Free amino acids of the blood and some organs in hypokinesia

The metabolic fund of amino acids of the blood and tissues of rats under hypokinesia was investigated. The content of free amino acids was determined for the liver, kidney, brain, and the skeletal and cardiac muscles after established periods of hypokinesia. It was found that the total content of free amino acids in the experimental animals was, on the average 19 percent lower than in the controls. The results of the quantity of individual compounds indicate that the level of some were reduced while others were increased. It was also found that there was an unequal content of individual amino acids in the different tissues

Post-operative reflux esophagitis as a predictor of choice of restrictive operation in patients with metabolic syndrome.

The purpose of this study was to conduct a comparative analysis of the retrospective results of laparoscopic sleeve gastrectomy (LSG), laparoscopic gastroplication (LGP) and laparoscopic fundogastroplication (LFGP) (simultaneous performance of fundoplication by Nissen and gastroplication) obtained at the follow-up period of 1 year, to evaluate and compare the effectiveness of prevention of short-term postoperative complications, which are manifested in the form of GERD, by performing preventive antireflux procedure in combination with restrictive bariatric surgery. Evaluation of the effectiveness and long-term effects of the presented restrictive operations was carried out on the basis of retrospective data obtained during the supervision of 46 patients with obesity and metabolic syndrome (men / women - 16/30, average age – 41.19±6.07, body weight – 128.26±7.37 kg, abdominal circumference – 133.4±4.71 cm, body mass index (BMI) – 42.66±2.41 kg/m2, I-III ASA). In the preoperative and postoperative periods, during consultations, in all patients measurements of anthropometric indicators were performed, laboratory data and results of instrumental research were considered. All metabolic procedures presented were performed at the basis of the Department of Surgery and Vascular Surgery of NMAPE named after P.L. Shupik in the period from 2016 to 2019. 13 patients underwent LSG, 20 – LGP and 13 - LFGP. In order to control the results, repeated consultations were carried out at 1, 3, 6 and 12 months of the postoperative period. The average duration of the operation was: LSG – 88.5±6.49 min, LGP - 120±5.42 min, LFGP – 135.38±7.48 min. The average period of hospitalization was: LSG – 3.2±0.63 days, LGP – 3.53±0.62 days, and LFGP – 3.5±0.67 days. After a year, the body mass index (BMI) was: LSG – 31.17±0.31 kg/m2, LGP – 32.48±0.23 kg/m2, LFGP – 32.43±0.21 kg/m2. According to the results of a repeated questio­ning of patients one year after the operation, 3 (23.07%) of the LSG group and 5 (25.0%) of the LGP group had symptoms of GERD, which failed to be eliminated with the help of conservative therapy, life quality of patients became significantly worse. In the group of patients who underwent LFGP, this complication was absent. After the control gastroscopy, 1 year after, de novo signs of reflux esophagitis were detected (according to the Los Angeles clas­sification): in the LSG group – 3 (23.07%) patients (2 - grade A and 1 - grade B), in the LGP group – 5 (25.0%) patients (3 – grade A and 2 – grade B). Among patients who underwent LFGP, there were no signs of reflux esophagitis. Considering the possible development of GERD and reflux esophagitis in one year after the restrictive surgery, the use of preventive measures consisting in the simultaneous performance of antireflux and metabolic operations is relevant, this is demonstrated by the example of LFGP. We recommend to give preference to simultaneous operations for the achievement of not only high rates of weight loss, but also for improvement of the quality of patients` life in the future

Multiphase composite coatings: structure and properties

The paper discusses the results of the research into the formation of ion-plasma multiphase coatings. The types of the formed structures are found to be not so diverse, as those formed, for example, in alloy crystallization. The structures observed are basically of globular type and, more rarely, of unclosed dissipative and cellular structures. It is shown that the properties of the coating formed in deposition are largely determined by its surface energy or surface tension. Since the magnitude of the surface tension (surface energy) in most cases is an additive quantity, each of the elements of the coating composition contributes to the total surface energy. In case of simultaneous sputtering of multiphase cathodes, high entropy coatings with an ordered cellular structure and improved mechanical properties are formed

Multiphase composite coatings: structure and properties

The paper discusses the results of the research into the formation of ion-plasma multiphase coatings. The types of the formed structures are found to be not so diverse, as those formed, for example, in alloy crystallization. The structures observed are basically of globular type and, more rarely, of unclosed dissipative and cellular structures. It is shown that the properties of the coating formed in deposition are largely determined by its surface energy or surface tension. Since the magnitude of the surface tension (surface energy) in most cases is an additive quantity, each of the elements of the coating composition contributes to the total surface energy. In case of simultaneous sputtering of multiphase cathodes, high entropy coatings with an ordered cellular structure and improved mechanical properties are formed

Effect of ion-plasma treatment on oxidation-reduction processes in lithium-titanium-zinc ferrites

We examined the effect of nitrogen, oxygen and argon plasma on the diffusion-controlled oxidation-reduction processes in lithium-titanium-zinc ferrite ceramics by measuring the activation energy of electrical conductivity in the depth of the sample. The experimental results show that the high-temperature treatment in polycrystalline ferrites by nitrogen or argon ion plasma greatly accelerates the oxidation-reduction processes in ferrites and changes the process direction depending on the partial pressure of oxygen

AIGO: towards a unified framework for the analysis and the inter-comparison of GO functional annotations

BACKGROUND: In response to the rapid growth of available genome sequences, efforts have been made to develop automatic inference methods to functionally characterize them. Pipelines that infer functional annotation are now routinely used to produce new annotations at a genome scale and for a broad variety of species. These pipelines differ widely in their inference algorithms, confidence thresholds and data sources for reasoning. This heterogeneity makes a comparison of the relative merits of each approach extremely complex. The evaluation of the quality of the resultant annotations is also challenging given there is often no existing gold-standard against which to evaluate precision and recall. RESULTS: In this paper, we present a pragmatic approach to the study of functional annotations. An ensemble of 12 metrics, describing various aspects of functional annotations, is defined and implemented in a unified framework, which facilitates their systematic analysis and inter-comparison. The use of this framework is demonstrated on three illustrative examples: analysing the outputs of state-of-the-art inference pipelines, comparing electronic versus manual annotation methods, and monitoring the evolution of publicly available functional annotations. The framework is part of the AIGO library (http://code.google.com/p/aigo) for the Analysis and the Inter-comparison of the products of Gene Ontology (GO) annotation pipelines. The AIGO library also provides functionalities to easily load, analyse, manipulate and compare functional annotations and also to plot and export the results of the analysis in various formats. CONCLUSIONS: This work is a step toward developing a unified framework for the systematic study of GO functional annotations. This framework has been designed so that new metrics on GO functional annotations can be added in a very straightforward way

Stochastic effects at ripple formation processes in anisotropic systems with multiplicative noise

We study pattern formation processes in anisotropic system governed by the Kuramoto-Sivashinsky equation with multiplicative noise as a generalization of the Bradley-Harper model for ripple formation induced by ion bombardment. For both linear and nonlinear systems we study noise induced effects at ripple formation and discuss scaling behavior of the surface growth and roughness characteristics. It was found that the secondary parameters of the ion beam (beam profile and variations of an incidence angle) can crucially change the topology of patterns and the corresponding dynamics

Effect of ion irradiation on tribological properties of composite coatings

The paper discusses the results of the research in the effect of ion irradiation on tribological properties of multiphase ion-plasma coatings. It is shown that all the investigated coatings behave differently under ion irradiation: the Zn-Al, Fe-Al, Zn-Cu-Al coating is radiation-resistant and the friction coefficient does not virtually change; the Cr-Mn-Si-Cu-Fe- Al coating exhibits twofold increase in the friction coefficient, and that for Mn-Fe-Cu-Al coating decreases threefold. These changes are related to changes which occur in the coating surface under ion bombardment