520 research outputs found
Including diverse knowledges and worldviews in environmental assessment and planning: the Brazilian Amazon Kaxinawá Nova Olinda Indigenous Land case.
The concepts of 'ecosystem services' (ES) and 'nature's contributions to people' (NCP) inform environmental frameworks that set out to include Indigenous and Local Knowledge systems (ILK) and worldviews in policy and planning processes. These frameworks aim to enhance biodiversity conservation and human well-being in a legitimate and effective way. In this article, we explore how the concept of People's Contributions to Nature (PCN) is complementary to NCP. We use it to investigate challenges that planners and locals face in realizing the legitimate inclusion of diverse knowledges and worldviwes that account for people and ecosystems in a relational way. We introduce a case study where planners drew on ES and NCP and used participatory methods to implement a REDD+ policy in the Kaxinawá Nova Olinda Indigenous Land (Acre-Brazil). We find that both Kaxinawás and planners emphasize both NCP and PCN in their discourses. Nevertheless, differences between knowledge systems and disciplines, uneven power relations between Kaxinawás and planners, and an underconsideration of PCN by global frameworks challenge the legitimate inclusion of the Kaxinawá knowlege and worldviews to craft assessment and planning. We conclude that by explicitly addressing these challenges, science-policy interfaces can further advance knowledge legitimacy and policy effectiveness
Hydrodynamic limit for a boundary driven stochastic lattice gas model with many conserved quantities
We prove the hydrodynamic limit for a particle system in which particles may
have different velocities. We assume that we have two infinite reservoirs of
particles at the boundary: this is the so-called boundary driven process. The
dynamics we considered consists of a weakly asymmetric simple exclusion process
with collision among particles having different velocities
Hidden geometric correlations in real multiplex networks
Real networks often form interacting parts of larger and more complex
systems. Examples can be found in different domains, ranging from the Internet
to structural and functional brain networks. Here, we show that these multiplex
systems are not random combinations of single network layers. Instead, they are
organized in specific ways dictated by hidden geometric correlations between
the individual layers. We find that these correlations are strong in different
real multiplexes, and form a key framework for answering many important
questions. Specifically, we show that these geometric correlations facilitate:
(i) the definition and detection of multidimensional communities, which are
sets of nodes that are simultaneously similar in multiple layers; (ii) accurate
trans-layer link prediction, where connections in one layer can be predicted by
observing the hidden geometric space of another layer; and (iii) efficient
targeted navigation in the multilayer system using only local knowledge, which
outperforms navigation in the single layers only if the geometric correlations
are sufficiently strong. Our findings uncover fundamental organizing principles
behind real multiplexes and can have important applications in diverse domains.Comment: Supplementary Materials available at
http://www.nature.com/nphys/journal/v12/n11/extref/nphys3812-s1.pd
Chemical characterization, cytotoxic evaluation and anti-SARS-CoV2 activity of plant extracts rich in hydrolysable tannins
info:eu-repo/semantics/publishedVersio
Implicações geomorfológicas e paleogeográficas das crostas fosfáticas do Arquipélago de São Pedro e São Paulo, Atlântico Norte
Host-defense peptides AC12, DK16 and RC11 with immunomodulatory activity isolated from Hypsiboas raniceps skin secretion
Inflammation is a natural defense mechanism of the immune system; however, when unregulated, it can lead to chronic illness. Glucocorticoids are the most commonly used agents to effectively treat inflammatory conditions, including autoimmune diseases, however these substances can trigger a number of side effects. Thus, viable alternatives to the use of these drugs would be advantageous. In this study, we have analyzed the anti-inflammatory profile of three synthetic peptides first identified in skin secretion of the tree frog Hypsiboas raniceps. Structural characterization was performed using NMR spectroscopy and Mass Spectrometry, and the peptides were tested in vitro in RAW 264.7 cells and in vivo in Balb/c mice for their functional properties. The samples did not show a significant antimicrobial profile. NMR spectroscopy indicated that AC12 (ACFLTRLGTYVC) has a disulfide bond between C2 and C11 and a β-sheet-turn-β-sheet conformation in aqueous solution. This peptide showed no cytotoxic effect in mammalian cells and it was the most effective in reducing anti-inflammatory markers, such as NO, TNF-α and IL-12. Peptide DK16 (DKERPICSNTFRGRKC) demonstrated anti-inflammatory properties in vitro, while RC11 (RCFRRRGKLTC) significantly altered the cell viability in RAW 264.7 but was shown to be safe in Balb/c erythrocytes. Our results indicate that, of the three peptides studied, AC12 is the most efficient in reducing anti-inflammatory markers, and it could be a potential agent for the treatment of inflammatory diseases.publishe
Computational fact checking from knowledge networks
Traditional fact checking by expert journalists cannot keep up with the
enormous volume of information that is now generated online. Computational fact
checking may significantly enhance our ability to evaluate the veracity of
dubious information. Here we show that the complexities of human fact checking
can be approximated quite well by finding the shortest path between concept
nodes under properly defined semantic proximity metrics on knowledge graphs.
Framed as a network problem this approach is feasible with efficient
computational techniques. We evaluate this approach by examining tens of
thousands of claims related to history, entertainment, geography, and
biographical information using a public knowledge graph extracted from
Wikipedia. Statements independently known to be true consistently receive
higher support via our method than do false ones. These findings represent a
significant step toward scalable computational fact-checking methods that may
one day mitigate the spread of harmful misinformation
In vitro maturation impacts cumulus–oocyte complex metabolism and stress in cattle
FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOThe influence of in vitro maturation (IVM) in oocytes is still not totally understood. The aim of this study was to determine the influence of IVM on the metabolism and homeostasis of bovine cumulus-oocyte complexes. In the present study, we demonstrated1546881893FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO2014/21034-32014/03281-32014/22887-02013/08135-22012/50533-2306978/2014-8The authors would like to thank the staff and students at the LMMD, Marcos Chiaratti, Gustavo Duarte, Marcel Nakashima, Hélio Alves Martins Júnior, José Luis Paz Jara, Patricia Kubo Fontes and Augusto de Castro Netto for their assistance with the sample
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