4,846 research outputs found
Towards a framework for adaptive web applications
We have developed a framework to support adaptive elements in Web pages. In particular we focus on adaptive menus. Developers are able to define rules for menu adaptation according to the features of the device and browser in use. This paper briefly describes the selected adaptation patterns and their implementation.This work is funded by ERDF - European Regional Development
Fund through the COMPETE Programme (operational programme
for competitiveness) and by National Funds through the FCT - Fundação para
a Ciência e a Tecnologia (Portuguese Foundation for Science and Technology)
within project FCOMP-01-0124-FEDER-015095
The hydrostatic equilibrium and Tsallis equilibrium for self-gravitating systems
Self-gravitating systems are generally thought to behavior non-extensively
due to the long-range nature of gravitational forces. We obtain a relation
between the nonextensive parameter q of Tsallis statistics, the temperature
gradient and the gravitational potential based on the equation of hydrostatic
equilibrium of self-gravitating systems. It is suggested that the nonextensive
parameter in Tsallis statistics has a clear physical meaning with regard to the
non-isothermal nature of the systems with long-range interactions and Tsallis
equilibrium distribution for the self-gravitating systems describes the
property of hydrostatic equilibrium of the systems.Comment: 7 pages, 9 Reference
Direct interaction between EgFABP1, a fatty acid binding protein from echinococcus granulosus, and phospholipid membranes
<p>Background: Growth and maintenance of hydatid cysts produced by Echinococcus granulosus have a high requirement for host lipids for biosynthetic processes, membrane building and possibly cellular and developmental signalling. This requires a high degree of lipid trafficking facilitated by lipid transporter proteins. Members of the fatty acid binding protein (FABP) family have been identified in Echinococcus granulosus, one of which, EgFABP1 is expressed at the tegumental level in the protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of a considerable amount of structural and biophysical information on the FABPs in general, their specific functions remain mysterious.</p>
<p>Methodology/Principal Findings: We have investigated the way in which EgFABP1 may interact with membranes using a variety of fluorescence-based techniques and artificial small unilamellar vesicles. We first found that bacterial recombinant EgFABP1 is loaded with fatty acids from the synthesising bacteria, and that fatty acid binding increases its resistance to proteinases, possibly due to subtle conformational changes induced on EgFABP1. By manipulating the composition of lipid vesicles and the ionic environment, we found that EgFABP1 interacts with membranes in a direct contact, collisional, manner to exchange ligand, involving both ionic and hydrophobic interactions. Moreover, we observed that the protein can compete with cytochrome c for association with the surface of small unilamellar vesicles (SUVs).</p>
<p>Conclusions/Significance: This work constitutes a first approach to the understanding of protein-membrane interactions of EgFABP1. The results suggest that this protein may be actively involved in the exchange and transport of fatty acids between different membranes and cellular compartments within the parasite.</p>
Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial
<p><b>Background and Purpose:</b>Although magnesium is neuroprotective in animal stroke models, no clinical benefit was confirmed in the Intravenous Magnesium Efficacy in Stroke (IMAGES) trial of acute stroke patients. The Magnetic
Resonance in IMAGES (MR IMAGES) substudy investigated the effects of magnesium on the imaging surrogate
outcome of infarct growth.</p>
<p><b>Methods:</b> IMAGES trial patients in participating centers were randomized to receive either intravenous magnesium or placebo within 12 hours of stroke onset. Infarct growth was defined as volume difference between baseline diffusion-weighted imaging and day 90 fluid-attenuated inversion recovery image lesions. Patients who died were imputed the largest infarct growth observed.</p>
<p><b>Results:</b> Among the 90 patients included in the primary analysis, there was no difference in infarct growth (median absolute growth, P=0.639; median percentage growth, P=0.616; proportion with any growth, P=0.212) between the
46 treated with magnesium and 44 with placebo. Infarct growth correlated with NIHSS score change from baseline to
day 90. There was a trend showing baseline serum glucose correlated with infarct growth with magnesium treatment,
but not in the placebo group. The mismatch frequency was reduced from 73% to 47% by increasing the mismatch
threshold from >20% to >100% of core volume.</p>
<p><b>Conclusions:</b> Infarct growth, confirmed here as a surrogate for clinical progression, was similar between magnesium and placebo treatment, paralleling the main IMAGES trial clinical outcomes. Glucose was a covariate for infarct growth with magnesium treatment. A more stringent mismatch threshold to define penumbra more appropriately would have
excluded half of the patients in this 12-hour time window stroke study.</p>
Statistical assessment of feeding corn with higher oil content to piglets in the starter phase
The aim of this study was to assess the digestibility coefficients (DC) of corn [maize] with an oil content above 3.46% and its effects on the performance of piglets when fed as dry grain (DG) and as rehydrated corn grain silage (RCGS). In Experiment I, 15 piglets (22.51 + 2.39 kg) were allocated to a reference diet (RD) and to two test diets in which corn in the RD was replaced with DG or RCGS. There were five replications of each treatment. Experiment II involved 36 piglets (14.76 ± 2.72 kg), which were assigned to a control diet with common corn grain and to diets in which DG or RCGS replaced the common corn. There were six replications of each treatment. Data were analysed with four statistical models. Model 1 included only the effect of treatment. Model 2 was similar to Model 1 but included initial bodyweight as a covariate. Model 3 was similar to model 1 but included the interaction of diet and period. Model 4 was similar to Model 3 but included the covariate. The more complicated models were generally preferred to Model 1 as they controlled more of the nuisance variation. Feeding a diet that contained RCGS reduced feed intake and improved feed conversion ratio (FCR)
What does the nonextensive parameter q stand for in self-gravitating systems ?
It is natural important question for us to ask what the nonextensive
parameter stands for when Tsallis statistics is applied to the self-gravitating
systems. In this paper, some properties of the nonextensive parameter and
Tsallis equilibrium distribution for the self-gravitating system are discussed
in the framework of nonextensive kinetic theory. On the basis of the solid
mathematical foundation, the nonextensive parameter can be expressed by a
formula with temperature gradient and the gravitational potential and can be
presented the physical meaning with regard to the non-isothermal
(nonequilibrium stationary state) nature of the systems with long-range
interactions. We come to the conclusion that Tsallis equilibrium distribution
is corresponding to the physical state of self-gravitating system at the
hydrostatic equilibrium.Comment: 11 pages, 25 references. The Twelfth United Nations/European Space
Agency workshop on basic space science. May 24-28 2004, Beijing, Chin
Effect of replacing wheat bran with spineless cactus plus urea in sugarcane-based diets for sheep
In times of drought, the availability of feed is reduced, and the use of concentrate ingredients, such as wheat bran, becomes costly for animal production. Thus, the use of spineless cactus emerges as a potential solution to the shortage of feed and water during prolonged drought periods. The objective of this study was to evaluate the effects of replacing wheat bran with spineless cactus plus urea (0%, 25%, 50%, 75%, and 100%) in sugarcane-based diets for sheep on nutrient intake, feeding behaviour, nitrogen balance and microbial protein synthesis. Five male Santa Ines sheep with average initial bodyweight of 34.0 ± 3.6 kg were used in a 5 × 5 Latin square. The maximum intakes of dry matter (DM) (1414 g/day), organic matter (OM) (1281 g/day), crude protein (CP) (204 g/day), neutral detergent fibre corrected for ash and protein (NDFap) (425 g/day), and total digestible nutrients (TDN) (890 g/day) were estimated with replacement levels of 80.2%, 75.3%, 88.6%, 50.5%, and 79.3% respectively. Feeding behaviour was not altered by replacing wheat bran with spineless cactus plus urea. Nitrogen retention increased by 0.10 g/day, while plasmatic urea nitrogen increased by 0.20 mg/day for every 1% level of replacement. The maximum production of microbial nitrogen (15.9 g/day) and microbial protein synthesis (99.4 g/day) were estimated with replacement levels of 45.8 and 45.7%, respectively. It is concluded that up to 80% wheat bran could be replaced with spineless cactus plus urea in sugarcane-based diets for sheep.Keywords: Alternative feed, drought, feeding behaviour, intake, microbial protei
A critical review on the numerical simulation related to Physical Vapour Deposition
Physical Vapour Deposition (PVD) is a process usually used for the production of advanced coatings regarding its application in several industrial and current products, such as optical lens, moulds and dies, decorative parts or tools. This process has several variants due to its strong evolution along the last decades. The process is commonly assisted by plasma, creating a particular low pressure and medium temperature atmosphere, which is responsible for the transition of atomic particles between the target and the parts to be coated into a vacuum reactor. Several parameters are directly affecting the deposition, namely the substrate temperature, pressure inside the reactor, assisting gases used, type of current, power supply, bias, substrate and target materials, samples holder and corresponding rotation, deposition time, among others. Many mathematical models have been developed in order to allow the generation of numerical simulation applications, trying to combine parameters and expect the corresponding results. Numerical simulation applications were created around the mathematical models previously developed, which can play an important role in the prediction of the coating properties and structure. This paper intends to describe the numerical simulation evolution in the last years, namely the use of Finite Elements Method (FEM) and Computational Fluid Dynamics (CFD).info:eu-repo/semantics/publishedVersio
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