Measurement properties of quality of life measurement instruments for infants, children and adolescents with eczema: protocol for a systematic review

Background: Eczema is a common chronic or chronically relapsing skin disease that has a substantial impact on quality of life (QoL). By means of a consensus-based process, the Harmonising Outcome Measures in Eczema (HOME) initiative has identified QoL as one of the four core outcome domains to be assessed in all eczema trials. Few measurement instruments exist to measure QoL in infants and children with eczema, but there is a great variability in both content and quality (for example, reliability and validity) of the instruments used, and it is not always clear if the best instrument is being used. Therefore, the aim of the proposed research is a comprehensive systematic assessment of the measurement properties of the existing measurement instruments that were developed and/or validated for the measurement of patient-reported QoL in infants and children with eczema. Methods/Design: This study is a systematic review of the measurement properties of patient-reported measures of QoL developed and/or validated for infants and children with eczema. Medline via PubMed and EMBASE will be searched using a selection of relevant search terms. Eligible studies will be primary empirical studies evaluating, describing, or comparing measurement properties of QoL instruments for infants and children with eczema. Eligibility assessment and data abstraction will be performed independently by two reviewers. Evidence tables will be generated for study characteristics, instrument characteristics, measurement properties, and interpretability. The adequacy of the measurement properties will be assessed using predefined criteria. Methodological quality of studies will be assessed using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist. A best evidence synthesis will be undertaken if more than one study has investigated a particular measurement property. Discussion: The proposed systematic review will produce a comprehensive assessment of measurement properties of existing QoL instruments in infants and children with eczema. We aim to identify one best currently available instrument to measure QoL in infants and/or children with eczema

Electronic structure and magnetic properties of Li_2ZrCuO_4 - a spin 1/2 Heisenberg system in vicinity to a quantum critical point

Based on density functional calculations, we present a detailed theoretical study of the electronic structure and the magnetic properties of the quasi-one dimensional chain cuprate Li_2ZrCuO_4 (Li_2CuZrO_4). For the relevant ratio of the next-nearest neighbor exchange J_2 to the nearest neighbor exchange J_1 we find alpha = -J_2/J_1 = 0.22\pm0.02 which is very close to the critical point at 1/4. Owing this vicinity to a ferromagnetic-helical critical point, we study in detail the influence of structural peculiarities such as the reported Li disorder and the non-planar chain geometry on the magnetic interactions combining the results of LDA based tight-binding models with LDA+U derived exchange parameters. Our investigation is complemented by an exact diagonalization study of a multi-band Hubbard model for finite clusters predicting a strong temperature dependence of the optical conductivity for Li_2ZrCuO_4

The PSI np data and their effect on the charge Π−N−N\Pi-N-N coupling constant

Differential cross sections of elastic neutron-proton scattering have been measured for the energy range from 200 MeV to 580 MeV. The angular interval for the detection of the recoiling proton ranges up to 48 degree in the laboratory system. This corresponds to an interval of the scattering angle from 80 degree to 180 degree in the centre-of-mass system. For absolute normalization the simultaneously measured np --> d Pi^o reaction was used above 280 MeV. The charged Pi-NN coupling constant has been determined to f^2_{Pi-n-p} = 0.076+-0.001

Devroye Inequality for a Class of Non-Uniformly Hyperbolic Dynamical Systems

In this paper, we prove an inequality, which we call "Devroye inequality", for a large class of non-uniformly hyperbolic dynamical systems (M,f). This class, introduced by L.-S. Young, includes families of piece-wise hyperbolic maps (Lozi-like maps), scattering billiards (e.g., planar Lorentz gas), unimodal and H{\'e}non-like maps. Devroye inequality provides an upper bound for the variance of observables of the form K(x,f(x),...,f^{n-1}(x)), where K is any separately Holder continuous function of n variables. In particular, we can deal with observables which are not Birkhoff averages. We will show in \cite{CCS} some applications of Devroye inequality to statistical properties of this class of dynamical systems.Comment: Corrected version; To appear in Nonlinearit

An algorithm for correcting CoRoT raw light curves

We introduce the CoRoT detrend algorithm (CDA) for detrending CoRoT stellar light curves. The algorithm CDA has the capability to remove random jumps and systematic trends encountered in typical CoRoT data in a fully automatic fashion. Since enormous jumps in flux can destroy the information content of a light curve, such an algorithm is essential. From a study of 1030 light curves in the CoRoT IRa01 field, we developed three simple assumptions which upon CDA is based. We describe the algorithm analytically and provide some examples of how it works. We demonstrate the functionality of the algorithm in the cases of CoRoT0102702789, CoRoT0102874481, CoRoT0102741994, and CoRoT0102729260. Using CDA in the specific case of CoRoT0102729260, we detect a candidate exoplanet around the host star of spectral type G5, which remains undetected in the raw light curve, and estimate the planetary parameters to be Rp=6.27Re and P=1.6986 days.Comment: 8 pages, 13 figure

Fusion energy from the Moon for the twenty-first century

It is shown in this paper that the D-He-3 fusion fuel cycle is not only credible from a physics standpoint, but that its breakeven and ignition characteristics could be developed on roughly the same time schedule as the DT cycle. It was also shown that the extremely low fraction of power in neutrons, the lack of significant radioactivity in the reactants, and the potential for very high conversion efficiencies, can result in definite advantages for the D-He-3 cycle with respect to DT fusion and fission reactors in the twenty-first century. More specifically, the D-He-3 cycle can accomplish the following: (1) eliminate the need for deep geologic waste burial facilities and the wastes can qualify for Class A, near-surface land burial; (2) allow 'inherently safe' reactors to be built that, under the worst conceivable accident, cannot cause a civilian fatality or result in a significant (greater than 100 mrem) exposure to a member of the public; (3) reduce the radiation damage levels to a point where no scheduled replacement of reactor structural components is required, i.e., full reactor lifetimes (approximately 30 FPY) can be credibly claimed; (4) increase the reliability and availability of fusion reactors compared to DT systems because of the greatly reduced radioactivity, the low neutron damage, and the elimination of T breeding; and (5) greatly reduce the capital costs of fusion power plants (compared to DT systems) by as much as 50 percent and present the potential for a significant reduction on the COE. The concepts presented in this paper tie together two of the most ambitious high-technology endeavors of the twentieth century: the development of controlled thermonuclear fusion for civilian power applications and the utilization of outer space for the benefit of mankind on Earth