(8,0) Quantum mechanics and symmetry enhancement in type I' superstrings

The low-energy supersymmetric quantum mechanics describing D-particles in the background of D8-branes and orientifold planes is analyzed in detail, including a careful discussion of Gauss' law and normal ordering of operators. This elucidates the mechanism that binds D-particles to an orientifold plane, in accordance with the predictions of heterotic/type I duality. The ocurrence of enhanced symmetries associated with massless bound states of a D-particle with one orientifold plane is illustrated by the enhancement of $SO(14) \times U(1)$ to $E_8$ and $SO(12)\times U(1)$ to $E_7$ at strong type I' coupling. Enhancement to higher-rank groups involves both orientifold planes. For example, the enhanced $E_8 \times E_8 \times SU(2)$ symmetry at the self-dual radius of the heterotic string is seen as the result of two D8-branes coinciding midway between the orientifold planes, while the enhanced $SU(18)$ symmetry results from the coincidence of all sixteen D8-branes and $SO(34)$ when they also coincide with an orientifold plane. As a separate by-product, the s-rule of brane-engineered gauge theories is derived by relating it through a chain of dualities to the Pauli exclusion principle.Comment: 30 pages LaTeX, Five figures. Two references added as well as some Comments in section4. v4: Missing backslashes added to four reference citations

Rapid Evolutionary Rewiring of a Structurally Constrained Eye Enhancer

SummaryBackgroundEnhancers are genomic cis-regulatory sequences that integrate spatiotemporal signals to control gene expression. Enhancer activity depends on the combination of bound transcription factors as well as—in some cases—the arrangement and spacing of binding sites for these factors. Here, we examine evolutionary changes to the sequence and structure of sparkling, a Notch/EGFR/Runx-regulated enhancer that activates the dPax2 gene in cone cells of the developing Drosophila eye.ResultsDespite functional and structural constraints on its sequence, sparkling has undergone major reorganization in its recent evolutionary history. Our data suggest that the relative strengths of the various regulatory inputs into sparkling change rapidly over evolutionary time, such that reduced input from some factors is compensated by increased input from different regulators. These gains and losses are at least partly responsible for the changes in enhancer structure that we observe. Furthermore, stereotypical spatial relationships between certain binding sites (“grammar elements”) can be identified in all sparkling orthologs—although the sites themselves are often recently derived. We also find that low binding affinity for the Notch-regulated transcription factor Su(H), a conserved property of sparkling, is required to prevent ectopic responses to Notch in noncone cells.ConclusionsRapid DNA sequence turnover does not imply either the absence of critical cis-regulatory information or the absence of structural rules. Our findings demonstrate that even a severely constrained cis-regulatory sequence can be significantly rewired over a short evolutionary timescale

Remarks on Resonant Scalars in the AdS/CFT Correspondence

The special properties of scalars having a mass such that the two possible dimensions of the dual scalar respect the unitarity and the Breitenlohner-Freedman bounds and their ratio is integral (``resonant scalars'') are studied in the AdS/CFT correspondence. The role of logarithmic branches in the gravity theory is related to the existence of a trace anomaly and to a marginal deformation in the Conformal Field Theory. The existence of asymptotic charges for the conformal group in the gravity theory is interpreted in terms of the properties of the corresponding CFT.Comment: 16 pages, 1 figur

General solutions of the Wess-Zumino consistency condition for the Weyl anomalies

The general solutions of the Wess-Zumino consistency condition for the conformal (or Weyl, or trace) anomalies are derived. The solutions are obtained, in arbitrary dimensions, by explicitly computing the cohomology of the corresponding Becchi-Rouet-Stora-Tyutin differential in the space of integrated local functions at ghost number unity. This provides a purely algebraic, regularization-independent classification of the Weyl anomalies in arbitrary dimensions. The so-called type-A anomaly is shown to satisfy a non-trivial descent of equations, similarly to the non-Abelian chiral anomaly in Yang-Mills theory.Comment: 9 pages. RevTeX fil

Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease.

ObjectiveNonalcoholic fatty liver disease (NAFLD) affects 9.6% of children and may put these children at elevated risk of high blood pressure and subsequent cardiovascular morbidity and mortality. Therefore, we sought to determine the prevalence of and risk factors for high blood pressure in children with NAFLD.MethodsCohort study performed by the NIDDK NASH Clinical Research Network. There were 484 children with NAFLD ages 2 to 17 at enrollment; 382 children were assessed both at enrollment and 48 weeks afterwards. The main outcomes were high blood pressure at baseline and persistent high blood pressure at both baseline and 48 weeks.ResultsPrevalence of high blood pressure at baseline was 35.8% and prevalence of persistent high blood pressure was 21.4%. Children with high blood pressure were significantly more likely to have worse steatosis than children without high blood pressure (mild 19.8% vs. 34.2%, moderate 35.0% vs. 30.7%, severe 45.2% vs. 35.1%; P = 0.003). Higher body mass index, low-density lipoprotein, and uric acid were independent risk factors for high blood pressure (Odds Ratios: 1.10 per kg/m2, 1.09 per 10 mg/dL, 1.25 per mg/dL, respectively). Compared to boys, girls with NAFLD were significantly more likely to have persistent high blood pressure (28.4% vs.18.9%; P = 0.05).ConclusionsIn conclusion, NAFLD is a common clinical problem that places children at substantial risk for high blood pressure, which may often go undiagnosed. Thus blood pressure evaluation, control, and monitoring should be an integral component of the clinical management of children with NAFLD

Building bridges within the field of philosophy of education. Construyendo puentes en el campo de la filosofía de la educación.

En este ensayo, introducimos los diferentes contenidos de los que se ocupa este número monográfico dedicado a la filosofía de la educación que edita Bajo Palabra. Revista de Filosofía. El proyecto pretende introducir la filosofía de la educación como una nueva sección en esta publicación y dar a conocer en el ámbito de trabajo más estrictamente filosófico qué temáticas y aproximaciones circulan en el área de la filosofía de la educación. Se ha buscado, además, establecer el perfil de la filosofía de la educación con respecto, en primer lugar, a los trabajos que se han venido haciendo en su nombre y, en segundo lugar, a lo que queda aún por hacer. Estas preguntas son respondidas por los diferentes colaboradores a lo largo de tres secciones. En la primera se ofrecen diferentes visiones de lo que es la filosofía de la educación, en la segunda se presentan varios trabajos representativos de lo que se está investigando actualmente en la filosofía de la educación y en la tercera, se ofrecen tres recensiones críticas sobre publicaciones recientemente aparecidas en tres contextos lingüísticos diferentes relativas a la filosofía de la educación. Esperamos que los lectores de este número monográfico, disfruten de la riqueza de pensamiento y las inesperadas relaciones que aparecen cuando se inicia una conversación en el campo de la filosofía de la educaciónPalabras clave: Filosofía de la educación, área de conocimiento, líneas temáticas, enfoques filosóficos.Abstract:In this paper we introduce this special issue of Bajo Palabra. Journal of Philosophy, devoted to philosophy of education. The project marks the introduction of philosophy of education as a new section within the Bajo Palabra, and aims to present to a broader philosophical audience those themes and approaches which are circulating within the field of philosophy of education. It has been our intention to raise the profile of philosophy of education in respect of both the work which has been done and is being done in its name on the one hand and the work that ought to be done in its name on the other. Happily, these intentions have been addressed by the various contributors. We have arranged the contents of this edition into three sections. The first offers different visions of what the philosophy of education is and ought to be, the second presents several papers which are representative of what is currently being investigated in the philosophy of education, and the third offers three book reviews of recent introductions to the philosophy of education, each from a different linguistic context. We hope readers of the present volume will by stimulated to further reflection by the fruitful thoughts and unexpected relations that emerge when a conversation within the field of philosophy of education starts up.Keywords: Philosophy of education, area of knowledge, research lines, philosophical approaches

N-String Vertices in String Field Theory

We give the general form of the vertex corresponding to the interaction of an arbitrary number of strings. The technique employed relies on the ``comma" representation of String Field Theory where string fields and interactions are represented as matrices and operations between them such as multiplication and trace. The general formulation presented here shows that the interaction vertex of N strings, for any arbitrary N, is given as a function of particular combinations of matrices corresponding to the change of representation between the full string and the half string degrees of freedom.Comment: 22 pages, A4-Latex (latex twice), FTUV IFI

Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease.

BackgroundReliable non-invasive markers to characterize inflammation, hepatocellular ballooning, and fibrosis in nonalcoholic fatty liver disease (NAFLD) are lacking. We investigated the relationship between plasma cytokine levels and features of NAFLD histology to gain insight into cellular pathways driving NASH and to identify potential non-invasive discriminators of NAFLD severity and pattern.MethodsCytokines were measured from plasma obtained at enrollment in pediatric participants in NASH Clinical Research Network studies with liver biopsy-proven NAFLD. Cytokines were chosen a priori as possible discriminators of NASH and its components. Minimization of Akaike Information Criterion (AIC) was used to determine cytokines retained in multivariable models.ResultsOf 235 subjects, 31% had "Definite NASH" on liver histology, 43% had "Borderline NASH", and 25% had NAFLD but not NASH. Total plasminogen activator inhibitor 1 (PAI1) and activated PAI1 levels were higher in pediatric participants with Definite NASH and with lobular inflammation. Interleukin-8 (IL-8) was higher in those with stage 3-4 fibrosis and lobular inflammation. sIL-2rα was higher in children with stage 3-4 fibrosis and portal inflammation. In multivariable analysis, PAI1 variables were discriminators of Borderline/Definite NASH, definite NASH, lobular inflammation and ballooning. IL-8 increased with steatosis and fibrosis severity; sIL-2rα increased with fibrosis severity and portal inflammation. IL-7 decreased with portal inflammation and fibrosis severity.ConclusionsPlasma cytokines associated with histology varied considerably among NASH features, suggesting promising avenues for investigation. Future, more targeted analysis is needed to identify the role of these markers in NAFLD and to evaluate their potential as non-invasive discriminators of disease severity

Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease

OBJECTIVE: To determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, and Blood Institute guidelines. STUDY DESIGN: This multicenter, longitudinal cohort study included children with NAFLD enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Nonalcoholic Steatohepatitis Clinical Research Network. Fasting lipid profiles were obtained at diagnosis. Standardized dietary recommendations were provided. After 1 year, lipid profiles were repeated and interpreted according to National Heart, Lung, and Blood Institute Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction. Main outcomes were meeting criteria for clinically actionable dyslipidemia at baseline, and either achieving lipid goal at follow-up or meeting criteria for ongoing intervention. RESULTS: There were 585 participants, with a mean age of 12.8 years. The prevalence of children warranting intervention for low-density lipoprotein cholesterol at baseline was 14%. After 1 year of recommended dietary changes, 51% achieved goal low-density lipoprotein cholesterol, 27% qualified for enhanced dietary and lifestyle modifications, and 22% met criteria for pharmacologic intervention. Elevated triglycerides were more prevalent, with 51% meeting criteria for intervention. At 1 year, 25% achieved goal triglycerides with diet and lifestyle changes, 38% met criteria for advanced dietary modifications, and 37% qualified for antihyperlipidemic medications. CONCLUSIONS: More than one-half of children with NAFLD met intervention thresholds for dyslipidemia. Based on the burden of clinically relevant dyslipidemia, lipid screening in children with NAFLD is warranted. Clinicians caring for children with NAFLD should be familiar with lipid management