Statistics of Multiple Sign Changes in a Discrete Non-Markovian Sequence

We study analytically the statistics of multiple sign changes in a discrete non-Markovian sequence ,\psi_i=\phi_i+\phi_{i-1} (i=1,2....,n) where \phi_i's are independent and identically distributed random variables each drawn from a symmetric and continuous distribution \rho(\phi). We show that the probability P_m(n) of m sign changes upto n steps is universal, i.e., independent of the distribution \rho(\phi). The mean and variance of the number of sign changes are computed exactly for all n>0. We show that the generating function {\tilde P}(p,n)=\sum_{m=0}^{\infty}P_m(n)p^m\sim \exp[-\theta_d(p)n] for large n where the `discrete' partial survival exponent \theta_d(p) is given by a nontrivial formula, \theta_d(p)=\log[{{\sin}^{-1}(\sqrt{1-p^2})}/{\sqrt{1-p^2}}] for 0\le p\le 1. We also show that in the natural scaling limit when m is large, n is large but but keeping x=m/n fixed, P_m(n)\sim \exp[-n \Phi(x)] where the large deviation function \Phi(x) is computed. The implications of these results for Ising spin glasses are discussed.Comment: 4 pages revtex, 1 eps figur

The tail of the maximum of smooth Gaussian fields on fractal sets

We study the probability distribution of the maximum $M_S$ of a smooth stationary Gaussian field defined on a fractal subset $S$ of $\R^n$. Our main result is the equivalent of the asymptotic behavior of the tail of the distribution $\P(M_S>u)$ as $u\rightarrow +\infty.$ The basic tool is Rice formula for the moments of the number of local maxima of a random field

Scaled Correlations of Critical Points of Random Sections on Riemann Surfaces

In this paper we prove that as N goes to infinity, the scaling limit of the correlation between critical points z1 and z2 of random holomorphic sections of the N-th power of a positive line bundle over a compact Riemann surface tends to 2/(3pi^2) for small sqrt(N)|z1-z2|. The scaling limit is directly calculated using a general form of the Kac-Rice formula and formulas and theorems of Pavel Bleher, Bernard Shiffman, and Steve Zelditch.Comment: 55 pages. LaTeX. output.txt is the output of running heisenberg_simpler.mpl through maple. heisenberg_simpler.mpl can be run by maple at the command line by saying 'maple -q heisenberg_simpler.mpl' to see the maple calculations that generated the matrices U(t) and D(t) described in the paper's appendix. It may also be run by opening it with GUI mapl

Exact Analysis of Level-Crossing Statistics for (d+1)-Dimensional Fluctuating Surfaces

We carry out an exact analysis of the average frequency $\nu_{\alpha x_i}^+$ in the direction $x_i$ of positive-slope crossing of a given level $\alpha$ such that, $h({\bf x},t)-\bar{h}=\alpha$, of growing surfaces in spatial dimension $d$. Here, $h({\bf x},t)$ is the surface height at time $t$, and $\bar{h}$ is its mean value. We analyze the problem when the surface growth dynamics is governed by the Kardar-Parisi-Zhang (KPZ) equation without surface tension, in the time regime prior to appearance of cusp singularities (sharp valleys), as well as in the random deposition (RD) model. The total number $N^+$ of such level-crossings with positive slope in all the directions is then shown to scale with time as $t^{d/2}$ for both the KPZ equation and the RD model.Comment: 22 pages, 3 figure

Defect Statistics in the Two Dimensional Complex Ginsburg-Landau Model

The statistical correlations between defects in the two dimensional complex Ginsburg-Landau model are studied in the defect-coarsening regime. In particular the defect-velocity probability distribution is determined and has the same high velocity tail found for the purely dissipative time-dependent Ginsburg-Landau (TDGL) model. The spiral arms of the defects lead to a very different behavior for the order parameter correlation function in the scaling regime compared to the results for the TDGL model.Comment: 24 page

The Blackbody Radiation Spectrum Follows from Zero-Point Radiation and the Structure of Relativistic Spacetime in Classical Physics

The analysis of this article is entirely within classical physics. Any attempt to describe nature within classical physics requires the presence of Lorentz-invariant classical electromagnetic zero-point radiation so as to account for the Casimir forces between parallel conducting plates at low temperatures. Furthermore, conformal symmetry carries solutions of Maxwell's equations into solutions. In an inertial frame, conformal symmetry leaves zero-point radiation invariant and does not connect it to non-zero-temperature; time-dilating conformal transformations carry the Lorentz-invariant zero-point radiation spectrum into zero-point radiation and carry the thermal radiation spectrum at non-zero temperature into thermal radiation at a different non-zero-temperature. However, in a non-inertial frame, a time-dilating conformal transformation carries classical zero-point radiation into thermal radiation at a finite non-zero-temperature. By taking the no-acceleration limit, one can obtain the Planck radiation spectrum for blackbody radiation in an inertial frame from the thermal radiation spectrum in an accelerating frame. Here this connection between zero-point radiation and thermal radiation is illustrated for a scalar radiation field in a Rindler frame undergoing relativistic uniform proper acceleration through flat spacetime in two spacetime dimensions. The analysis indicates that the Planck radiation spectrum for thermal radiation follows from zero-point radiation and the structure of relativistic spacetime in classical physics.Comment: 21 page

Equation of state and magnetic susceptibility of spin polarized isospin asymmetric nuclear matter

Properties of spin polarized isospin asymmetric nuclear matter are studied within the framework of the Brueckner--Hartree--Fock formalism. The single-particle potentials of neutrons and protons with spin up and down are determined for several values of the neutron and proton spin polarizations and the asymmetry parameter. It is found an almost linear and symmetric variation of the single-particle potentials as increasing these parameters. An analytic parametrization of the total energy per particle as a function of the asymmetry and spin polarizations is constructed. This parametrization is employed to compute the magnetic susceptibility of nuclear matter for several values of the asymmetry from neutron to symmetric matter. The results show no indication of a ferromagnetic transition at any density for any asymmetry of nuclear matter.Comment: 23 pages, 8 figures, 2 tables (submitted to Phys. Rev. C

In vitro assessment of antibiotic-resistance reversal of a methanol extract from Rosa canina L.

The crude methanol extract of Rosa canina (RC) fruit was tested against multidrug-resistant (MDR) bacterial strains, including methicillin-resistant Staphylococcus aureus SA1199B, EMRSA16 and XU212 harbouring NorA, PBP2a and TetK resistance mechanisms, respectively, as well as S. aureus ATCC25923, a standard antimicrobial susceptible laboratory strain. The inhibition of the conjugal transfer of plasmid PKM101 and TP114 by the RC extract was also evaluated. The RC extract demonstrated a mild to poor antibacterial activity against the panel of bacteria having MIC values ranging from 256 to >512 μg/mL but strongly potentiated tetracycline activity (64-fold) against XU212, a tetracycline-effluxing and resistant strain. Furthermore, the extract showed moderate capacity to inhibit the conjugal transfer of TP114 and PKM101; transfer frequencies were between 40% and 45%. Cytotoxicity analysis of the RC extract against HepG2 cells line showed the IC50 > 500 mg/L and, thus, was considered non-toxic towards human cells. Phytochemical characterisation of the extracts was performed by the assessment of total phenolic content (RC: 60.86 mg TAE/g) and HPLC fingerprints with five main peaks at 360 nm. The results from this study provide new mechanistic evidence justifying, at least in part, the traditional use of this extract. However, the inhibition of bacterial plasmid conjugation opens the possibility of combination therapies to overcome antibiotic resistance

Real Roots of Random Polynomials and Zero Crossing Properties of Diffusion Equation

We study various statistical properties of real roots of three different classes of random polynomials which recently attracted a vivid interest in the context of probability theory and quantum chaos. We first focus on gap probabilities on the real axis, i.e. the probability that these polynomials have no real root in a given interval. For generalized Kac polynomials, indexed by an integer d, of large degree n, one finds that the probability of no real root in the interval [0,1] decays as a power law n^{-\theta(d)} where \theta(d) > 0 is the persistence exponent of the diffusion equation with random initial conditions in spatial dimension d. For n \gg 1 even, the probability that they have no real root on the full real axis decays like n^{-2(\theta(2)+\theta(d))}. For Weyl polynomials and Binomial polynomials, this probability decays respectively like \exp{(-2\theta_{\infty}} \sqrt{n}) and \exp{(-\pi \theta_{\infty} \sqrt{n})} where \theta_{\infty} is such that \theta(d) = 2^{-3/2} \theta_{\infty} \sqrt{d} in large dimension d. We also show that the probability that such polynomials have exactly k roots on a given interval [a,b] has a scaling form given by \exp{(-N_{ab} \tilde \phi(k/N_{ab}))} where N_{ab} is the mean number of real roots in [a,b] and \tilde \phi(x) a universal scaling function. We develop a simple Mean Field (MF) theory reproducing qualitatively these scaling behaviors, and improve systematically this MF approach using the method of persistence with partial survival, which in some cases yields exact results. Finally, we show that the probability density function of the largest absolute value of the real roots has a universal algebraic tail with exponent {-2}. These analytical results are confirmed by detailed numerical computations.Comment: 32 pages, 16 figure

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types