complex acceptors that have lower formation energies and smaller hole localization energies than isolated MgGa. Our results help explain the different doping behaviors in samples grown by different methods