Chylous ascites and chylothorax: a case study

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A Minimal Model of Metabolism Based Chemotaxis

Since the pioneering work by Julius Adler in the 1960's, bacterial chemotaxis has been predominantly studied as metabolism-independent. All available simulation models of bacterial chemotaxis endorse this assumption. Recent studies have shown, however, that many metabolism-dependent chemotactic patterns occur in bacteria. We hereby present the simplest artificial protocell model capable of performing metabolism-based chemotaxis. The model serves as a proof of concept to show how even the simplest metabolism can sustain chemotactic patterns of varying sophistication. It also reproduces a set of phenomena that have recently attracted attention on bacterial chemotaxis and provides insights about alternative mechanisms that could instantiate them. We conclude that relaxing the metabolism-independent assumption provides important theoretical advances, forces us to rethink some established pre-conceptions and may help us better understand unexplored and poorly understood aspects of bacterial chemotaxis

Cognitive Neuropsychology of HIV-Associated Neurocognitive Disorders

Advances in the treatment of the human immunodeficiency virus (HIV) have dramatically improved survival rates over the past 10 years, but HIV-associated neurocognitive disorders (HAND) remain highly prevalent and continue to represent a significant public health problem. This review provides an update on the nature, extent, and diagnosis of HAND. Particular emphasis is placed on critically evaluating research within the realm of cognitive neuropsychology that aims to elucidate the component processes of HAND across the domains of executive functions, motor skills, speeded information processing, episodic memory, attention/working memory, language, and visuoperception. In addition to clarifying the cognitive mechanisms of HAND (e.g., impaired cognitive control), the cognitive neuropsychology approach may enhance the ecological validity of neuroAIDS research and inform the development of much needed novel, targeted cognitive and behavioral therapies

Fragmented realities: The ‘sectarianisation’of space among Iraqi Shias in London

How do the spaces we inhabit shape our lived experiences? And how do those lived experiences in turn come to shape and influence our political subjectivity? Such questions are rendered all the more important in studies of migrant or diaspora populations who, by definition, conduct their daily lives in spaces and places that were initially alien to them. The way in which migrants interact with the spaces around them can tell us much about the social, political, and religious engagements they invest in, as well as the very real way in which they experience their local milieu. Through a detailed study of Iraqi Shiis living in London, specifically in the north-western borough of Brent, this article will seek to trace the ways in which religious institutions have carved up the physical and social landscape of north-west London in ways that have enduring effect on the communities with which they engage. The increasing diversification of different religious establishments, I argue, has led to a fragmentation of the city-as-lived, in which the vast majority of practising Iraqi Shiis engage with only small isolated pockets of the urban environment on a daily basis. Moreover, the growing number of specifically Shia schools, charities, mosques, community centres and other such institutions has resulted in what I call a ‘sectarianisation’ of space in Brent, in which individuals hailing from different branches of Islam inhabit different spaces within the city despite often living within metres of each other. Drawing on a mixture of interviews, participant observation, and mapping techniques, I bring together theory and practice in order to sketch out the ways migrant lives can come to be localised in certain spaces, and what that can ultimately mean in terms of their political subjectivity and engagement

Cell proliferation inhibited by MyoD1 independently of myogenic differentiation

5sinoneCell growth and differentiation are usually mutually exclusive. Transformation of myoblasts by retroviruses containing the myc oncogene inhibits differentiation, preventing cells from withdrawing from the cell cycle. If cell-cycle withdrawal is a prerequisite for myoblast differentiation, it is probably an early event in terminal cell differentiation, but this has not yet been established. MyoD1 regulates myogenesis. It is expressed only in skeletal muscle, but can convert other cells to muscle cells. The MyoD1 protein, a nuclear phosphoprotein in part similar to the myc family of proteins, is a DNA-binding protein binding to the enhancer sequences of the muscle-specific creatine phosphokinase gene. Thus, introduction of MyoD1 into cells provides a simple approach to study the effect of induction of differentiation on cell growth. In cultured NIH 3T3 cells, inhibition of cell proliferation occurs within 18 hours, and expression of myosin starts after 72 hours. Furthermore, injection of MyoD1 into quiescent NIH 3T3 cells inhibit cell proliferation independently of induction of differentiation. Deletion of the myc-like domain in the MyoD1 gene eliminates the inhibition of DNA synthesis, but substitution of the basic domain with the analogous domain from the E12 transcription factor inhibits growth yet fails to induce differentiation. Inhibition of DNA synthesis, therefore, seems to be controlled separately from myogenic differentiation.noneSorrentino, V. ; Pepperkok, R.; Davis, R. L. ; Ansorge, W. ; Philipson, L.Sorrentino, V.; Pepperkok, R.; Davis, R. L.; Ansorge, W.; Philipson, L