The classical Lenz vector and the two-dimensional quantum harmonic oscillator

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Prejudices towards people with intellectual disabilities: reliability and validity of the Italian Modern and Classical Prejudices Scale

Background Prejudices and negative attitudes towards intellectual disabilities (IDs) may hinder social inclusion of ID individuals, limiting their well‐being. This study investigated the psychometric characteristics of the Italian Modern and Classical Prejudices Scale (MCPS‐IT) towards people with ID and the effects of gender, age and socio‐economic status (SES) on prejudices. Method The MCPS‐IT was administered to 474 adults (69% women, age range 18–70 years, M = 33.13) in conjunction with a questionnaire evaluating socio‐demographic information (SES), the contact and the education about ID people and the social dominance orientation. Results Results confirmed that Italian MCPS has a two‐factor structure that measures in a reliable and valid way prejudice towards people with ID. Multivariate analyses of variance confirmed a weak gender difference in both scales and age differences in modern scale. No SES differences were found. Conclusion The Italian MCPS represents a valid scale that can be used to monitor the social context of people with ID

Distribution of the surface energy budget: Preliminary analysis on the incoming solar radiation. the case study of the Forni Glacier (Italy)

This study represents a contribution to distribution of the surface energy budget of the Forni Glacier (Ortles-Cevedale Group, Upper Valtellina, Italy). The analyses are based on data acquired at S. Caterina Valfurva (a village in the glacier valley at 1768 m ellipsoidal elevation WGS84) by an Automatic Weather Station (AWS) installed and managed by the Lombardy Agency for the Environment ("ARPA Lombardia"). We focus on the two most important meteorological parameters affecting surface energy budget: air temperature (T) and incoming shortwave radiation (SWin). Data collected from the ARPA AWS are used to evaluate these parameters at the glacier surface during the meteorological summer 2009 (from 1st June to 31st August 2009) and then the computations are validated through comparison with data recorded by an AWS installed at the surface of Forni Glacier tongue ("AWS1 Forni", 2669 m ellipsoidal elevation WGS84). The analysis of the distributed air temperature data enabled identification of the lowest value (-11.9 degrees C), found at the Mount S. Matteo peak (3669 m) on 22nd June at 8: 00 pm, and the highest value (+16.1 degrees C), recorded at the glacier terminus (2497 m) on 23 rd July at 2: 00 pm. The seasonal temperature amplitude (Tmax-Tmin) was 28 degrees C. The hottest week was 20th-26th July 2009 and the coldest was 1st-7th June 2009. Regarding daily SWin distribution, the maximum value (406.9 Wm(-2)) was recorded on 13th June and the minimum (28.5 Wm(-2)) on 6th June. From the analysis of hourly SWin values we could distinguish between days with clear sky conditions and days with intense cloud cover. Weekly mean SWin data showed the greatest value (327.1 Wm(-2)) from 20th-26th July 2009 and the lowest (207.8 Wm(-2)) from 22nd-28th June 2009. Furthermore, in analysing SWin it is critical to take into account the problem of shading. Using the Hillshade tool of ArcGIS, which takes into account only the slope and the aspect of each grid cell neglecting the surrounding topography effect, we compiled 66 shadow maps. Finally this study represents a first approach in modelling the distributed incoming solar radiation. In fact the considered driving factors are the elevation, the slope and the aspect of each grid cell. The next step will consist in taking into account the surrounding topography and the actual atmosphere conditions as well

A comparison between the β-globin gene clusters of domestic sheep (Ovis aries) and Sardinian mouflon (Ovis gmelini musimon)

International audienc

Airborne Radio Echo Sounding (RES) measures on Alpine Glaciers to evaluate ice thickness and bedrock geometry: preliminary results from pilot tests performed in the Ortles Cevedale Group (Italian Alps)

Radar exploration supports glaciological studies playing several roles in ice exploration such as determining ice thickness and volume, describing ice and snow internal layering and characterizing crevassed areas. The method, widely used with full success on Polar areas, encounters more difficulties when applied to survey mountain glaciers like the Alpine and Himalayan ones. Among them, these difficulties can be addressed to the different physical characteristics of temperate ice and to logistic difficulties related to performing field operations at high elevations on areas where crevasses, seracs and ice-falls are present, making more complicate and complex the glacier surface. In the framework of the SHARE-PAPRIKA and the SHARE-STELVIO Projects, we performed some preliminary measurements on Careser, Sforzellina and Forni glaciers (Ortles-Cevedale Group, Italy), to evaluate efficiency and applicability of a Radio Echo Sounding (RES) instrument specifically designed, developed and modified by the INGV (Istituto Nazionale di Geofisica e Vulcanologia) laboratories. This paper reports the results we obtained investigating each glacier, the hampering factors and the cost to benefit ratio introduced by the airborne survey

Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development

Histone deacetylases (HDACs) catalyze the removal of acetyl molecules from histone and nonhistone substrates playing important roles in chromatin remodeling and control of gene expression. Class I HDAC1 is a critical regulator of cell cycle progression, cellular proliferation and differentiation during development; it is also regulated by many post-translational modifications (PTMs). Herein we characterize a new mitosis-specific phosphorylation of HDAC1 driven by Aurora kinases A and B. We show that this phosphorylation affects HDAC1 enzymatic activity and it is critical for the maintenance of a proper proliferative and developmental plan in a complex organism. Notably, we find that Aurora-dependent phosphorylation of HDAC1 regulates histone acetylation by modulating the expression of genes directly involved in the developing zebrafish central nervous system. Our data represent a step towards the comprehension of HDAC1 regulation by its PTM code, with important implications in unravelling its roles both in physiology and pathology

The WMO SPICE snow-on-ground intercomparison: an overview of sensor assessment and recommendations on best practices

Comunicación presentada en: TECO-2016 (Technical Conference on Meteorological and Environmental Instruments and Methods of Observation) celebrada en Madrid, del 27 al 30 de septiembre de 2016.One of the objectives of the WMO Solid Precipitation Intercomparison Experiment (SPICE) was to assess the performance and capabilities of automated sensors for measuring snow on the ground (SoG), including sensors that measure snow depth and snow water equivalent (SWE). The intercomparison focused on five snow depth sensors (models SHM30, SL300, SR50A, FLS-CH 10 and USH-8) and two SWE sensors (models CS725 and SSG1000) over two winter seasons (2013/2014 and 2014/2015). A brief discussion of the measurement reference(s) and an example of the intercomparisons are included. Generally, each of the sensors under test operated according to the manufacturer’s specifications and compared well with the site references, exhibiting high correlations with both the manual and automated reference measurements. The use of natural and artificial surface targets under snow depth sensors were examined in the context of providing a stable and representative surface for snow depth measurements. An assessment of sensor derived measurement quality and sensor return signal strength, where available as an output option, were analysed to help explain measurement outliers and sources of uncertainty with the goal of improving data quality and maximizing the sensor capabilities. Finally, where possible, relationships are established between the gauge measurement of solid precipitation and the measurement of snow on the ground. This paper will provide a brief summary of these results with more detail included in the WMO SPICE Final Report

Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer

Introduction: In developed countries, ovarian cancer is the fourth most common cancer in women. Due to the nonspecific symptomatology associated with the disease many patients with ovarian cancer are diagnosed late, which leads to significantly poorer prognosis. Apart from surgery and radiotherapy, a substantial number of ovarian cancer patients will undergo chemotherapy and platinum based agents are the mainstream first-line therapy for this disease. Despite the initial efficacy of these therapies, many women relapse; therefore, strategies for second-line therapies are required. Regulation of DNA transcription is crucial for tumour progression, metastasis and chemoresistance which offers potential for novel drug targets. Methods: We have reviewed the existing literature on the role of histone deacetylases, nuclear enzymes regulating gene transcription. Results and conclusion: Analysis of available data suggests that a signifant proportion of drug resistance stems from abberant gene expression, therefore HDAC inhibitors are amongst the most promising therapeutic targets for cancer treatment. Together with genetic testing, they may have a potential to serve as base for patient-adapted therapies

A dual role for Hdac1 : oncosuppressor in tumorigenesis, oncogene in tumor maintenance

Aberrant recruitment of histone deacetylases (HDACs) by the oncogenic fusion protein PML-RAR is involved in the pathogenesis of acute promyelocytic leukemia (APL). PML-RAR, however, is not sufficient to induce disease in mice, but requires additional oncogenic lesions during the pre-leukemic phase. Here, we show that knock-down of Hdac1 and Hdac2 dramatically accelerates leukemogenesis in transgenic pre-leukemic mice. These events are not restricted to APL, since lymphomagenesis driven by deletion of p53, or to a lesser extent by c-myc overexpression, was also accelerated by Hdac1 knock-down. In the pre-leukemic phase of APL Hdac1 counter-acts the activity of PML-RAR in: i) blocking differentiation, ii) impairing genomic stability and iii) increasing self-renewal in hematopoietic progenitors as all of these events are affected by the reduction in Hdac1 levels. This led to an expansion of a subpopulation of PML-RAR expressing cells that is the major source of leukemic stem cells in the full leukemic stage. Remarkably, short-term treatment of pre-leukemic mice with an HDAC inhibitor accelerated leukemogenesis. In contrast, knock-down of Hdac1 in APL mice led to enhanced survival of the leukemic animals. Thus, Hdac1 has a dual role in tumorigenesis: oncosuppressive in the early stages, and oncogenic in established tumor cells