An ALMA survey of the SCUBA-2 Cosmology Legacy Survey UKIDSS/UDS field: halo masses for submillimetre galaxies

We present an analysis of the spatial clustering of a large sample of high-resolution, interferometically identified, submillimetre galaxies (SMGs). We measure the projected cross-correlation function of ∼350 SMGs in the UKIDSS Ultra Deep-Survey Field across a redshift range of z = 1.5–3 utilizing a method that incorporates the uncertainties in the redshift measurements for both the SMGs and cross-correlated galaxies through sampling their full probability distribution functions. By measuring the absolute linear bias of the SMGs, we derive halo masses of log10(Mhalo[h−1M⊙]) ∼ 12.8 with no evidence of evolution in the halo masses with redshift, contrary to some previous work. From considering models of halo mass growth rates, we predict that the SMGs will reside in haloes of mass log10(Mhalo[h−1M⊙]) ∼ 13.2 at z = 0, consistent with the expectation that the majority of z = 1.5–3 SMGs will evolve into present-day spheroidal galaxies. Finally, comparing to models of stellar-to-halo mass ratios, we show that SMGs may correspond to systems that are maximally efficient at converting their gas reservoirs into stars. We compare them to a simple model for gas cooling in haloes that suggests that the unique properties of the SMG population, including their high levels of star formation and their redshift distribution, are a result of the SMGs being the most massive galaxies that are still able to accrete cool gas from their surrounding intragalactic medium

An ALMA/NOEMA survey of the molecular gas properties of high-redshift star-forming galaxies

We have used ALMA and NOEMA to study the molecular gas reservoirs in 61 ALMA-identified submillimetre galaxies (SMGs) in the COSMOS, UDS, and ECDFS fields. We detect 12CO (⁠Jup= 2–5) emission lines in 50 sources, and [C I](3P1 − 3P0) emission in eight, at z= 1.2–4.8 and with a median redshift of 2.9 ± 0.2. By supplementing our data with literature sources, we construct a statistical CO spectral line energy distribution and find that the 12CO line luminosities in SMGs peak at Jup ∼ 6, consistent with similar studies. We also test the correlations of the CO, [C I], and dust as tracers of the gas mass, finding the three to correlate well, although the CO and dust mass as estimated from the 3-mm continuum are preferable. We estimate that SMGs lie mostly on or just above the star-forming main sequence, with a median gas depletion timescale, tdep = Mgas/SFR, of 210 ± 40 Myr for our sample. Additionally, tdep declines with redshift across z ∼ 1–5, while the molecular gas fraction, μgas = Mgas/M*, increases across the same redshift range. Finally, we demonstrate that the distribution of total baryonic mass and dynamical line width, Mbaryon–σ, for our SMGs is consistent with that followed by early-type galaxies in the Coma cluster, providing strong support to the suggestion that SMGs are progenitors of massive local spheroidal galaxies. On the basis of this, we suggest that the SMG populations above and below an 870-μm flux limit of S870 ∼ 5 mJy may correspond to the division between slow and fast rotators seen in local early-type galaxies

Comparative maturation of cynomolgus monkey oocytes in vivo and in vitro

BACKGROUND: In vitro maturation (IVM) of oocytes followed by fertilization in vitro (IVF) and embryo transfer offers an alternative to conventional IVF treatment that minimises drug administration and avoids ovarian hyperstimulation. However, the technique is less efficient than maturation in vivo. In the present study, a non-human primate model was used to address the hypothesis that the number of oocytes is increased and their nuclear and cytoplasmic maturity after IVM are improved when maturation is initiated in vivo by priming with hCG. METHODS: Young, adult cynomolgus monkeys were given recombinant human (rh) gonadotropins to stimulate the development of multiple follicles, and oocytes were aspirated 0, 12, 24, or 36 h after injection of an ovulatory dose of rhCG. The nuclear status of oocytes was determined at the time of recovery and after culture for a total elapsed time of 40–44 hours after hCG. RESULTS: Priming with hCG significantly increased the number of oocytes harvested, especially after delaying aspiration for 24 h or longer. Nuclear maturation after the full period in culture was also enhanced by priming: 71.5, 83.6, and 94.6% of oocytes collected at 0, 12, and 24 h hCG had progressed to MII by the end of the culture period, compared to 87.8% of oocytes that were retrieved at 36 h. A large proportion of oocytes reaching the MII stage had either or both abnormal spindles (>40%) and misaligned chromosomes (>60%), judging by immunofluorescence microscopy, but these abnormalities were independent of culture time. The mitochondria were evenly distributed throughout the cytoplasm at all stages of maturation. Importantly, there was no microscopic evidence that the duration of culture had any injurious effects on the cells. CONCLUSION: In conclusion, the evidence supports this non-human primate as a model for human IVM and the practice of priming with hCG to promote developmental potential

Lessons Learnt From the 2009 Padang Indonesia, 2011 Tōhoku Japan and 2016 Muisne Ecuador Earthquakes

This paper presents the observations during the UK Earthquake Engineering Field Investigation Team (EEFIT)'s post-earthquake reconnaissance missions to the September 20, 2009 Padang (Mw7.6), March 11, 2011 Tōhoku (Mw9.0) and April 16, 2016 Muisne (Mw7.8) earthquakes. The performance of buildings and geotechnical structures within the affected regions were investigated to gain insights on their design and construction deficiencies. Findings on these damages observed are compared along with the characteristics of the earthquake and nature of building codes in these countries. They include building damages attributed to a combination of structural resonance, deficiencies in reinforcement detailing, vulnerability to soft story collapse, ground settlement, soil liquefaction, and landslides. It was demonstrated that buildings which were severely damaged had natural building frequencies coinciding with the dominant frequencies of the ground shaking. The locations of damage of several such buildings showed insufficient confining reinforcements and lapping of stirrup links. Soft story collapses were also observed in the three earthquakes, although many were attributed to old building codes that were less effective. In areas affected by the Muisne earthquake, soft story collapses were mainly found at mid height of the building rather than at the ground floor as observed in the Padang and Tōhoku earthquakes, likely due to extension of building long after the bottom floors were completed. Such extension of building can either lead to local reduction in capacity due to weaker concrete-rebar bonding, possibly insufficient lapping of reinforcement, as well as increased axial loads. In the aspect of geotechnical failure, foundations of buildings found on piles performed reasonably well, except for areas affected by soil liquefaction. Landslides occurred following these earthquakes led to large concentration of casualties and property losses, motivating the EEFIT teams to invest efforts in hazard mapping and ground-truthing exercises using satellite images at Padang and Muisne earthquakes respectively. Such geospatial tools applied in these three earthquakes were reviewed and demonstrated to be capable of identifying landslide sites and producing reliable landslide hazard map

Identification of Potent EGFR Inhibitors from TCM Database@Taiwan

Overexpression of epidermal growth factor receptor (EGFR) has been associated with cancer. Targeted inhibition of the EGFR pathway has been shown to limit proliferation of cancerous cells. Hence, we employed Traditional Chinese Medicine Database (TCM Database@Taiwan) (http://tcm.cmu.edu.tw) to identify potential EGFR inhibitor. Multiple Linear Regression (MLR), Support Vector Machine (SVM), Comparative Molecular Field Analysis (CoMFA), and Comparative Molecular Similarities Indices Analysis (CoMSIA) models were generated using a training set of EGFR ligands of known inhibitory activities. The top four TCM candidates based on DockScore were 2-O-caffeoyl tartaric acid, Emitine, Rosmaricine, and 2-O-feruloyl tartaric acid, and all had higher binding affinities than the control Iressa®. The TCM candidates had interactions with Asp855, Lys716, and Lys728, all which are residues of the protein kinase binding site. Validated MLR (r² = 0.7858) and SVM (r² = 0.8754) models predicted good bioactivity for the TCM candidates. In addition, the TCM candidates contoured well to the 3D-Quantitative Structure-Activity Relationship (3D-QSAR) map derived from the CoMFA (q² = 0.721, r² = 0.986) and CoMSIA (q² = 0.662, r² = 0.988) models. The steric field, hydrophobic field, and H-bond of the 3D-QSAR map were well matched by each TCM candidate. Molecular docking indicated that all TCM candidates formed H-bonds within the EGFR protein kinase domain. Based on the different structures, H-bonds were formed at either Asp855 or Lys716/Lys728. The compounds remained stable throughout molecular dynamics (MD) simulation. Based on the results of this study, 2-O-caffeoyl tartaric acid, Emitine, Rosmaricine, and 2-O-feruloyl tartaric acid are suggested to be potential EGFR inhibitors.National Science Council of Taiwan (NSC 99-2221-E-039-013-)Committee on Chinese Medicine and Pharmacy (CCMP100-RD-030)China Medical University (CMU98-TCM)China Medical University (CMU99-TCM)China Medical University (CMU99-S-02)China Medical University (CMU99-ASIA-25)China Medical University (CMU99-ASIA-26)China Medical University (CMU99-ASIA-27)China Medical University (CMU99-ASIA-28)Asia UniversityTaiwan Department of Health. Clinical Trial and Research Center of Excellence (DOH100-TD-B-111-004)Taiwan Department of Health. Cancer Research Center of Excellence (DOH100-TD-C-111-005

Post Earthquake Field Investigation of the Mw 7.6 Padang Earthquake of 30th September 2009

The UK based Earthquake Engineering Field Investigation Team (EEFIT) conducted a reconnaissance mission to the Padang region of Sumatra in Indonesia, to study the effects of the Mw 7.6 earthquake that occurred on 30th September 2009. The purpose of this mission was to gain insight into how buildings and infrastructure performed during this earthquake and the consequent effects on the local community. As part of the mission, the feasibility of using remote sensing technologies to determine the vulnerability of landslides was assessed. The results of this mission are presented in this paper

The submillimetre view of massive clusters at z ∼ 0.8–1.6

We analyse 850 μm continuum observations of eight massive X-ray detected galaxy clusters at z ∼ 0.8–1.6 taken with SCUBA-2 on the James Clerk Maxwell Telescope. We find an average overdensity of 850 μm-selected sources of a factor of 4 ± 2 per cluster within the central 1 Mpc compared to the field. We investigate the multiwavelength properties of these sources and identify 34 infrared counterparts to 26 SCUBA-2 sources. Their colours suggest that the majority of these counterparts are probable cluster members. We use the multi-wavelength far-infrared photometry to measure the total luminosities and total cluster star-formation rates demonstrating that they are roughly three orders of magnitude higher than local clusters. We predict the H-band luminosities of the descendants of our cluster submillimetre galaxies and find that their stellar luminosity distribution is consistent with that of passive elliptical galaxies in z ∼ 0 clusters. Together, the faded descendants of the passive cluster population already in place at z ∼ 1 and the cluster submillimetre galaxies are able to account for the total luminosity function of early-type cluster galaxies at z ∼ 0. This suggests that the majority of the luminous passive population in z ∼ 0 clusters are likely to have formed at z ≫ 1 through an extreme, dust-obscured starburst event