47,804 research outputs found

    ACUTE Heart Failure Risk Stratification: A Step Closer to the Holy Grail?

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    Fractal templates in the escape dynamics of trapped ultracold atoms

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    We consider the dynamic escape of a small packet of ultracold atoms launched from within an optical dipole trap. Based on a theoretical analysis of the underlying nonlinear dynamics, we predict that fractal behavior can be seen in the escape data. This data would be collected by measuring the time-dependent escape rate for packets launched over a range of angles. This fractal pattern is particularly well resolved below the Bose-Einstein transition temperature--a direct result of the extreme phase space localization of the condensate. We predict that several self-similar layers of this novel fractal should be measurable and we explain how this fractal pattern can be predicted and analyzed with recently developed techniques in symbolic dynamics.Comment: 11 pages with 5 figure

    Moments of a single entry of circular orthogonal ensembles and Weingarten calculus

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    Consider a symmetric unitary random matrix V=(vij)1i,jNV=(v_{ij})_{1 \le i,j \le N} from a circular orthogonal ensemble. In this paper, we study moments of a single entry vijv_{ij}. For a diagonal entry viiv_{ii} we give the explicit values of the moments, and for an off-diagonal entry vijv_{ij} we give leading and subleading terms in the asymptotic expansion with respect to a large matrix size NN. Our technique is to apply the Weingarten calculus for a Haar-distributed unitary matrix.Comment: 17 page

    Mihai Gheorghiade, MD-Life and Concepts

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    How do you capture an idea, shape it, and then bring it into the world? Of his many talents, this ability was a fundamental characteristic of Mihai Gheorghiade. A quick glance through PubMed confirms his prodigious output, likely to overwhelm any novice or even expert scholar. His contribution to heart failure, especially acute heart failure (AHF), is profound, He authored several major concepts in acute heart failure, disseminated further by his students. Most concepts remained indelibly linked to his name: Digoxin trials research(1–3), AHFS (acute heart failure syndromes) definition(4), hemodynamic congestion(5), hospitalized heart failure (HHF) (6), the vulnerable phase(7,8), neutral hemodynamic agents(9), registries(10–12) and pre-trial registries(13), the “6-axis model”(14) and then the “8-axis model”(15). His work shaped the field of AHF

    Multi-Behavioral Endpoint Testing Of An 87-Chemical Compound Library In Freshwater Planarians

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    There is an increased recognition in the field of toxicology of the value of medium-to-high-throughput screening methods using in vitro and alternative animal models. We have previously introduced the asexual freshwater planarian Dugesia japonica as a new alternative animal model and proposed that it is particularly well-suited for the study of developmental neurotoxicology. In this paper, we discuss how we have expanded and automated our screening methodology to allow for fast screening of multiple behavioral endpoints, developmental toxicity, and mortality. Using an 87-compound library provided by the National Toxicology Program (NTP), consisting of known and suspected neurotoxicants, including drugs, flame retardants, industrial chemicals, polycyclic aromatic hydrocarbons (PAHs), pesticides and presumptive negative controls, we further evaluate the benefits and limitations of the system for medium-throughput screening, focusing on the technical aspects of the system. We show that, in the context of this library, planarians are the most sensitive to pesticides with 16/16 compounds causing toxicity and the least sensitive to PAHs, with only 5/17 causing toxicity. Furthermore, while none of the presumptive negative controls were bioactive in adult planarians, 2/5, acetaminophen and acetylsalicylic acid, were bioactive in regenerating worms. Notably, these compounds were previously reported as developmentally toxic in mammalian studies. Through parallel screening of adults and developing animals, planarians are thus a useful model to detect such developmental-specific effects, which was observed for 13 chemicals in this library. We use the data and experience gained from this screen to propose guidelines for best practices when using planarians for toxicology screens

    General moments of the inverse real Wishart distribution and orthogonal Weingarten functions

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    Let WW be a random positive definite symmetric matrix distributed according to a real Wishart distribution and let W1=(Wij)i,jW^{-1}=(W^{ij})_{i,j} be its inverse matrix. We compute general moments E[Wk1k2Wk3k4...Wk2n1k2n]\mathbb{E} [W^{k_1 k_2} W^{k_3 k_4} ... W^{k_{2n-1}k_{2n}}] explicitly. To do so, we employ the orthogonal Weingarten function, which was recently introduced in the study for Haar-distributed orthogonal matrices. As applications, we give formulas for moments of traces of a Wishart matrix and its inverse.Comment: 29 pages. The last version differs from the published version, but it includes Appendi

    Transverse momentum dependent parton distributions in a light-cone quark model

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    The leading twist transverse momentum dependent parton distributions (TMDs) are studied in a light-cone description of the nucleon where the Fock expansion is truncated to consider only valence quarks. General analytic expressions are derived in terms of the six amplitudes needed to describe the three-quark sector of the nucleon light-cone wave function. Numerical calculations for the T-even TMDs are presented in a light-cone constituent quark model, and the role of the so-called pretzelosity is investigated to produce a nonspherical shape of the nucleon.Comment: references added and typos corrected; version to appear in Phys. Rev.
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