A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic

The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and regions (n = 21,644) were randomly assigned to one of two brief reappraisal interventions (reconstrual or repurposing) or one of two control conditions (active or passive). Results revealed that both reappraisal interventions (vesus both control conditions) consistently reduced negative emotions and increased positive emotions across different measures. Reconstrual and repurposing interventions had similar effects. Importantly, planned exploratory analyses indicated that reappraisal interventions did not reduce intentions to practice preventive health behaviours. The findings demonstrate the viability of creating scalable, low-cost interventions for use around the world

Chemical Characterization Of Sapucaia Nuts (lecythis Pisonis Cambess.) From Zona Da Mata Mineira Region [caracterização Química Da Castanha De Sapucaia (lecythis Pisonis Cambess.) Da Região Da Zona Da Mata Mineira]

Currently the nuts have received special attention of researchers because they are natural sources of vitamins, minerals, protein and essential fatty acids, could also contribute to the diet of humans and animals. Recent research confirms that these foods are also sources of bioactive compounds, which can bring significant benefits to human health through regular consumption. This study evaluated the chemical composition of sapucaia nut (Lecythis pisonis Cambess.) of the state of Minas Gerais. We analyzed the chemical composition (lipids, proteins, carbohydrates, ash and moisture), and the mineral content by mass spectrometry, and the lipid profile by gas chromatography. The chemical composition showed 54,8% lipids; 26,82% protein; 5,01% carbohydrates; 3,17% ash and 10,2% moisture. The lipid, 43,1% were polyunsaturated fatty acids, monounsaturated fatty acids 41,7% and 15,2% saturated fatty acids. The minerals phosphorus, magnesium and manganese are highlighted by high levels, 941; 343 and 4,8 mg.100-1, respectively. Sapucaia nut is a potential protein-energy and minerals source, but its toxicity must be evaluated.286971977Bidlngmeyer, B.A., Cohen, S.A., Tarvin, T.L., Rapid analysis of aminoacids using pre-column derivatization (1984) Journal of Chromatography, 336 (1), pp. 93-104. , Amsterdan(1998) Princípios Gerais Para O Estabelecimento De Níveis Máximos De Contaminantes Químicos Em Alimentos, pp. 28-29. , BRASIL. Agência Nacional de Vigilância Sanitária - Ministério da Saúde. Portaria no 685 de 27 de agosto de 1998, Diário Oficial da União n° 165-E, Seção I, Brasília, agoChaves, M.H., Barbosa, A.S., Moita, N.J.M., Aued-Pimentel, S., Lago, J.H.G., Caracterizaçao química do óleo da amêndoa de Sterculia striata St Hill et Nauda (2004) Química Nova, 27 (3), pp. 404-408. , São PauloCosta, P.A., Ballus, C.A., Teixeira-Filho, J., Godoy, H.T., Phytosterols and tocopherols content of pulps and nuts of Brazilian fruits (2010) Food Research International, 43 (6), pp. 1-4. , TorontoDenadai, S.M.S., Hiane, P.A., Marangoni, S., Baldasso, P.A., Miguel, A.M.R.O., Macedo, M.L.R., In vitro digestibility of globulins from sapucaia (Lecythis pisonis Camb.) nuts by mammalian digestive proteinases (2007) Ciência E Tecnologia De Alimentos, 27 (3), pp. 535-543. , Campinas(1991), FAO/WHO. Report of a joint FAO/WHO expert consultation held in Bethseda, MD, USA. Dec 1989. Protein quality evaluation. 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Pisonis, , http://www.jardimdeflores.com.br/floresefolhas/A47sapucaia.htm, Disponível em:, Acesso em: 01 de junRos, E., Mataix, J., Fatty acid composition of nuts - implications for cardiovascular health (2006) British Journal of Nutrition, 96 (2), pp. 29-35. , CambrigdeRos, E., Nuts and novel biomarkers os cardiovascular disease (2009) American Journal of Clinical Nutrition, 89, pp. 1649-1656. , BethesdaRosa, J.C., Izumi, C., Beltramini-Sabbag, L.M., Greene, L.J., Quantitative HPLC analysis of phenylisothio-carbamyl-amino acids at picomol levels (1987) Arquivos De Biologia E Tecnologia, 30 (1), p. 35. , CuritibaRyan, E., Galvin, K., O'connor, T.P., Maguire, A.R., O'Brien, N.M., Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts (2006) International Journal of Food Sciences and Nutrition, 57 (3), pp. 219-228. , LondonSinha, R., Radha, C., Prakash, J., Kaul, P., Whey protein hydrolysate: Functional properties, nutritional quality and utilization in beverage formulation (2007) Food Chemistry, 101 (4), pp. 1484-1491. , BarkingSouza, V.A.B., Carvalho, M.G., Santos, K.S., Ferreira, C.S., Características físicas de frutos e amêndoas e características químico-nutricionais de amêndoas de acessos de sapucaia (2008) Revista Brasileira De Fruticultura, 30 (4), pp. 946-952. , JaboticabalVallilo, M.I., Tavares, M., Pimentel, S.A., Campos, N.C., Moita, N.J.M., Lecythis pisonis Camb. nuts: Oil characterization, fatty acids and minerals (1999) Food Chemstry, 66, pp. 197-200. , BarkingVallilo, M.I., Tavares, M., Pimentel, S.A., Badolato, E.S.G., Inomata, E.I., Caracterização química parcial das sementes de Lecythis pisonis Camb. 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Brazilian Biologic Registry: Biobada Brasil Implementation Process And Preliminary Results

Objectives: The present study aimed at describing the implementation process of a national registry in a developing country (Brazil) and at reporting the main preliminary results of the BiobadaBrasil registry. Material and methods: Through a PANLAR agreement, the Biobadaser protocol was used as a model for implementing the new registry in our country. During the first two years of this effort, the original protocol was adapted, translated, and presented to all Brazilian rheumatologists. For ten months, data of 1,037 patients (750 subjects treated with biological drugs and 287 control subjects) from 15 centers were collected. Results: Most patients had rheumatoid arthritis (RA) (n = 723). Infliximab was the most frequently used anti-TNF agent, and the total exposure to biologic drugs was 2,101 patient-years. The most common reason for interrupting drug use was lack or loss of efficacy (50%), while 30% withdrew from the treatment arm due to adverse events. Three cases of tuberculosis were observed in the biologic group, with an incidence higher than that of the general Brazilian population. Infections were observed in 23% of the biologic group, and the upper respiratory tract was the most commonly affected site. Only one case of tuberculoid leprosy was observed. No deaths or malignancies attributed to drug effects were observed as of February 2010. Conclusions: The implementation of the BiobadaBrasil registry was successful, and, although recent, the registry has provided important data. ©Elsevier Editora Ltda.51214515

Salacia campestris root bark extract: peroxidase inhibition, antioxidant and antiradical profile

Reactive oxygen species (ROS) and free radical species have been implicated in initiating or accompanying many diseases in living organisms; there is thus, a continual need for antioxidants molecules to inactivate ROS/free radicals. Many studies of plants crude extracts have demonstrated free-radical scavenging and antioxidant action. Salacia species have long been used, in several countries, as traditional medicines against certain diseases and for their anti-inflammatory properties. In this study, Salacia campestris Walp (Hippocrateaceae) root bark ethanol extract (ScEtOH) was assessed for its ability to scavenge free radicals and reactive oxygen species; the results were expressed as percentage inhibition of the active species. ScEtOH was efficient against studied species: DPPH radical (obtained inhibition = 30%), ABTS•+ (IC50 = 1.8±0.8 &#956;g/mL), HOCl (IC50 = 1.7 ± 0.1 &#956;g/mL), O2•- (obtained inhibition = 32%), and NO• (obtained inhibition = 18 %). Peroxidase activity inhibition was evaluated through the guaiacol oxidation reaction catalyzed by hemin, HRP and myeloperoxidase (MPO); data showed that ScEtOH at 10 &#956;g/mL led to 54 and 51% of inhibition, respectively, for the hemin and HRP systems. In the MPO system, ScEtOH promoted a 50% inhibition at 8.9 &#956;g/mL, whereas quercetin, a powerful MPO inhibitor, inhibited this system at 1.35 &#956;g/mL.<br>Espécies reativas do oxigênio (ERO) e radicais livres estão relacionados ao início ou à exacerbação de muitas doenças em organismos vivos; existindo portanto uma necessidade contínua por moléculas antioxidantes que inativem as ERO e radicais livres. Muitos estudos com extratos brutos de plantas têm demonstrado propriedades antioxidantes e seqüestradoras de radicais livres. Espécies de Salacia são utilizadas, em muitos países, como remédio tradicional contra certas doenças e por suas propriedades antiinflamatórias. Neste estudo, o extrato bruto etanólico da casca da raiz da Salacia campestris Walp (Hippocrateaceae) foi avaliado quanto à sua habilidade em seqüestrar radicais livres e espécies reativas do oxigênio; os resultados são expressos como porcentagem de inibição das espécies ativas. ScEtOH mostrou-se eficiente frente as espécies estudadas: radical DPPH (inibição obtida = 30%), ABTS•+ (IC50 = 1,8±0,8 &#956;g/mL), HOCl (IC50 = 1,7 ± 0,1 &#956;g/mL), O2•- (inibição obtida = 32%), and NO• (inibição obtida = 18%). A inibição da atividade peroxidásica foi avaliada através da oxidação do guaiacol catalisada pela hemina, HRP e mieloperoxidase (MPO); os dados mostram que 10 &#956;g/mL de ScEtOH promovem 54 e 51% de inibição, respectivamente para os sistemas da hemina e da HRP. No sistema da MPO, ScEtOH promoveu 50% de inibição na dose de 8,9 &#956;g/mL, enquanto a quercetina, um potente inibidor da MPO promoveu tal inibição com 1,35 &#956;g/mL

A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic

Abstract: The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and regions (n = 21,644) were randomly assigned to one of two brief reappraisal interventions (reconstrual or repurposing) or one of two control conditions (active or passive). Results revealed that both reappraisal interventions (vesus both control conditions) consistently reduced negative emotions and increased positive emotions across different measures. Reconstrual and repurposing interventions had similar effects. Importantly, planned exploratory analyses indicated that reappraisal interventions did not reduce intentions to practice preventive health behaviours. The findings demonstrate the viability of creating scalable, low-cost interventions for use around the world. Protocol registration: The stage 1 protocol for this Registered Report was accepted in principle on 12 May 2020. The protocol, as accepted by the journal, can be found at https://doi.org/10.6084/m9.figshare.c.4878591.v1 © 2021, The Author(s), under exclusive licence to Springer Nature Limited