4,736 research outputs found
ΠΡΠ½ΠΎΠ²Π½Ρ Π°ΡΠΏΠ΅ΠΊΡΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½Ρ Π²Π½ΡΡΡΡΡΠ½ΡΡ Π°ΡΠ΄ΠΈΡΡΠ² ΡΠΈΡΡΠ΅ΠΌΠΈ Π΅Π½Π΅ΡΠ³Π΅ΡΠΈΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΡ Π² Π·Π°ΠΊΠ»Π°Π΄Π°Ρ ΠΎΡ ΠΎΡΠΎΠ½ΠΈ Π·Π΄ΠΎΡΠΎΠ²βΡ
Aim. To analyze the main components of conducting and forming recommendations for the effective implementation of internal audits of the energy management system in healthcare institutions.
Materials and methods. To achieve the goal, we applied such methods as informative, retrospective, analytical ones based on the study of scientific literature, materials of Internet-resources and our own conclusions regarding the results of the work carried out.
Results and discussion. The article analyzes the main aspects of effective implementation of internal audits of the energy management system in healthcare institutions. It has been shown that internal audits are not conducted effectively and do not add the expected value. The causes for low performance have been analyzed and systematized. It has been proven that the problem of improving the effectiveness of internal audits of the energy management system should be solved systematically, using the methods and approaches developed by the authors and proposed in the article.
Conclusions. Internal audits of the energy management system should be given closer attention in each healthcare institution since a properly organized audit process is an effective tool for analyzing the energy management system and provides important and relevant information for timely corrective and preventive actions.ΠΠ΅ΡΠΎΡ ΡΠΎΠ±ΠΎΡΠΈ Ρ Π°Π½Π°Π»ΡΠ· ΠΎΡΠ½ΠΎΠ²Π½ΠΈΡ
ΡΠΊΠ»Π°Π΄ΠΎΠ²ΠΈΡ
ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½Ρ ΡΠ° ΡΠΎΡΠΌΡΠ²Π°Π½Π½Ρ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΡΠΉ ΡΠΎΠ΄ΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π·Π΄ΡΠΉΡΠ½Π΅Π½Π½Ρ Π²Π½ΡΡΡΡΡΠ½ΡΡ
Π°ΡΠ΄ΠΈΡΡΠ² ΡΠΈΡΡΠ΅ΠΌΠΈ Π΅Π½Π΅ΡΠ³Π΅ΡΠΈΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΡ Π² Π·Π°ΠΊΠ»Π°Π΄Π°Ρ
ΠΎΡ
ΠΎΡΠΎΠ½ΠΈ Π·Π΄ΠΎΡΠΎΠ²βΡ.
ΠΠ°ΡΠ΅ΡΡΠ°Π»ΠΈ ΡΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΈ. ΠΠ»Ρ Π΄ΠΎΡΡΠ³Π½Π΅Π½Π½Ρ Π²ΠΈΠ·Π½Π°ΡΠ΅Π½ΠΎΡ ΠΌΠ΅ΡΠΈ Π½Π°ΠΌΠΈ Π±ΡΠ»ΠΎ Π·Π°ΡΡΠΎΡΠΎΠ²Π°Π½ΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΈ: ΡΠ½ΡΠΎΡΠΌΠ°ΡΡΠΉΠ½ΠΈΠΉ, ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΈΠΉ, Π°Π½Π°Π»ΡΡΠΈΡΠ½ΠΈΠΉ, Π·Π°ΡΠ½ΠΎΠ²Π°Π½Ρ Π½Π° Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π½Π°ΡΠΊΠΎΠ²ΠΎΡ Π»ΡΡΠ΅ΡΠ°ΡΡΡΠΈ, ΠΌΠ°ΡΠ΅ΡΡΠ°Π»ΡΠ² ΠΠ½ΡΠ΅ΡΠ½Π΅Ρ-ΡΠ΅ΡΡΡΡΡΠ², Π° ΡΠ°ΠΊΠΎΠΆ Π½Π° Π²Π»Π°ΡΠ½ΠΈΡ
Π²ΠΈΡΠ½ΠΎΠ²ΠΊΠ°Ρ
ΡΠΎΠ΄ΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡΠ² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎΡ ΡΠΎΠ±ΠΎΡΠΈ.
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠ° ΡΡ
ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Π½Ρ. Π£ ΡΡΠ°ΡΡΡ ΠΏΡΠΎΠ°Π½Π°Π»ΡΠ·ΠΎΠ²Π°Π½ΠΎ ΠΎΡΠ½ΠΎΠ²Π½Ρ Π°ΡΠΏΠ΅ΠΊΡΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π·Π΄ΡΠΉΡΠ½Π΅Π½Π½Ρ Π²Π½ΡΡΡΡΡΠ½ΡΡ
Π°ΡΠ΄ΠΈΡΡΠ² ΡΠΈΡΡΠ΅ΠΌΠΈ Π΅Π½Π΅ΡΠ³Π΅ΡΠΈΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΡ Π² Π·Π°ΠΊΠ»Π°Π΄Π°Ρ
ΠΎΡ
ΠΎΡΠΎΠ½ΠΈ Π·Π΄ΠΎΡΠΎΠ²βΡ. ΠβΡΡΠΎΠ²Π°Π½ΠΎ, ΡΠΎ Π²Π½ΡΡΡΡΡΠ½Ρ Π°ΡΠ΄ΠΈΡΠΈ Π½Π°ΡΠ°Π·Ρ Π½Π΅ Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΈΠ²Π½Ρ ΠΉ Π½Π΅ Π΄ΠΎΠ΄Π°ΡΡΡ ΠΎΡΡΠΊΡΠ²Π°Π½ΠΎΡ ΡΡΠ½Π½ΠΎΡΡΡ. ΠΡΠΈΡΠΈΠ½ΠΈ Π½ΠΈΠ·ΡΠΊΠΎΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΎΠ°Π½Π°Π»ΡΠ·ΠΎΠ²Π°Π½ΠΎ Ρ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·ΠΎΠ²Π°Π½ΠΎ. ΠΠΎΠ²Π΅Π΄Π΅Π½ΠΎ, ΡΠΎ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΠΏΡΠ΄Π²ΠΈΡΠ΅Π½Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΈΠ²Π½ΠΎΡΡΡ Π²Π½ΡΡΡΡΡΠ½ΡΡ
Π°ΡΠ΄ΠΈΡΡΠ² ΡΠΈΡΡΠ΅ΠΌΠΈ Π΅Π½Π΅ΡΠ³Π΅ΡΠΈΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΡ ΡΡΠ΅Π±Π° ΡΠΎΠ·Π²βΡΠ·ΡΠ²Π°ΡΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎ, ΡΠ· Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½ΡΠΌ ΡΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΈΡ
Π°Π²ΡΠΎΡΠ°ΠΌΠΈ Ρ Π·Π°ΠΏΡΠΎΠΏΠΎΠ½ΠΎΠ²Π°Π½ΠΈΡ
Ρ ΡΡΠ°ΡΡΡ ΠΌΠ΅ΡΠΎΠ΄ΡΠ² Ρ ΠΏΡΠ΄Ρ
ΠΎΠ΄ΡΠ².
ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. ΠΠ½ΡΡΡΡΡΠ½ΡΠΌ Π°ΡΠ΄ΠΈΡΠ°ΠΌ ΡΠΈΡΡΠ΅ΠΌΠΈ Π΅Π½Π΅ΡΠ³Π΅ΡΠΈΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΡ ΡΡΠ΅Π±Π° ΠΏΡΠΈΠ΄ΡΠ»ΡΡΠΈ Π±ΡΠ»ΡΡ ΠΏΠΈΠ»ΡΠ½Ρ ΡΠ²Π°Π³Ρ Π² ΠΊΠΎΠΆΠ½ΠΎΠΌΡ Π·Π°ΠΊΠ»Π°Π΄Ρ ΠΎΡ
ΠΎΡΠΎΠ½ΠΈ Π·Π΄ΠΎΡΠΎΠ²βΡ, Π°Π΄ΠΆΠ΅ ΠΏΡΠ°Π²ΠΈΠ»ΡΠ½ΠΎ ΠΎΡΠ³Π°Π½ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΡΠΎΡΠ΅Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½Ρ Π°ΡΠ΄ΠΈΡΡΠ² Ρ Π΄ΡΡΠ²ΠΈΠΌ ΡΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠΌ Π°Π½Π°Π»ΡΠ·ΡΠ²Π°Π½Π½Ρ ΡΠΈΡΡΠ΅ΠΌΠΈ Π΅Π½Π΅ΡΠ³ΠΎΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΡ Ρ Π½Π°Π΄Π°Ρ Π²Π°ΠΆΠ»ΠΈΠ²Ρ ΠΉ Π°ΠΊΡΡΠ°Π»ΡΠ½Ρ ΡΠ½ΡΠΎΡΠΌΠ°ΡΡΡ Π΄Π»Ρ ΡΠ²ΠΎΡΡΠ°ΡΠ½ΠΎΠ³ΠΎ Π²ΠΆΠΈΡΡΡ ΠΊΠΎΡΠΈΠ³ΡΠ²Π°Π»ΡΠ½ΠΈΡ
Ρ Π·Π°ΠΏΠΎΠ±ΡΠΆΠ½ΠΈΡ
Π΄ΡΠΉ
Estimation of synchronous generator participation in low-frequency oscillations damping based on synchronized phasor measurements
Large-scale centralized power systems interconnected by weak tie-lines is a typical feature of the state-of-the-industry power engineering. Another trend is distributed generation units integration with the resulting decrease of power system inertia constant and increasing sensitivity to small disturbances. In particular, in the case of significant power imbalance, periodic low-frequency oscillations of power system performance parameters may arise. Low frequency oscillations in power systems are inherently non-linear and non-stationary processes representing a superposition of numerous rotating masses movement components having mutual influence in a power region or power center. These situations imply the crucial role of monitoring each generator damping capability which is determined by the adjustment of the system regulators in use. To estimate the synchronous generator capability to maintain synchronous operation under deviating frequency and load angle conditions synchronizing torque and corresponding synchronizing power are proposed to be used. The possibility to determine the synchronous machine synchronizing power is subject to the presence of the load angle variation data with the techniques for defining load angle without direct measurement using a system of assumptions have been analyzed. Numerous simulations have shown that the effect of assumptions can be evaluated as acceptable. The main focus of the paper is the analysis of synchronizing power corresponding to the actual generator involved in the oscillations which had arisen after a disturbance in the Unified Energy System of Russia. The supposed cause of the oscillations is improper automatic excitation controller operation. Β© 2014 WIT Press.International Journal of Safety and Security Engineering;International Journal of Sustainable Development and Planning;WIT Transactions on Ecology and the Environmen
Sterile neutrinos in neutrinoless double beta decay
We study possible contribution of the Majorana neutrino mass eigenstate
dominated by a sterile neutrino component to neutrinoless double beta
() decay. From the current experimental lower bound on the
-decay half-life of Ge we derive stringent constraints
on the mixing in a wide region of the values of mass. We
discuss cosmological and astrophysical status of in this mass region.Comment: 6 pages, 1 figure; v2 added comments and reference
Π‘ΠΈΠ½ΡΠ΅Π· ΡΠ° Π°Π½ΡΠΈΠΌΡΠΊΡΠΎΠ±Π½Π° Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ 1-Π°Π»ΠΊΡΠ»-5-ΠΌΠ΅ΡΠΈΠ»-3-ΡΠ΅Π½ΡΠ»-6-(5-ΡΠ΅Π½ΡΠ»-1,3,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-2-ΡΠ»)ΡΡΡΠ½ΠΎ[2,3-d]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-2,4(1H,3H)-Π΄ΡΠΎΠ½ΡΠ²
An effective approach for synthesis of 5-methyl-3-phenyl-6-(5-phenyl-1,3,4-oxadiazol-2-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione by 1,1β-carbonyldiimidazole promoted interaction of 5-methyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylic acid with benzohydrazide has been developed. The procedure also includes cyclization of Nβ-benzoyl-5-methyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carbohydrazide obtained by boiling in phosphorous oxychloride and further hydrolysis of the chlorine atom at position 2 of the thieno[2,3-d]pyrimidine system. Alkylation of the assembly of two heterocyclic units obtained with benzyl chlorides, chloroacetamides, and 5-(chloromethyl)-3-aryl-1,2,4-oxadiazoles has allowed obtaining of 1-alkyl-5-methyl-3-phenyl-6-(5-phenyl-1,3,4-oxadiazol-2-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-diones. The structures of the compounds obtained have been confirmed by the 1H NMR, chromato-mass spectral and elemental microanalysis data. The results of the screening performed by the agar diffusion method (βwell methodβ) have shown the absence of the antimicrobial activity for 1-benzyl-5-methyl-3-phenyl-6-(5-phenyl-1,3,4-oxadiazol-2-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-diones and 2-[5-methyl-2,4-dioxo-3-phenyl-6-(5-phenyl-1,3,4-oxadiazol-2-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-1(2H)-yl]-N-arylacetamides; but the activity for 1-{[3-aryl-1,2,4-oxadiazol-5-yl]methyl}-5-methyl-3-phenyl-6-(5-phenyl-1,3,4-oxadiazol-2-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-diones has been found. The compounds of this range appeared to be active against the strains of Staphylococcus aureus, Escherichia coli and Bacillus subtilis; the diameters of their growth inhibition zones were similar to those for the reference drugs Metronidazole and Streptomycin.Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ ΠΊ ΡΠΈΠ½ΡΠ΅Π·Ρ 5-ΠΌΠ΅ΡΠΈΠ»-3-ΡΠ΅Π½ΠΈΠ»-6-(5-ΡΠ΅Π½ΠΈΠ»-1,3,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-2-ΠΈΠ»)ΡΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½-2,4(1H,3H)-Π΄ΠΈΠΎΠ½Π° ΠΏΡΡΠ΅ΠΌ ΠΏΡΠΎΠΌΠΎΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ 1,1β-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΈΠ»Π΄ΠΈΠΈΠΌΠΈΠ΄Π°Π·ΠΎΠ»ΠΎΠΌ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ 5-ΠΌΠ΅ΡΠΈΠ»-2,4-Π΄ΠΈΠΎΠΊΡΠΎ-3-ΡΠ΅Π½ΠΈΠ»-1,2,3,4-ΡΠ΅ΡΡΠ°Π³ΠΈΠ΄ΡΠΎΡΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½-6-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Ρ Π±Π΅Π½Π·ΠΎΠ³ΠΈΠ΄ΡΠ°Π·ΠΈΠ΄ΠΎΠΌ. ΠΡΠΎΡΠ΅Π΄ΡΡΠ° ΡΠ°ΠΊΠΆΠ΅ Π²ΠΊΠ»ΡΡΠ°Π΅Ρ ΡΠΈΠΊΠ»ΠΈΠ·Π°ΡΠΈΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ Nβ-Π±Π΅Π½Π·ΠΎΠΈΠ»-5-ΠΌΠ΅ΡΠΈΠ»-2,4-Π΄ΠΈΠΎΠΊΡΠΎ-3-ΡΠ΅Π½ΠΈΠ»-1,2,3,4-ΡΠ΅ΡΡΠ°Π³ΠΈΠ΄ΡΠΎΡΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½-6-ΠΊΠ°ΡΠ±ΠΎΠ³ΠΈΠ΄ΡΠ°Π·ΠΈΠ΄Π° ΠΊΠΈΠΏΡΡΠ΅Π½ΠΈΠ΅ΠΌ Π² Ρ
Π»ΠΎΡΠΎΠΊΠΈΡΠΈ ΡΠΎΡΡΠΎΡΠ° ΠΈ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠΈΠΉ Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ· Π°ΡΠΎΠΌΠ° Ρ
Π»ΠΎΡΠ° Π² ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ 2 ΡΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ. ΠΠ»ΠΊΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ Π΄Π²ΡΡ
Π·Π²Π΅Π½Π½ΠΎΠ³ΠΎ Π°Π½ΡΠ°ΠΌΠ±Π»Ρ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»ΠΎΠ² Π±Π΅Π½Π·ΠΈΠ»Ρ
Π»ΠΎΡΠΈΠ΄Π°ΠΌΠΈ, Ρ
Π»ΠΎΡΠ°ΡΠ΅ΡΠ°ΠΌΠΈΠ΄Π°ΠΌΠΈ ΠΈ 5-(Ρ
Π»ΠΎΡΠΌΠ΅ΡΠΈΠ»)-3-Π°ΡΠΈΠ»-1,2,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»Π°ΠΌΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΠΏΠΎΠ»ΡΡΠΈΡΡ 1-Π°Π»ΠΊΠΈΠ»-5-ΠΌΠ΅ΡΠΈΠ»-3-ΡΠ΅Π½ΠΈΠ»-6-(5-ΡΠ΅Π½ΠΈΠ»-1,3,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-2-ΠΈΠ»)ΡΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½-2,4(1H,3H)-Π΄ΠΈΠΎΠ½Ρ. Π‘ΡΡΡΠΊΡΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π±ΡΠ»ΠΈ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π΄Π°Π½Π½ΡΡ
1Π Π―ΠΠ , Ρ
ΡΠΎΠΌΠ°ΡΠΎΠΌΠ°Ρ ΡΠΏΠ΅ΠΊΡΡΠΎΠ² ΠΈ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°. ΠΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³Π° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π΄ΠΈΡΡΡΠ·ΠΈΠΈ Π² Π°Π³Π°Ρ (Β«ΠΌΠ΅ΡΠΎΠ΄ ΠΊΠΎΠ»ΠΎΠ΄ΡΠ΅Π²Β») ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Ρ 1-Π±Π΅Π½Π·ΠΈΠ»-5-ΠΌΠ΅ΡΠΈΠ»-3-ΡΠ΅Π½ΠΈΠ»-6-(5-ΡΠ΅Π½ΠΈΠ»-1,3,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-2-ΠΈΠ»)ΡΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½-2,4(1H,3H)-Π΄ΠΈΠΎΠ½ΠΎΠ² ΠΈ 2-[5-ΠΌΠ΅ΡΠΈΠ»-2,4-Π΄ΠΈΠΎΠΊΡΠΎ-3-ΡΠ΅Π½ΠΈΠ»-6-(5-ΡΠ΅Π½ΠΈΠ»-1,3,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-2-ΠΈΠ»)-3,4-Π΄ΠΈΠ³ΠΈΠ΄ΡΠΎΡΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½-1(2H)-ΠΈΠ»]-N-Π°ΡΠΈΠ»Π°ΡΠ΅ΡΠ°ΠΌΠΈΠ΄ΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π΄Π»Ρ 1-{[3-Π°ΡΠΈΠ»-1,2,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-5-ΠΈΠ»]ΠΌΠ΅ΡΠΈΠ»}-5-ΠΌΠ΅ΡΠΈΠ»-3-ΡΠ΅Π½ΠΈΠ»-6-(5-ΡΠ΅Π½ΠΈΠ»-1,3,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-2-ΠΈΠ»)ΡΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½-2,4(1H,3H)-Π΄ΠΈΠΎΠ½ΠΎΠ². ΠΠ°Π½Π½ΡΠ΅ Π²Π΅ΡΠ΅ΡΡΠ²Π° ΠΏΡΠΎΡΠ²ΠΈΠ»ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΌΠΈΠΊΡΠΎΠ±Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΒ ΠΊ ΡΡΠ°ΠΌΠΌΠ°ΠΌ Staphylococcus aureus, Escherichia coli ΠΈ BaΡillus subtilis ΡΠΎ Π·Π½Π°ΡΠ΅Π½ΠΈΡΠΌΠΈ Π·ΠΎΠ½ Π·Π°Π΄Π΅ΡΠΆΠΊΠΈ ΡΠΎΡΡΠ°, Π±Π»ΠΈΠ·ΠΊΠΈΠΌΠΈ ΠΊ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΠΌΠ΅ΡΡΠΎΠ½ΠΈΠ΄Π°Π·ΠΎΠ»Ρ ΠΈ ΡΡΡΠ΅ΠΏΡΠΎΠΌΠΈΡΠΈΠ½Ρ.Π ΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΎ Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΈΠΉ ΠΏΡΠ΄Ρ
ΡΠ΄ Π΄ΠΎ ΡΠΈΠ½ΡΠ΅Π·Ρ 5-ΠΌΠ΅ΡΠΈΠ»-3-ΡΠ΅Π½ΡΠ»-6-(5-ΡΠ΅Π½ΡΠ»-1,3,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-2-ΡΠ»)ΡΡΡΠ½ΠΎ[2,3-d]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-2,4(1H,3H)-Π΄ΡΠΎΠ½Ρ ΡΠ»ΡΡ
ΠΎΠΌ ΠΏΡΠΎΠΌΠΎΡΠΎΠ²Π°Π½ΠΎΡ 1,1β-ΠΊΠ°ΡΠ±ΠΎΠ½ΡΠ»Π΄ΡΡΠΌΡΠ΄Π°Π·ΠΎΠ»ΠΎΠΌ Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡ 5-ΠΌΠ΅ΡΠΈΠ»-2,4-Π΄ΡΠΎΠΊΡΠΎ-3-ΡΠ΅Π½ΡΠ»-1,2,3,4-ΡΠ΅ΡΡΠ°Π³ΡΠ΄ΡΠΎΡΡΡΠ½ΠΎ[2,3-d]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-6-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ Π· Π±Π΅Π½Π·ΠΎΠ³ΡΠ΄ΡΠ°Π·ΠΈΠ΄ΠΎΠΌ. ΠΡΠΎΡΠ΅Π΄ΡΡΠ° ΡΠ°ΠΊΠΎΠΆ Π²ΠΊΠ»ΡΡΠ°Ρ Π½Π°ΡΡΡΠΏΠ½Ρ ΡΠΈΠΊΠ»ΡΠ·Π°ΡΡΡ ΠΎΡΡΠΈΠΌΠ°Π½ΠΎΠ³ΠΎ Nβ-Π±Π΅Π½Π·ΠΎΡΠ»-5-ΠΌΠ΅ΡΠΈΠ»-2,4-Π΄ΡΠΎΠΊΡΠΎ-3-ΡΠ΅Π½ΡΠ»-1,2,3,4-ΡΠ΅ΡΡΠ°-Π³ΡΠ΄ΡΠΎΡΡΡΠ½ΠΎ[2,3-d]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-6-ΠΊΠ°ΡΠ±ΠΎΠ³ΡΠ΄ΡΠ°Π·ΠΈΠ΄Ρ ΠΊΠΈΠΏβΡΡΡΠ½Π½ΡΠΌ Ρ Ρ
Π»ΠΎΡΠΎΠΊΠΈΡΡ ΡΠΎΡΡΠΎΡΡ ΡΠ° ΠΏΠΎΠ΄Π°Π»ΡΡΠΈΠΉ Π³ΡΠ΄ΡΠΎΠ»ΡΠ·Β Π°ΡΠΎΠΌΠ° Ρ
Π»ΠΎΡΡ Ρ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ 2 ΡΡΡΠ½ΠΎ[2,3-d]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½ΠΎΠ²ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ. ΠΠ»ΠΊΡΠ»ΡΠ²Π°Π½Π½Ρ ΠΎΡΡΠΈΠΌΠ°Π½ΠΎΠ³ΠΎ Π΄Π²ΠΎΠ»Π°Π½ΠΊΠΎΠ²ΠΎΠ³ΠΎ Π°Π½ΡΠ°ΠΌΠ±Π»Ρ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»ΡΠ² Π±Π΅Π½Π·ΠΈΠ»Ρ
Π»ΠΎΡΠΈΠ΄Π°ΠΌΠΈ, Ρ
Π»ΠΎΡΠΎΠ°ΡΠ΅ΡΠ°ΠΌΡΠ΄Π°ΠΌΠΈ ΡΠ° 5-(Ρ
Π»ΠΎΡΠΎΠΌΠ΅ΡΠΈΠ»)-3-Π°ΡΠΈΠ»-1,2,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎ-Π»Π°ΠΌΠΈ Π΄ΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΠΎΡΡΠΈΠΌΠ°ΡΠΈ 1-Π°Π»ΠΊΡΠ»-5-ΠΌΠ΅ΡΠΈΠ»-3-ΡΠ΅Π½ΡΠ»-6-(5-ΡΠ΅Π½ΡΠ»-1,3,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-2-ΡΠ»)ΡΡΡΠ½ΠΎ[2,3-d]ΠΏΡΡΠΈΠΌΡ-Π΄ΠΈΠ½-2,4(1H,3H)-Π΄ΡΠΎΠ½ΠΈ. Π‘ΡΡΡΠΊΡΡΡΠΈ ΠΎΡΡΠΈΠΌΠ°Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ Π±ΡΠ»ΠΈ ΠΏΡΠ΄ΡΠ²Π΅ΡΠ΄ΠΆΠ΅Π½Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Ρ Π΄Π°Π½ΠΈΡ
1Π Π―ΠΠ , Ρ
ΡΠΎΠΌΠ°ΡΠΎΠΌΠ°Ρ ΡΠΏΠ΅ΠΊΡΡΡΠ² ΡΠ° Π΅Π»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΡΠ·Ρ. ΠΠ° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌΠΈ ΡΠΊΡΠΈΠ½ΡΠ½Π³Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π΄ΠΈΡΡΠ·ΡΡ Π² Π°Π³Π°Ρ (Β«ΠΌΠ΅ΡΠΎΠ΄ ΠΊΠΎΠ»ΠΎΠ΄ΡΠ·ΡΠ²Β») Π²ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ Π²ΡΠ΄ΡΡΡΠ½ΡΡΡΡ Π°Π½ΡΠΈΠΌΡΠΊΡΠΎΠ±Π½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Ρ 1-Π±Π΅Π½Π·ΠΈΠ»-5-ΠΌΠ΅ΡΠΈΠ»-3-ΡΠ΅Π½ΡΠ»-6-(5-ΡΠ΅Π½ΡΠ»-1,3,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-2-ΡΠ»)ΡΡΡΠ½ΠΎ[2,3-d]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-2,4(1H,3H)-Π΄ΡΠΎΠ½ΡΠ² ΡΠ° 2-[5-ΠΌΠ΅ΡΠΈΠ»-2,4-Π΄ΡΠΎΠΊΡΠΎ-3-ΡΠ΅Π½ΡΠ»-6-(5-ΡΠ΅Π½ΡΠ»-1,3,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-2-ΡΠ»)-3,4-Π΄ΠΈΠ³ΡΠ΄ΡΠΎΡΡΡΠ½ΠΎ[2,3-d]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-1(2H)-ΡΠ»]-N-Π°ΡΠΈΠ»Π°ΡΠ΅ΡΠ°ΠΌΡΠ΄ΡΠ², Π° ΡΠ°ΠΊΠΎΠΆ Π½Π°ΡΠ²Π½ΡΡΡΡ Π°Π½ΡΠΈΠΌΡΠΊΡΠΎΠ±Π½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π΄Π»Ρ 1-{[3-Π°ΡΠΈΠ»-1,2,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-5-ΡΠ»]ΠΌΠ΅ΡΠΈΠ»}-5-ΠΌΠ΅ΡΠΈΠ»-3-ΡΠ΅Π½ΡΠ»-6-(5-ΡΠ΅Π½ΡΠ»-1,3,4-ΠΎΠΊΡΠ°-Π΄ΡΠ°Π·ΠΎΠ»-2-ΡΠ»)ΡΡΡΠ½ΠΎ[2,3-d]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-2,4(1H,3H)-Π΄ΡΠΎΠ½ΡΠ². ΠΠ°Π½Ρ ΡΠ΅ΡΠΎΠ²ΠΈΠ½ΠΈ Π²ΠΈΡΠ²ΠΈΠ»ΠΈ Π°Π½ΡΠΈΠΌΡΠΊΡΠΎΠ±Π½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ Π΄ΠΎ ΡΡΠ°ΠΌΡΠ² Staphylococcus aureus, Escherichia coli ΡΠ° BaΡillus subtilis ΡΠ· Π·Π½Π°ΡΠ΅Π½Π½ΡΠΌΠΈ Π·ΠΎΠ½ Π·Π°ΡΡΠΈΠΌΠΊΠΈ ΡΠΎΡΡΡ, Π±Π»ΠΈΠ·ΡΠΊΠΈΠΌΠΈ Π΄ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡΠ² ΠΏΠΎΡΡΠ²Π½ΡΠ½Π½Ρ ΠΌΠ΅ΡΡΠΎΠ½ΡΠ΄Π°Π·ΠΎΠ»Ρ ΡΠ° ΡΡΡΠ΅ΠΏΡΠΎΠΌΡΡΠΈΠ½Ρ
Decay times of 4-(dimethylamino)benzonitrile in acetonitrile and conclusions on entropy of activation.
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