317 research outputs found
Effect of an Alcohol-Based Caries Detector on the Surface Tension of Sodium Hypochlorite Preparations
Search for supersymmetric particles in scenarios with a gravitino LSP and stau NLSP
Sleptons, neutralinos and charginos were searched for in the context of
scenarios where the lightest supersymmetric particle is the gravitino. It was
assumed that the stau is the next-to-lightest supersymmetric particle. Data
collected with the DELPHI detector at a centre-of-mass energy near 189 GeV were
analysed combining the methods developed in previous searches at lower
energies. No evidence for the production of these supersymmetric particles was
found. Hence, limits were derived at 95% confidence level.Comment: 31 pages, 14 figure
KONTAKT© for Australian adolescents on the autism spectrum: protocol of a randomized control trial
Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible?
Although the plant and animal kingdoms were separated more than 1,6 billion years ago, multicellular development is for both guided by similar transcriptional, epigenetic and posttranscriptional machinery. One may ask to what extent there are similarities and differences in the gene regulation circuits and their dynamics when it comes to important processes like stem cell regulation. The key players in mouse embryonic stem cells governing pluripotency versus differentiation are Oct4, Sox2 and Nanog. Correspondingly, the WUSCHEL and CLAVATA3 genes represent a core in the Shoot Apical Meristem regulation for plants. In addition, both systems have designated genes that turn on differentiation. There is very little molecular homology between mammals and plants for these core regulators. Here, we focus on functional homologies by performing a comparison between the circuitry connecting these players in plants and animals and find striking similarities, suggesting that comparable regulatory logics have been evolved for stem cell regulation in both kingdoms. From in silico simulations we find similar differentiation dynamics. Further when in the differentiated state, the cells are capable of regaining the stem cell state. We find that the propensity for this is higher for plants as compared to mammalians. Our investigation suggests that, despite similarity in core regulatory networks, the dynamics of these can contribute to plant cells being more plastic than mammalian cells, i.e. capable to reorganize from single differentiated cells to whole plants-reprogramming. The presence of an incoherent feed-forward loop in the mammalian core circuitry could be the origin of the different reprogramming behaviour.This work was supported Swedish Research Council, grant VR 621-2013-4547 to CP; the Swedish Foundation for Strategic Research, grant A3 04 159p to CP; the Gatsby Charitable Foundation (GB), grant GAT3395-PR4 to HJ and the Swedish Research Council, grant VR 621- 2013-4632 to HJ
New Methodology for the Identification of the Leakage Paths and Guidelines for the Design of Common Rail Injectors With Reduced Leakage
The Issue of Identity in Children Without Identity Card: a Grounded Theory Study from Tehran, Iran
Azzrbaycan Respublikasinin Yeyinti SSnayesinin TTkmilllldirmm stiqammtllri (Improvement Directions of Food Industry of the Republic of Azerbaijan)
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