313 research outputs found
Evolving localizations in reaction-diffusion cellular automata
We consider hexagonal cellular automata with immediate cell neighbourhood and
three cell-states. Every cell calculates its next state depending on the
integral representation of states in its neighbourhood, i.e. how many
neighbours are in each one state. We employ evolutionary algorithms to breed
local transition functions that support mobile localizations (gliders), and
characterize sets of the functions selected in terms of quasi-chemical systems.
Analysis of the set of functions evolved allows to speculate that mobile
localizations are likely to emerge in the quasi-chemical systems with limited
diffusion of one reagent, a small number of molecules is required for
amplification of travelling localizations, and reactions leading to stationary
localizations involve relatively equal amount of quasi-chemical species.
Techniques developed can be applied in cascading signals in nature-inspired
spatially extended computing devices, and phenomenological studies and
classification of non-linear discrete systems.Comment: Accepted for publication in Int. J. Modern Physics
Ant Colony Optimisation for Exploring Logical Gene-Gene Associations in Genome Wide Association Studies.
In this paper a search for the logical variants of gene-gene
interactions in genome-wide association study (GWAS) data using ant
colony optimisation is proposed. The method based on stochastic algorithms
is tested on a large established database from the Wellcome
Trust Case Control Consortium and is shown to discover logical operations
between combinations of single nucleotide polymorphisms that can
discriminate Type II diabetes. A variety of logical combinations are explored
and the best discovered associations are found within reasonable
computational time and are shown to be statistically significantThis study makes use of data generated by the Wellcome Trust Case Control
Consortium. A full list of the investigators who contributed to the generation
of the data is available from http://www.wtccc.org.uk. Funding for the project
was provided by the Wellcome Trust under award 076113.
The work contained in this paper was funded by an EPSRC First Grant
(EP/J007439/1) and we acknowledge their kind support
Subset-Based Ant Colony Optimisation for the Discovery of Gene-Gene Interactions in Genome Wide Association Studies
In this paper an ant colony optimisation approach for the discovery of gene-gene interactions in genome-wide association study (GWAS) data is proposed. The subset-based approach includes a novel encoding mechanism and tournament selection to analyse full scale GWAS data consisting of hundreds of thousands of variables to discover associations between combinations of small DNA changes and Type II diabetes. The method is tested on a large established database from the Wellcome Trust Case Control Consortium and is shown to discover combinations that are statistically significant and biologically relevant within reasonable computational time.The work contained in this paper was supported by an
EPSRC First Grant (EP/J007439/1).
This study makes use of data generated by the Wellcome
Trust Case Control Consortium. A full list of the inves-
tigators who contributed to the generation of the data is
available from http://www.wtccc.org.uk. Funding for the
project was provided by the Wellcome Trust under award
076113
Seminario regional sobre el desarrollo de las bibliotecas universitarias en América Latina
La conveniencia de realizar un Seminario de la índole y jerarquía del que se ha llevado a cabo en Mendoza ya había sido destacada tanto en el Consejo Económico y Social de OEA como en la Conferencia sobre Educación y Desarrollo Económico y Social en América Latina de UNESCO. En efecto, en las Declaraciones de Punta del Este (agosto de 1961) y en las de Santiago de Chile (marzo de 1962), se señaló el valor de los servicios bibliotecarios para las tareas educativas y se acordó encomendar a un Seminario el planeamiento de aquellos servicios que deberán afrontar las bibliotecas universitarias en relación con los más modernos objetivos de la educación superior y con las exigencias del desarrollo económico y social. Al mismo tiempo, se recomendaba que dicho Seminario señalase los costos y las prioridades adecuadas, para el financiamiento de los correspondientes planes de acción. El Seminario que recogió estas sugerencias fue el realizado en la ciudad de Mendoza, del 24 de setiembre al 5 de octubre ppdo.Universidad Nacional de La Plat
ISSP 2017 module on social network and social ressources : Reasoning report for the draft source questionnaire
The Real-World Observational Prospective Study of Health Outcomes with Dulaglutide and Liraglutide in Type 2 Diabetes Patients (TROPHIES): Baseline Patient-Reported Outcomes
Introduction: Although patient-reported outcome (PRO) measures provide important information beyond clinical data, studies that assess the PROs of type 2 diabetes mellitus (T2DM) patients initiating injectable glucose-lowering medications in routine clinical practice are limited. We describe the perspectives of patients based on a diversified panel of generic and disease-specific PRO measures at the time of enrollment (baseline) in the TROPHIES study. Methods: TROPHIES is a 24-month prospective observational study performed in France, Germany, and Italy in patients with T2DM who initiated their first injectable glucose-lowering medication with once-weekly dulaglutide or once-daily liraglutide. To better understand the perspectives of these patients regarding their overall health, treatment satisfaction, and quality of life and work, the patients’ responses to the following questionnaires were collected at baseline before they initiated treatment with dulaglutide or liraglutide: EQ-5D-5L (scale: 0–1), EQ-VAS (visual analog scale: 0–100), Impact of Weight on Self-Perceptions Questionnaire (IW-SP; scale: 0–100), Diabetes Treatment Satisfaction Questionnaire Status (DTSQs; scale: 0–36), and Diabetes Productivity Measure (DPM; scale: 0–100). Analyses were descriptive in nature, with higher scores reflecting better outcomes. Results: Data from patients at the time of enrollment were analyzed. At baseline, patients initiating dulaglutide (N = 1130) or liraglutide (N = 1051) rated their quality of life in terms of mean EQ-5D-5L index as 0.84 and 0.83, and in terms of mean EQ-VAS as 67.5 and 67.5, respectively. The mean baseline scores in patients initiating dulaglutide or liraglutide were 59.8 and 61.3 for IW-SP, 24.6 and 25.8 for DTSQs, 78.6 and 79.5 for DPM Life Productivity, and 87.5 and 86.8 for DPM Work Productivity, respectively. Conclusion: The information from this varied panel of PRO instruments collected at baseline complements clinical outcomes data
The Real-World Observational Prospective Study of Health Outcomes with Dulaglutide and Liraglutide in Type 2 Diabetes Patients (TROPHIES): Design and Baseline Characteristics
Introduction: The TROPHIES observational study enrolled patients with type 2 diabetes mellitus (T2DM) initiating their first injectable treatment with the glucagon-like peptide 1 receptor agonists (GLP-1 RAs) dulaglutide or liraglutide. This manuscript focuses on the study design, baseline characteristics of the enrolled population, and factors associated with GLP-1 RA choice. Methods: TROPHIES is a prospective, observational, 24-month study conducted in France, Germany, and Italy. Inclusion criteria include adult patients with T2DM, naïve to injectable antihyperglycemic treatments, initiating dulaglutide or liraglutide per routine clinical practice. The primary outcome is the duration of treatment on dulaglutide or liraglutide without a significant treatment change. Results: The analysis included 2181 patients (dulaglutide, 1130; liraglutide, 1051) (cutoff date May 15, 2019). The population was 56% male with mean [standard deviation (SD)] patient characteristics at baseline as follows: age, 59.2 (11.0) years; body mass index (BMI), 33.9 (6.6) kg/m2; T2DM duration, 8.5 (6.9) years; and glycated hemoglobin (HbA1c), 8.2 (1.3)%. Between-cohort demographic and clinical characteristics were balanced. The mean (SD) HbA1c and BMI values for French, German, and Italian patients were, respectively, 8.6 (1.4)%, 8.2 (1.4)%, 8.0 (0.8)%; 33.3 (6.1) kg/m2, 36.0 (7.2) kg/m2, and 32.6 (5.9) kg/m2. Conclusion: This study analysis at baseline provides an opportunity to evaluate between-country differences in baseline HbA1c, weight, macrovascular complications, and factors driving GLP-1 RA selection for patients with T2DM in daily practice
Universal computation with limited resources: Belousov-Zhabotinsky and Physarum computers
Using the examples of an excitable chemical system (Belousov-Zhabotinsky
medium) and plasmodium of Physarum polycephalum we show that universal
computation in a geometrically unconstrained medium is only possible when
resources (excitability or concentration of nutrients) are limited. In
situations of limited resources the systems studied develop travelling
localizations. The localizations are elementary units of dynamical logical
circuits in collision-based computing architectures.Comment: Int. J. Bifurcation and Chaos (2008), accepte
Preanalytical, Analytical, and Computational Factors Affect Homeostasis Model Assessment Estimates
OBJECTIVE—We investigated how β-cell function and insulin sensitivity or resistance are affected by the type of blood sample collected or choice of insulin assay and homeostatis model assessment (HOMA) calculator (http://www.dtu.ox.ac.uk)
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