11 research outputs found
A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside
Full text linkAn Accurate, Flexible and Small Optical Fiber Sensor: A Novel Technological Breakthrough for Real-Time Analysis of Dynamic Blood Flow Data In Vivo
No full textEffectiveness of a serological tool to predict malaria transmission intensity in an elimination setting
No full textA nano-LC/UV method for the analysis of principal phenolic compounds in commercial citrus juices and evaluation of antioxidant potential
No full textComparative effects of pristine and ball-milled graphene oxide on physico-chemical characteristics of cement mortar nanocomposites
No full textExperimental and analytical studies on the vibration serviceability of long-span prestressed concrete floor
No full textMolecular genetics of MARVELD2 and clinical phenotype in Pakistani and Slovak families segregating DFNB49 hearing loss
No full textAlzheimer's disease; a review of the pathophysiological basis and therapeutic interventions
No full textIron and Cancer: More Ore To Be Mined
Get PDFIron is an essential nutrient that facilitates cell proliferation and growth. However, iron also has the capacity to engage in redox cycling and free radical formation. Therefore, iron can contribute to both tumour initiation and tumour growth; recent work has also shown that iron has a role in the tumour microenvironment and in metastasis. Pathways of iron acquisition, efflux, storage and regulation are all perturbed in cancer, suggesting that reprogramming of iron metabolism is a central aspect of tumour cell survival. Signalling through hypoxia-inducible factor (HIF) and WNT pathways may contribute to altered iron metabolism in cancer. Targeting iron metabolic pathways may provide new tools for cancer prognosis and therapy
