1,844 research outputs found
Majocchi’s Granuloma by Trichophytum rubrum in a kidney transplant patient - A case report
Introduction: Trichophytum rubrum is a filamentous fungus, with worldwide distribution, that usually causes
superficial infections of skin and nails, namely tinea pedis, tinea corporis, tinea cruris and onychomycosis.
Rarely, severe dermatophytosis can occur, presenting as deep dermatophytosis, Majocchi’s Granuloma or
extensive dermatophytosis.
Objectives and Methods: Case report of Majocchi’s Granuloma in a kidney transplant patient.
Results: A case of a 55-year-old woman who underwent a kidney transplant 7 months before, under
immunosuppressive therapy with tacrolimus and mycophenolate mofetil. She attended a Dermatology
consultation to clarify skin lesions that appeared 6 months earlier. The skin exam revealed hard and painful
plaque lesions on both legs, with an ulcer on the left leg lesion, violaceous papular lesions on the dorsum of
the left foot and toes and a hard consistency nodule on the left leg. Some of the toe nails presented dystrophy
or onycholysis. The patient denied any previous trauma or contact with plants or soil.
Biopsies of lesions of the left leg and foot dorsum where sent for histology and mycological culture and toe
nails for mycological culture. The histological examinations showed, in the reticular dermis and reaching the
hypodermis, suppurative granulomas with multinucleated giant cells and areas of necrosis. PAS (Periodic Acid-
Schiff) and GMS (Grocott’s Methenamine Silver) staining revealed multiple spores and septate hypha within the
granulomas but not in the stratum corneum. No remnants of hair follicles where found.
Culture of skin biopsies were positive for Tricophytum rubrum but nails´ culture was negative.
Identification was further confirmed by sequencing of ITS region of ribosomal DNA (GenBank accession
number MK967277).
Oral Itraconazole 100mg bid and topic Sertoconazole where initiated. The patient was observed one month
after and reported general malaise, tiredness, exertional dyspnea, whitish stools and increased abdominal
volume. The physician chose to discontinue itraconazole and initiate oral terbinafine 250mg id. After two
months on oral terbinafine, there was regression of the legs´ and left foot lesions with ulcer healing and
disappearance of the left leg nodule.
Conclusion: Diagnosis of deeper dermatophytosis is difficult, in part because there is no specific clinical
presentation and, in many cases, it is even polymorphic. However, especially in patients with
immunodeficiency, this hypothesis should be weighed. Confirmation is achieved by finding hyphae compatible
with dermatophytes in the dermis and a positive culture for a dermatophyte.
Treatment should include systemic antifungal agents, to which topical medication may be associated. Multiple
therapeutic regimens have been proposed, but randomized trials or large case series are lacking. Antifungal
therapy should be continued until the lesions are completely resolved. Surgical treatment has been reported as
an option for highly localized lesions.info:eu-repo/semantics/publishedVersio
Effect of inhomogeneities on the expansion rate of the Universe
While the expansion rate of a homogeneous isotropic Universe is simply
proportional to the square-root of the energy density, the expansion rate of an
inhomogeneous Universe also depends on the nature of the density
inhomogeneities. In this paper we calculate to second order in perturbation
variables the expansion rate of an inhomogeneous Universe and demonstrate
corrections to the evolution of the expansion rate. While we find that the mean
correction is small, the variance of the correction on the scale of the Hubble
radius is sensitive to the physical significance of the unknown spectrum of
density perturbations beyond the Hubble radius.Comment: 19 pages, 2 figures Version 2 includes some changes in numerical
factors and corrected typos. It is the version accepted for publication in
Physical review
On the spatial distribution of dark matter halos
We study the spatial distribution of dark matter halos in the Universe in
terms of their number density contrast, related to the underlying dark matter
fluctuation via a non-local and non-linear bias random field. The description
of the matter dynamics is simplified by adopting the `truncated' Zel'dovich
approximation to obtain both analytical results and simulated maps. The halo
number density field in our maps and its probability distribution reproduce
with excellent accuracy those of halos in a high-resolution N-body simulation
with the same initial conditions. Our non-linear and non-local bias
prescription matches the N-body halo distribution better than any Eulerian
linear and local bias.Comment: 4 pages, LaTeX (uses emulateapj; included psfig.tex), 3 figures, 1
table. Shortened version, matching the size requirements of ApJ Letters.
Accepted for publicatio
Celiac disease and headache in children: A narrative state of the art
Celiac disease (CD) is one of the most important entity of the wide spectrum of gluten-related disorders (GRDs). It is well known that neurological manifestation can be present either at the onset of CD, or appear during the development of the pathology, and different can be the neurologic findings. Clinical features are very variable, ranging from typical manifestations of gastrointestinal involvement to neurologic symptom. The most frequent neurologic signs reported were headache, epileptic seizure, migraine, mental retardation, ataxia and attention deficit and hyperactive disorder. Headache either in form of migraine, or in non-specific form represents one of the main clinical presentation in CD. The aim of this work is to provide a narrative review of the pediatric literature focused on the cephalalgic features of children with CD evaluating the potential benefits of a gluten free diet (GFD). Papers were identified by searching for related literature in Medline (PubMed) and Embase using the words “Celiac Disease” and “Headache” or “Migraine” by specifying “children”/“paediatric age” for reports published since 1972 till 31th October 2018. According to our inclusion criteria, a total of 25 papers has been evaluated. Although it is still controversial if headache is prevalent in CD children a correct compliance to a GFD seems to improve the neurological symptoms even if the underlying pathogenic relationship between CD and neurologic system involvement is still not fully understood. (www.actabiomedica.it)
Modelo fĂsico de sistema de produção de leite para as mesorregiões metropolitana de BelĂ©m e Nordeste paraense.
Publicado também na página 230
CMB Anisotropies at Second Order I
We present the computation of the full system of Boltzmann equations at
second-order describing the evolution of the photon, baryon and cold dark
matter fluids. These equations allow to follow the time evolution of the Cosmic
Microwave Background (CMB) anisotropies at second-order at all angular scales
from the early epoch, when the cosmological perturbations were generated, to
the present through the recombination era. This paper sets the stage for the
computation of the full second-order radiation transfer function at all scales
and for a a generic set of initial conditions specifying the level of
primordial non-Gaussianity. In a companion paper, we will present the
computation of the three-point correlation function at recombination which is
so relevant for the issue of non-Gaussianity in the CMB anisotropies.Comment: 26 pages, LaTeX file, typos correcte
General Relativistic Dynamics of Irrotational Dust: Cosmological Implications
The non--linear dynamics of cosmological perturbations of an irrotational
collisionless fluid is analyzed within General Relativity. Relativistic and
Newtonian solutions are compared, stressing the different role of boundary
conditions in the two theories. Cosmological implications of relativistic
effects, already present at second order in perturbation theory, are studied
and the dynamical role of the magnetic part of the Weyl tensor is elucidated.Comment: 12 pages , DFPD 93/A/6
Weak antilocalization in quasi-two-dimensional electronic states of epitaxial LuSb thin films
Observation of large non-saturating magnetoresistance in rare-earth
monopnictides has raised enormous interest in understanding the role of its
electronic structure. Here, by a combination of molecular-beam epitaxy,
low-temperature transport, angle-resolved photoemssion spectroscopy, and hybrid
density functional theory we have unveiled the bandstructure of LuSb, where
electron-hole compensation is identified as a mechanism responsible for large
magnetoresistance in this topologically trivial compound. In contrast to bulk
single crystal analogues, quasi-two-dimensional behavior is observed in our
thin films for both electron and holelike carriers, indicative of dimensional
confinement of the electronic states. Introduction of defects through growth
parameter tuning results in the appearance of quantum interference effects at
low temperatures, which has allowed us to identify the dominant inelastic
scattering processes and elucidate the role of spin-orbit coupling. Our
findings open up new possibilities of band structure engineering and control of
transport properties in rare-earth monopnictides via epitaxial synthesis.Comment: 20 pages, 12 figures; includes supplementary informatio
Dba-free" Palladium Intermediates Of The Heck-matsuda Reaction."
The dba-free Heck-Matsuda reaction was investigated via direct ESI-MS(/MS) monitoring. Palladium species involved in the reduction of Pd(II) during a Wacker type reaction and several dba-free arylpalladium transient complexes were detected and characterized. Based on these findings, a more comprehensible catalytic cycle for this pivotal reaction is suggested.113277-8
Accessible technologies for kinetic and kinematic analysis of people with disabilities: a literature review/ Tecnologias acessĂveis para análise cinĂ©tica e cinemática da pessoa com deficiĂŞncia: uma revisĂŁo da literatura
Locomotion is the process by which a being moves from one place to another, including stopping, changing speed, changes in direction and adaptation to changes in terrain. Human walking follows a pattern, and it is one of the forms of locomotion that most calls the attention of researchers. Its variation among a group may indicate pathological conditions that influence the treatment and rehabilitation of patients with low mobility. The objective of this article is to carry out a review for the development of a low-cost instrumented treadmill that can assist in the rehabilitation, treatment and follow-up of patients with stroke, and for that, a search of articles related to the topic was carried out in databases such as ScienceDirect, PubMed and others. The results obtained were satisfactory and enabled the creation of a good database. It was possible to conclude that there is a diversity of existing resources and that it is up to the professionals to direct their choice to the one that suits them best
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