186 research outputs found
Observations of quasi-periodic solar X-ray emission as a result of MHD oscillations in a system of multiple flare loops
We investigate the solar flare of 20 October 2002. The flare was accompanied
by quasi-periodic pulsations (QPP) of both thermal and nonthermal hard X-ray
emissions (HXR) observed by RHESSI in the 3-50 keV energy range. Analysis of
the HXR time profiles in different energy channels made with the Lomb
periodogram indicates two statistically significant time periods of about 16
and 36 seconds. The 36-second QPP were observed only in the nonthermal HXR
emission in the impulsive phase of the flare. The 16-second QPP were more
pronounced in the thermal HXR emission and were observed both in the impulsive
and in the decay phases of the flare. Imaging analysis of the flare region, the
determined time periods of the QPP and the estimated physical parameters of
magnetic loops in the flare region allow us to interpret the observations as
follows. 1) In the impulsive phase energy was released and electrons were
accelerated by successive acts with the average time period of about 36 seconds
in different parts of two spatially separated, but interacting loop systems of
the flare region. 2) The 36-second periodicity of energy release could be
caused by the action of fast MHD oscillations in the loops connecting these
flaring sites. 3) During the first explosive acts of energy release the MHD
oscillations (most probably the sausage mode) with time period of 16 seconds
were excited in one system of the flare loops. 4) These oscillations were
maintained by the subsequent explosive acts of energy release in the impulsive
phase and were completely damped in the decay phase of the flare.Comment: 14 pages, 4 figure
The Glauber model and the heavy ion reaction cross section
We reexamine the Glauber model and calculate the total reaction cross section
as a function of energy in the low and intermediate energy range, where many of
the corrections in the model, are effective.
The most significant effect in this energy range is by the modification of
the trajectory due to the Coulomb field. The modification in the trajectory due
to nuclear field is also taken into account in a self consistent way.
The energy ranges in which particular corrections are effective, are
quantified and it is found that when the center of mass energy of the system
becomes 30 times the Coulomb barrier, none of the trajectory modification to
the Glauber model is really required.
The reaction cross sections for light and heavy systems, right from near
coulomb barrier to intermediate energies have been calculated. The exact
nuclear densities and free nucleon-nucleon (NN) cross sections have been used
in the calculations. The center of mass correction which is important for light
systems, has also been taken into account.
There is an excellent agreement between the calculations with the modified
Glauber model and the experimental data. This suggests that the heavy ion
reactions in this energy range can be explained by the Glauber model in terms
of free NN cross sections without incorporating any medium modification.Comment: RevTeX, 21 pages including 9 Postscript figures, submitted to Phys.
Rev.
Dental implants in dentate primary and secondary Sjögren's syndrome patients:A multicenter prospective cohort study
Objectives: To prospectively assess the clinical performance and patient-reported outcomes of dental implants in dentate patients with primary and secondary Sjögren's syndrome (pSS and sSS, respectively) compared to patients without SS. Materials and Methods: Thirty-seven implants were placed in 17 patients with pSS/sSS and 26 implants in 17 non-SS patients to replace missing (pre)molars. Clinical performance, marginal bone-level changes, patient satisfaction, and oral health-related quality of life (OHRQoL) were assessed at 1 (T1), 6 (T6), 12 (T12), and 18 (T18) months after placement of the superstructure. Marginal bone-level changes were measured on standardized dental radiographs. Clinical parameters included implant and crown survival, plaque, bleeding and gingival indices, and probing depth. Patient satisfaction and OHRQoL were assessed with validated questionnaires. Results: Implant survival at T18 was 100% in the patients with pSS/sSS and 96.2% in the non-SS group. Mean marginal bone loss at T18 did not differ between patients with pSS/sSS and non-SS patients, 1.10 ± 1.04 and 1.04 ± 0.75 mm, respectively (p =.87). Clinical performance was good with no differences between the groups for all outcome measures (p >.05). OHRQoL in patients with pSS/sSS had improved significantly after placement of implant supported crowns at all measuring moments compared to baseline (p <.05). Nevertheless, patient satisfaction and OHRQoL remained significantly higher for patients without SS at all measuring moments (p <.05). Conclusion: Dental implants can be successfully applied in dentate patients with pSS/sSS and have a positive effect on OHRQoL
Inhibiting CDK4/6 in Breast Cancer with Palbociclib, Ribociclib, and Abemaciclib: Similarities and Differences
The cyclin-dependent kinase (CDK) 4/6 inhibitors belong to a new class of drugs that interrupt proliferation of malignant cells by inhibiting progression through the cell cycle. Three such inhibitors, palbociclib, ribociclib, and abemaciclib were recently approved for breast cancer treatment in various settings and combination regimens. On the basis of their impressive efficacy, all three CDK4/6 inhibitors now play an important role in the treatment of patients with HR+, HER2− breast cancer; however, their optimal use still needs to be established. The three drugs have many similarities in both pharmacokinetics and pharmacodynamics. However, there are some differences on the basis of which the choice for a particular CDK4/6 inhibitor for an individual patient can be important. In this article, the clinical pharmacokinetic and pharmacodynamic profiles of the three CDK4/6 inhibitors are reviewed and important future directions of the clinical applicability of CDK4/6 inhibitors will be discussed
Phenomenology of Particle Production and Propagation in String-Motivated Canonical Noncommutative Spacetime
We outline a phenomenological programme for the search of effects induced by
(string-motivated) canonical noncommutative spacetime. The tests we propose are
based, in analogy with a corresponding programme developed over the last few
years for the study of Lie-algebra noncommutative spacetimes, on the role of
the noncommutativity parameters in the dispersion relation. We focus on
the role of deformed dispersion relations in particle-production collision
processes, where the noncommutativity parameters would affect the threshold
equation, and in the dispersion of gamma rays observed from distant
astrophysical sources. We emphasize that the studies here proposed have the
advantage of involving particles of relatively high energies, and may therefore
be less sensitive to "contamination" (through IR/UV mixing) from the UV sector
of the theory. We also explore the possibility that the relevant deformation of
the dispersion relations could be responsible for the experimentally-observed
violations of the GZK cutoff for cosmic rays and could have a role in the
observation of hard photons from distant astrophysical sources.Comment: With respect to the experimental information available at the time of
writing version 1 of this manuscript (hep-th/0109191v1) the situation has
evolved significantly. Our remarks on the benefits of high-energy
observations found additional encouragement from the results reported in
hep-th/020925
Discovery of the Binary Pulsar PSR B1259-63 in Very-High-Energy Gamma Rays around Periastron with H.E.S.S
We report the discovery of very-high-energy (VHE) gamma-ray emission of the
binary system PSR B1259-63/SS 2883 of a radio pulsar orbiting a massive,
luminous Be star in a highly eccentric orbit. The observations around the 2004
periastron passage of the pulsar were performed with the four 13 m Cherenkov
telescopes of the H.E.S.S. experiment, recently installed in Namibia and in
full operation since December 2003. Between February and June 2004, a gamma-ray
signal from the binary system was detected with a total significance above 13
sigma. The flux was found to vary significantly on timescales of days which
makes PSR B1259-63 the first variable galactic source of VHE gamma-rays
observed so far. Strong emission signals were observed in pre- and
post-periastron phases with a flux minimum around periastron, followed by a
gradual flux decrease in the months after. The measured time-averaged energy
spectrum above a mean threshold energy of 380 GeV can be fitted by a simple
power law F_0(E/1 TeV)^-Gamma with a photon index Gamma =
2.7+-0.2_stat+-0.2_sys and flux normalisation F_0 = (1.3+-0.1_stat+-0.3_sys)
10^-12 TeV^-1 cm^-2 s^-1. This detection of VHE gamma-rays provides unambiguous
evidence for particle acceleration to multi-TeV energies in the binary system.
In combination with coeval observations of the X-ray synchrotron emission by
the RXTE and INTEGRAL instruments, and assuming the VHE gamma-ray emission to
be produced by the inverse Compton mechanism, the magnetic field strength can
be directly estimated to be of the order of 1 G.Comment: 10 pages, 8 figures, accepted in Astronomy and Astrophysics on 2 June
2005, replace: document unchanged, replaced author field in astro-ph entry -
authors are all members of the H.E.S.S. collaboration and three additional
authors (99+3, see document
Opinion dynamics: models, extensions and external effects
Recently, social phenomena have received a lot of attention not only from
social scientists, but also from physicists, mathematicians and computer
scientists, in the emerging interdisciplinary field of complex system science.
Opinion dynamics is one of the processes studied, since opinions are the
drivers of human behaviour, and play a crucial role in many global challenges
that our complex world and societies are facing: global financial crises,
global pandemics, growth of cities, urbanisation and migration patterns, and
last but not least important, climate change and environmental sustainability
and protection. Opinion formation is a complex process affected by the
interplay of different elements, including the individual predisposition, the
influence of positive and negative peer interaction (social networks playing a
crucial role in this respect), the information each individual is exposed to,
and many others. Several models inspired from those in use in physics have been
developed to encompass many of these elements, and to allow for the
identification of the mechanisms involved in the opinion formation process and
the understanding of their role, with the practical aim of simulating opinion
formation and spreading under various conditions. These modelling schemes range
from binary simple models such as the voter model, to multi-dimensional
continuous approaches. Here, we provide a review of recent methods, focusing on
models employing both peer interaction and external information, and
emphasising the role that less studied mechanisms, such as disagreement, has in
driving the opinion dynamics. [...]Comment: 42 pages, 6 figure
Pulsar-wind nebulae and magnetar outflows: observations at radio, X-ray, and gamma-ray wavelengths
We review observations of several classes of neutron-star-powered outflows:
pulsar-wind nebulae (PWNe) inside shell supernova remnants (SNRs), PWNe
interacting directly with interstellar medium (ISM), and magnetar-powered
outflows. We describe radio, X-ray, and gamma-ray observations of PWNe,
focusing first on integrated spectral-energy distributions (SEDs) and global
spectral properties. High-resolution X-ray imaging of PWNe shows a bewildering
array of morphologies, with jets, trails, and other structures. Several of the
23 so far identified magnetars show evidence for continuous or sporadic
emission of material, sometimes associated with giant flares, and a few
possible "magnetar-wind nebulae" have been recently identified.Comment: 61 pages, 44 figures (reduced in quality for size reasons). Published
in Space Science Reviews, "Jets and Winds in Pulsar Wind Nebulae, Gamma-ray
Bursts and Blazars: Physics of Extreme Energy Release
Age-related difference in health care use and costs of patients with chronic kidney disease and matched controls
_Background_ The financial burden of chronic kidney disease (CKD) is increasing due to the ageing population and increased prevalence of comorbid diseases. Our aim was to evaluate age-related differences in health care use and costs in Stage G4/G5 CKD without renal replacement therapy (RRT), dialysis and kidney transplant patients and compare them to the general population.
_Methods_ Using Dutch health care claims, we identified CKD patients and divided them into three groups: CKD Stage G4/G5 without RRT, dialysis and kidney transplantation. We matched them with two controls per patient. Total health care costs and hospital costs unrelated to CKD treatment are presented in four age categories (19–44, 45–64, 65–74 and ≥75 years).
_Results_ Overall, health care costs of CKD patients ≥75 years of age were lower than costs of patients 65–74 years of age. In dialysis patients, costs were highest in patients 45–64 years of age. Since costs of controls increased gradually with age, the cost ratio of patients versus controls was highest in young patients (19–44 years). CKD patients were in greater need of additional specialist care than the general population, which was already evident in young patients.
_Conclusion_ Already at a young age and in the earlier stages of CKD, patients are in need of additional care with corresponding health care costs far exceeding those of the general population. In contrast to the general population, the oldest patients (≥75 years) of all CKD patient groups have lower costs than patients 65–74 years of age, which is largely explained by lower hospital and medication costs
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