Naturally occurring ingredients as potential antiaging cosmetics

The criteria adopted for establishing whether a determined substance has potential as a cosmetic constituent are based on the present legislation of each country. In this study, natural antiaging constituents as Fomes officinalis, rice protein and glutamic acid were pharmacologically evaluated using neuromuscular preparation. These constituents induced a neuromuscular blockade, individually and also in mixture, simulating a Botox®, but not, dimethylaminoethanol-effect. The pharmacological knowledge is beneficial since the real effect of each ingredient becomes apparent, increasing the consumer's confidence on the antiaging cosmetic.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Naturally occurring ingredients as potential antiaging cosmetics

The criteria adopted for establishing whether a determined substance has potential as a cosmetic constituent are based on the present legislation of each country. In this study, natural antiaging constituents as Fomes officinalis, rice protein and glutamic acid were pharmacologically evaluated using neuromuscular preparation. These constituents induced a neuromuscular blockade, individually and also in mixture, simulating a Botox®, but not, dimethylaminoethanol-effect. The pharmacological knowledge is beneficial since the real effect of each ingredient becomes apparent, increasing the consumer's confidence on the antiaging cosmetic.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Aplicación de TIG en la reconstrucción de las disfunciones territoriales históricas de sistemas de dunas de Canarias

En este trabajo se presenta un ejemplo de integración de fuentes y técnicas para la reconstrucción de las condiciones naturales y de los usos del suelo acaecidos en períodos históricos próximos, con el fin de caracterizar disfunciones territoriales en sistemas frágiles desde el punto de vista natural, y estratégicos desde el punto de vista económico, como son los campos de dunas de Canarias. Se procede por medio del desarrollo de métodos de análisis histórico, como el contraste entre fuentes (interpretación de fotografías aéreas, análisis de textos históricos y de otros documentos y entrevistas a personas mayores), cuyos resultados se integran en un SIG. El contraste entre esta información y la obtenida de documentos recientes o actuales, permite reconstruir la evolución espacio-temporal acaecida desde que sucedieran tales hechos históricos, y entender la dinámica actual de los sistemas objeto de estudio. Se muestran en este trabajo algunos resultados obtenidos en el sistema de dunas de Maspalomas y en el extinto campo de dunas de Guanarteme, ambos en la isla de Gran Canaria, que han permitido interpretar de forma más exacta algunos procesos relacionados con la dinámica natural de estos sistemas.In this paper we present an example of integration of sources and techniques for the reconstruction of natural conditions and land use development in recent historical periods, in order to characterize some dysfunctions in the dune fields of the Canary Islands, which are fragile systems from an environmental point of view, and strategic in economic terms. We proceeded through the development of methods of historical analysis, as the contrast between sources (aerial photo interpretation, analysis of historical texts and other documents and interviews to older people), whose results were integrated into a GIS. The contrast between this information and recent documents allowed us the reconstruction of the evolution during the period since the occurrence of such historical facts, and understand the current dynamics of the systems under study. We show in this paper some results obtained in the Maspalomas dune system and in the late dune field of Guanarteme, both of them located in the island of Gran Canaria. These results have allowed us to accurate the interpretation of some processes related to the natural dynamics of these systems

Naturally occurring ingredients as potential antiaging cosmetics

The criteria adopted for establishing whether a determined substance has potential as a cosmetic constituent are based on the present legislation of each country. In this study, natural antiaging constituents as Fomes officinalis, rice protein and glutamic acid were pharmacologically evaluated using neuromuscular preparation. These constituents induced a neuromuscular blockade, individually and also in mixture, simulating a Botox®, but not, dimethylaminoethanol-effect. The pharmacological knowledge is beneficial since the real effect of each ingredient becomes apparent, increasing the consumer's confidence on the antiaging cosmetic.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Predictive Model of School Dropouts in Higher Education: An Approach From Data Mining Using the CRISP-DM Methodology

Este artículo presenta el desarrollo de un modelo para predecir, de manera temprana y oportuna, casos de estudiantes que muestren un potencial riesgo de deserción escolar, mediante el uso de técnicas de minería de datos. La deserción escolar a nivel superior es un problema multifactorial y complejo de analizar por la intervención de elementos de diversa índole, como factores familiares, académicos, educacionales, la situación económica familiar, las habilidades intelectuales de los estudiantes o la didáctica de los profesores. Este gran volumen de información a analizar no es fácilmente manejable con técnicas estadísticas tradicionales, sino que se precisa buscar estrategias que permitan operar con los bancos de datos de modo más eficiente y rápido. En el desarrollo de la propuesta se aplicó de una manera novedosa la minería de datos, para explorar los cambios en los comportamientos de los estudiantes, vinculados a diferentes causas de abandono escolar, utilizando la metodología CRISP-DM, con datos de 1,374 estudiantes de una institución de educación superior. Los resultados muestran las técnicas utilizadas para identificar y seleccionar factores asociados a la deserción estudiantil y los algoritmos para generar los modelos predictivos, de los cuáles pudo seleccionarse el más preciso, con mayor puntuación y facilidad de interpretación.This article presents the development of a model to predict, in an early and timely manner, cases of students who show a potential risk of dropping out of school, through the use of data mining techniques. High school dropout is a multifactorial and complex problem to analyze due to the intervention of diverse elements, such as family, academic, educational factors, the family economic situation, the intellectual abilities of the students or the didactics of the teachers. This large volume of information to be analyzed is not easily manageable with traditional statistical techniques, but it is necessary to find strategies that allow operating with data banks more efficiently and quickly. In the development of the proposal, data mining was applied in a novel way to explore changes in student behaviors, linked to different causes of school dropout, using the CRISP-DM methodology, with data from 1,374 students from an institution of higher education. The results show the techniques used to identify and select factors associated with student dropout, and the algorithms to generate predictive models, from which the most precise one could be selected, with the highest score and ease of interpretation

Modelling spectral and timing properties of accreting black holes: the hybrid hot flow paradigm

The general picture that emerged by the end of 1990s from a large set of optical and X-ray, spectral and timing data was that the X-rays are produced in the innermost hot part of the accretion flow, while the optical/infrared (OIR) emission is mainly produced by the irradiated outer thin accretion disc. Recent multiwavelength observations of Galactic black hole transients show that the situation is not so simple. Fast variability in the OIR band, OIR excesses above the thermal emission and a complicated interplay between the X-ray and the OIR light curves imply that the OIR emitting region is much more compact. One of the popular hypotheses is that the jet contributes to the OIR emission and even is responsible for the bulk of the X-rays. However, this scenario is largely ad hoc and is in contradiction with many previously established facts. Alternatively, the hot accretion flow, known to be consistent with the X-ray spectral and timing data, is also a viable candidate to produce the OIR radiation. The hot-flow scenario naturally explains the power-law like OIR spectra, fast OIR variability and its complex relation to the X-rays if the hot flow contains non-thermal electrons (even in energetically negligible quantities), which are required by the presence of the MeV tail in Cyg X-1. The presence of non-thermal electrons also lowers the equilibrium electron temperature in the hot flow model to <100 keV, making it more consistent with observations. Here we argue that any viable model should simultaneously explain a large set of spectral and timing data and show that the hybrid (thermal/non-thermal) hot flow model satisfies most of the constraints.Comment: 26 pages, 13 figures. To be published in the Space Science Reviews and as hard cover in the Space Sciences Series of ISSI - The Physics of Accretion on to Black Holes (Springer Publisher

New and conventional strategies for lung recruitment in acute respiratory distress syndrome

Mechanical ventilation is a supportive and life saving therapy in patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Despite advances in critical care, mortality remains high. During the last decade, the fact that mechanical ventilation can produce morphologic and physiologic alterations in the lungs has been recognized. In this context, the use of low tidal volumes (VT) and limited inspiratory plateau pressure (Pplat) has been proposed when mechanically ventilating the lungs of patients with ALI/ARDS, to prevent lung as well as distal organ injury. However, the reduction in VT may result in alveolar derecruitment, cyclic opening and closing of atelectatic alveoli and distal small airways leading to ventilator-induced lung injury (VILI) if inadequate low positive end-expiratory pressure (PEEP) is applied. On the other hand, high PEEP levels may be associated with excessive lung parenchyma stress and strain and negative hemodynamic effects, resulting in systemic organ injury. Therefore, lung recruitment maneuvers have been proposed and used to open up collapsed lung, while PEEP counteracts alveolar derecruitment due to low VT ventilatio

Neuronal pentraxin 2 : a synapse-derived CSF biomarker in genetic frontotemporal dementia

Introduction: Synapse dysfunction is emerging as an early pathological event in frontotemporal dementia (FTD), however biomarkers are lacking. We aimed to investigate the value of cerebrospinal fluid (CSF) neuronal pentraxins (NPTXs), a family of proteins involved in homeostatic synapse plasticity, as novel biomarkers in genetic FTD. Methods: We included 106 presymptomatic and 54 symptomatic carriers of a pathogenic mutation in GRN, C9orf72 or MAPT, and 70 healthy non-carriers participating in the Genetic Frontotemporal dementia Initiative (GENFI), all of whom had at least one CSF sample. We measured CSF concentrations of NPTX2 using an in-house ELISA, and NPTX1 and NPTX receptor (NPTXR) by Western blot. We correlated NPTX2 with corresponding clinical and neuroimaging datasets as well as with CSF neurofilament light chain (NfL) using linear regression analyses. Results: Symptomatic mutation carriers had lower NPTX2 concentrations (median 643 pg/mL, IQR (301-872)) than presymptomatic carriers (1003 pg/mL (624-1358), p&lt;0.001) and non-carriers (990 pg/mL (597-1373), p&lt;0.001) (corrected for age). Similar results were found for NPTX1 and NPTXR. Among mutation carriers, NPTX2 concentration correlated with several clinical disease severity measures, NfL and grey matter volume of the frontal, temporal and parietal lobes, insula and whole brain. NPTX2 predicted subsequent decline in phonemic verbal fluency and Clinical Dementia Rating scale plus FTD modules. In longitudinal CSF samples, available in 13 subjects, NPTX2 decreased around symptom onset and in the symptomatic stage. Discussion: We conclude that NPTX2 is a promising synapse-derived disease progression biomarker in genetic FTD