Doping effect on the evolution of the pairing symmetry in n-type superconductor near antiferromagnetic phase boundary

We present the investigation results of the in-plane \{rho}(T) resistivity tensor at the temperature range 0.4-40 K in magnetic fields up to 90kOe (H||c, J||ab) for electron-doped Nd{2-x}Ce{x}CuO{4+{\delta}} with different degree of disorder near antiferromagnetic - superconducting phase boundary. We have experimentally found that for optimally doped compound both the upper critical field slope and the critical temperature decrease with increasing of the disorder parameter (d-wave pairing) while in the case of the underdoped system the critical temperature remains constant and (dHc2/dT)|Tc increases with increasing of the disorder (s-wave pairing). These features suggest a possible implementation of the complex mixture state as the (s+id)-pairing.Comment: 9 pages, 2 figure

RSA cryptosystem for dedekind rings

© 2016, Pleiades Publishing, Ltd.May soon be invented quantum computer and some known cryptosystems (such as RSA) will be threatened breaking. This paper is aimed at establishing necessary conditions for the maximum possible algebraic generalization of the classical RSA algorithm. We substitute ideals of a Dedekind ring for integers. Ideals in Dedekind rings allow the unique decomposition into a product of maximal ideals, but may not be the principal ideals. Also we define Euler’s ϕ-function for ideal of a Dedekind ring and describe some properties of this function. We hope that our proposed method will help to develop algorithms for encryption, which is hard to crack using a quantum computer

The Development Impact of the System of Federal Educational and Methodological Associations On the Quality of Secondary Vocational Education

The article considers the importance of qualifications of workers in the development of the real sector of the Russian economy. Trends of expected demand for middle-level specialists, the most in-demand occupations and expectations of employers regarding knowledge, skills and experience of technical specialists are analyzed. The main tasks and functional capabilities of federal educational and methodological associations as well as their role in the development of the secondary vocational education system are presented. The article highlights the need to update the lists of professions and specialties that are currently promising. The article presents the experience of the federal educational and methodological association in the system of secondary vocational education in enlarged groups of professions and specialties 12.00.00 Photonics, Instrument Making, Optical and Biotechnical Systems and Technologies.Рассмотрено значение квалификаций рабочих кадров в развитии реального сектора российской экономики. Анализируются тенденции ожидаемого спроса на специалистов среднего звена, наиболее востребованные профессии, а также ожидания работодателей в отношении знаний, навыков и опыта, необходимых для квалифицированных специалистов. Раскрыты основные задачи и функциональные возможности федеральных учебно-методических объединений, их роль в развитии системы среднего профессионального образования. Особое внимание обращается на необходимость актуализации перечней профессий и специальностей, перспективных в настоящее время. Представлен опыт работы федерального учебно-методического объединения в системе среднего профессионального образования по укрупненным группам профессий, специальностей 12.00.00 Фотоника, приборостроение, оптические и биотехнические системы и технологии

Nonbacterial and bacterial osteomyelitis in children: a case–control retrospective study

PurposeOsteomyelitis is a group of bone infectious (bacterial osteomyeilitis—BO) and noninfectious inflammatory diseases (nonbacterial osteomyelitis—NBO) with similar clinical, radiology, and laboratory features. Many patients with NBO are misdiagnosed as BO and receive unnecessary antibiotics and surgery. Our study aimed to compare clinical and laboratory features of NBO and BO in children, to define key discriminative criteria, and to create an NBO diagnostic score (NBODS).MethodsThe retrospective multicenter cohort study included clinical, laboratory, and instrumental information about histologically confirmed NBO (n = 91) and BO (n = 31). The variables allowed us to differentiate both conditions used to construct and validate the NBO DS.ResultsThe main differences between NBO and BO are as follows: onset age—7.3 (2.5; 10.6) vs. 10.5 (6.5; 12.7) years (p = 0.03), frequency of fever (34.1% vs. 90.6%, p = 0.0000001), symptomatic arthritis (67% vs. 28.1%, p = 0.0001), monofocal involvement (28.6% vs. 100%, p = 0.0000001), spine (32% vs. 6%, p = 0.004), femur (41% vs. 13%, p = 0.004), foot bones (40% vs. 13%, p = 0.005), clavicula (11% vs. 0%, p = 0.05), and sternum (11% vs. 0%, p = 0.039) involvement. The following four criteria are included in the NBO DS: CRP ≤ 55 mg/l (56 points), multifocal involvement (27 points), femur involvement (17 points), and neutrophil bands ≤ 220 cell/μl (15 points). The sum > 17 points allowed to differentiate NBO from BO with a sensitivity of 89.0% and a specificity of 96.9%.ConclusionThe diagnostic criteria may help discriminate NBO and BO and avoid excessive antibacterial treatment and surgery

Studying the content of phenolic compounds of Bupleurum scorzonerifolium Willd., growing in the Baikal region with HPLC

Phenolic compounds of plants have a wide spectrum of pharmacological action. A number of effective herbal medicines and biologically active additives have been developed on the basis of raw materials and natural polyphenols. The sources of phenolic compounds are plants of the genus Bupleurum L. In Russia Bupleurum scorzonerifolium used in folk medicine. Infusions and decoctions were taken for diseases of the liver, gall bladder, topically as an anti-inflammatory agent. The composition of phenolic compounds in the above-ground organs of the B. scorzonerifolium studied by HPLC on the device "GILSTON". Samples of raw materials (above-ground organs) were collected in the southern areas of the Irkutsk region. For the analysis of the herb B. scorzonerifolium 70% extract ethyl alcohol was used. Separation was performed on substances Kromasil C18 column (4,6 x 250 mm, 5 micron). Detection was carried out using a UV detector "GILSTON" UV/VIS model 151, at a wavelength of 254 nm. In comparison with standard samples we identified 8 flavonoids (prevailing - izoquercetin, hyperoside, izoramnetin-3-glucoside), 5 aromatic acids (predominantly acid - cinnamic, gallic, chicory). The study established the content of epicatechin, catechin, epigallocatechingallate, coumarin. For the first time the content of acids - coffee, chlorogenic, gallic, chicory, cinnamon; flavonoids - vitsenin, lyuteolin-7-glucoside, isoramnetin-3-glucoside, apigenin; epicatechin, catechin, epigallocatechingallate; coumarin -was established in B. scorzonerifolium

Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci

Alopecia areata (AA) is a prevalent autoimmune disease with 10 known susceptibility loci. Here we perform the first meta-analysis of research on AA by combining data from two genome-wide association studies (GWAS), and replication with supplemented ImmunoChip data for a total of 3,253 cases and 7,543 controls. The strongest region of association is the major histocompatibility complex, where we fine-map four independent effects, all implicating human leukocyte antigen-DR as a key aetiologic driver. Outside the major histocompatibility complex, we identify two novel loci that exceed the threshold of statistical significance, containing ACOXL/BCL2L11(BIM) (2q13); GARP (LRRC32) (11q13.5), as well as a third nominally significant region SH2B3(LNK)/ATXN2 (12q24.12). Candidate susceptibility gene expression analysis in these regions demonstrates expression in relevant immune cells and the hair follicle. We integrate our results with data from seven other autoimmune diseases and provide insight into the alignment of AA within these disorders. Our findings uncover new molecular pathways disrupted in AA, including autophagy/apoptosis, transforming growth factor beta/Tregs and JAK kinase signalling, and support the causal role of aberrant immune processes in AA

Accumulation of phenolic compounds in the aerial organs of Bupleurum scorzonerifolium Willd., growing in the Baikal region

A plant of the genus Bupleurum L. is being introduced into medical practice and being used in traditional medicine as an anti-inflammatory agent in diseases of the gastrointestinal tract, treatment of diseases of the liver and gall bladder. In folk medicine, infusionfrom the herb Bupleurum scorzonerifolium Willd. is used externally for inflammatory diseases of the eyes and skin diseases. B. scorzonerifolium is widespread and abundantly grows in the area of Ural Mountains, Altai, Tuva, in the Krasnoyarsk region, Baikal region, and Buryatia. Detection of phenolic compounds in B. scorzonerifolium was performed using qualitative analytical reactions. Studying the composition of flavonoids and phenol carbonic acids was carried out by paper chromatography. We established that the leaves of B. scorzonerifolium contain quercetin, kaempferol, rutin, hyperoside and isorhamnetin, stems - quercetin, kaempferol, rutin and isorhamnetin, flowers - quercetin, hyperoside and rutin. The leaves, flowers and stems found to contain caffeic, chlorogenic and ferulic acids. The quantitative content of tannins was determined by permanganometry method, flavonoids and phenol carbonic acids -by spectrophotometric method. The maximum quantity of phenolic compounds is detected in leaves and flowers. Thus, as a medicinal plant, the grass B. scorzonerifolium can be recommended for harvesting during the flowering period

Специфика воспроизводства знаний в цифровой экономике: социальный аспект

Introduction. The formation of the digital economy, which began in the second half of the 20th century, posed a lot of different problems to humanity. Many of them are associated with the specifics of the digitalization of social production, which, along with human capital, becomes the main resource for development. At the same time, the local digital transformation of economic relations entails changes in their entire scope. First of all, such changes concern the process of reproduction of knowledge, or rather, the technology of its «translation» from a «simple» to an «expanded» state. Purpose setting. The logic of the article is built in the discourse of theorizing the process of cooperation between a machine (AI) and a human. Cooperation (technology, tool) leads to changes in the very nature of work and, accordingly, the transformation of education as its service subsystem. The purpose of the article is to consider the process of knowledge reproduction in the educational architecture of the digital economy. Methodology and methods of the study. The analysis of such meta-processes involves an interdisciplinary analysis, and a structural approach will allow interpreting the main stages of knowledge reproduction in historical discourse. Taking into account the considerable number of economic and socio-philosophical studies, the article necessarily used the latest developments of domestic and foreign scientists. Results. The authors proposed a working definition of the digital economy. It is considered as a modern, historically conditioned way of economic development of society, which is based on the intensive expanded reproduction of knowledge in the form of cooperation between a machine (AI) and a human. The purpose and meaning of this type of reproduction is the use of the subjectivity of an individual in the direction of increasing his creative principle. Creativity is understood as the ability to generate knowledge based not only on material (rational), but also on irrational (ideal) values and meanings. According to these theses, the transformation of all service architectures of social development and, first of all, education should be carried out. Conclusion. The development of intangible assets should be a defining task in the formation of human capital in the digital economy. In turn, the holistic development of the individual»s intelligence in all its modifications (primarily cognitive, emotional and digital), that do not contradict each other is the general task of the education system.Введение. Формирование цифровой экономики, начавшееся во второй половине XX в., поставило перед человечеством большое количество различных проблем. Многие из них связываются со спецификой цифровизации общественного производства, которая становится наряду с человеческим капиталом основным ресурсом развития. Вместе с тем локальная цифровая трансформация отношений в сфере экономики влечет за собой изменения во всем их объеме. В первую очередь подобные изменения касаются процесса воспроизводства знания, а точнее, технологии его «перевода» из «простого» в «расширенное» состояние. Постановка задачи. Логика статьи выстроена в дискурсе теоретизации процесса кооперации машины (ИИ) и человека. Кооперация (технология, инструмент) ведет к изменениям в самом характере труда и, соответственно, трансформации образования как его сервисной подсистемы. Целью статьи является рассмотрение процесса воспроизводства знания в образовательной архитектуре цифровой экономики. Методика и методология исследования. Аналитика подобного рода метапроцессов предполагает проведение междисциплинарного анализа, а структурный подход позволит интерпретировать основные этапы воспроизводства знания в историческом дискурсе. Учитывая значительное количество исследований экономического и социально-философского плана, в статье с необходимостью использовались последние разработки отечественных и зарубежных ученых. Результаты. Авторами предложено рабочее определение цифровой экономики. Она рассмотрена как современный, исторически обусловленный уклад экономического развития общества, в основе которого лежит интенсивное расширенное воспроизводство знания в форме кооперации машины (ИИ) и человека. Целью и смыслом такого типа воспроизводства является применение субъектности индивида в сторону повышения его креативного начала. Под креативностью понимается способность генерации знания, основанного не только на материальных (рациональных), но и на иррациональных (идеальных) ценностях и смыслах. Соответственно этим тезисам должна быть проведена трансформация всех сервисных архитектур общественного развития и, в первую очередь, образования. Выводы. Развитие нематериальных активов должно стать определяющей задачей в формировании человеческого капитала в условиях цифровой экономики. В свою очередь целостное развитие интеллекта индивида во всех его модификациях (в первую очередь когнитивного, эмоционального и цифрового), непротиворечащих друг другу, является генеральной задачей системы образования

Standardization of the Vygotsky — Sakharov Method for Concept Learning

The study was carried out in order to standardize the methodology for creating artificial concepts of Vygotsky — Sakharov. Group norms were established for the amount of time, moves made for the solution and indicators according to the formula of thinking productivity. Criteria for assessing levels of conceptual thinking were formulated and significant correlations were found in the groups of successful and unsuccessful problem solving.Настоящее исследование было проведено в целях стандартизации методики создания искусственных понятий Выготского — Сахарова. Установлены групповые нормы по количеству времени, сделанных ходов для решения и показателей по формуле производительности мышления. Сформулированы критерии оценки уровней понятийного мышления и найдены значимые корреляционные связи в группах успешного и неуспешного выполнения