Real-time monitoring shows substantial excess all-cause mortality during second wave of COVID-19 in Europe, October to December 2020

The European monitoring of excess mortality for public health action (EuroMOMO) network monitors weekly excess all-cause mortality in 27 European countries or subnational areas. During the first wave of the coronavirus disease (COVID-19) pandemic in Europe in spring 2020, several countries experienced extraordinarily high levels of excess mortality. Europe is currently seeing another upsurge in COVID-19 cases, and EuroMOMO is again witnessing a substantial excess all-cause mortality attributable to COVID-19.</p

Tracking India within precambrian supercontinent cycles

The term supercontinent generally implies grouping of formerly dispersed continents and/or their fragments in a close packing accounting for about 75% of earth’s landmass in a given interval of geologic time. The assembly and disruption of supercontinents rely on plate tectonic processes, and therefore, much speculation is involved particularly considering the debates surrounding the applicability of differential plate motion, the key to plate tectonics during the early Precambrian. The presence of Precambrian orogenic belts in all major continents is often considered as the marker of ancient collisional or accretionary sutures, which provide us clues to the history of periodic assembly of ancient supercontinents. Testing of any model assembly/breakup depends on precise age data and paleomagnetic pole reconstruction. The record of dispersal of the continents and release of enormous stress lie in extensional geological features, such as rift valleys, regionally extensive flood basalts, granite-rhyolite terrane, anorthosite complexes, mafic dyke swarms, and remnants of ancient mid-oceanic ridges. Indian shield with extensive Precambrian rock records is known to bear signatures of the past supercontinents in a fragmentary manner. Vast tracts of Precambrian rocks exposed in peninsular India and in the Lesser Himalaya and the Shillong plateau further north and east provide valuable clues to global tectonic reconstructions and the geodynamics of the respective periods. The Indian shield is a mosaic of Archean cratonic nuclei surrounded by Proterozoic orogenic belts, which preserve the records of geologic events since the Paleoarchean/Eoarchean. Here we discuss the sojourn of the Indian plate from the Archean through Proterozoic, in light of available models for supercontinent assembly and breakup in the Precambrian. We also discuss the issues in constraining the configuration, which is mainly due to scanty exposures, lack of reliable paleomagnetic poles from different cratons, and their time of formation or amalgamation. In this chapter, we briefly review Precambrian geology of India to track her participation in the making of the supercontinents through time.Sarbani Patranabis-Deb, Dilip Saha, and M. Santos

Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis

Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a metaanalysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien–Dindo Grades III–V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery formalignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49–2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46–0.75, P < 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease