Frontline police employees' social construction of client service.

The social construction of frontline employees’ client service plays a major role in organisational success. This study illuminated why frontline personnel are reluctant to accept organisational change which is in line with new policing philosophies. Applying modernist qualitative methodology, and particularly grounded theory within a case study design a ‘process satisfaction model’ was developed with the aim to improve employee satisfaction with internal processes and ultimately service delivery. This model may be used for change in the South African Police Service (SAPS) and other government departments

Wettability versus roughness of engineering surfaces

Wetting of real engineering surfaces occurs in many industrial applications (liquid coating, lubrication, printing, painting, ...). Forced and natural wetting can be beneficial in many cases, providing lubrication and therefore reducing friction and wear. However the wettability of surfaces can be strongly affected by surface roughness. This influence can be very significant for static and dynamic wetting [1]. In this paper authors experimentally investigate the roughness influence on contact angle measurements and propose a simple model combining Wenzel and Cassie-Baxter theories with simple 2D roughness profile analysis. The modelling approach is applied to real homogeneous anisotropic surfaces, manufactured on a wide range of engineering materials including aluminium alloy, iron alloy, copper, ceramic, plastic (poly-methylmethacrylate: PMMA) and titanium alloy

A rim-and-spoke hypothesis to explain the biomechanical roles for cytoplasmic intermediate filament networks

Textbook images of keratin intermediate filament (IF) networks in epithelial cells and the functional compromization of the epidermis by keratin mutations promulgate a mechanical role for this important cytoskeletal component. In stratified epithelia, keratin filaments form prominent radial spokes that are focused onto cell-cell contact sites, i.e. the desmosomes. In this Hypothesis, we draw attention to a subset of keratin filaments that are apposed to the plasma membrane. They form a rim of filaments interconnecting the desmosomes in a circumferential network. We hypothesize that they are part of a rim-and-spoke arrangement of IFs in epithelia. From our review of the literature, we extend this functional role for the subplasmalemmal rim of IFs to any cell, in which plasma membrane support is required, provided these filaments connect directly or indirectly to the plasma membrane. Furthermore, cytoplasmic IF networks physically link the outer nuclear and plasma membranes, but their participation in mechanotransduction processes remain largely unconsidered. Therefore, we also discuss the potential biomechanical and mechanosensory role(s) of the cytoplasmic IF network in terms of such a rim (i.e. subplasmalemmal)-and-spoke arrangement for cytoplasmic IF networks

Reframing the mammoth steppe: Insights from analysis of isotopic niches

Woolly mammoth (Mammuthus primigenius), horse (Equus spp.) and bison (Bison spp.) coexisted with a variety of mammalian megafauna across the Pleistocene mammoth steppe – a megacontinental ecosystem that spanned northern Eurasia and northwestern North America. Previous research has suggested that highly conserved niches with minimal niche overlap allowed high levels of species diversity on the mammoth steppe. Here we evaluate previously published and some new collagen carbon and nitrogen isotope data (δ13C, δ15N) for mammoth steppe megaherbivores using Stable Isotope Bayesian Ellipses in R (SIBER) and linear regression models to determine isotopic niches for individual species during broad time intervals (pre-, during and post-Last Glacial Maximum (LGM)) at multiple geographic regions across the mammoth steppe. Individual species maintained relatively consistent isotopic niche positions at different geographic locations and during different times. Diet and habitat niches for any given species appear to have been similar across the mammoth steppe. Between some regions and times, however, species' isotopic niches changed, suggesting adaptation to local climatic conditions and/or changes in the nitrogen isotope patterns at the base of the food web. Isotopic niche overlap, including at the level of core niche overlap (>60% overlap), was observed in at least one time and region for most species. This overlap suggests high levels of functional redundancy in the ecosystem, whereby one species could fulfil another's ecological role in the latter's absence. Despite spatial and temporal environmental variation, species' adaptability and functional redundancy within the ecosystem would have made the mammoth steppe a highly resilient ecosystem

High salt reduces the activation of IL-4- and IL-13-stimulated macrophages

A high intake of dietary salt (NaCl) has been implicated in the development of hypertension, chronic inflammation, and autoimmune diseases. We have recently shown that salt has a proinflammatory effect and boosts the activation of Th17 cells and the activation of classical, LPS-induced macrophages (M1). Here, we examined how the activation of alternative (M2) macrophages is affected by salt. In stark contrast to Th17 cells and M1 macrophages, high salt blunted the alternative activation of BM-derived mouse macrophages stimulated with IL-4 and IL-13, M(IL-4+IL-13) macrophages. Salt-induced reduction of M(IL-4+IL-13) activation was not associated with increased polarization toward a proinflammatory M1 phenotype. In vitro, high salt decreased the ability of M(IL-4+IL-13) macrophages to suppress effector T cell proliferation. Moreover, mice fed a high salt diet exhibited reduced M2 activation following chitin injection and delayed wound healing compared with control animals. We further identified a high salt-induced reduction in glycolysis and mitochondrial metabolic output, coupled with blunted AKT and mTOR signaling, which indicates a mechanism by which NaCl inhibits full M2 macrophage activation. Collectively, this study provides evidence that high salt reduces noninflammatory innate immune cell activation and may thus lead to an overall imbalance in immune homeostasis

Possible Role of Meckel's Scan Fused with SPECT CT Imaging: Unraveling the Cause of Abdominal Pain and Obscure-Overt Gastrointestinal Bleeding

A 27-year-old male presented with recurrent abdominal pain and high volume hematochezia despite undergoing extensive testing and a right hemicolectomy 3 years prior for a linear bleeding ulceration in the ascending colon. Studies at the University of Michigan included esophagogastroduodenoscopy (EGD), colonoscopy and video capsule endoscopy (VCE), revealing an arteriovenous malformation (AVM) in the terminal ileum. He was hospitalized for recurrent symptoms. His presentation suggested a small bowel source of obscure-overt GI bleeding based on prior non-diagnostic colonoscopy and EGD and a bilious nasogastric lavage. Tagged red blood cell scan localized bleeding to the right lower quadrant. Colonoscopy showed fresh blood in the terminal ileum without a clear source. Angiography showed no evidence of bleeding or terminal ileal AVM. A novel Meckel's scan fused with SPECT imaging showed focal uptake in the terminal ileum. The patient underwent Meckel's diverticulectomy with sparing of adjacent bowel and has remained asymptomatic for 19 months. This case illustrates that patients with obscure-overt GI bleeding require a step-wise multi-modality diagnostic work-up. Because Meckel's scans are false-positive in 28% of adults, Meckel's scan fused with SPECT imaging may offer an approach to refine diagnostic accuracy of either scan alone, but requires further investigation. Exploratory laparotomy should be reserved as a last option and is best performed with intraoperative endoscopy

Fast Neutron Detection with 6Li-loaded Liquid Scintillator

We report on the development of a fast neutron detector using a liquid scintillator doped with enriched Li-6. The lithium was introduced in the form of an aqueous LiCl micro-emulsion with a di-isopropylnaphthalene-based liquid scintillator. A Li-6 concentration of 0.15 % by weight was obtained. A 125 mL glass cell was filled with the scintillator and irradiated with fission-source neutrons. Fast neutrons may produce recoil protons in the scintillator, and those neutrons that thermalize within the detector volume can be captured on the Li-6. The energy of the neutron may be determined by the light output from recoiling protons, and the capture of the delayed thermal neutron reduces background events. In this paper, we discuss the development of this 6Li-loaded liquid scintillator, demonstrate the operation of it in a detector, and compare its efficiency and capture lifetime with Monte Carlo simulations. Data from a boron-loaded plastic scintillator were acquired for comparison. We also present a pulse-shape discrimination method for differentiating between electronic and nuclear recoil events based on the Matusita distance between a normalized observed waveform and nuclear and electronic recoil template waveforms. The details of the measurements are discussed along with specifics of the data analysis and its comparison with the Monte Carlo simulation

Modified granular impact force laws for the OSIRIS-REx touchdown on the surface of asteroid (101955) Bennu

The OSIRIS-REx mission collected a sample from the surface of the asteroid (101955) Bennu in October 2020. Here we study the impact of the OSIRIS-REx Touch-and-Go Sampling Acquisition Mechanism (TAGSAM) interacting with the surface of an asteroid in the framework of granular physics. Traditional approaches to estimating the penetration depth of a projectile into a granular medium include force laws and scaling relationships formulated from laboratory experiments in terrestrial-gravity conditions. However, it is unclear that these formulations extend to the OSIRIS-REx scenario of a 1300-kg spacecraft interacting with regolith in a microgravity environment. We studied the TAGSAM interaction with Bennu through numerical simulations using two collisional codes, pkdgrav and GDC-i. We validated their accuracy by reproducing the results of laboratory impact experiments in terrestrial gravity. We then performed TAGSAM penetration simulations varying the following geotechnical properties of the regolith: packing fraction (P), bulk density, inter-particle cohesion (σc), and angle of friction (ϕ). We find that the outcome of a spacecraft-regolith impact has a non-linear dependence on packing fraction. Closely packed regolith (P≳0.6) can effectively resist the penetration of TAGSAM if ϕ≳28° and/or σc≳50 Pa. For loosely packed regolith (P≲0.5), the penetration depth is governed by a drag force that scales with impact velocity to the 4/3 power, consistent with energy conservation. We discuss the importance of low-speed impact studies for predicting and interpreting spacecraft-surface interactions. We show that these low-energy events also provide a framework for interpreting the burial depths of large boulders in asteroidal regolith