1,932 research outputs found
Systematic review of the effects of bisphosphonates on bone density and fracture incidence in childhood acute lymphoblastic leukaemia
Skeletal fragility is a common complication of childhood acute lymphoblastic leukaemia (ALL) but the impact of bisphosphonate therapy on bone mass and fracture is unclear. We aim to conduct a systematic review to evaluate the effects of bisphosphonates on bone mineral density (BMD) and fracture incidence in children with ALL. EMBASE, Medline and the Cochrane Library were thoroughly searched by two researchers. Inclusion criteria was any child under the age of 18Â years with a diagnosis of ALL, who had received any bisphosphonate treatment and had serial measurements of bone density performed thereafter. All primary research studies of any study design, excluding case reports, were included. Ten full text papers were identified with two exclusively meeting the inclusion criteria. Both studies administered bisphosphonates to children receiving maintenance chemotherapy for varying durations. Bone density was assessed at regular intervals by dual x-ray absorptiometry (DXA). The majority of participants had an improvement in bone density at the end of each study. However, no size adjustment of DXA data was performed. Limited information on fracture occurrence was provided by one study but did not include routine screening for vertebral fractures. This systematic review identified that there is insufficient evidence to support routine use of prophylactic bisphosphonate therapy in childhood ALL for prevention of fracture and improvement of bone mass. Future well-designed clinical trials in those at highest risk of fractures in ALL are now needed
Fictitious fluxes in doped antiferromagnets
In a tight binding model of charged spin-1/2 electrons on a square lattice, a
fully polarized ferromagnetic spin configuration generates an apparent U(1)
flux given by times the skyrmion charge density of the ferromagnetic
order parameter. We show here that for an antiferromagnet, there are two
``fictitious'' magnetic fields, one staggered and one unstaggered. The
staggered topological flux per unit cell can be varied between
with a negligible change in the value of the effective
nearest neighbor coupling constant whereas the magnitude of the unstaggered
flux is strongly coupled to the magnitude of the second neighbor effective
coupling.Comment: RevTeX, 5 pages including 4 figure
Brane decay of a (4+n)-dimensional rotating black hole: spin-0 particles
In this work, we study the `scalar channel' of the emission of Hawking
radiation from a (4+n)-dimensional, rotating black hole on the brane. We
numerically solve both the radial and angular part of the equation of motion
for the scalar field, and determine the exact values of the absorption
probability and of the spheroidal harmonics, respectively. With these, we
calculate the particle, energy and angular momentum emission rates, as well as
the angular variation in the flux and power spectra -- a distinctive feature of
emission during the spin-down phase of the life of the produced black hole. Our
analysis is free from any approximations, with our results being valid for
arbitrarily large values of the energy of the emitted particle, angular
momentum of the black hole and dimensionality of spacetime. We finally compute
the total emissivities for the number of particles, energy and angular momentum
and compare their relative behaviour for different values of the parameters of
the theory.Comment: 24 pages, 13 figure
Semiclassical Trace Formulas for Noninteracting Identical Particles
We extend the Gutzwiller trace formula to systems of noninteracting identical
particles. The standard relation for isolated orbits does not apply since the
energy of each particle is separately conserved causing the periodic orbits to
occur in continuous families. The identical nature of the particles also
introduces discrete permutational symmetries. We exploit the formalism of
Creagh and Littlejohn [Phys. Rev. A 44, 836 (1991)], who have studied
semiclassical dynamics in the presence of continuous symmetries, to derive
many-body trace formulas for the full and symmetry-reduced densities of states.
Numerical studies of the three-particle cardioid billiard are used to
explicitly illustrate and test the results of the theory.Comment: 29 pages, 11 figures, submitted to PR
Exact asymptotics of the freezing transition of a logarithmically correlated random energy model
We consider a logarithmically correlated random energy model, namely a model
for directed polymers on a Cayley tree, which was introduced by Derrida and
Spohn. We prove asymptotic properties of a generating function of the partition
function of the model by studying a discrete time analogy of the KPP-equation -
thus translating Bramson's work on the KPP-equation into a discrete time case.
We also discuss connections to extreme value statistics of a branching random
walk and a rescaled multiplicative cascade measure beyond the critical point
Brane Decay of a (4+n)-Dimensional Rotating Black Hole. II: spin-1 particles
The present works complements and expands a previous one, focused on the
emission of scalar fields by a (4+n)-dimensional rotating black hole on the
brane, by studying the emission of gauge fields on the brane from a similar
black hole. A comprehensive analysis of the particle, energy and angular
momentum emission rates is undertaken, for arbitrary angular momentum of the
black hole and dimensionality of spacetime. Our analysis reveals the existence
of a number of distinct features associated with the emission of spin-1 fields
from a rotating black hole on the brane, such as the behaviour and magnitude of
the different emission rates, the angular distribution of particles and energy,
the relative enhancement compared to the scalar fields, and the magnitude of
the superradiance effect. Apart from their theoretical interest, these features
can comprise clear signatures of the emission of Hawking radiation from a
brane-world black hole during its spin-down phase upon successful detection of
this effect during an experiment.Comment: 35 pages, 19 figures, Latex fil
Brane Decay of a (4+n)-Dimensional Rotating Black Hole. III: spin-1/2 particles
In this work, we have continued the study of the Hawking radiation on the
brane from a higher-dimensional rotating black hole by investigating the
emission of fermionic modes. A comprehensive analysis is performed that leads
to the particle, power and angular momentum emission rates, and sheds light on
their dependence on fundamental parameters of the theory, such as the spacetime
dimension and angular momentum of the black hole. In addition, the angular
distribution of the emitted modes, in terms of the number of particles and
energy, is thoroughly studied. Our results are valid for arbitrary values of
the energy of the emitted particles, dimension of spacetime and angular
momentum of the black hole, and complement previous results on the emission of
brane-localised scalars and gauge bosons.Comment: Latex file, JHEP style, 34 pages, 16 figures Energy range in plots
increased, minor changes, version published in JHE
A reanalysis of the luminosities of clusters of galaxies in the EMSS sample with 0.3 < z < 0.6
The X-ray luminosities of the Einstein Extended Medium Sensitivity Survey
(EMSS) clusters of galaxies with redshifts 0.3<z<0.6 are remeasured using ROSAT
PSPC data. It is found that the new luminosities are on average 1.18 +/- 0.08
times higher than previously measured but that this ratio depends strongly on
the X-ray core radii we measure. For the clusters with small core radii, in
general we confirm the EMSS luminosities, but for clusters with core radii >250
kpc (the constant value assumed in the EMSS), the new luminosities are 2.2 +/-
0.15 times the previous measurements. The X-ray luminosity function (XLF) at
0.3<z<0.6 is recalculated and is found to be consistent with the local XLF. The
constraints on the updated properties of the 0.3<z<0.6 EMSS sample, including a
comparison with the number of clusters predicted from local XLFs, indicate that
the space density of luminous, massive clusters has either not evolved or has
increased by a small factor ~2 since z=0.4. The implications of this result are
discussed in terms of constraints on the cosmological parameter Omega_0.Comment: 12 pages, 7 figures. Accepted for publication in MNRA
Radiative Corrections to One-Photon Decays of Hydrogenic Ions
Radiative corrections to the decay rate of n=2 states of hydrogenic ions are
calculated. The transitions considered are the M1 decay of the 2s state to the
ground state and the E1(M2) decays of the and states to
the ground state. The radiative corrections start in order , but the method used sums all orders of . The leading
correction for the E1 decays is calculated and compared
with the exact result. The extension of the calculational method to parity
nonconserving transitions in neutral atoms is discussed.Comment: 22 pages, 2 figure
- âŠ