As Imagens do Levantamento. O levantamento e o diagrama na metodologia de projeto

No entendimento do design enquanto disciplina que poderá promover uma estrutura consolidada de projeto, encontrou-se na fase do levantamento, um conceito em que os seus princípios de ação e da experiência, nas suas dimensões técnica mas, também, exploratória e experimental poderão fazer uma revisão e proposta à atividade projetiva. Este projeto/dissertação explora o levantamento enquanto etapa e auxiliar essencial da metodologia processual do designer. Recorrendo à revisão de casos, entrevistas e a uma prática experimental, a representação gráfica do levantamento é analisada através do conceito de diagrama. Partindo destes conceitos procura-se compreender de que forma é possível uma renovação do discurso e da operabilidade do design. Pretendeu-se centralizar estes conceitos, não como instrumentos teóricos desligados da prática, mas como conceitos operativos que nos ajudam na construção de um design mais flexível face aos desafios da atualidade. Desenvolveu-se, assim, uma análise aos elementos gráficos enquanto conceitos que segundo uma articulação com o levantamento e o diagrama, nos ajudam a perceber de forma mais clara a prática real do design

A new viewpoint on the etiopathogenesis of depression : insights from the neurophysiology of deep brain stimulation in Parkinson's Disease and treatment-resistant depression

Copyright © 2021 Silva-dos-Santos, Sales, Sebastião and Gusmão. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.In this opinion article, we humbly propose a new viewpoint on the etiopathogenesis of depression. We base the model on our interpretation of selected recent neurophysiological findings, mainly regarding Deep Brain Stimulation (DBS) to treat Parkinson’s Disease and also DBS to treat Treatment-Resistant Depression (TRD). We coin the idea a mental kindling-like mechanism. However, future clinical research, possibly complemented with human laboratory research or animal experiments, will be needed to test the validity of our proposed model. On the current manuscript framework, following the first and introductory section, we will set the stage by presenting selected studies and insights mainly from DBS to treat TRD and PD, on the second and middle section. Finally, we will discuss the proposed viewpoint on the third and last section of the present work.info:eu-repo/semantics/publishedVersio

Estimation of endogenous contribution and urinary excretion of purine derivatives from the total digestible nutrient intake in Nellore heifers

The objectives of this experiment were to estimate the endogenous excretion of purine derivatives (PD), the intake and digestibility of nutrients, the urinary excretion of PD from the intake of total digestible nutrients (TDN) and digestible organic matter (DOM) in Nellore heifers. Eight heifers, 267±17 kg body weight (BW), were assigned to two 4 × 4 latin squares. The planned treatments were four dry matter intake (DMI) levels: 10, 14, 18 and 22 g/kg BW. The diet contained 70% corn silage and 30% concentrate. The endogenous losses were obtained by regression between excretion of PD (mmol/BW0.75) and DMI (g/BW0.75). When PD excretion (mmol/d) was related to the intake of DOM and TDN (kg/d), the following equations were obtained: ŶPD= 32.98 + 21.94*DOM and ŶPD= 32.47 + 20.40*TDN, respectively. The excretion of PD (mmol/d) was a function of DMI (kg/d): ŶPD = 0.605 + 0.014 x (r2 = 0.46), and 0.60 mmol/BW0.75 was the endogenous fraction of PD. The endogenous losses of PD and nitrogen compounds obtained when the animals were fasted for 5 d, with free access to water, were 0.332 mmol/BW0.75 and 0.384 gN/BW0.75, respectively. The net protein requirement for maintenance was estimated at 2.4 g/BW0.75. Creatinine excretion is not affected by feed restriction