814 research outputs found
Design and expression of a retro doublet of cecropin with enhanced activity
Novel doublet molecules of cecropin A from Drosophila melanogaster
were designed and constructed combining the regular (CECdir) with the
inverted (CECret) coding sequence of the standard CEC A1 gene resulting
in the following configurations: CECdir-CECret and CECret-CECdir. These
two recombinant molecules were generated using a three-primer driven
PCR reaction yielding composite single functional aminoacidic molecules
with the coding sequences of CECdir linked in frame with the coding
sequence of CECret and vice versa. In order to obtain these
constructions, a retropeptide DNA-coding sequence was chemically
synthesized to match the expected polarity of the newly generated
CECret sequence. Both doublet antimicrobial peptides (drAMPs) were
cloned in the T7 promoter driven expression plasmid pET27b+ and
expressed in E. coli BL21 without any fusion protein. Only the former
recombinant peptide was expressed and purified from cell extracts and
its specific activity against two different bacteria showed to be
higher than those displayed by their monomer parental counterparts
Quantum interference between non-magnetic impurities in d_x2-y2-wave superconductors
We study quantum interference of electronic waves that are scattered by
multiple non-magnetic impurities in a d_x2-y2-wave superconductor. We show that
the number of resonance states in the density-of-states (DOS), as well as their
frequency and spatial dependence change significantly as the distance between
the impurities or their orientation relative to the crystal lattice is varied.
Since the latter effect arises from the momentum dependence of the
superconducting gap, we argue that quantum interference is a novel tool to
identify the symmetry of unconventional superconductors.Comment: 4 pages, 4 figure
COSMOGRAIL: XVII. Time delays for the quadruply imaged quasar PG 1115+080
IndexaciĂłn: Scopus.Acknowledgements. The authors would like to thank R. Gredel for his help in setting up the program at the ESO MPIA 2.2 m telescope, and the anonymous referee for his or her comments on this work. This work is supported by the Swiss National Fundation. This research made use of Astropy, a community-developed core Python package for Astronomy (Astropy Collaboration et al. 2013, 2018) and the 2D graphics environment Matplotlib (Hunter 2007). K.R. acknowledge support from PhD fellowship FIB-UV 2015/2016 and Becas de Doctorado Nacional CONICYT 2017 and thanks the LSSTC Data Science Fellowship Program, her time as a Fellow has benefited this work. M.T. acknowledges support by the DFG grant Hi 1495/2-1. G. C.-F. C. acknowledges support from the Ministry of Education in Taiwan via Government Scholarship to Study Abroad (GSSA). D. C.-Y. Chao and S. H. Suyu gratefully acknowledge the support from the Max Planck Society through the Max Planck Research Group for S. H. Suyu. T. A. acknowledges support by the Ministry for the Economy, Development, and Tourismâs Programa Inicativa CientĂfica Milenio through grant IC 12009, awarded to The Millennium Institute of Astrophysics (MAS).We present time-delay estimates for the quadruply imaged quasar PG 1115+080. Our results are based on almost daily observations for seven months at the ESO MPIA 2.2 m telescope at La Silla Observatory, reaching a signal-to-noise ratio of about 1000 per quasar image. In addition, we re-analyze existing light curves from the literature that we complete with an additional three seasons of monitoring with the Mercator telescope at La Palma Observatory. When exploring the possible source of bias we considered the so-called microlensing time delay, a potential source of systematic error so far never directly accounted for in previous time-delay publications. In 15 yr of data on PG 1115+080, we find no strong evidence of microlensing time delay. Therefore not accounting for this effect, our time-delay estimates on the individual data sets are in good agreement with each other and with the literature. Combining the data sets, we obtain the most precise time-delay estimates to date on PG 1115+080, with Ît(AB) = 8.3+1.5 -1.6 days (18.7% precision), Ît(AC) = 9.9+1.1 -1.1 days (11.1%) and Ît(BC) = 18.8+1.6 -1.6 days (8.5%). Turning these time delays into cosmological constraints is done in a companion paper that makes use of ground-based Adaptive Optics (AO) with the Keck telescope. © ESO 2018.https://www.aanda.org/articles/aa/abs/2018/08/aa33287-18/aa33287-18.htm
Cosmological distance indicators
We review three distance measurement techniques beyond the local universe:
(1) gravitational lens time delays, (2) baryon acoustic oscillation (BAO), and
(3) HI intensity mapping. We describe the principles and theory behind each
method, the ingredients needed for measuring such distances, the current
observational results, and future prospects. Time delays from strongly lensed
quasars currently provide constraints on with < 4% uncertainty, and with
1% within reach from ongoing surveys and efforts. Recent exciting discoveries
of strongly lensed supernovae hold great promise for time-delay cosmography.
BAO features have been detected in redshift surveys up to z <~ 0.8 with
galaxies and z ~ 2 with Ly- forest, providing precise distance
measurements and with < 2% uncertainty in flat CDM. Future BAO
surveys will probe the distance scale with percent-level precision. HI
intensity mapping has great potential to map BAO distances at z ~ 0.8 and
beyond with precisions of a few percent. The next years ahead will be exciting
as various cosmological probes reach 1% uncertainty in determining , to
assess the current tension in measurements that could indicate new
physics.Comment: Review article accepted for publication in Space Science Reviews
(Springer), 45 pages, 10 figures. Chapter of a special collection resulting
from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in
the Space Ag
Vortex structure in d-density wave scenario of pseudogap
We investigate the vortex structure assuming the d-density wave scenario of
the pseudogap. We discuss the profiles of the order parameters in the vicinity
of the vortex, effective vortex charge and the local density of states. We find
a pronounced modification of these quantities when compared to a purely
superconducting case. Results have been obtained for a clean system as well as
in the presence of a nonmagnetic impurity. We show that the competition between
superconductivity and the density wave may explain some experimental data
recently obtained for high-temperature superconductors. In particular, we show
that the d-density wave scenario explains the asymmetry of the gap observed in
the vicinity of the vortex core.Comment: 8 pages, 10 figure
Spatial competition and agglomeration in the visitor attraction sector
This paper provides a theoretical and empirical contribution to understanding spatial competition by examining visitor attractions in two contrasting clusters of lower and higher levels of agglomeration of businesses in Cornwall, the UK. The study found that competition is mainly for customers and labour and is related differently to the levels of agglomeration, spatial proximity and thematic product similarity between visitor attractions at the local compared to the regional scale. Location can be used differently for employing âweakâ and âstrongâ competitive strategies. The study contributes to the knowledge on the spatiality of competition and the locational strategies of service businesses
Fully Gapped Single-Particle Excitations in the Lightly Doped Cuprates
The low-energy excitations of the lightly doped cuprates were studied by
angle-resolved photoemission spectroscopy. A finite gap was measured over the
entire Brillouin zone, including along the d_{x^2 - y^2} nodal line. This
effect was observed to be generic to the normal states of numerous cuprates,
including hole-doped La_{2-x}Sr_{x}CuO_{4} and Ca_{2-x}Na_{x}CuO_{2}Cl_{2} and
electron-doped Nd_{2-x}Ce_{x}CuO_{4}. In all compounds, the gap appears to
close with increasing carrier doping. We consider various scenarios to explain
our results, including the possible effects of chemical disorder, electronic
inhomogeneity, and a competing phase.Comment: To appear in Phys. Rev.
A terminal assessment of stages theory : introducing a dynamic states approach to entrepreneurship
Stages of Growth models were the most frequent theoretical approach to understanding entrepreneurial business growth from 1962 to 2006; they built on the growth imperative and developmental models of that time. An analysis of the universe of such models (N=104) published in the management literature shows no consensus on basic constructs of the approach, nor is there any empirical confirmations of stages theory. However, by changing two propositions of the stages models, a new dynamic states approach is derived. The dynamic states approach has far greater explanatory power than its precursor, and is compatible with leading edge research in entrepreneurship
Toward an internally consistent astronomical distance scale
Accurate astronomical distance determination is crucial for all fields in
astrophysics, from Galactic to cosmological scales. Despite, or perhaps because
of, significant efforts to determine accurate distances, using a wide range of
methods, tracers, and techniques, an internally consistent astronomical
distance framework has not yet been established. We review current efforts to
homogenize the Local Group's distance framework, with particular emphasis on
the potential of RR Lyrae stars as distance indicators, and attempt to extend
this in an internally consistent manner to cosmological distances. Calibration
based on Type Ia supernovae and distance determinations based on gravitational
lensing represent particularly promising approaches. We provide a positive
outlook to improvements to the status quo expected from future surveys,
missions, and facilities. Astronomical distance determination has clearly
reached maturity and near-consistency.Comment: Review article, 59 pages (4 figures); Space Science Reviews, in press
(chapter 8 of a special collection resulting from the May 2016 ISSI-BJ
workshop on Astronomical Distance Determination in the Space Age
A Binary Lensing Event Toward the LMC: Observations and Dark Matter Implications
The MACHO collaboration has recently analyzed 2.1 years of photometric data
for about 8.5 million stars in the Large Magellanic Cloud (LMC). This analysis
has revealed 8 candidate microlensing events and a total microlensing optical
depth of . This significantly
exceeds the number of events (1.1) and the microlensing optical depth predicted
from known stellar populations: , but it is
consistent with models in which about half of the standard dark halo mass is
composed of Machos of mass \sim 0.5 \msun. One of these 8 events appears to
be a binary lensing event with a caustic crossing that is partially resolved
which allows us to estimate the distance to the lenses. If the source star is
not a short period binary star, then we show that the lens system is very
likely to reside in the LMC. However, if we assume that the optical depth for
LMC-LMC lensing is large enough to account for our entire lensing signal, then
the binary event does not appear to be consistent with lensing of a single LMC
source star by a binary residing in the LMC. Thus, while the binary lens may
indeed reside in the LMC, there is no indication that most of the lenses reside
in the LMC.Comment: 5 pages, 3 postscript figures included; To appear in the Proceedings
of the Dark Matter '96 Conference held in Santa Monica, CA, Feb., 199
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