Evidence for early life in Earth’s oldest hydrothermal vent precipitates

Although it is not known when or where life on Earth began, some of the earliest habitable environments may have been submarine-hydrothermal vents. Here we describe putative fossilized microorganisms that are at least 3,770 million and possibly 4,280 million years old in ferruginous sedimentary rocks, interpreted as seafloor-hydrothermal vent-related precipitates, from the Nuvvuagittuq belt in Quebec, Canada. These structures occur as micrometre-scale haematite tubes and filaments with morphologies and mineral assemblages similar to those of filamentous microorganisms from modern hydrothermal vent precipitates and analogous microfossils in younger rocks. The Nuvvuagittuq rocks contain isotopically light carbon in carbonate and carbonaceous material, which occurs as graphitic inclusions in diagenetic carbonate rosettes, apatite blades intergrown among carbonate rosettes and magnetite–haematite granules, and is associated with carbonate in direct contact with the putative microfossils. Collectively, these observations are consistent with an oxidized biomass and provide evidence for biological activity in submarine-hydrothermal environments more than 3,770 million years ago

Neuromuscular Factors Related to Hamstring Muscle Function, Performance and Injury

Hamstring function is influenced by a number of neural, architectural and morphological factors, and the adaptability of these characteristics has important implications for optimizing performance and reducing injury risk. High rates of maximal or near-maximal hamstring force development are required to generate peak horizontal velocities during running, and this is largely determined by the extent to which these muscles can be voluntarily activated. Greater eccentric hamstring strength also correlates with better acceleration capacity and likely improves the ability to decelerate the lower limb during the presumably injurious terminal swing phase of high-speed running. The intra- and intermuscular coordination of the hamstrings appears to influence both hamstring muscle fatiguability and the risk of muscle strain injury. Muscle volume and architectural features such as fascicle length and pennation angle also influence hamstring function, and these vary considerably between hamstring muscles, between individuals and with training status. The adaptability of these features has been explored to a significant extent in recent times, and careful exercise selection allows selective targeting of individual hamstring muscles or muscle segments and this appears to influence the pattern of chronic adaptations such as muscle hypertrophy. Short fascicles within the often-injured long head of biceps femoris may predispose athletes to strain injury but these appear to respond in a contraction-mode-specific manner; lengthening after eccentric training and shortening after concentric training of 4 or more weeks. Conventional training with eccentric and concentric phases in each repetition can also lengthen fascicles, possibly in an excursion (muscle length)-dependent manner. A large biceps femoris muscle to proximal aponeurosis width ratio has been proposed as a potential risk factor for hamstring strain injury, although this is only supported by biomechanical modelling at the time of writing. High levels of anterior pelvic tilt and lateral trunk flexion during sprint running may also predispose athletes to hamstring strain injury, although the quantity of evidence for this is small at the moment. At present, the optimal methods for altering coordination and running technique are not known

Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe

We report the construction and analysis of 4,836 heterozygous diploid deletion mutants covering 98.4% of the fission yeast genome providing a tool for studying eukaryotic biology. Comprehensive gene dispensability comparisons with budding yeast-the only other eukaryote for which a comprehensive knockout library exists-revealed that 83% of single-copy orthologs in the two yeasts had conserved dispensability. Gene dispensability differed for certain pathways between the two yeasts, including mitochondrial translation and cell cycle checkpoint control. We show that fission yeast has more essential genes than budding yeast and that essential genes are more likely than nonessential genes to be present in a single copy, to be broadly conserved and to contain introns. Growth fitness analyses determined sets of haploinsufficient and haploproficient genes for fission yeast, and comparisons with budding yeast identified specific ribosomal proteins and RNA polymerase subunits, which may act more generally to regulate eukaryotic cell growth.11351326sciescopu

What Doesn't Kill you: Early Life Health and Nutrition in Anglo-Saxon East Anglia

YesEarly life is associated with high vulnerability to morbidity and mortality - risks which can be reduced in infancy and early childhood through strategically high levels of parental or alloparental investment, particularly in the case of maternal breastfeeding. Recent evidence has supported links between early-life health and care patterns and long-term population health. This growing body of research regarding the broader impacts of infant-parent interactions transcends a traditional partitioning of research into discrete life stages. It also highlights implications of childhood data for our understanding of population health and behaviour. Skeletal and environmental data indicate that the 5-7th century cemeteries at Littleport and Edix Hill (Barrington A), Cambridgeshire represent populations of similar material culture but contrasting environments and health. The high prevalence of skeletal stress markers at Littleport indicates a community coping with unusual levels of biological stress, potentially a consequence of endemic malaria present in the marshy Fen environs. In contrast, Edix Hill was an inland site which exhibited lower skeletal stress marker prevalence comparable to wider British data for the early medieval period. Early life patterns relating to diet and physiological stress at Littleport (n=5) and Edix Hill (n=8) were investigated through analyses of carbon and nitrogen stable isotopes from incrementally-sampled deciduous dentine. Meaningful variation in isotopic values within and between populations was observed, and should be a focus of future interdisciplinary archaeological childhood studies.The Society for the Study of Human Biology, the Durham University Institute of Medieval and Early Modern Studies, and by the Rosemary Cramp Fund

Optimising Hamstring Strength and Function for Performance After Hamstring Injury

Hamstring strain injury often results in neuromuscular performance deficits that persist beyond rehabilitation and the return to full training and competitive sport. It seems appropriate to address these deficits as a part of a sport-specific training program which primarily aims to enhance performance. Prolonged deficits in horizontal ground reaction forces in sprinting, repeat sprint performance, knee flexor eccentric strength and biceps femoris long head fascicle lengths have been observed in multiple studies of hamstring strain injury. Why such deficits persist beyond the return to sport is not known, although persistent neuromuscular inhibition of the injured muscles has been proposed. There is limited and mixed evidence for sprint running kinematic (technique) differences between previously injured and uninjured limbs or athletes, although more work in this area seems warranted. While there is some uncertainty about the optimal mix of methods for addressing the aforementioned deficits, sport-specific running programs in conjunction with continued monitoring of acceleration phase sprint performance and repeated sprint ability seem appropriate. Heavy strength training with at least some eccentrically biased exercises is also recommended to address deficits in eccentric strength and muscle fascicle lengths