Terror threat perception and its consequences in contemporary Britain

The terrorist attacks of 9/11, and subsequent terrorist acts around the world, have alerted social psychologists to the need to examine the antecedents and consequences of terrorist threat perception. In these two studies we examined the predictive power of demographic factors (age, sex, location), individual values and normative influences on threat perception and the consequences of this perception for behavioural change and close relationships. In study 1 (N = 100) gender, benevolence values and normative influences were all correlates of threat perception, whilst sense of personal threat was correlated with increased contact with friends and family. In study 2 (N = 240) age, sex, location, and the values of Openness to Change and Hedonism, all predicted threat perception, which in turn predicted behavioural change and relationship contact. Such findings point to the important role social psychologists should play in understanding responses to these new terrorist threats

Exact Symmetries realized on the Renormalized Group Flow

We show that symmetries are preserved exactly along the (Wilsonian) renormalization group flow, though the IR cutoff deforms concrete forms of the transformations. For a gauge theory the cutoff dependent Ward-Takahashi identity is written as the master equation in the antifield formalism: one may read off the renormalized BRS transformation from the master equation. The Maxwell theory is studied explicitly to see how it works. The renormalized BRS transformation becomes non-local but keeps off-shell nilpotency. Our formalism is applicable for a generic global symmetry. The master equation considered for the chiral symmetry provides us with the continuum analog of the Ginsparg-Wilson relation and the L{\" u}scher's symmetry.Comment: Latex, 10 page

Realization of Global Symmetries in the Wilsonian Renormalization Group

We present a method to solve the master equation for the Wilsonian action in the antifield formalism. This is based on a representation theory for cutoff dependent global symmetries along the Wilsonian renormalization group (RG) flow. For the chiral symmetry, the master equation for the free theory yields a continuum version of the Ginsparg-Wilson relation. We construct chiral invariant operators describing fermionic self-interactions. The use of canonically transformed variables is shown to simplify the underlying algebraic structure of the symmetry. We also give another non-trivial example, a realization of SU(2) vector symmetry. Our formalism may be used for a non-perturbative truncation of the Wilsonian action preserving global symmetries.Comment: 11 page

Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults.

Neutrophils and monocytes are key components of the innate immune system that undergo age-associated declines in function. This study compared the impact of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on immune function in sedentary adults. Twenty-seven (43 ± 11 years) healthy sedentary adults were randomized into ten weeks of either a HIIT (>90% maximum heart rate) or MICT (70% maximum heart rate) group training program. Aerobic capacity (VO2peak), neutrophil and monocyte bacterial phagocytosis and oxidative burst, cell surface receptor expression, and systemic inflammation were measured before and after the training. Total exercise time commitment was 57% less for HIIT compared to that for MICT while both significantly improved VO2peak similarly. Neutrophil phagocytosis and oxidative burst and monocyte phagocytosis and percentage of monocytes producing an oxidative burst were improved by training similarly in both groups. Expression of monocyte but not neutrophil CD16, TLR2, and TLR4 was reduced by training similarly in both groups. No differences in systemic inflammation were observed for training; however, leptin was reduced in the MICT group only. With similar immune-enhancing effects for HIIT compared to those for MICT at 50% of the time commitment, our results support HIIT as a time efficient exercise option to improve neutrophil and monocyte function

Peptide-directed co-assembly of nanoprobes on multimaterial patterned solid surfaces

This is the published version. Copyright 2012 Royal Society of ChemistryBiocombinatorially selected solid-binding peptides, through their unique material affinity and selectivity, are a promising platform for building up complex hierarchical assemblies of nanoscale materials and molecular probes, targeted to specific practical solid surfaces. Here, we demonstrate the material-specific characteristics of engineered gold-binding and silica-binding peptides through co-assembly onto micro- and nano-patterned gold surfaces on silica substrates. To build hierarchical nanostructures on patterned solid surfaces, we utilize peptides as molecular tools and monitor their behavior by either conjugating biotin to them for specific affinity to streptavidin-coated QDot nanoparticles or labelling them with small fluorescent labels. This biomimetic peptide-based approach could be used as an alternative to conventional chemical coupling and surface functionalization techniques with substantial advantages, allowing simultaneous assembly of two or more inorganic nano-entities and/or molecular probes onto patterned inorganic solid substrates. The results have significant implications in a wide range of potential applications, including controlled assembly of hybrid nanostructures in bionanophotonic and biosensing devices

Classification of crystallization outcomes using deep convolutional neural networks

The Machine Recognition of Crystallization Outcomes (MARCO) initiative has assembled roughly half a million annotated images of macromolecular crystallization experiments from various sources and setups. Here, state-of-the-art machine learning algorithms are trained and tested on different parts of this data set. We find that more than 94% of the test images can be correctly labeled, irrespective of their experimental origin. Because crystal recognition is key to high-density screening and the systematic analysis of crystallization experiments, this approach opens the door to both industrial and fundamental research applications

Extended Knowledge-How

According to reductive intellectualists about knowledge-how :147–190, 2008; Philos Phenomenol Res 78:439–467, 2009) knowledge-how is a kind of knowledge-that. To the extent that this is right, then insofar as we might conceive of ways knowledge could be extended with reference to active externalist :7–19, 1998; Clark in Supersizing the mind: embodiment, action, and cognitive extension: embodiment, action, and cognitive extension. Oxford University Press, Oxford, 2008) approaches in the philosophy of mind, we should expect no interesting difference between the two. However, insofar as anti-intellectualist approaches to knowledge-how are a viable option, there is an overlooked issue of how knowledge-how might be extended, via active externalism, in ways very differently from knowledge-that. This paper explores this overlooked space, and in doing so, illustrates how a novel form of extended knowledge-how emerges from a pairing of active externalism in the philosophy of mind with anti-intellectualism in the theory of knowledge. Crucial to our argument will be a new way of thinking about the extended mind thesis, as it pertains to the kinds of state one is in when one knows how to do something, and how this state connects with non-accidentally successful performanc

Fatal Necrotizing Fasciitis Due to Streptococcus pneumoniae: A Case Report

Necrotizing fasciitis is known to be a highly lethal infection of deep-seated subcutaneous tissue and superficial fascia. Reports of necrotizing fasciitis due to Streptococcus pneumoniae are exceedingly rare. We report a case of necrotizing fasciitis in a 62-yr-old man with liver cirrhosis and diabetes mellitus. He presented with painful swelling of left leg and right hand. On the day of admission, compartment syndrome was aggravated and the patient underwent surgical exploration. Intra-operative findings revealed necrotizing fasciitis and cultures of two blood samples and wound aspirates showed S. pneumoniae. The patient died despite debridement and proper antimicrobial treatment. To the best of our knowledge, this is the first case of fatal necrotizing fasciitis with meningitis reported in Korea. We also review and discuss the literature on pneumococcal necrotizing fasciitis

Imaging Findings of Central Nervous System Vasculitis Associated with Goodpasture's Syndrome: a Case Report

Glomerulonephritis and pulmonary hemorrhage are features of Goodpasture's syndrome. Goodpasture's syndrome accompanied with central nervous system (CNS) vasculitis is extremely rare. Herein, we report a rare case of CNS vasculitis associated with Goodpasture's syndrome in a 34-year-old man, who presented with a seizure and sudden onset of right sided weakness. He also had recurrent hemoptysis of one month's duration. Goodpasture's syndrome is histologically diagnosed by intense linear deposits of IgG along the glomerular basement membrane in both renal and lung tissues