СРЕДНЕКЕДРОВАЯ ПАЛЕОСЕЙСМОДИСЛОКАЦИЯ В БАЙКАЛЬСКОМ ХРЕБТЕ: СТРУКТУРА И ОЦЕНКА СМЕЩЕНИЙ ПО ДАННЫМ ГЕОРАДИОЛОКАЦИИ

Our study aimed to clarify the seismic potential of the Severobaikalsk fault and to discover the structural features of active faults on the NW shores of Lake Baikal. Seismogenic faults and large seismogravitational structures were mapped in the area of the Srednekedrovaya paleoseismodislocation, one of the most remarkable seismotectonic structures in the Baikal region. During the field trip, we tested the capacities of an OKO‐2 georadar and an ABDL‐ Triton antenna used to study cross‐sections of the Baikal ridge. Its slopes are steep, covered with Pinus pumila and abundant screes, many of which developed into boulder streams (‘kurumnik’). The first studies of the Sredneked‐ rovaya paleoseismodislocation were conducted by V.P. Solonenko and his team in 1964–1965. To some extent, this zone can be viewed as a reference object that can provide much information and thus deserves an in‐depth investiga‐ tion using new technologies. Our study combined the field observation and the interpretation of high‐resolution satel‐ lite images provided by DigitalGlobe (US) and downloaded by SAS.Planet. The consolidated database was sufficient for constructing a new schematic map showing the seismogenic faults associated with the Srednekedrovaya paleoseis‐ modislocation. The cumulative length of the ruptures observed on the surface amounted to almost 29.5 km. Some ruptures are separate from each other, and the rupture spacing ranges from the first tens of meters to the first kilome‐ ters. The width of the widest rupture zone is 1.9 km. The length of individual ruptures varies from 5.0 m to 2.7 km. Morphologically, the Srednekedrovaya paleoseismodislocation is represented by ledges and ditches that often comprise complex grabens disturbing the bedrock and slope deposits. The fault structure of this zone is a typical set‐ ting of orthogonal and slightly oblique crustal stretching, but its manifestation differs in the zone segments. In general, it is a combination of steeply dipping and listric faults traced to the depth of 13 m. In plan, the faults are observed to form the systems of subparallel ruptures that mainly strike at 30°. A linear relationship is established between the heights of the seismogenic ledges and the throws estimated from the ground‐penetrating radar data. The former are larger by 0.5–2.0 m than the throw measured from the radargrams. Apparently, this reflects the magnitude of expan‐ sion of the ledge upward along the sloping slope. In the zone of the main fault plane coinciding with the main ledge, the maximum and mean arithmetic throws are 8.3 and 4.93 m, respectively. On other fault planes, the throws range from 0.4 to 4.6 m. The paleoearthquake magnitude ranges from 6.8 to 7.6, according to the estimations from the seis‐ mic rock collapse volume, fault length, and the displacements. Our study of the Srednekedrovaya paleoseismodisloca‐ tion confirms that listric normal faulting is widespread along the western side of the North Baikal basin and gives in‐ direct evidence that conditions for accumulation and release of seismic energy are different on the western and east‐ ern shores of Lake Baikal. It should be noted, however, that in the studied near‐surface layer of the crust, the blocks of loose material may move along the flat planes due to gravitational sliding that increases under the impact of cryogenic processes on the steep slopes of the Baikal ridge.Для уточнения сейсмического потенциала Северобайкальского разлома и выявления особенностей строения активных нарушений северо‐западного побережья озера Байкал нами проведено картирование сейсмогенных разрывов и крупных сейсмогравитационных проявлений в районе Среднекедровой палеосейсмодислокации – одной из самых примечательных сейсмотектонических структур в Байкальском регионе. Одновременно мы испытывали возможности применения георадара ОКО‐2 с антенным блоком АБДЛ Тритон для изучения разрезов в условиях крутых склонов Байкальского хребта, покрытых стланиковыми соснами и осыпями, значительная часть которых преобразована в курумники. Впервые изученная в 1964–1965 гг. под руководством В.П. Солоненко Среднекедровая палеосейсмодислокация стала в некоторой степени эталонным объектом, который в силу своей выразительности требует более тщательного изучения в связи с новыми методическими возможностями. В результате выполненных работ нами на основе полевых наблюдений и дешифрирования спутниковых снимков высокого разрешения, предоставляемых американской компанией DigitalGlobe и доступных через программу SAS.Планета, составлена новая схема сейсмогенных нарушений, ассоциированных с палеосейсмодислокацией Среднекедровой. Общая протяженность видимых на поверхности разрывов составила не менее 29.5 км. Некоторые из них отстоят друг от друга на расстоянии от первых десятков метров до первых километров. Наибольшая ширина зоны разрывов составляет 1.9 км. Длина отдельных трещин изменяется от 5 м до 2.7 км. Морфологически Среднекедровая палеосейсмодислокация представлена уступами и рвами, нередко формирующими сложные грабены, которые нарушают коренные породы и склоновые отложения. Разломная структура зоны типична для обстановки ортогонального или чуть косого растяжения, но по‐разному проявляется на отдельных ее сегментах. В целом для нее характерно сочетание крутопадающих и листрических сбросов, прослеженных до глубины 13 м. В плане они образуют системы субпараллельных разрывов с преобладающим простиранием 30°. Полученные высоты сейсмогенных уступов и вертикальные смещения по данным георадиолокации линейно связаны между собой. Значения первых больше величин подвижек, измеренных на радарограммах, на 0.5–2.0 м, что отражает, по‐видимому, величину расширения уступа вверх по осыпному склону. Максимальная и средняя арифметическая вертикальные амплитуды сброса по зоне главного сместителя, совпадающей с главным уступом, имеют значения 8.3 и 4.93 м, соответственно. По отдельным сместителям смещения колеблются от 0.4 до 4.6 м. Оценки магнитуд палеоземлетрясения, рассчитанные по разным зависимостям с использованием объема сейсмообвала, длины разрыва и смещений, колеблются от 6.8 до 7.6. Изучение Среднекедровой палеосейсмодислокации подтвердило, что листрическое сбросообразование широко распространено вдоль западного борта Северобайкальской впадины, что является косвенным свидетельством различных условий накопления и реализации сейсмической энергии на западном и восточном побережье озера Байкал. В то же время в изученном близповерхностном слое земной коры некоторый вклад в движение блоков рыхлого материала по пологим плоскостям может вносить гравитационное скольжение, которое усиливается под воздействием криогенных процессов в условиях крутых склонов Байкальского хребта

EMPOWER-lung 1: A randomized, open-label, multi-national, phase III trial of cemiplimab, a human PD-1 monoclonal antibody, versus chemotherapy in first-line treatment of advanced non-small cell lung cancer (NSCLC) with PD-L1 50%

Background: Most patients (pts) with NSCLC present with advanced disease at diagnosis. Systemic therapy with platinum-based doublet chemotherapy regimens has been the standard first-line treatment for pts with advanced NSCLC whose tumours do not have EGFR, ALK, or ROS 1 mutations, but there is a need for effective treatments to improve long-term survival. With the recognition that NSCLC tumours express PD-L1, checkpoint inhibitors are being investigated in several clinical trials. There is currently only one PD-1 inhibitor approved as monotherapy in first-line treatment of NSCLC with PD-L1 expression ≥50%. In a phase 1 dose escalation and NSCLC expansion cohort, cemiplimab (REGN2810), a human monoclonal anti-PD-1, has demonstrated antitumour activity with an acceptable safety profile in anti-PD-1 naïve, pre-treated pts with NSCLC. Trial design: This is a randomised (1:1), multicentre, open-label, phase 3 study of cemiplimab versus platinum-based doublet chemotherapy in systemic treatment-naïve pts (≥18 years) with stage IIIB, IIIC or IV squamous or non-squamous NSCLC whose tumours express PD-L1 in ≥ 50% of tumour cells (NCT03088540)

Multijet production in neutral current deep inelastic scattering at HERA and determination of α_{s}

Multijet production rates in neutral current deep inelastic scattering have been measured in the range of exchanged boson virtualities 10 5 GeV and –1 < η_{LAB}^{jet} < 2.5. Next-to-leading-order QCD calculations describe the data well. The value of the strong coupling constant α_{s} (M_{z}), determined from the ratio of the trijet to dijet cross sections, is α_{s} (M_{z}) = 0.1179 ± 0.0013 (stat.)_{-0.0046}^{+0.0028}(exp.)_{-0.0046}^{+0.0028}(th.)

An NLO QCD analysis of inclusive cross-section and jet-production data from the ZEUS experiment

The ZEUS inclusive differential cross-section data from HERA, for charged and neutral current processes taken with e+ and e- beams, together with differential cross-section data on inclusive jet production in e+ p scattering and dijet production in \gamma p scattering, have been used in a new NLO QCD analysis to extract the parton distribution functions of the proton. The input of jet data constrains the gluon and allows an accurate extraction of \alpha_s(M_Z) at NLO; \alpha_s(M_Z) = 0.1183 \pm 0.0028(exp.) \pm 0.0008(model) An additional uncertainty from the choice of scales is estimated as \pm 0.005. This is the first extraction of \alpha_s(M_Z) from HERA data alone.Comment: 37 pages, 14 figures, to be submitted to EPJC. PDFs available at http://durpdg.dur.ac.uk/hepdata in LHAPDFv

Measurement of event shapes in deep inelastic scattering at HERA

Inclusive event-shape variables have been measured in the current region of the Breit frame for neutral current deep inelastic ep scattering using an integrated luminosity of 45.0 pb^-1 collected with the ZEUS detector at HERA. The variables studied included thrust, jet broadening and invariant jet mass. The kinematic range covered was 10 < Q^2 < 20,480 GeV^2 and 6.10^-4 < x < 0.6, where Q^2 is the virtuality of the exchanged boson and x is the Bjorken variable. The Q dependence of the shape variables has been used in conjunction with NLO perturbative calculations and the Dokshitzer-Webber non-perturbative corrections (`power corrections') to investigate the validity of this approach.Comment: 7+25 pages, 6 figure

The dependence of dijet production on photon virtuality in ep collisions at HERA

The dependence of dijet production on the virtuality of the exchanged photon, Q^2, has been studied by measuring dijet cross sections in the range 0 < Q^2 < 2000 GeV^2 with the ZEUS detector at HERA using an integrated luminosity of 38.6 pb^-1. Dijet cross sections were measured for jets with transverse energy E_T^jet > 7.5 and 6.5 GeV and pseudorapidities in the photon-proton centre-of-mass frame in the range -3 < eta^jet <0. The variable xg^obs, a measure of the photon momentum entering the hard process, was used to enhance the sensitivity of the measurement to the photon structure. The Q^2 dependence of the ratio of low- to high-xg^obs events was measured. Next-to-leading-order QCD predictions were found to generally underestimate the low-xg^obs contribution relative to that at high xg^obs. Monte Carlo models based on leading-logarithmic parton-showers, using a partonic structure for the photon which falls smoothly with increasing Q^2, provide a qualitative description of the data.Comment: 35 pages, 6 eps figures, submitted to Eur.Phys.J.

Inclusive jet cross sections and dijet correlations in D∗±D^{*\pm} photoproduction at HERA

Inclusive jet cross sections in photoproduction for events containing a $D^*$ meson have been measured with the ZEUS detector at HERA using an integrated luminosity of $78.6 {\rm pb}^{-1}$. The events were required to have a virtuality of the incoming photon, $Q^2$, of less than 1 GeV$^2$, and a photon-proton centre-of-mass energy in the range $130<W_{\gamma p}<280 {\rm GeV}$. The measurements are compared with next-to-leading-order (NLO) QCD calculations. Good agreement is found with the NLO calculations over most of the measured kinematic region. Requiring a second jet in the event allowed a more detailed comparison with QCD calculations. The measured dijet cross sections are also compared to Monte Carlo (MC) models which incorporate leading-order matrix elements followed by parton showers and hadronisation. The NLO QCD predictions are in general agreement with the data although differences have been isolated to regions where contributions from higher orders are expected to be significant. The MC models give a better description than the NLO predictions of the shape of the measured cross sections.Comment: 43 pages, 12 figures, charm jets ZEU

Beauty photoproduction measured using decays into muons in dijet events in ep collisions at s\sqrt{s}=318 GeV

The photoproduction of beauty quarks in events with two jets and a muon has been measured with the ZEUS detector at HERA using an integrated luminosity of 110 pb$^{- 1}$. The fraction of jets containing b quarks was extracted from the transverse momentum distribution of the muon relative to the closest jet. Differential cross sections for beauty production as a function of the transverse momentum and pseudorapidity of the muon, of the associated jet and of $x_{\gamma}^{jets}$, the fraction of the photon's momentum participating in the hard process, are compared with MC models and QCD predictions made at next-to-leading order. The latter give a good description of the data.Comment: 32 pages, 6 tables, 7 figures Table 6 and Figure 7 revised September 200

Search for lepton-flavor violation at HERA

A search for lepton-flavor-violating interactions $e p \to \mu X$ and $e p\to \tau X$ has been performed with the ZEUS detector using the entire HERA I data sample, corresponding to an integrated luminosity of 130 pb^{-1}. The data were taken at center-of-mass energies, $\sqrt{s}$, of 300 and 318 GeV. No evidence of lepton-flavor violation was found, and constraints were derived on leptoquarks (LQs) that could mediate such interactions. For LQ masses below $\sqrt{s}$, limits were set on $\lambda_{eq_1} \sqrt{\beta_{\ell q}}$, where $\lambda_{eq_1}$ is the coupling of the LQ to an electron and a first-generation quark $q_1$, and $\beta_{\ell q}$ is the branching ratio of the LQ to the final-state lepton $\ell$ ($\mu$ or $\tau$) and a quark $q$. For LQ masses much larger than $\sqrt{s}$, limits were set on the four-fermion interaction term $\lambda_{e q_\alpha} \lambda_{\ell q_\beta} / M_{\mathrm{LQ}}^2$ for LQs that couple to an electron and a quark $q_\alpha$ and to a lepton $\ell$ and a quark $q_\beta$, where $\alpha$ and $\beta$ are quark generation indices. Some of the limits are also applicable to lepton-flavor-violating processes mediated by squarks in $R$-Parity-violating supersymmetric models. In some cases, especially when a higher-generation quark is involved and for the process $e p\to \tau X$, the ZEUS limits are the most stringent to date.Comment: 37 pages, 10 figures, Accepted by EPJC. References and 1 figure (Fig. 6) adde