2,622 research outputs found
The Post-Pericenter Evolution of the Galactic Center Source G2
In early 2014 the fast-moving near-infrared source G2 reached its closest
approach to the supermassive black hole Sgr A* in the Galactic Center. We
report on the evolution of the ionized gaseous component and the dusty
component of G2 immediately after this event, revealed by new observations
obtained in 2015 and 2016 with the SINFONI integral field spectrograph and the
NACO imager at the ESO VLT. The spatially resolved dynamics of the Br
line emission can be accounted for by the ballistic motion and tidal shearing
of a test-particle cloud that has followed a highly eccentric Keplerian orbit
around the black hole for the last 12 years. The non-detection of a drag force
or any strong hydrodynamic interaction with the hot gas in the inner accretion
zone limits the ambient density to less than a few 10 cm at the
distance of closest approach (1500 ), assuming G2 is a spherical cloud
moving through a stationary and homogeneous atmosphere. The dust continuum
emission is unresolved in L'-band, but stays consistent with the location of
the Br emission. The total luminosity of the Br and L' emission
has remained constant to within the measurement uncertainty. The nature and
origin of G2 are likely related to that of the precursor source G1, since their
orbital evolution is similar, though not identical. Both object are also likely
related to a trailing tail structure, which is continuously connected to G2
over a large range in position and radial velocity.Comment: 17 pages, 12 figures; accepted for publication in Ap
Respiratory Control: Central and Peripheral Mechanisms
Understanding of the respiratory control system has been greatly improved by technological and methodological advances. This volume integrates results from many perspectives, brings together diverse approaches to the investigations, and represents important additions to the field of neural control of breathing.
Topics include membrane properties of respiratory neurons, in vitro studies of respiratory control, chemical neuroanatomy, central integration of respiratory afferents, modulation of respiratory pattern by peripheral afferents, respiratory chemoreception, development of respiratory control, behavioral control of breathing, and human ventilatory control.
Forty-seven experts in the field report research and discuss novel issues facing future investigations in this collection of papers from an international conference of nearly two hundred leading scientists held in October 1990. This research is of vital importance to respiratory physiologists and those in neurosciences and neurobiology who work with integrative sensory and motor systems and is pertinent to both basic and clinical investigations.
Respiratory Control is destined to be widely cited because of the strength of the contributors and the dearth of similar works.
The four editors are affiliated with the University of Kentucky: Dexter F. Speck is associate professor of physiology and biophysics, Michael S. Dekin is assistant professor of biological sciences, W. Robert Revelette is research scientist of physiology and biophysics, and Donald T. Frazier is professor and chairman of physiology and biophysics.
Experts in the field report current research and discuss novel issues facing future investigations. —SciTech Book Newshttps://uknowledge.uky.edu/upk_biology/1002/thumbnail.jp
Neuroprotective role for RORA in Parkinson’s disease revealed by analysis of post-mortem brain and a dopaminergic cell line
Parkinson's disease (PD) is almost twice as prevalent in men, which has largely been attributed to neuroprotective effect of oestradiol in women. RORA (retinoic acid receptor-related orphan receptor alpha) regulates the transcription of central aromatase, the enzyme responsible for local oestradiol synthesis, simultaneously, RORA expression is regulated by sex hormones. Moreover, RORA protects neurones against oxidative stress, a key mechanism contributing to the loss of dopaminergic neurones in PD. Therefore, we hypothesized that there would be sex differences in RORA expression in the substantia nigra pars compacta (SNpc), which could contribute to sex differences observed in PD prevalence and pathogenesis. In a case control study, qPCR and western blot analyses were used to quantify gene and protein expression in the SNpc of post-mortem brains (n = 14 late-stage PD and 11 age and sex matched controls). The neuroprotective properties of a RORA agonist were then investigated directly using a cell culture toxin-based model of PD coupled with measures of viability, mitochondrial function and apoptosis. RORA was expressed at significantly higher levels in the SNpc from control females' brains compared to males. In PD, we found a significant increase in SNpc RORA expression in male PD compared to female PD. Treatment with a RORA agonist showed a significant neuroprotection in our cell culture model of PD and revealed significant effects on intracellular factors involved in neuronal survival and demise. This study is the first to demonstrate a sex specific pattern of RORA protein and gene expression in the SNpc of controls post-mortem human brains, and to show that this is differentially altered in male and female PD subjects, thus supporting a role for RORA in sex-specific aspects of PD. Furthermore, our in vitro PD model indicates mechanisms whereby a RORA agonist exerts its neuroprotective effect, thereby highlighting the translational potential for RORA ligands in PD
Resonant Energy Exchange between Atoms in Dispersing and Absorbing Surroundings
Within the framework of quantization of the macroscopic electromagnetic
field, a master equation describing both the resonant dipole-dipole interaction
(RDDI) and the resonant atom-field interaction (RAFI) in the presence of
dispersing and absorbing macroscopic bodies is derived, with the relevant
couplings being expressed in terms of the surroundings-assisted Green tensor.
It is shown that under certain conditions the RDDI can be regarded as being
governed by an effective Hamiltonian. The theory, which applies to both weak
and strong atom-field coupling, is used to study the resonant energy exchange
between two (two-level) atoms sharing initially a single excitation. In
particular, it is shown that in the regime of weak atom-field coupling there is
a time window, where the energy transfer follows a transfer-rate law of the
type obtained by ordinary second-order perturbation theory. Finally, the
spectrum of the light emitted during the energy transfer is studied and the
line splittings are discussed.Comment: 9 pages, 5 figs, Proceedings of ICQO'2002, Raubichi, to appear in
Optics and Spectroscop
X-band crab cavities for the CLIC beam delivery system
The CLIC machine incorporates a 20 mrad crossing angle at the IP to aid the
extraction of spent beams. In order to recover the luminosity lost through the
crossing angle a crab cavity is proposed to rotate the bunches prior to
collision. The crab cavity is chosen to have the same frequency as the main
linac (11.9942 GHz) as a compromise between size, phase stability requirements
and beam loading. It is proposed to use a HE11 mode travelling wave structure
as the CLIC crab cavity in order to minimise beam loading and mode separation.
The position of the crab cavity close to the final focus enhances the effect of
transverse wake-fields so effective wake-field damping is required. A damped
detuned structure is proposed to suppress and de-cohere the wake-field hence
reducing their effect. Design considerations for the CLIC crab cavity will be
discussed as well as the proposed high power testing of these structures at
SLAC.Comment: Proceedings of X-Band Structures and Beam Dynamics Workshop (XB08),
44th ICFA beam dynamics workshop, Cockcroft Institute, UK, 1-4 dec. 200
Completeness and Incompleteness of Synchronous Kleene Algebra
Synchronous Kleene algebra (SKA), an extension of Kleene algebra (KA), was
proposed by Prisacariu as a tool for reasoning about programs that may execute
synchronously, i.e., in lock-step. We provide a countermodel witnessing that
the axioms of SKA are incomplete w.r.t. its language semantics, by exploiting a
lack of interaction between the synchronous product operator and the Kleene
star. We then propose an alternative set of axioms for SKA, based on Salomaa's
axiomatisation of regular languages, and show that these provide a sound and
complete characterisation w.r.t. the original language semantics.Comment: Accepted at MPC 201
Interleukin 3 stimulates proliferation via protein kinase C activation without increasing inositol lipid turnover.
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