SERIMI: Class-Based Matching for Instance Matching Across Heterogeneous Datasets

State-of-the-art instance matching approaches do not perform well when used for matching instances across heterogeneous datasets. This shortcoming derives from their core operation depending on direct matching, which involves a direct comparison of instances in the source with instances in the target dataset. Direct matching is not suitable when the overlap between the datasets is small. Aiming at resolving this problem, we propose a new paradigm called class-based matching. Given a class of instances from the source dataset, called the class of interest, and a set of candidate matches retrieved from the target, class-based matching refines the candidates by filtering out those that do not belong to the class of interest. For this refinement, only data in the target is used, i.e., no direct comparison between source and target is involved. Based on extensive experiments using public benchmarks, we show our approach greatly improves the quality of state-of-the-art systems; especially on difficult matching tasks

CWI at TREC 2012, KBA track and Session Track

We participated in two tracks: Knowledge Base Acceleration (KBA) Track and Session Track. In the KBA track, we focused on experi- menting with different approaches as it is the first time the track is launched. We experimented with supervised and unsupervised re- trieval models. Our supervised approach models include language models and a string-learning system. Our unsupervised approaches include using: 1)DBpedia labels and 2) Google-Cross-Lingual Dic- tionary (GCLD). While the approach that uses GCLD targets the central and relvant bins, all the rest target the central bin. The GCLD and the string-learning system have outperformed the oth- ers in their respective targeted bins. The goal of the Session track submission is to evaluate whether and how a logic framework for representing user interactions with an IR system can be used for improving the approximation of the relevant term distribution that another system that is supposed to have access to the session infor- mation will then calculate. the documents in the stream corpora. Three out of the seven runs used a Hadoop cluster provide by Sara.nl to process the stream cor- pora. The other 4 runs used a federated access to the same corpora distributed among 7 workstations

Effect of heat treatment on the wear and corrosion behaviors of a gray cast iron coated with a COLMONOY 88 alloy deposited by high velocity oxygen fuel (HVOF) thermal spray

The present work has been conducted in order to determine the influence of heat treatment on the wear and corrosion behaviours of a gray cast iron substrate coated with a Ni base coating deposited by HVOF thermal spray. The wear resistance of the coatings was obtained using a reciprocating wear tester by rubbing a 10 mm diameter steel ball on the coatings at normal atmospheric conditions. Corrosion tests were performed using potentiodynamic polarization measurements in a 3,5 % NaCl solution. It was observed that the corrosion and wear resistance of the coatings increased along with the reduction of porosity and roughness by the heat treatment

Comprehensive genomic analysis of refractory multiple myeloma reveals a complex mutational landscape associated with drug resistance and novel therapeutic vulnerabilities

The outcomes of patients with multiple myeloma (MM) refractory to immunomodulatory agents (IMiDs) and proteasome inhibitors (PIs) remain poor. In this study, we performed whole genome and transcriptome sequencing of 39 heavily pretreated relapsed/refractory MM (RRMM) patients to identify mechanisms of resistance and potential therapeutic targets. We observed a high mutational load and indications of increased genomic instability. Recurrently mutated genes in RRMM, which had not been previously reported or only observed at a lower frequency in newly diagnosed MM, included NRAS, BRAF, TP53, SLC4A7, MLLT4, EWSR1, HCFC2, and COPS3. We found multiple genomic regions with bi-allelic events affecting tumor suppressor genes and demonstrated a significant adverse impact of bi-allelic TP53 alterations on survival. With regard to potentially resistance conferring mutations, recurrently mutated gene networks included genes with relevance for PI and IMiD activity; the latter particularly affecting members of the Cereblon and the COP9 signalosome complex. We observed a major impact of signatures associated with exposure to melphalan or impaired DNA double-strand break homologous recombination repair in RRMM. The latter coincided with mutations in genes associated with PARP inhibitor sensitivity in 49% of RRMM patients; a finding with potential therapeutic implications. In conclusion, this comprehensive genomic characterization revealed a complex mutational and structural landscape in RRMM and highlights potential implications for therapeutic strategies

Calcium phosphate formation from sea urchin - (brissus latecarinatus) via modified mechano-chemical (ultrasonic) conversion method

This study aims to produce apatite structures, such as hydroxyapatite (HA) and fluorapatite (FA), from precursor calcium phosphates of biological origin, namely from sea urchin, with mechano-chemical stirring and hot-plating conversion method. The produced materials were heat treated at 800 °C for 4 hours. X-ray diffraction and scanning electron microscopy (SEM) studies were conducted. Calcium phosphate phases were developed. The SEM images showed the formation of micro to nano-powders. The experimental results suggest that sea urchin, Brissus latecarinatus skeleton could be an alternative source for the production of various mono or biphasic calcium phosphates with simple and economic mechano-chemical (ultrasonic) conversion method

Widespread intronic polyadenylation diversifies immune cell transcriptomes

Alternative cleavage and polyadenylation (ApA) is known to alter untranslated region (3ʹUTR) length but can also recognize intronic polyadenylation (IpA) signals to generate transcripts that lose part or all of the coding region. We analyzed 46 3ʹ-seq and RNA-seq profiles from normal human tissues, primary immune cells, and multiple myeloma (MM) samples and created an atlas of 4927 high-confidence IpA events represented in these cell types. IpA isoforms are widely expressed in immune cells, differentially used during B-cell development or in different cellular environments, and can generate truncated proteins lacking C-terminal functional domains. This can mimic ectodomain shedding through loss of transmembrane domains or alter the binding specificity of proteins with DNA-binding or protein–protein interaction domains. MM cells display a striking loss of IpA isoforms expressed in plasma cells, associated with shorter progression-free survival and impacting key genes in MM biology and response to lenalidomide

On limit theorems for continued fractions

It is shown that for sums of functionals of digits in continued fraction expansion the Kolmogorov-Feller weak laws of large numbers and the Khinchine-L\'evy-Feller-Raikov characterization of the domain of attraction of the normal law hold.Comment: 16 page

miR-23b/SP1/c-myc forms a feed-forward loop supporting multiple myeloma cell growth

Deregulated microRNA (miR)/transcription factor (TF)-based networks represent a hallmark of cancer. We report here a novel c-Myc/miR-23b/Sp1 feed-forward loop with a critical role in multiple myeloma (MM) and Waldenstrom's macroglobulinemia (WM) cell growth and survival. We have found miR-23b to be downregulated in MM and WM cells especially in the presence of components of the tumor bone marrow milieu. Promoter methylation is one mechanism of miR-23b suppression in myeloma. In gain-of-function studies using miR-23b mimics-transfected or in miR-23b-stably expressing MM and WM cell lines, we observed a significant decrease in cell proliferation and survival, along with induction of caspase-3/7 activity over time, thus supporting a tumor suppressor role for miR-23b. At the molecular level, miR-23b targeted Sp1 3'UTR and significantly reduced Sp1-driven nuclear factor-kappa B activity. Finally, c-Myc, an important oncogenic transcription factor known to stimulate MM cell proliferation, transcriptionally repressed miR-23b. Thus MYC-dependent miR-23b repression in myeloma cells may promote activation of oncogenic Sp1-mediated signaling, representing the first feed-forward loop with critical growth and survival role in myeloma