Cultural differentiation or self-exclusion. On young Turks’ and Repatriates’ dealing with experiences of discrimination in Germany

Based upon Bourdieu’s ‘theory of capital’ and Willis’s ‘theory of cultural production’, the article scrutinizes the interrelation between perceived discrimination, self-exclusion and cultural differentiation. The empirical analysis is based on a longitudinal study by the German Youth Institute, which was set up to explore the transition of young Turks from school to vocational training and employment. The data point out that young immigrants who are dealing with experiences of devaluation of their (origin-)specific cultural capital and who are disadvantaged regarding the accessibility of dominant cultural capital bring about a production of a counterculture. They are less likely to exclude themselves in the sense of internalizing the rightness of the dominant culture

The Impact of COVID-19 on immigration: the transformation of Norwegian migration policy on asylum seekers

Until just a year ago, hardly anyone believed that the increasingly unrestrained growth in mobility could be so abruptly interrupted by a radical immobilisation of large population groups. Neither mobility studies nor other research fields had foreseen this kind of scenario in their mobility and migration models. And why should have they? In the past decades, the belief in unconstrained mobility, as well as the practice of mobility and its scientific modelling, relied on the idea of unbounded growth at the sub-national, national and supra-national level. The article focuses on immigration to Norway, showing how institutional constraints were used to deal with the spread of COVID-19 and how they affected immigration to the country. Due to complexity reasons, we focus exclusively on the situation of asylum seekers, giving additional attention to unaccompanied minors. These groups’ migration status is assumed to make them especially susceptible to the newly established immigration measures. Drawing upon a combined focus of data on migration regulations and asylum application statistics, we examine what impact mobility-related COVID-19 measures implemented in Norway since January 2020 had on asylum procedures, asylum mobility and asylum applications in Norway

Stress-Optimised Shape Memory Devices for the Use in Microvalves

A gas valve of 6x6x2 mm3 size has been developed for high pressure applications. Stress-optimised shape memory microbeams of 100 µm thickness are used to control the deflection of a membrane above a valve chamber. The shape memory thin sheets have been fabricated by melting and rolling, which creates specific textures. Investigations by X-ray diffraction revealed major orientations of [111] and [011] in rolling direction. The corresponding maximum anisotropy of transformation strain was 20%. The microbeams have been fabricated by laser cutting. For stress-optimisation, the lateral widths of the beams are designed for homogeneous stress distributions along the beam surfaces allowing an optimised use of the shape memory effect and a minimisation of fatigue effects. For actuation, a rhombohedral phase transformation is used. This allows operation below pressure differences of 1200 hPa in designs with one valve chamber and below 4500 hPa in pressure-compensated designs with a second valve chamber above the membrane. Maximum gas flows of 1600 sccm (sccm = cm2 at standart conditions / minute) and work outputs of 35 µNm are achieved for a driving power of 210 mW. The response times for closing the valves vary between 0.5 and 1.2 s and for opening between 1 and 2 s depending on the applied pressure difference

Genetic variations in microRNA-binding sites of solute carrier transporter genes as predictors of clinical outcome in colorectal cancer

One of the principal mechanisms of chemotherapy resistance in highly frequent solid tumors, such as colorectal cancer (CRC), is the decreased activity of drug transport into tumor cells due to low expression of important membrane proteins, such as solute carrier (SLC) transporters. Sequence complementarity is a major determinant for target gene recognition by microRNAs (miRNAs). Single-nucleotide polymorphisms (SNPs) in target sequences transcribed into messenger RNA may therefore alter miRNA binding to these regions by either creating a new site or destroying an existing one. miRSNPs may explain the modulation of expression levels in association with increased/decreased susceptibility to common diseases as well as in chemoresistance and the consequent inter-individual variability in drug response. In the present study, we investigated whether miRSNPs in SLC transporter genes may modulate CRC susceptibility and patient's survival. Using an in silico approach for functional predictions, we analyzed 26 miRSNPs in 9 SLC genes in a cohort of 1368 CRC cases and 698 controls from the Czech Republic. After correcting for multiple tests, we found several miRSNPs significantly associated with patient's survival. SNPs in SLCO3A1, SLC22A2 and SLC22A3 genes were defined as prognostic factors in the classification and regression tree analysis. In contrast, we did not observe any significant association between miRSNPs and CRC risk. To the best of our knowledge, this is the first study investigating miRSNPs potentially affecting miRNA binding to SLC transporter genes and their impact on CRC susceptibility or patient's prognosis