HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium

Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational exposure to chemicals.This work has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author's organizations and/or Ministries. Luxembourg entered the study at a later stage and thus financed the study at its own means.S

HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium

Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium , Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational expo-sure to chemicals

Resonant electron-phonon coupling in CeAl₂

The resonant coupling of the Γ⁺₅ phonon to the Γ₇-Γ₈ CEF excitations in CeAl₂ is probed by Raman scattering via the simultaneous observation of the renormalized (Γ̃⁺₆) phonon and the phonon bound state. This represents the “phononic analogue” to the instantaneous observation of electronic charge fluctuations by XPS in intermediate valence compounds

Exact algorithms for linear matrix inequalities

International audienceLet $A(x)=A_0+x_1A_1+...+x_nA_n$ be a linear matrix, or pencil, generated by given symmetric matrices $A_0,A_1,...,A_n$ of size $m$ with rational entries. The set of real vectors x such that the pencil is positive semidefinite is a convex semi-algebraic set called spectrahedron, described by a linear matrix inequality (LMI). We design an exact algorithm that, up to genericity assumptions on the input matrices, computes an exact algebraic representation of at least one point in the spectrahedron, or decides that it is empty. The algorithm does not assume the existence of an interior point, and the computed point minimizes the rank of the pencil on the spectrahedron. The degree $d$ of the algebraic representation of the point coincides experimentally with the algebraic degree of a generic semidefinite program associated to the pencil. We provide explicit bounds for the complexity of our algorithm, proving that the maximum number of arithmetic operations that are performed is essentially quadratic in a multilinear B\'ezout bound of $d$. When $m$ (resp. $n$) is fixed, such a bound, and hence the complexity, is polynomial in $n$ (resp. $m$). We conclude by providing results of experiments showing practical improvements with respect to state-of-the-art computer algebra algorithms

ON THE NATURE OF THE GENERATING SERIES OF WALKS IN THE QUARTER PLANE

International audienceIn the present paper, we introduce a new approach, relying on the Galois theory of difference equations, to study the nature of the generating series of walks in the quarter plane. Using this approach, we are not only able to recover many of the recent results about these series, but also to go beyond them. For instance, we give for the first time hypertranscendency results, i.e., we prove that certain of these generating series do not satisfy any nontrivial nonlinear algebraic differential equation with rational coefficients