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Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS.
Lipoproteins isolated from normal human plasma can bind and neutralize bacterial lipopolysaccharide (LPS) and may represent an important mechanism in host defense against gram-negative septic shock. Recent studies have shown that experimentally elevating the levels of circulating high-density lipoproteins (HDL) provides protection against death in animal models of endotoxic shock. We sought to define the components of HDL that are required for neutralization of LPS. To accomplish this we have studied the functional neutralization of LPS by native and reconstituted HDL using a rapid assay that measures the CD14-dependent activation of leukocyte integrins on human neutrophils. We report here that reconstituted HDL particles (R-HDL), prepared from purified apolipoprotein A-I (apoA-I) combined with phospholipid and free cholesterol, are not sufficient to neutralize the biologic activity of LPS. However, addition of recombinant LPS binding protein (LBP), a protein known to transfer LPS to CD14 and enhance responses of cells to LPS, enabled prompt binding and neutralization of LPS by R-HDL. Thus, LBP appears capable of transferring LPS not only to CD14 but also to lipoprotein particles. In contrast with R-HDL, apoA-I containing lipoproteins (LpA-I) isolated from plasma by selected affinity immunosorption (SAIS) on an anti-apoA-I column, neutralized LPS without addition of exogenous LBP. Several lines of evidence demonstrated that LBP is a constituent of LpA-I in plasma. Passage of plasma over an anti-apoA-I column removed more than 99% of the LBP detectable by ELISA, whereas 31% of the LBP was recovered by elution of the column. Similarly, the ability of plasma to enable activation of neutrophils by LPS (LBP/Septin activity) was depleted and recovered by the same process. Furthermore, an immobilized anti-LBP monoclonal antibody coprecipitated apoA-I. The results described here suggest that in addition to its ability to transfer LPS to CD14, LBP may also transfer LPS to lipoproteins. Since LBP appears to be physically associated with lipoproteins in plasma, it is positioned to play an important role in the neutralization of LPS
Triboson interpretations of the ATLAS diboson excess
The ATLAS excess in fat jet pair production is kinematically compatible with
the decay of a heavy resonance into two gauge bosons plus an extra particle.
This hypothesis would explain the absence of such a large excess in the
analogous CMS analysis of fat dijet final states, as well as the negative
results of diboson resonance searches in the semi-leptonic decay modes. If the
extra particle is the Higgs boson, this hypothesis might also explain
-statistical fluctuations aside- why the CMS search for WH resonances in the
semi-leptonic channel finds some excess while in the fully hadronic one it does
not have a significant deviation.Comment: LaTeX 17 pages. v2: Enlarged discussion to address CMS WH excess. v3:
Added discussion of diboson helicities. Final version to appear in JHE
Measuring the Polarization of Boosted Hadronic Tops
We propose a new technique for measuring the polarization of hadronically
decaying boosted top quarks. In particular, we apply a subjet-based technique
to events where the decay products of the top are clustered within a single
jet. The technique requires neither b-tagging nor W-reconstruction, and does
not rely on assumptions about either the top production mechanism or the
sources of missing energy in the event. We include results for various new
physics scenarios made with different Monte Carlo generators to demonstrate the
robustness of the technique.Comment: v2: version accepted for publication in JHE
Static non-reciprocity in mechanical metamaterials
Reciprocity is a fundamental principle governing various physical systems,
which ensures that the transfer function between any two points in space is
identical, regardless of geometrical or material asymmetries. Breaking this
transmission symmetry offers enhanced control over signal transport, isolation
and source protection. So far, devices that break reciprocity have been mostly
considered in dynamic systems, for electromagnetic, acoustic and mechanical
wave propagation associated with spatio-temporal variations. Here we show that
it is possible to strongly break reciprocity in static systems, realizing
mechanical metamaterials that, by combining large nonlinearities with suitable
geometrical asymmetries, and possibly topological features, exhibit vastly
different output displacements under excitation from different sides, as well
as one-way displacement amplification. In addition to extending non-reciprocity
and isolation to statics, our work sheds new light on the understanding of
energy propagation in non-linear materials with asymmetric crystalline
structures and topological properties, opening avenues for energy absorption,
conversion and harvesting, soft robotics, prosthetics and optomechanics.Comment: 19 pages, 3 figures, Supplementary information (11 pages and 5
figures
Emergence of non-centrosymmetric topological insulating phase in BiTeI under pressure
The spin-orbit interaction affects the electronic structure of solids in
various ways. Topological insulators are one example where the spin-orbit
interaction leads the bulk bands to have a non-trivial topology, observable as
gapless surface or edge states. Another example is the Rashba effect, which
lifts the electron-spin degeneracy as a consequence of spin-orbit interaction
under broken inversion symmetry. It is of particular importance to know how
these two effects, i.e. the non-trivial topology of electronic states and
Rashba spin splitting, interplay with each other. Here we show, through
sophisticated first-principles calculations, that BiTeI, a giant bulk Rashba
semiconductor, turns into a topological insulator under a reasonable pressure.
This material is shown to exhibit several unique features such as, a highly
pressure-tunable giant Rashba spin splitting, an unusual pressure-induced
quantum phase transition, and more importantly the formation of strikingly
different Dirac surface states at opposite sides of the material.Comment: 5 figures are include
Electron-Spin Precession in Dependence of the Orientation of the External Magnetic Field
Electron-spin dynamics in semiconductor-based heterostructures has been investigated in oblique magnetic fields. Spins are generated optically by a circularly polarized light, and the dynamics of spins in dependence of the orientation (θ) of the magnetic field are studied. The electron-spin precession frequency, polarization amplitude, and decay rate as a function ofθare obtained and the reasons for their dependences are discussed. From the measured data, the values of the longitudinal and transverse components of the electrong-factor are estimated and are found to be in good agreement with those obtained in earlier investigations. The possible mechanisms responsible for the observed effects are also discussed
Silicon-based spin and charge quantum computation
Silicon-based quantum-computer architectures have attracted attention because
of their promise for scalability and their potential for synergetically
utilizing the available resources associated with the existing Si technology
infrastructure. Electronic and nuclear spins of shallow donors (e.g.
phosphorus) in Si are ideal candidates for qubits in such proposals due to the
relatively long spin coherence times. For these spin qubits, donor electron
charge manipulation by external gates is a key ingredient for control and
read-out of single-qubit operations, while shallow donor exchange gates are
frequently invoked to perform two-qubit operations. More recently, charge
qubits based on tunnel coupling in P substitutional molecular ions in Si
have also been proposed. We discuss the feasibility of the building blocks
involved in shallow donor quantum computation in silicon, taking into account
the peculiarities of silicon electronic structure, in particular the six
degenerate states at the conduction band edge. We show that quantum
interference among these states does not significantly affect operations
involving a single donor, but leads to fast oscillations in electron exchange
coupling and on tunnel-coupling strength when the donor pair relative position
is changed on a lattice-parameter scale. These studies illustrate the
considerable potential as well as the tremendous challenges posed by donor spin
and charge as candidates for qubits in silicon.Comment: Review paper (invited) - to appear in Annals of the Brazilian Academy
of Science
Functional Locomotor Consequences of Uneven Forefeet for Trot Symmetry in Individual Riding Horses
ABSTRACT: Left-right symmetrical distal limb conformation can be an important prerequisite for a successful performance, and it is often hypothesized that asymmetric or uneven feet are important enhancing factors for the development of lameness. On a population level, it has been demonstrated that uneven footed horses are retiring earlier from elite level competition, but the biomechanical consequences are not yet known. The objectives of this study were to compare the functional locomotor asymmetries of horses with uneven to those with even feet. Hoof kinetics and distal limb kinematics were collected from horses (n = 34) at trot. Dorsal hoof wall angle was used to classify horses as even or uneven (1.5° difference between forefeet respectively) and individual feet as flat (55°). Functional kinetic parameters were compared between even and uneven forefeet using MANOVA followed by ANOVA. The relative influences of differences in hoof angle between the forefeet and of absolute hoof angle on functional parameters were analysed using multiple regression analysis (P<0.05). In horses with uneven feet, the side with the flatter foot showed a significantly larger maximal horizontal braking and vertical ground reaction force, a larger vertical fetlock displacement and a suppler fetlock spring. The foot with a steeper hoof angle was linearly correlated with an earlier braking-propulsion transition. The conformational differences between both forefeet were more important for loading characteristics than the individual foot conformation of each individual horse. The differences in vertical force and braking force between uneven forefeet could imply either an asymmetrical loading pattern without a pathological component or a subclinical lameness as a result of a pathological development in the steeper foot
New Physics Signals in Longitudinal Gauge Boson Scattering at the LHC
We introduce a novel technique designed to look for signatures of new physics
in vector boson fusion processes at the TeV scale. This functions by measuring
the polarization of the vector bosons to determine the relative longitudinal to
transverse production. In studying this ratio we can directly probe the high
energy E^2-growth of longitudinal vector boson scattering amplitudes
characteristic of models with non-Standard Model (SM) interactions. We will
focus on studying models parameterized by an effective Lagrangian that include
a light Higgs with non-SM couplings arising from TeV scale new physics
associated with the electroweak symmetry breaking, although our technique can
be used in more general scenarios. We will show that this technique is stable
against the large uncertainties that can result from variations in the
factorization scale, improving upon previous studies that measure cross section
alone
Building for the future: essential infrastructure for rodent ageing studies
When planning ageing research using rodent models, the logistics of supply, long term housing and infrastructure provision are important factors to take into consideration. These issues need to be prioritised to ensure they meet the requirements of experiments which potentially will not be completed for several years. Although these issues are not unique to this discipline, the longevity of experiments and indeed the animals, requires a high level of consistency and sustainability to be maintained throughout lengthy periods of time. Moreover, the need to access aged stock or material for more immediate experiments poses many issues for the completion of pilot studies and/or short term intervention studies on older models. In this article, we highlight the increasing demand for ageing research, the resources and infrastructure involved, and the need for large-scale collaborative programmes to advance studies in both a timely and a cost-effective way
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