A generalization of the "probléme des rencontres"

In this paper, we study a generalization of the classical \emph{probl\'eme des rencontres} (\emph{problem of coincidences}), consisting in the enumeration of all permutations \pi \in \SS_n with $k$ fixed points, and, in particular, in the enumeration of all permutations \pi \in \SS_n with no fixed points (derangements). Specifically, we study this problem for the permutations of the $n+m$ symbols $1$, $2$, \ldots, $n$, $v_1$, $v_2$, \ldots, $v_m$, where $v_i \not\in\{1,2,\ldots,n\}$ for every $i=1,2,\ldots,m$. In this way, we obtain a generalization of the derangement numbers, the rencontres numbers and the rencontres polynomials. For these numbers and polynomials, we obtain the exponential generating series, some recurrences and representations, and several combinatorial identities. Moreover, we obtain the expectation and the variance of the number of fixed points in a random permutation of the considered kind. Finally, we obtain some asymptotic formulas for the generalized rencontres numbers and the generalized derangement numbers

USE OF SATELLITE SAR DATA FOR SEISMIC RISK MANAGEMENT: RESULTS FROM THE PRE-OPERATIONAL ASI-SIGRIS PROJECT

In the framework of the National Space Programme, and of the European GMES Programme, the Italian Space Agency (ASI) has funded several pilot projects aimed at demonstrating the full potential of Earth Observation data in the monitoring and management of natural hazards. The SIGRIS (Earth Observation System for Seismic Risk Management) pilot project has developed a hardware/software infrastructure for the generation of decision support products for the seismic risk management. A pre-operational demonstration of the SIGRIS system is being carried out since June 2009 and various products to be used by civil protection authorities in either the Knowledge & Prevention or Crisis Management phases of seismic risk management, have been generated. SIGRIS products to support the Knowledge & Prevention activities are based on the integration of satellite and ground-based observations to constrain analytical and numerical models of the tectonic strain accumulation and of its long-term effects on the earthquake source. They include crustal deformation maps from time series DInSAR and GPS, and fault models to improve the seismic hazard assessment. SIGRIS products for the Crisis Management phase are instead focused on the quick generation of value added information needed to devise damage or event scenarios, and typically consist of damage assessment maps from high resolution optical and SAR data, co-seismic displacements maps from DInSAR analysis, seismic source models, maps of earthquake-induced environmental effects (landslides, surface fractures, ecc.). For these products a near-real time capability is required and new constellations, as COSMO-SkyMed , can now provide the necessary temporal revisit to fulfil this need. The SIGRIS system is also depending on other SAR satellites to ensure a faster and better coverage of the disaster areas: ENVISAT, Radarsat, TerraSar X, ALOS. We will present examples of the SIGRIS decision support products based on the integration of Earth Observation and ground data and discuss important issues related to disaster applications, as EO data programming, fast data access, data archival

A Quantitative Functional Central Limit Theorem for Shallow Neural Networks

We prove a Quantitative Functional Central Limit Theorem for one-hidden-layer neural networks with generic activation function. The rates of convergence that we establish depend heavily on the smoothness of the activation function, and they range from logarithmic in non-differentiable cases such as the Relu to $\sqrt{n}$ for very regular activations. Our main tools are functional versions of the Stein-Malliavin approach; in particular, we exploit heavily a quantitative functional central limit theorem which has been recently established by Bourguin and Campese (2020)

EvAAL: Evaluating AAL Systems through Competitive Benchmarking

Owing to the complexity of Ambient Assisted Living (AAL) systems and platforms, the evaluation of AAL solutions is a complex task that will challenge researchers for years to come. However, the analysis and comparison of proposed solutions is paramount to enable us to assess research results in this area. We have thus organized an international contest called EvAAL: Evaluating AAL Systems through Competitive Benchmarking. Its aims are to raise interest within the research and developer communities in the multidisciplinary research fields enabling AAL, and to create benchmarks for the evaluation and comparison of AAL systems

The galectin-3/RAGE dyad modulates vascular osteogenesis in atherosclerosis

Vascular calcification correlates with inflammation and plaque instability in a dual manner, depending on the spotty/granular (micro) or sheet-like/lamellated (macro) pattern of calcification. Modified lipoproteins trigger both inflammation and calcification via receptors for advanced lipoxidation/glycation endproducts (ALEs/AGEs). This study compared the roles of galectin-3 and receptor for AGEs (RAGE), two ALEs/AGEs-receptors with diverging effects on inflammation and bone metabolism, in the process of vascular calcification. We evaluated galectin-3 and RAGE expression/localization in 62 human carotid plaques and its relation to calcification pattern, plaque phenotype, and markers of inflammation and vascular osteogenesis; and the effect of galectin-3 ablation and/or exposure to an ALE/AGE on vascular smooth muscle cell (VSMC) osteogenic differentiation. While RAGE co-localized with inflammatory cells in unstable regions with microcalcification, galectin-3 was expressed also by VSMCs, especially in macrocalcified areas, where it co-localized with alkaline phosphatase. Expression of galectin-3 and osteogenic markers was higher in macrocalcified plaques, whereas the opposite occurred for RAGE and inflammatory markers. Galectin-3-deficient VSMCs exhibited defective osteogenic differentiation, as shown by altered expression of osteogenic transcription factors and proteins, blunted activation of pro-osteoblastogenic Wnt/β-catenin signalling and proliferation, enhanced apoptosis, and disorganized mineralization. These abnormalities were associated with RAGE up-regulation, but were only in part prevented by RAGE silencing, and were partially mimicked or exacerbated by treatment with an AGE/ALE. These data indicate a novel molecular mechanism by which galectin-3 and RAGE modulate in divergent ways, not only inflammation, but also vascular osteogenesis, by modulating Wnt/β-catenin signalling, and independently of ALEs/AGEs

TIMIT-TTS: a Text-to-Speech Dataset for Multimodal Synthetic Media Detection

With the rapid development of deep learning techniques, the generation and counterfeiting of multimedia material are becoming increasingly straightforward to perform. At the same time, sharing fake content on the web has become so simple that malicious users can create unpleasant situations with minimal effort. Also, forged media are getting more and more complex, with manipulated videos that are taking the scene over still images. The multimedia forensic community has addressed the possible threats that this situation could imply by developing detectors that verify the authenticity of multimedia objects. However, the vast majority of these tools only analyze one modality at a time. This was not a problem as long as still images were considered the most widely edited media, but now, since manipulated videos are becoming customary, performing monomodal analyses could be reductive. Nonetheless, there is a lack in the literature regarding multimodal detectors, mainly due to the scarsity of datasets containing forged multimodal data to train and test the designed algorithms. In this paper we focus on the generation of an audio-visual deepfake dataset. First, we present a general pipeline for synthesizing speech deepfake content from a given real or fake video, facilitating the creation of counterfeit multimodal material. The proposed method uses Text-to-Speech (TTS) and Dynamic Time Warping techniques to achieve realistic speech tracks. Then, we use the pipeline to generate and release TIMIT-TTS, a synthetic speech dataset containing the most cutting-edge methods in the TTS field. This can be used as a standalone audio dataset, or combined with other state-of-the-art sets to perform multimodal research. Finally, we present numerous experiments to benchmark the proposed dataset in both mono and multimodal conditions, showing the need for multimodal forensic detectors and more suitable data

Analyses of TIMS and AVIRIS data, integrated with field and laboratory spectra, for lithological and mineralogical interpretation of Vulcano Island, Italy

Vulcano Island is part of the Eolian archipelago, located about 25 km from the northeast coast of Sicily. The archipelago comprises seven major volcanic islands, two of which are active volcanoes (Vulcano and Stromboli). Vulcano covers an area of about 50 square km, and is about 10 km long. Explosive volcanic activity has predominated in the geological evolution of Vulcano Island, and there is no evidence that this pattern has ceased. Rather, the current situation is one of unrest, so a strict regimen of continuous geophysical and geochemical monitoring has been undertaken over the last decade. Though the year-round population of Vulcano is small (under 1000), during the summer the island becomes a very popular resort, and has thousands of additional tourists at any time throughout the high season, thus substantially increasing the number of people potentially at risk from an explosive eruption or other hazards such as noxious gas emissions (e.g., CO2, H2S, SO2). During the past ten years, remote sensing data have been repetitively acquired with optical and microwave airborne sensors. The present work shows the preliminary results of a study based on the integration of various remote sensing data sets with field spectroscopy, and other laboratory analyses, for the geological and geomorphological mapping of the island. It is hoped that such work will also usefully contribute to the evaluation of the volcanic hazard potential of the islands as well as to the evaluation of the status of its current activity

Contribution of the EVER-EST project to the community of the Geohazard Supersites initiative

The EVER-EST project (European Virtual Environment for Research - Earth Science Themes: a solution) is a H2020 project (2015-2018) aimed at the creation of a Virtual Research Environment (VRE) focused on the requirements of the Earth Science community. The VRE is intended to enhance the ability to collaborate, interoperate and share knowledge and experience between all relevant stakeholders, including researchers, monitoring teams and civil protection agencies. Among the innovations of the project is the exploitation of the “Research Object” concept.PublishedVIenna,Austria1VV. Altr

Monocytes of Patients with Systemic Sclerosis (Scleroderma) Spontaneously Release In Vitro Increased Amounts of Superoxide Anion

It has been suggested that toxic oxygen free radicals can be involved in the pathogenesis of systemic sclerosis (scleroderma) (SSc). Because the cells that contribute to the generation of free radicals are not known, our aim was (i) to evaluate the ability of unmanipulated and phorbol 12-myristate 13-acetate-stimulated monocytes and polymorphonucleate neutrophils of SSc patients to generate superoxide anion (O2·–); and (ii) to investigate whether the O2·– produced by these cells involved the activation of nicotinamide-adenine dinucleotide diphosphate oxidase biochemical pathway. Employing the superoxide dismutase-inhibitable reduction of cytochrome c to evaluate the generation of O2·–, unmanipulated monocytes of SSc patients generated more O2·– than primary Raynaud’s phenomenon patients and normal control monocytes (p= 0.0001), and the release was higher in patients with diffuse cutaneous involvement and 5 y or less disease duration (p = 0.02). The involvement of nicotinamide-adenine dinucleotide diphosphate oxidase in the enhanced O2·– production was demonstrated by the finding that the cytosolic components of the enzyme, p47phox and p67phox, were both translocated to the plasma membrane of enriched but otherwise unmanipulated monocytes of SSc patients. The involvement of mitochondrial oxidases was excluded by the lack of inhibition of O2·– production when monocytes were incubated in the presence of rotenone, a mitochondrial oxidase inhibitor. Upon stimulation with phorbol 12-myristate 13-acetate, monocytes of SSc patients produced more O2·– than controls. In SSc patients untreated polymorphonucleate neutrophils generated significantly less O2·– than monocytes (p = 0.0001) and only slightly more than polymorphonucleate neutrophils of primary Raynaud’s phenomenon patients and normal controls (p = 0.03). In conclusion, we demonstrate that in patients with scleroderma, unmanipulated and phorbol 12-myristate 13-acetate-stimulated monocytes release in vitro increased amounts of superoxide anion through the activation of nicotinamide-adenine dinucleotide diphosphate oxidase and, thus, contribute to the oxidative stress found in this disease

Peripheral blood regulatory T cell measurements correlate with serum vitamin D level in patients with psoriasis

OBJECTIVE:Vitamin D is the precursor of a hormone (1,25-dihydroxyvitamin D3), which has many biological effects in the skin. The immune modulator properties of vitamin D are mediated in part through effects on regulatory T cells (T-reg). Currently, in psoriasis, the relationship between vitamin D and T-reg has not well elucidated. We assess whether vitamin D status is correlated with circulating T-reg in patients affected by psoriasis and if there is a correlation with the severity of the disease evaluated with Psoriasis Area Severity Index (PASI) score. PATIENTS AND METHODS:For each patient we have analyzed, PASI-score, serum levels vitamin D and regulatory T cell percentages. Spearmen's coefficient was used between serum vitamin D levels and the predictors. Subsequently, the independent predictive factors were assessed by Multiple Regression. RESULTS:A total of 26 patients were included in our analysis. Using no parametric Spearman's Coefficient test between serum levels of vitamin D and the single variables, we found an association with T-reg population (p < 0.001) and with PASI-score (p = 0.04). CONCLUSIONS:While vitamin D treatment induces a cytokine profile known to favor the differentiation of T cells with suppressive activity, at the same time, several studies showed how vitamin D can prime for tolerogenic dendritic cells able to favor the differentiation of Treg from T naïve cells. Low levels of vitamin-D may decrease the number of circulatory T-reg, disrupting the immunological homeostasis in psoriatic patients and encouraging the inflammatory activity