Unrestricted Charging Controllar Design Magnitude

This paper presents to be routine in DC/DC phase of Bi-directional battery charger. The neutral is to analyst the filter latitude that will additional shrink the system cost and capacity. Key area is to moderate current ripple of the charging current which produce will approximately ripple unrestricted charging for batteries. Ripple unrestricted charging will shrink the further warmth triggered by the current ripple and surge the battery life. The filter-centered controller is project to transaction with the latent variability problem carried by a high order filter. The filter-centered technique has the compensations of effortlessly operation and no essential of additional current or voltage sensors. This dc/dc phase communicate converter to ease the charging purpose. Together low pass filter centered controller and nick filter based controller are evaluated and nick filter based controller has improved routine

Frequency of Firearm Injuries, Deaths and Related Factors in Kanpur, India; an Original Study with Review of Literature

Background:Studies on fatal firearm injuries have been published in various countries. However, their pattern and incidence in various regions of India has largely gone unreported. Methods: Present study was conducted to evaluate fatal firearm injuries, their pattern, associated factors, cause of deathand postmortem findings among their victims referred to the mortuary of Kanpur medical college and comparing it with the pattern seen in other countries. Results:Sixty six firearm fatalities autopsied during the August 2008 to July 2010 were studied. 92% were victims of homicidal attacks, 2% suicidal and 2% accidental. In 4% deaths motive could not be ascertained. Conclusion:This is in sharp contrast to the pattern seen in other countries where suicides were the predominant group. In maximum cases, illegal country made firearms was involved with the norm of single firing. Abdomen (39%) and head (30.30%) were the two most common entry sites for the bullets, a pattern somewhat similar to that of other countries. Survival time, cause of death and motives of incidence were also studied. 

Traditional Phytotherapy used in the Treatment of Malaria by Rural People of Bhopal, District of Madhya Pradesh, India

Malaria is caused by Plasmodium and transmitted through female Anopheles mosquito. The disease is common in rural areas. Although a number of synthetic medicines have been used for the treatment of malaria, but they have adverse effects and their high cost is beyond the reach of common people. It is, therefore, worthwhile to look towards antimalarial herbal drugs. Herbal drugs are cheaper, easily available and with no fear of any side effects. The present paper enumerates the herbs used in malaria by the rural people of Bhopal district of Madhya Pradesh, India

Etiopathological study of oral and oropharyngeal carcinoma

Background: Oral cancer is thought to be the sixth most common form of cancer causing upto 50% of all malignancies in parts of India and South-East Asia, and an increasing trend in oral cancer mortality have been observed in several countries. The aim of the study was to evaluate the etiological factors contributing to oral and oropharyngeal carcinomas and its association with histopathological findings.Methods: This one year duration study was carried out on 100 patients diagnosed as oral and oropharyngeal cancer attending the Department of Otorhinolaryngology and Head and Neck Surgery, Gajra Raja Medical College and J.A. Group of Hospitals, Gwalior, Madhya Pradesh, India.Results: 98% of the patients were histologically squamous cell carcinomas, with well differentiated carcinoma being the most common i.e. 59%. The etiological factors which were found to have statistically significant association in oral cancers were poor oral hygiene, tobacco chewing and pan chewing. Other factors like cigarette/bidi smoking, alcoholism were also common.Conclusions: Any irritation or ulceration in the mouth not attributed to a recognizable causal factor and not healing within four weeks, especially in presence of risk factors must be investigated for its malignant potential. There is a need for improvement in early detection of oral and oropharyngeal carcinomas, because in the initial stages, treatment is more effective and the morbidity is minimal. Keywords:

Formulation and Evaluation of Polyherbal Anthelmintic Preparation

The present study was done with the aim to formulate an anthelmintic preparation and to evaluate anthelmintic activity of formulation containing traditionally user herbs viz., Plumbago zeylanica (leaves), Hyoscyamus niger (roots) and Abultion indicum (leaves) using adult earthworm Pheritima posthuma. The aqueous and ethanolic extract of the crude drug of different concentration were tested which involve determination of paralysis time and time to kill the worms. Piperazine citrate was used as standard and it was found that the PHFEE activity is higher than PHFAE

Age at Menarche and Menstrual Problems Among School‑Going Adolescent Girls of a North Indian District

Background: Menstruation and related problems are difficult issues for adolescent girls and are a common reason for consulting healthcare providers.Objectives: To study age at menarche and menstrual problems among school girls in Lucknow district of north India.Materials and Methods: A cross‑sectional study was carried out in urban as well as rural schools of Lucknow district from October 2008 to September 2009. Multistage random sampling was used to select the requisite number of girls. A total of 847 school‑going adolescent girls between 10 and 19 years of age were interviewed and examined. Statistical analyses were done using percentage and Chi‑square test. Results: Out of 847 adolescent girls, 76.7% (650) girls had attained menarche. The overall mean age at menarche was 12.84 (1.4) years. The age at menarche and duration of menstrual flow were significantly associated with place of schools. About one‑fourth of the girls in all the three age groups (10‑13, 14‑16 and 17‑19 years) had irregular menstrual cycle. Overall, 73.7% (479/650) girls had dysmenorrhea, with 74.3% (323/435) girls in urban schools and 72.6% (156/215) girls in rural schools. There was no significant association between reproductive tract illnesses and place of schools.Conclusion: Menstruation is an important milestone for adolescent girls and menstrual problems are common among adolescent girls. So, there is a need to explain everything correctly about menstruation. It was suggested that a strong need exists for strong health educational activities among the adolescent girls, their parents, and teachers for effective management of menstrual problems among all adolescent girls. Keywords: Adolescent girls, dysmenorrhea, Lucknow district, menstruatio

Current therapeutic status of corticosteroid in human immunodeficiency virus patients with tuberculous meningitis

Human immunodeficiency virus (HIV) poses risk for severe manifestation of TB. These may be in the form of pulmonary or extra pulmonary. According to the level of immunosupression there is risk of developing tuberculous meningitis (TBM). HIV alters pathogenesis, clinical features and prognosis throwing diagnostic and therapeutic challenges.

Specificity and ligand affinities of the cocaine aptamer: impact of structural features and physiological NaCl

The cocaine aptamer has been seen as a good candidate for development as a probe for cocaine in many contexts. Here, we demonstrate that the aptamer binds cocaine, norcocaine, and cocaethylene with similar affinities and aminoglycosides with similar or higher affinities in a mutually exclusive manner with cocaine. Analysis of its affinities for a series of cocaine derivatives shows that the aptamer specificity is the consequence of its interaction with all faces of the cocaine molecule. Circular dichroism spectroscopy and 2-aminopurine (2AP) fluorescence studies show no evidence of large structural rearrangement of the cocaine aptamer upon ligand binding, which is contrary to the general view of this aptamer. The aptamer’s affinity for cocaine and neomycin-B decreases with the inclusion of physiological NaCl. The substitution of 2AP for A in position 6 (2AP6) of the aptamer sequence eliminated the effect of NaCl on its affinities for cocaine and analogues, but not for neomycin-B, showing a selective effect of 2AP substitution on cocaine binding. The affinity for cocaine also decreased with increasing concentrations of serum or urine, with the 2AP6 substitution blunting the effect of urine. Its low affinities for cocaine and metabolites and its ability to bind irrelevant compounds limit the opportunities for application of this aptamer in its current form as a selective and reliable sensor for cocaine. However, these studies also show that a small structural adjustment to the aptamer (2AP exchanged for adenine) can increase its specificity for cocaine in physiological NaCl relative to an off-target ligand

FORMULATION AND CHARACTERIZATION OF MICROSPHERES OF NITAZOXANIDE BY CHEMICAL CROSSLINKING METHOD

The work investigated the design and evaluation of microspheres of Nitazoxanide by Ionotropic gelation technique met. 32 Factorial designs were used and concentration of polymer carbopol-934 (X1) and Ethyl cellulose (X2) were selected as the independent variables. The surface morphology study by SEM indicated that microspheres were spherical with smooth surface. There was no interaction between the drug and polymers, as studied by FTIR study. The prepared microspheres were characterized by entrapment efficiency, particle size micromeritic properties. It was observed that on increasing polymer concentration of formulations, % yield, the entrapment efficiency and particle size were increased whereas % drug release decreased. The In Vitro release study was done using U.S.P. dissolution rate basket type apparatus in phosphate buffer pH 7.4 for 10 hr. It shows that on increasing polymer concentration the drug release of all formulations was gradually decreased. In Vitro mucoadhesion study depicts that as the polymer concentration increased, mucoadhesive nature of the formulation was also increased. The microspheres of NTZ (formulation F9) showed best results due to highest drug entrapment efficiency (85.50%), and percentage drug release after 10.0 hr. was 50.25%. The rate of release followed First order kinetics. The microspheres exhibits good mucoadhesive properties in  in- vitro wash-off test at pH 7.4 (Intestinal pH) than pH 1.2 (gastric pH),because the drug was completely absorbed in Gastrointestinal tract, Therefore, it can be concluded that Nitazoxanide Loaded algino-carbopol-934 microspheres can be formulated for sustained drug delivery of Nitazoxanide used in Chronic Hipatitis-C. Keywords: Mucoadhesive microspheres, Nitazoxanide, Carbopol-934, Ethyl cellulose, Sodium Alginate, Factorial design

Essential organizational variables for the Implementation of Quality 4.0: Empirical evidence from the Indian furniture industry

Purpose-Quality 4.0 represents the integration of quality management principles with digital technologies to drive continuous improvement and innovation in organizations. The purpose of this paper is to explore the essential Organizational Variables (OVs) for the successful implementation of Quality 4.0 in the Indian furniture industry. Design/methodology/approach-Through a broad literature review, data from the Indian furniture industry, and experts’ judgments a list of nineteen OVs have been recognized and classified into four major categories of Digitalization, Design, Continuous Improvement, and Employee training and up-skilling. The analytic hierarchy process (AHP) has been used to give comparative importance and prioritize the identified nineteen OVs of Quality 4.0 in the context of the Indian furniture industry. Findings-The results of this study reveal that the identified variables are very important for successful Quality 4.0 implementation and have been supported by empirical evidence from the Indian furniture industry. The variable ‘Automation’ under the digitalization-related category is a significant variable having a maximum weightage of 26.8% followed by Cloud computing (DI4) having a global weight of 12.8%. Research limitations/implications-In addition to offering valuable insights and practical recommendations, the study recognizes a few limitations, such as industry-specific, and the limited sample size. To diminish these limitations, future research should believe in conducting similar studies in different industries and extend the scope of the study. Originality/value-Quality 4.0 is a term that refers to the integration of advanced digital technologies and smart data analytics into quality management systems to implement it considering organizational variables