Chronic muscular Pain treatment with Muscular Acoustic Modulator Device in elderly

Background Muscles Contractures are an important part of multifactorial etiology of chronic pain. MAM® is an acoustic waves device modulated in power and frequency (0-50 Hz, 0-5 Bar) for treatment of muscular contractures. If the treatment of the chronic muscular contractures with MAM® can improve quality life in elderly. Materials and methods We have analyzed the results of a comprehensive examination of 5 over 60 age patients (Group 1: aged 76+/-5,2 years) and 5 control over 60 age patients (Group 2; aged 74+/-2,2 years). Every group was studied with a manual objective examination of the skeletal muscle apparatus to find perceived and evoked contractures reported on a paper map support. This map allows to transfer with accuracy to the physiotherapist which are the points on which he must make MAM® treatment.(Group 1: contractures 22,8 +/-1,47 ; Group 2: contractures 23,4 +/-2,03). To each group was given a BPI-sf (Brief Pain Inventory) to have a review of quality life the first day of examination and at the last day of treatment. Group 1 was treated with an acoustic wave modulator device (MAM®) , once a week, for four weeks. Each point was treated three times every sitting (16 sec for point). Group 2 was not treated Results We have observed in Group 1 a reduction of contracture points after IV treatment with MAM® and an improvement of quality life value with BPI test taking average of all the averages of VAS respect Group two, as shown in Table 1 and Figure 1. Conclusions Treatment of chronic muscular pain with acoustic MAM® device reduces VAS value in BPI from 5,8+/-3,46 to 0,5+/-0,93, reduces of 70% muscular contractures and improve quality life in elderly

Are the deficits in navigational abilities present in the Williams syndrome related to deficits in the backward inhibition?

Williams syndrome (WS) is associated with a distinct profile of relatively proficient skills within the verbal domain compared to the severe impairment of visuo-spatial processing. Abnormalities in executive functions and deficits in planning ability and spatial working memory have been described. However, to date little is known about the influence of executive function deficits on navigational abilities in WS. This study aimed at analyzing in WS individuals a specific executive function, the backward inhibition (BI) that allows individuals to flexibly adapt to continuously changing environments. A group of WS individuals and a mental age- and gender-matched group of typically developing children were subjected to three task-switching experiments requiring visuospatial or verbal material to be processed. Results showed that WS individuals exhibited clear BI deficits during visuospatial task-switching paradigms and normal BI effect during verbal task-switching paradigm. Overall, the present results suggest that the BI involvement in updating environment representations during navigation may influence WS navigational abilitie

Forecast B-modes detection at large scales in presence of noise and foregrounds

We investigate the detectability of the primordial CMB polarization B-mode power spectrum on large scales in the presence of instrumental noise and realistic foreground contamination. We have worked out a method to estimate the errors on component separation and to propagate them up to the power spectrum estimation. The performances of our method are illustrated by applying it to the instrumental specifications of the Planck satellite and to the proposed configuration for the next generation CMB polarization experiment COrE. We demonstrate that a proper component separation step is required in order achieve the detection of B-modes on large scales and that the final sensitivity to B-modes of a given experiment is determined by a delicate balance between noise level and residual foregrounds, which depend on the set of frequencies exploited in the CMB reconstruction, on the signal-to-noise of each frequency map, and on our ability to correctly model the spectral behavior of the foreground components. We have produced a flexible software tool that allows the comparison of performances on B-mode detection of different instrumental specifications (choice of frequencies, noise level at each frequency, etc.) as well as of different proposed approaches to component separation.Comment: 7 pages, 2 tables, 1 figure, accepted by MNRA

Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab

Background: The aim of our study was to evaluate whether a panel of biomarkers, prospectively analysed might be able to predict patients' clinical outcome more accurately than RAS status alone. Methods: K-RAS (exons 2, 3, 4) wild type colorectal cancer patients, candidates to second/third-line cetuximab with chemotherapy were prospectively allocated into 2 groups on the basis of their profile: favourable (BRAF and PIK3CA exon 20 wild type, EGFR GCN ≥ 2.6, HER-3 Rajkumar score ≤ 8, IGF-1 immunostaining < 2) or unfavourable (any of the previous markers altered or mutated). After the introduction of N-RAS status (exons 2, 3, 4) only RAS wild type patients were considered eligible. Results: Forty-six patients were enrolled. Seventeen patients (37%) were allocated to the favourable and 29 patients (63%) to the unfavourable profile. RR in the favourable and unfavourable group was 11/17 (65%) and 2/29 (7%) (p = 0.007) respectively. The favourable group also showed an improved PFS (8months vs. 3months, p < 0.0001) and OS (15months vs. 6months, p < 0.0001). Conclusions: Our results suggest that prospective selection of optimal candidates for cetuximab treatment is feasible and may be able to improve clinical outcom

Learning by observation: insights from Williams syndrome.

Observing another person performing a complex action accelerates the observer's acquisition of the same action and limits the time-consuming process of learning by trial and error. Observational learning makes an interesting and potentially important topic in the developmental domain, especially when disorders are considered. The implications of studies aimed at clarifying whether and how this form of learning is spared by pathology are manifold. We focused on a specific population with learning and intellectual disabilities, the individuals with Williams syndrome. The performance of twenty-eight individuals with Williams syndrome was compared with that of mental age- and gender-matched thirty-two typically developing children on tasks of learning of a visuo-motor sequence by observation or by trial and error. Regardless of the learning modality, acquiring the correct sequence involved three main phases: a detection phase, in which participants discovered the correct sequence and learned how to perform the task; an exercise phase, in which they reproduced the sequence until performance was error-free; an automatization phase, in which by repeating the error-free sequence they became accurate and speedy. Participants with Williams syndrome beneficiated of observational training (in which they observed an actor detecting the visuo-motor sequence) in the detection phase, while they performed worse than typically developing children in the exercise and automatization phases. Thus, by exploiting competencies learned by observation, individuals with Williams syndrome detected the visuo-motor sequence, putting into action the appropriate procedural strategies. Conversely, their impaired performances in the exercise phases appeared linked to impaired spatial working memory, while their deficits in automatization phases to deficits in processes increasing efficiency and speed of the response. Overall, observational experience was advantageous for acquiring competencies, since it primed subjects' interest in the actions to be performed and functioned as a catalyst for executed action

Quantum state correction of relic gravitons from quantum gravity

The semiclassical approach to quantum gravity would yield the Schroedinger formalism for the wave function of metric perturbations or gravitons plus quantum gravity correcting terms in pure gravity; thus, in the inflationary scenario, we should expect correcting effects to the relic graviton (Zel'dovich) spectrum of the order (H/mPl)^2

Validation of the italian version of the behavioral inhibition questionnaire (Biq) for preschool children

Behavioral Inhibition (BI) is a temperamental trait characterized by fear and wariness in reaction to new and unfamiliar stimuli, both social and non-social. BI has been recognized as possible forerunner of anxiety disorders, especially social anxiety and phobia; therefore, its assessment is clinically relevant. The present study aimed to examine the psychometric properties of the Italian adaptation of the Behavioral Inhibition Questionnaire (BIQ), which measures BI in preschool children. The BIQ was completed by 417 Italian parents (230 mothers, 187 fathers) of 270 preschoolers aged 3–5. Confirmatory factor analysis showed a good internal validity: the factorial structure was corresponding to the original six-factor version. Results showed excellent internal consistency, significant item-total correlations, good inter-rater reliability, convergent validity (by correlating the BIQ with the Italian Questionnaires of Temperament-QUIT, the Anxiety-Shy Conner’s Scale and the Laboratory Temperament Assessment Battery) and discriminant validity (i.e., no correlation with Conners’ ADHD scale). Significant correlations emerged between BI indexes and total BIQ scores of parents and maternal (but not paternal) versions of the questionnaire. Altogether, the results are promising and consistent with previous validation studies, suggesting the BIQ as a reliable and valid measure for evaluating parents’ perception of BI in Italian preschoolers