Macronutrient status and yield stability of arecanut (Kahikuchi) under integrated nutrient management practice in Assam

A long term field   experiment was carried out in clay-loam soil at ICAR-CPCRI, Kahikuchi campus,   Guwahati, Assam during 2000-2012 with arecanut variety Kahikuchi with seven   nutrient combinations. The treatments included control (T1), 100 per cent   vermicompost (T2), 200 per cent vermicompost (T3), 100 per cent chemical   fertilizer (T4), 50 per cent vermicompost + 50 per cent chemical fertilizer   (T5), 1/3rd vermicompost + 2/3rd chemical fertilizer   (T6) and 2/3rd vermicompost + 1/3rd chemical fertilizer   (T7). The treatment T7 produced highest fresh ripened arecanut yield of 16.7   kg i.e., about 3.6 kg dry chali per palm. Positive correlations were   obtained between yield of arecanut and soil available N, P, K content.   Significant and positive correlation was found between leaf N, P, K and   available N, P, K content in surface and sub-surface soil. Available N, P and   K content increased over the year under nutrient applied plot that reflected   in yield of arecanut. The average yield in various treatments followed in the   order of T7 > T5 = T6 > T2 = T3 > T4 > T1. The application of   targeted, sufficient and balanced quantities of organic and inorganic   fertilizer will be the need of the hour to make nutrients available for   higher yield, soil fertility maintenance and agricultural sustainability   without polluting environment

Sustainability of soil health and system productivity through arecanut based cropping system in the NE Region of India

The North-Eastern part of India contains seven states out of which, Assam is the major producer of arecanut. An attempt was made to study the impact of arecanut based multiple cropping system with proper utilization of recyclable resources on the long-term sustainability of acid soil at Kahikuchi. A long term arecanut based High-Density Multispecies Cropping System garden comprised of two models viz., Model-1 (M1): arecanut (Areca catechu), black pepper (Piper nigrum), banana (Musa spp.), citrus (Citrus limon) and clove (Syzygium aromaticum) and Model-2 (M2): arecanut, black pepper, banana, citrus and nutmeg (Myristica fragrans) as component crops was used. Both the models were sub-divided into three treatments viz., Full dose of recommended fertiliser (T1), 2/3rd of the recommended dose (T2) and 1/3rd of the recommended dose (T3) combined with treatment-wise recycling available biomass in the form of vermicompost and each treatment was replicated thrice. The results indicated that the quantity of recyclable biomass generated ranged between 8.27 to 12.23 t ha-1 year-1 and 8.11 to 12.38 t ha-1 year-1 in model-1 and model-2, respectively and revealed that the T2 treatment in both models improved the soil properties with respect to soil pH, organic carbon, available N, P and K status. Economics of the cropping system revealed that the maximum return was obtained from both Models under T2. The average benefit:cost ratio of T1, T2 & T3 was 3.38, 4.42 & 3.47 under model-1 and 3.34, 4.08 and 3.40 under model-2, respectively. Sustenance of soil pH above 5.0 over the years in the arecanut rhizosphere in both the models were found under T2, but T1 and T3 treatments showed a slow declining of pH towards increasing soil acidity

South Carolina’s Arts In Basic Curriculum Project : A History 1987-2007

The Arts in Basic Curriculum (ABC) Project is a multifaceted initiative that has positively impacted arts education in South Carolina and the nation. Founded in 1987 the ABC Project has become a national model and influenced the advancement of education in and through the arts with a multitude of programs, models, and schemes. This is an overview of the full history. Parts I and II will chronicle events that were foundational to the project from inception in 1987 to the celebration of its 20th anniversary in 2007. Part III gives detailed descriptions of ten of the most important facets of the project

Percolation on two- and three-dimensional lattices

In this work we apply a highly efficient Monte Carlo algorithm recently proposed by Newman and Ziff to treat percolation problems. The site and bond percolation are studied on a number of lattices in two and three dimensions. Quite good results for the wrapping probabilities, correlation length critical exponent and critical concentration are obtained for the square, simple cubic, HCP and hexagonal lattices by using relatively small systems. We also confirm the universal aspect of the wrapping probabilities regarding site and bond dilution.Comment: 15 pages, 6 figures, 3 table

Parity Violating Measurements of Neutron Densities

Parity violating electron nucleus scattering is a clean and powerful tool for measuring the spatial distributions of neutrons in nuclei with unprecedented accuracy. Parity violation arises from the interference of electromagnetic and weak neutral amplitudes, and the $Z^0$ of the Standard Model couples primarily to neutrons at low $Q^2$. The data can be interpreted with as much confidence as electromagnetic scattering. After briefly reviewing the present theoretical and experimental knowledge of neutron densities, we discuss possible parity violation measurements, their theoretical interpretation, and applications. The experiments are feasible at existing facilities. We show that theoretical corrections are either small or well understood, which makes the interpretation clean. The quantitative relationship to atomic parity nonconservation observables is examined, and we show that the electron scattering asymmetries can be directly applied to atomic PNC because the observables have approximately the same dependence on nuclear shape.Comment: 38 pages, 7 ps figures, very minor changes, submitted to Phys. Rev.

An Assessment of the Use of Chimpanzees in Hepatitis C Research Past, Present and Future: 2. Alternative Replacement Methods

The use of chimpanzees in hepatitis C virus (HCV) research was examined in the report associated with this paper (1: Validity of the Chimpanzee Model), in which it was concluded that claims of past necessity of chimpanzee use were exaggerated, and that claims of current and future indispensability were unjustifiable. Furthermore, given the serious scientific and ethical issues surrounding chimpanzee experimentation, it was proposed that it must now be considered redundant — particularly in light of the demonstrable contribution of alternative methods to past and current scientific progress, and the future promise that these methods hold. This paper builds on this evidence, by examining the development of alternative approaches to the investigation of HCV, and by reviewing examples of how these methods have contributed, and are continuing to contribute substantially, to progress in this field. It augments the argument against chimpanzee use by demonstrating the comprehensive nature of these methods and the valuable data they deliver. The entire life-cycle of HCV can now be investigated in a human (and much more relevant) context, without recourse to chimpanzee use. This also includes the testing of new therapies and vaccines. Consequently, there is no sound argument against the changes in public policy that propose a move away from chimpanzee use in US laboratories

108 AUROTHIOMALATE INHIBITS COX-2 EXPRESSION AND PGE2 PRODUCTION IN CHONDROCYTES BY INCREASING MKP-1 EXPRESSION AND DECREASING p38 AND JNK PHOSPHORYLATION

The very high occurrence of cardiovascular events presents a major public health issue, because treatment remains suboptimal. Lowering LDL cholesterol (LDL-C) with statins or ezetimibe in combination with a statin reduces major adverse cardiovascular events. The cardiovascular risk reduction in relation to the absolute LDL-C reduction is linear for most interventions without evidence of attenuation or increase in risk at low LDL-C levels. Opportunities for innovation in dyslipidaemia treatment should address the substantial risk of lipid-associated cardiovascular events among patients optimally treated per guidelines but who cannot achieve LDL-C goals and who could benefit from additional LDL-C-lowering therapy or experience side effects of statins. Fresh approaches are needed to identify promising drug targets early and develop them efficiently. The Cardiovascular Round Table of the European Society of Cardiology (ESC) convened a workshop to discuss new lipid-lowering strategies for cardiovascular risk reduction. Opportunities to improve treatment approaches and the efficient study of new therapies were explored. Circulating biomarkers may not be fully reliable proxy indicators of the relationship between treatment effect and clinical outcome. Mendelian randomization studies may better inform development strategies and refine treatment targets before Phase 3. Trials should match the drug to appropriate lipid and patient profile, and guidelines may move towards a precision-based approach to individual patient management. Stakeholder collaboration is needed to ensure continued innovation and better international coordination of both regulatory aspects and guidelines. It should be noted that risk may also be addressed through increased attention to other risk factors such as smoking, hypertension, overweight, and inactivity

Review of experimental methods to determine spontaneous combustion susceptibility of coal – Indian context

This paper presents a critical review of the different techniques developed to investigate the susceptibility of coal to spontaneous combustion and fire. These methods may be sub-classified into the two following areas: (1) Basic coal characterisation studies (chemical constituents) and their influence on spontaneous combustion susceptibility. (2) Test methods to assess the susceptibility of a coal sample to spontaneous combustion. This is followed by a critical literature review that summarises previous research with special emphasis given to Indian coals

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

The human proteome contains a plethora of short linear motifs (SLiMs) that serve as binding interfaces for modular protein domains. Such interactions are crucial for signaling and other cellular processes, but are difficult to detect because of their low to moderate affinities. Here we developed a dedicated approach, proteomic peptide-phage display (ProP-PD), to identify domain-SLiM interactions. Specifically, we generated phage libraries containing all human and viral C-terminal peptides using custom oligonucleotide microarrays. With these libraries we screened the nine PSD-95/ Dlg/ZO-1 (PDZ) domains of human Densin-180, Erbin, Scribble, and Disks large homolog 1 for peptide ligands. We identified several known and putative interactions potentially relevant to cellular signaling pathways and confirmed interactions between fulllength Scribble and the target proteins β-PIX, plakophilin-4, and guanylate cyclase soluble subunit a-2 using colocalization and coimmunoprecipitation experiments. The affinities of recombinant Scribble PDZ domains and the synthetic peptides representing the C termini of these proteins were in the 1- to 40-μM range. Furthermore, we identified several well-established host-virus protein- protein interactions, and confirmed that PDZ domains of Scribble interact with the C terminus of Tax-1 of human T-cell leukemia virus with micromolar affinity. Previously unknown putative viral protein ligands for the PDZ domains of Scribble and Erbin were also identified. Thus, we demonstrate that our ProP-PD libraries are useful tools for probing PDZ domain interactions. The method can be extended to interrogate all potential eukaryotic, bacterial, and viral SLiMs and we suggest it will be a highly valuable approach for studying cellular and pathogen-host protein-protein interactions