1,058 research outputs found
Electric-field noise from carbon-adatom diffusion on a Au(110) surface: first-principles calculations and experiments
The decoherence of trapped-ion quantum gates due to heating of their motional
modes is a fundamental science and engineering problem. This heating is
attributed to electric-field noise arising from the trap-electrode surfaces. In
this work, we investigate the source of this noise by focusing on the diffusion
of carbon-containing adsorbates on the surface of Au(110). We show by density
functional theory, based on detailed scanning probe microscopy, how the carbon
adatom diffusion on the gold surface changes the energy landscape, and how the
adatom dipole moment varies with the diffusive motion. A simple model for the
diffusion noise, which varies quadratically with the variation of the dipole
moment, qualitatively reproduces the measured noise spectrum, and the estimate
of the noise spectral density is in accord with measured values.Comment: 8 pages, 6 figure
Innovative marketing. The concept and function
This article is theoretical in nature. Any development of innovation begins with the development of creative ideas that will is the starting point for innovation Innovative marketing is aimed at the efficient introduction of these new ideas
The Molecular Line Opacity of MgH in Cool Stellar Atmospheres
A new, complete, theoretical rotational and vibrational line list for the A-X
electronic transition in MgH is presented. The list includes transition
energies and oscillator strengths for all possible allowed transitions and was
computed using the best available theoretical potential energies and dipole
transition moment function with the former adjusted to account for experimental
data. The A-X line list, as well as new line lists for the B'-X and the X-X
(pure rovibrational) transitions, were included in comprehensive stellar
atmosphere models for M, L, and T dwarfs and solar-type stars. The resulting
spectra, when compared to models lacking MgH, show that MgH provides
significant opacity in the visible between 4400 and 5600 Angstrom. Further,
comparison of the spectra obtained with the current line list to spectra
obtained using the line list constructed by Kurucz (1993) show that the Kurucz
list significantly overestimates the opacity due to MgH particularly for the
bands near 5150 and 4800 Angstrom with the discrepancy increasing with
decreasing effective temperature.Comment: 10 pages, 4 figures, 3 table
Observation of Quantum Effects in sub Kelvin Cold Reactions
There has been a long-standing quest to observe chemical reactions at low
temperatures where reaction rates and pathways are governed by quantum
mechanical effects. So far this field of Quantum Chemistry has been dominated
by theory. The difficulty has been to realize in the laboratory low enough
collisional velocities between neutral reactants, so that the quantum wave
nature could be observed. We report here the first realization of merged
neutral supersonic beams, and the observation of clear quantum effects in the
resulting reactions. We observe orbiting resonances in the Penning ionization
reaction of argon and molecular hydrogen with metastable helium leading to a
sharp increase in the absolute reaction rate in the energy range corresponding
to a few degrees kelvin down to 10 mK. Our method is widely applicable to many
canonical chemical reactions, and will enable a breakthrough in the
experimental study of Quantum Chemistry
Engineering of janus-like dendrimers with peptides derived from glycoproteins of herpes simplex virus type 1: Toward a versatile and novel antiviral platform
Novel antiviral nanotherapeutics, which may inactivate the virus and block it from entering host cells, represent an important challenge to face viral global health emergencies around the world. Using a combination of bioorthogonal copper-catalyzed 1,3-dipolar alkyne/azide cycloaddition (CuAAC) and photoinitiated thiol–ene coupling, monofunctional and bifunctional peptidodendrimer conjugates were obtained. The conjugates are biocompatible and demonstrate no toxicity to cells at biologically relevant concentrations. Furthermore, the orthogonal addition of multiple copies of two different antiviral peptides on the surface of a single dendrimer allowed the resulting biocon-jugates to inhibit Herpes simplex virus type 1 at both the early and the late stages of the infection process. The presented work builds on further improving this attractive design to obtain a new class of therapeutics
Nanoscale FasL Organization on DNA Origami to Decipher Apoptosis Signal Activation in Cells
Cell signaling is initiated by characteristic protein patterns in the plasma membrane, but tools to decipher their molecular organization and activation are hitherto lacking. Among the well-known signaling pattern is the death inducing signaling complex with a predicted hexagonal receptor architecture. To probe this architecture, DNA origami-based nanoagents with nanometer precise arrangements of the death receptor ligand FasL are introduced and presented to cells. Mimicking different receptor geometries, these nanoagents act as signaling platforms inducing fastest time-to-death kinetics for hexagonal FasL arrangements with 10 nm inter-molecular spacing. Compared to naturally occurring soluble FasL, this trigger is faster and 100x more efficient. Nanoagents with different spacing, lower FasL number or higher coupling flexibility impede signaling. The results present DNA origami as versatile signaling scaffolds exhibiting unprecedented control over molecular number and geometry. They define molecular benchmarks in apoptosis signal initiation and constitute a new strategy to drive particular cell responses
Patterning electro-osmotic flow with patterned surface charge
This Letter reports the measurement of electro-osmotic flows (EOF) in microchannels with surface charge patterned on the 200 mu m scale. We have investigated two classes of patterns: (1) Those in which the surface charge varies along a direction perpendicular to the electric field used to drive the EOF; this type of pattern generates multidirectional flow along the direction of the field. (2) Those in which the surface charge pattern varies parallel to the field; this pattern generates recirculating cellular flew, and thus causes motion both parallel and perpendicular to the external field. Measurements of both of these flours agree well with theory in the Limit of thin double layers and low surface potential
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