165 research outputs found

    The Near-Horizon Limit of the Extreme Rotating d=5 Black Hole as a Homogenous Spacetime

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    We show that the spacetime of the near-horizon limit of the extreme rotating d=5 black hole, which is maximally supersymmetric in N=2,d=5 supergravity for any value of the rotation parameter j in [-1,1], is locally isomorphic to a homogeneous non-symmetric spacetime corresponding to an element of the 1-parameter family of coset spaces SO(2,1)x SO(3)/SO(2)_j in which the subgroup SO(2)_j is a combination of the two SO(2) subgroups of SO(2,1) and SO(3).Comment: Some points clarified and misprints corrected. Version to be published in Classical and Quantum Gravit

    Paraneoplastic pemphigus with clinical features of lichen planus associated with low-grade B cell lymphoma

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    BACKGROUND: Neoplasia-induced lichen planus is described as a cell-mediated reaction to unknown epithelial antigens. Paraneoplastic pemphigus (PNP), characterized by the presence of a specific array of autoantibodies, probably represents a different form of presentation of the same autoimmune syndrome where the mucocutaneous expression depends on the dominant pathologic mechanism. METHODS: The authors report a case of PNP with predominant lichen planus-like lesions and review the relevant literature. We observed a 74-year-old female with vesico-bullous, erosive, target-shaped and flat papular lichenoid lesions on the lower legs, palms and soles, evolving for 3 weeks. Histopathology revealed a lichenoid dermatitis. Direct immunofluorescence showed C3 deposition around keratinocytes and epidermal IgG intranuclear deposition. Indirect immunofluorescence revealed circulating IgG with intercellular staining on rat bladder substrate. Immunoblotting demonstrated bands of 130, 190, 210 and 250 kDa antigens. A pararenal B cell lymphoma was found. RESULTS: Oral corticotherapy with 40 mg prednisolone daily was initiated with a good cutaneous response. Four months later, cyclophosphamide (50 mg/day) was introduced because of a discrete enlargement of the pararenal mass. The patient died on the seventh month of follow up as a result of respiratory insufficiency. CONCLUSION: PNP has different forms of presentation and the lack of a consensus about diagnostic criteria may contribute to underdiagnosed cases. Advances on the knowledge of the sensitivity and specificity of diagnostic criteria have allowed a better accuracy of diagnosis

    Bowel-associated dermatosis-arthritis syndrome in an adolescent with short bowel syndrome

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    Bowel-associated dermatosis-arthritis syndrome (BADAS) is a neutrophilic dermatosis, characterized by the occurrence of arthritis and skin lesions related to bowel disease with or without bowel bypass. We report an unusual case of BADAS in a 15-year-old white male with congenital aganglionosis of the colon and hypoganglionosis of the small intestine and multiple bowel surgeries in childhood complicated by short bowel syndrome. He presented with recurrent peripheral polyarthritis, tenosynovitis, and painful erythematous subcutaneous nodules located on the dorsolateral regions of the legs and on the dorsa of the feet. Histological examination disclosed a neutrophilic dermatosis confirming the diagnosis of BADAS.Although an uncommon disease, especially at pediatric age, it is important to evoke the diagnosis of BADAS in children and adolescents with bowel disease, because treatment options and prognosis are distinct from other rheumatologic conditions

    Einstein-Maxwell gravitational instantons and five dimensional solitonic strings

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    We study various aspects of four dimensional Einstein-Maxwell multicentred gravitational instantons. These are half-BPS Riemannian backgrounds of minimal N=2 supergravity, asymptotic to R^4, R^3 x S^1 or AdS_2 x S^2. Unlike for the Gibbons-Hawking solutions, the topology is not restricted by boundary conditions. We discuss the classical metric on the instanton moduli space. One class of these solutions may be lifted to causal and regular multi `solitonic strings', without horizons, of 4+1 dimensional N=2 supergravity, carrying null momentum.Comment: 1+30 page

    Acceso abierto y visibilidad de la investigación. El caso de Dadun, Depósito Digital de la Universidad de Navarra

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    Comunicación presentada en el Congreso «Humanidades digitales: visibilidad y difusión de la investigación», celebrado en Pamplona los días 23 y 24 de mayo de 2013. La presentación la realizaron Salomé Eslava y Arantxa Iturbide, del Servicio de Biblioteca de la Univeridad de Navarra

    Genetic and morphometric analyzes of Paralichthys species confirm the presence of P. brasiliensis in the Uruguayan waters

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    Paralichthys species have high commercial value and constitute a resource for demersal fisheries in the Southwestern Atlantic Ocean. Although six species have been described based on morphological characters for the Uruguayan and Argentinean waters, only the presence of three species is accepted, being their distribution still uncertain. Genetic tools are useful for species identification as a complement of morphological characters. This paper determines the genetic and morphometric variation between three species of Paralichthys that inhabiting Uruguayan waters. The interorbital width (IN) and the length from the mouth to the dorsal fin base (SD) of P. patagonicus differed significantly from the other two species (P. orbignyanus and P. brasiliensis). From a morphological perspective, individuals identified as P. orbignyanus formed two different groups. Clade Po_A included those belonging to oceanic coastal waters of Uruguay and deeper waters of the Rio de la Plata together with individuals of P. brasiliensis from ItajaÃ, Santa Catarina (Brazil). Individuals collected in the Rio de la Plata coastal and beach zone formed the clade Po_B group. Genetic analysis confirmed for the first time the presence of P. brasiliensis in Uruguayan and Rio de la Plata shelf waters and extends its known distribution area further south. Discriminant scores for P. orbygnianus separate individuals in two groups corresponding to the presence of two species. Molecular and morphological analysis showed individuals in the clade Po_A includes those collected in Uruguayan waters together with those collected in northern Brazilian waters belonging to the species P. brasiliensis

    Investigating SSH Research and Publication Practices in Disciplinary and Institutional Contexts. A Survey-Based Comparative Approach in Two Universities

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    In this paper, we comparatively analyze, present and discuss the results from a survey on increasing the visibility of research achievements in the social sciences and humanities (SSH) that was carried out at the University of Vienna (Austria) and the University of Navarra (Spain) in 2016 and 2017. Covering four major topics—searching and finding literature, publishing, the visibility of research, and the assessment of research outputs—we ask the following questions: are there disciplinary differences to be identified, and how do they present themselves in the two institutional contexts? Discussing the results, we showcase how disciplinary and institutional traditions and contexts are important factors that influence research and publication practices in the SSH. Our results indicate that the practices of searching and finding literature as well as publication practices and behavior are shaped by disciplinary traditions and epistemic cultures. On the contrary, assessment and valuation of research outputs are influenced by institutional and national contexts in which SSH research is organized and carried out

    Benign follicular tumors

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    Benign follicular tumors comprise a large and heterogeneous group of neoplasms that share a common histogenesis and display morphological features resembling one or several portions of the normal hair follicle, or recapitulate part of its embryological development. Most cases present it as clinically nondescript single lesions and essentially of dermatological relevance. Occasionally, however, these lesions be multiple and represent a cutaneous marker of complex syndromes associated with an increased risk of visceral neoplasms. In this article, the authors present the microscopic structure of the normal hair follicle as a basis to understand the type and level of differentiation of the various follicular tumors. The main clinicopathological features and differential diagnosis of benign follicular tumors are then discussed, including dilated pore of Winer, pilar sheath acanthoma, trichoadenoma, trichilemmoma, infundibuloma, proliferating trichilemmal cyst/tumor, trichoblastoma and its variants, pilomatricoma, trichodiscoma/fibrofolliculoma, neurofollicular hamartoma and trichofolliculoma. In addition, the main syndromes presenting with multiple follicular tumors are also discussed, namely Cowden, Birt-Hogg-Dubé, Rombo and Bazex-Dupré-Christol syndromes, as well as multiple tumors of follicular infundibulum (infundibulomatosis) and multiple trichoepitheliomas. Although the diagnosis of follicular tumors relies on histological examination, we highlight the importance of their knowledge for the clinician, especially when in presence of patients with multiple lesions that may be the cutaneous marker of a cancer-prone syndrome. The dermatologist is therefore in a privileged position to recognize these lesions, which is extremely important to provide further propedeutic, appropriate referral and genetic counseling for these patients.info:eu-repo/semantics/publishedVersio
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