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    ΠžΡΠ½ΠΎΠ²Π½Ρ– аспСкти Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ провСдСння Π²Π½ΡƒΡ‚Ρ€Ρ–ΡˆΠ½Ρ–Ρ… Π°ΡƒΠ΄ΠΈΡ‚Ρ–Π² систСми Π΅Π½Π΅Ρ€Π³Π΅Ρ‚ΠΈΡ‡Π½ΠΎΠ³ΠΎ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ‚Ρƒ Π² Π·Π°ΠΊΠ»Π°Π΄Π°Ρ… ΠΎΡ…ΠΎΡ€ΠΎΠ½ΠΈ здоров’я

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    Aim. To analyze the main components of conducting and forming recommendations for the effective implementation of internal audits of the energy management system in healthcare institutions. Materials and methods. To achieve the goal, we applied such methods as informative, retrospective, analytical ones based on the study of scientific literature, materials of Internet-resources and our own conclusions regarding the results of the work carried out. Results and discussion. The article analyzes the main aspects of effective implementation of internal audits of the energy management system in healthcare institutions. It has been shown that internal audits are not conducted effectively and do not add the expected value. The causes for low performance have been analyzed and systematized. It has been proven that the problem of improving the effectiveness of internal audits of the energy management system should be solved systematically, using the methods and approaches developed by the authors and proposed in the article. Conclusions. Internal audits of the energy management system should be given closer attention in each healthcare institution since a properly organized audit process is an effective tool for analyzing the energy management system and provides important and relevant information for timely corrective and preventive actions.ΠœΠ΅Ρ‚ΠΎΡŽ Ρ€ΠΎΠ±ΠΎΡ‚ΠΈ Ρ” Π°Π½Π°Π»Ρ–Π· основних складових провСдСння Ρ‚Π° формування Ρ€Π΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°Ρ†Ρ–ΠΉ Ρ‰ΠΎΠ΄ΠΎ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ здійснСння Π²Π½ΡƒΡ‚Ρ€Ρ–ΡˆΠ½Ρ–Ρ… Π°ΡƒΠ΄ΠΈΡ‚Ρ–Π² систСми Π΅Π½Π΅Ρ€Π³Π΅Ρ‚ΠΈΡ‡Π½ΠΎΠ³ΠΎ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ‚Ρƒ Π² Π·Π°ΠΊΠ»Π°Π΄Π°Ρ… ΠΎΡ…ΠΎΡ€ΠΎΠ½ΠΈ здоров’я. ΠœΠ°Ρ‚Π΅Ρ€Ρ–Π°Π»ΠΈ Ρ‚Π° ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈ. Для досягнСння Π²ΠΈΠ·Π½Π°Ρ‡Π΅Π½ΠΎΡ— ΠΌΠ΅Ρ‚ΠΈ Π½Π°ΠΌΠΈ Π±ΡƒΠ»ΠΎ застосовано ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈ: Ρ–Π½Ρ„ΠΎΡ€ΠΌΠ°Ρ†Ρ–ΠΉΠ½ΠΈΠΉ, рСтроспСктивний, Π°Π½Π°Π»Ρ–Ρ‚ΠΈΡ‡Π½ΠΈΠΉ, засновані Π½Π° дослідТСнні Π½Π°ΡƒΠΊΠΎΠ²ΠΎΡ— Π»Ρ–Ρ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€ΠΈ, ΠΌΠ°Ρ‚Π΅Ρ€Ρ–Π°Π»Ρ–Π² Π†Π½Ρ‚Π΅Ρ€Π½Π΅Ρ‚-рСсурсів, Π° Ρ‚Π°ΠΊΠΎΠΆ Π½Π° власних висновках Ρ‰ΠΎΠ΄ΠΎ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ–Π² ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΎΡ— Ρ€ΠΎΠ±ΠΎΡ‚ΠΈ. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈ Ρ‚Π° Ρ—Ρ… обговорСння. Π£ статті ΠΏΡ€ΠΎΠ°Π½Π°Π»Ρ–Π·ΠΎΠ²Π°Π½ΠΎ основні аспСкти Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ здійснСння Π²Π½ΡƒΡ‚Ρ€Ρ–ΡˆΠ½Ρ–Ρ… Π°ΡƒΠ΄ΠΈΡ‚Ρ–Π² систСми Π΅Π½Π΅Ρ€Π³Π΅Ρ‚ΠΈΡ‡Π½ΠΎΠ³ΠΎ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ‚Ρƒ Π² Π·Π°ΠΊΠ»Π°Π΄Π°Ρ… ΠΎΡ…ΠΎΡ€ΠΎΠ½ΠΈ здоров’я. З’ясовано, Ρ‰ΠΎ Π²Π½ΡƒΡ‚Ρ€Ρ–ΡˆΠ½Ρ– Π°ΡƒΠ΄ΠΈΡ‚ΠΈ Π½Π°Ρ€Π°Π·Ρ– Π½Π΅ Ρ” Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈΠ²Π½Ρ– ΠΉ Π½Π΅ Π΄ΠΎΠ΄Π°ΡŽΡ‚ΡŒ ΠΎΡ‡Ρ–ΠΊΡƒΠ²Π°Π½ΠΎΡ— цінності. ΠŸΡ€ΠΈΡ‡ΠΈΠ½ΠΈ Π½ΠΈΠ·ΡŒΠΊΠΎΡ— Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈΠ²Π½ΠΎΡΡ‚Ρ– ΠΏΡ€ΠΎΠ°Π½Π°Π»Ρ–Π·ΠΎΠ²Π°Π½ΠΎ Ρ– систСматизовано. Π”ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ, Ρ‰ΠΎ ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΡƒ підвищСння Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈΠ²Π½ΠΎΡΡ‚Ρ– Π²Π½ΡƒΡ‚Ρ€Ρ–ΡˆΠ½Ρ–Ρ… Π°ΡƒΠ΄ΠΈΡ‚Ρ–Π² систСми Π΅Π½Π΅Ρ€Π³Π΅Ρ‚ΠΈΡ‡Π½ΠΎΠ³ΠΎ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ‚Ρƒ Ρ‚Ρ€Π΅Π±Π° розв’язувати систСмно, Ρ–Π· застосуванням Ρ€ΠΎΠ·Ρ€ΠΎΠ±Π»Π΅Π½ΠΈΡ… Π°Π²Ρ‚ΠΎΡ€Π°ΠΌΠΈ Ρ– Π·Π°ΠΏΡ€ΠΎΠΏΠΎΠ½ΠΎΠ²Π°Π½ΠΈΡ… Ρƒ статті ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ–Π² Ρ– ΠΏΡ–Π΄Ρ…ΠΎΠ΄Ρ–Π². Висновки. Π’Π½ΡƒΡ‚Ρ€Ρ–ΡˆΠ½Ρ–ΠΌ Π°ΡƒΠ΄ΠΈΡ‚Π°ΠΌ систСми Π΅Π½Π΅Ρ€Π³Π΅Ρ‚ΠΈΡ‡Π½ΠΎΠ³ΠΎ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ‚Ρƒ Ρ‚Ρ€Π΅Π±Π° приділяти Π±Ρ–Π»ΡŒΡˆ ΠΏΠΈΠ»ΡŒΠ½Ρƒ ΡƒΠ²Π°Π³Ρƒ Π² ΠΊΠΎΠΆΠ½ΠΎΠΌΡƒ Π·Π°ΠΊΠ»Π°Π΄Ρ– ΠΎΡ…ΠΎΡ€ΠΎΠ½ΠΈ здоров’я, Π°Π΄ΠΆΠ΅ ΠΏΡ€Π°Π²ΠΈΠ»ΡŒΠ½ΠΎ ΠΎΡ€Π³Π°Π½Ρ–Π·ΠΎΠ²Π°Π½ΠΈΠΉ процСс провСдСння Π°ΡƒΠ΄ΠΈΡ‚Ρ–Π² Ρ” Π΄Ρ–Ρ”Π²ΠΈΠΌ інструмСнтом аналізування систСми Π΅Π½Π΅Ρ€Π³ΠΎΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ‚Ρƒ Ρ– Π½Π°Π΄Π°Ρ” Π²Π°ΠΆΠ»ΠΈΠ²Ρƒ ΠΉ Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρƒ Ρ–Π½Ρ„ΠΎΡ€ΠΌΠ°Ρ†Ρ–ΡŽ для своєчасного вТиття ΠΊΠΎΡ€ΠΈΠ³ΡƒΠ²Π°Π»ΡŒΠ½ΠΈΡ… Ρ– Π·Π°ΠΏΠΎΠ±Ρ–ΠΆΠ½ΠΈΡ… Π΄Ρ–ΠΉ

    Estimation of synchronous generator participation in low-frequency oscillations damping based on synchronized phasor measurements

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    Large-scale centralized power systems interconnected by weak tie-lines is a typical feature of the state-of-the-industry power engineering. Another trend is distributed generation units integration with the resulting decrease of power system inertia constant and increasing sensitivity to small disturbances. In particular, in the case of significant power imbalance, periodic low-frequency oscillations of power system performance parameters may arise. Low frequency oscillations in power systems are inherently non-linear and non-stationary processes representing a superposition of numerous rotating masses movement components having mutual influence in a power region or power center. These situations imply the crucial role of monitoring each generator damping capability which is determined by the adjustment of the system regulators in use. To estimate the synchronous generator capability to maintain synchronous operation under deviating frequency and load angle conditions synchronizing torque and corresponding synchronizing power are proposed to be used. The possibility to determine the synchronous machine synchronizing power is subject to the presence of the load angle variation data with the techniques for defining load angle without direct measurement using a system of assumptions have been analyzed. Numerous simulations have shown that the effect of assumptions can be evaluated as acceptable. The main focus of the paper is the analysis of synchronizing power corresponding to the actual generator involved in the oscillations which had arisen after a disturbance in the Unified Energy System of Russia. The supposed cause of the oscillations is improper automatic excitation controller operation. Β© 2014 WIT Press.International Journal of Safety and Security Engineering;International Journal of Sustainable Development and Planning;WIT Transactions on Ecology and the Environmen

    Sterile neutrinos in neutrinoless double beta decay

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    We study possible contribution of the Majorana neutrino mass eigenstate Ξ½h\nu_h dominated by a sterile neutrino component to neutrinoless double beta (0Ξ½Ξ²Ξ²0\nu\beta\beta) decay. From the current experimental lower bound on the 0Ξ½Ξ²Ξ²0\nu\beta\beta-decay half-life of 76^{76}Ge we derive stringent constraints on the Ξ½hβˆ’Ξ½e\nu_h-\nu_e mixing in a wide region of the values of Ξ½h\nu_h mass. We discuss cosmological and astrophysical status of Ξ½h\nu_h in this mass region.Comment: 6 pages, 1 figure; v2 added comments and reference

    Π‘ΠΈΠ½Ρ‚Π΅Π· Ρ‚Π° Π°Π½Ρ‚ΠΈΠΌΡ–ΠΊΡ€ΠΎΠ±Π½Π° Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ 1-Π°Π»ΠΊΡ–Π»-5-ΠΌΠ΅Ρ‚ΠΈΠ»-3-Ρ„Π΅Π½Ρ–Π»-6-(5-Ρ„Π΅Π½Ρ–Π»-1,3,4-оксадіазол-2-Ρ–Π»)Ρ‚Ρ–Ρ”Π½ΠΎ[2,3-d]ΠΏΡ–Ρ€ΠΈΠΌΡ–Π΄ΠΈΠ½-2,4(1H,3H)-Π΄Ρ–ΠΎΠ½Ρ–Π²

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    An effective approach for synthesis of 5-methyl-3-phenyl-6-(5-phenyl-1,3,4-oxadiazol-2-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione by 1,1’-carbonyldiimidazole promoted interaction of 5-methyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylic acid with benzohydrazide has been developed. The procedure also includes cyclization of N’-benzoyl-5-methyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carbohydrazide obtained by boiling in phosphorous oxychloride and further hydrolysis of the chlorine atom at position 2 of the thieno[2,3-d]pyrimidine system. Alkylation of the assembly of two heterocyclic units obtained with benzyl chlorides, chloroacetamides, and 5-(chloromethyl)-3-aryl-1,2,4-oxadiazoles has allowed obtaining of 1-alkyl-5-methyl-3-phenyl-6-(5-phenyl-1,3,4-oxadiazol-2-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-diones. The structures of the compounds obtained have been confirmed by the 1H NMR, chromato-mass spectral and elemental microanalysis data. The results of the screening performed by the agar diffusion method (β€œwell method”) have shown the absence of the antimicrobial activity for 1-benzyl-5-methyl-3-phenyl-6-(5-phenyl-1,3,4-oxadiazol-2-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-diones and 2-[5-methyl-2,4-dioxo-3-phenyl-6-(5-phenyl-1,3,4-oxadiazol-2-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-1(2H)-yl]-N-arylacetamides; but the activity for 1-{[3-aryl-1,2,4-oxadiazol-5-yl]methyl}-5-methyl-3-phenyl-6-(5-phenyl-1,3,4-oxadiazol-2-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-diones has been found. The compounds of this range appeared to be active against the strains of Staphylococcus aureus, Escherichia coli and Bacillus subtilis; the diameters of their growth inhibition zones were similar to those for the reference drugs Metronidazole and Streptomycin.Π Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½ эффСктивный ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ ΠΊ синтСзу 5-ΠΌΠ΅Ρ‚ΠΈΠ»-3-Ρ„Π΅Π½ΠΈΠ»-6-(5-Ρ„Π΅Π½ΠΈΠ»-1,3,4-оксадиазол-2-ΠΈΠ»)Ρ‚ΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡ€ΠΈΠΌΠΈΠ΄ΠΈΠ½-2,4(1H,3H)-Π΄ΠΈΠΎΠ½Π° ΠΏΡƒΡ‚Π΅ΠΌ ΠΏΡ€ΠΎΠΌΠΎΡ‚ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ 1,1’-ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΈΠ»Π΄ΠΈΠΈΠΌΠΈΠ΄Π°Π·ΠΎΠ»ΠΎΠΌ взаимодСйствия 5-ΠΌΠ΅Ρ‚ΠΈΠ»-2,4-диоксо-3-Ρ„Π΅Π½ΠΈΠ»-1,2,3,4-Ρ‚Π΅Ρ‚Ρ€Π°Π³ΠΈΠ΄Ρ€ΠΎΡ‚ΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡ€ΠΈΠΌΠΈΠ΄ΠΈΠ½-6-ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΎΠ²ΠΎΠΉ кислоты с Π±Π΅Π½Π·ΠΎΠ³ΠΈΠ΄Ρ€Π°Π·ΠΈΠ΄ΠΎΠΌ. ΠŸΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€Π° Ρ‚Π°ΠΊΠΆΠ΅ Π²ΠΊΠ»ΡŽΡ‡Π°Π΅Ρ‚ Ρ†ΠΈΠΊΠ»ΠΈΠ·Π°Ρ†ΠΈΡŽ ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½ΠΎΠ³ΠΎ N’-Π±Π΅Π½Π·ΠΎΠΈΠ»-5-ΠΌΠ΅Ρ‚ΠΈΠ»-2,4-диоксо-3-Ρ„Π΅Π½ΠΈΠ»-1,2,3,4-Ρ‚Π΅Ρ‚Ρ€Π°Π³ΠΈΠ΄Ρ€ΠΎΡ‚ΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡ€ΠΈΠΌΠΈΠ΄ΠΈΠ½-6-ΠΊΠ°Ρ€Π±ΠΎΠ³ΠΈΠ΄Ρ€Π°Π·ΠΈΠ΄Π° кипячСниСм Π² хлорокиси фосфора ΠΈ дальнСйший Π³ΠΈΠ΄Ρ€ΠΎΠ»ΠΈΠ· Π°Ρ‚ΠΎΠΌΠ° Ρ…Π»ΠΎΡ€Π° Π² ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ 2 Ρ‚ΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡ€ΠΈΠΌΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΎΠΉ систСмы. АлкилированиС ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½ΠΎΠ³ΠΎ Π΄Π²ΡƒΡ…Π·Π²Π΅Π½Π½ΠΎΠ³ΠΎ ансамбля Π³Π΅Ρ‚Π΅Ρ€ΠΎΡ†ΠΈΠΊΠ»ΠΎΠ² Π±Π΅Π½Π·ΠΈΠ»Ρ…Π»ΠΎΡ€ΠΈΠ΄Π°ΠΌΠΈ, Ρ…Π»ΠΎΡ€Π°Ρ†Π΅Ρ‚Π°ΠΌΠΈΠ΄Π°ΠΌΠΈ ΠΈ 5-(Ρ…Π»ΠΎΡ€ΠΌΠ΅Ρ‚ΠΈΠ»)-3-Π°Ρ€ΠΈΠ»-1,2,4-оксадиазолами ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΠΏΠΎΠ»ΡƒΡ‡ΠΈΡ‚ΡŒ 1-Π°Π»ΠΊΠΈΠ»-5-ΠΌΠ΅Ρ‚ΠΈΠ»-3-Ρ„Π΅Π½ΠΈΠ»-6-(5-Ρ„Π΅Π½ΠΈΠ»-1,3,4-оксадиазол-2-ΠΈΠ»)Ρ‚ΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡ€ΠΈΠΌΠΈΠ΄ΠΈΠ½-2,4(1H,3H)-Π΄ΠΈΠΎΠ½Ρ‹. Π‘Ρ‚Ρ€ΡƒΠΊΡ‚ΡƒΡ€Ρ‹ ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… соСдинСний Π±Ρ‹Π»ΠΈ ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½Ρ‹ Π½Π° основС Π΄Π°Π½Π½Ρ‹Ρ… 1Н ЯМР, хроматомас спСктров ΠΈ элСмСнтного Π°Π½Π°Π»ΠΈΠ·Π°. По Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°ΠΌ скрининга ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π΄ΠΈΡ„Ρ„ΡƒΠ·ΠΈΠΈ Π² Π°Π³Π°Ρ€ (Β«ΠΌΠ΅Ρ‚ΠΎΠ΄ ΠΊΠΎΠ»ΠΎΠ΄Ρ†Π΅Π²Β») установлСно отсутствиС ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠΌΠΈΠΊΡ€ΠΎΠ±Π½ΠΎΠΉ активности Ρƒ 1-Π±Π΅Π½Π·ΠΈΠ»-5-ΠΌΠ΅Ρ‚ΠΈΠ»-3-Ρ„Π΅Π½ΠΈΠ»-6-(5-Ρ„Π΅Π½ΠΈΠ»-1,3,4-оксадиазол-2-ΠΈΠ»)Ρ‚ΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡ€ΠΈΠΌΠΈΠ΄ΠΈΠ½-2,4(1H,3H)-Π΄ΠΈΠΎΠ½ΠΎΠ² ΠΈ 2-[5-ΠΌΠ΅Ρ‚ΠΈΠ»-2,4-диоксо-3-Ρ„Π΅Π½ΠΈΠ»-6-(5-Ρ„Π΅Π½ΠΈΠ»-1,3,4-оксадиазол-2-ΠΈΠ»)-3,4-Π΄ΠΈΠ³ΠΈΠ΄Ρ€ΠΎΡ‚ΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡ€ΠΈΠΌΠΈΠ΄ΠΈΠ½-1(2H)-ΠΈΠ»]-N-Π°Ρ€ΠΈΠ»Π°Ρ†Π΅Ρ‚Π°ΠΌΠΈΠ΄ΠΎΠ², Π° Ρ‚Π°ΠΊΠΆΠ΅ Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠΌΠΈΠΊΡ€ΠΎΠ±Π½ΠΎΠΉ активности для 1-{[3-Π°Ρ€ΠΈΠ»-1,2,4-оксадиазол-5-ΠΈΠ»]ΠΌΠ΅Ρ‚ΠΈΠ»}-5-ΠΌΠ΅Ρ‚ΠΈΠ»-3-Ρ„Π΅Π½ΠΈΠ»-6-(5-Ρ„Π΅Π½ΠΈΠ»-1,3,4-оксадиазол-2-ΠΈΠ»)Ρ‚ΠΈΠ΅Π½ΠΎ[2,3-d]ΠΏΠΈΡ€ΠΈΠΌΠΈΠ΄ΠΈΠ½-2,4(1H,3H)-Π΄ΠΈΠΎΠ½ΠΎΠ². Π”Π°Π½Π½Ρ‹Π΅ вСщСства проявили ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠΌΠΈΠΊΡ€ΠΎΠ±Π½ΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΒ ΠΊ ΡˆΡ‚Π°ΠΌΠΌΠ°ΠΌ Staphylococcus aureus, Escherichia coli ΠΈ Baсillus subtilis со значСниями Π·ΠΎΠ½ Π·Π°Π΄Π΅Ρ€ΠΆΠΊΠΈ роста, Π±Π»ΠΈΠ·ΠΊΠΈΠΌΠΈ ΠΊ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π°ΠΌ сравнСния ΠΌΠ΅Ρ‚Ρ€ΠΎΠ½ΠΈΠ΄Π°Π·ΠΎΠ»Ρƒ ΠΈ стрСптомицину.Π ΠΎΠ·Ρ€ΠΎΠ±Π»Π΅Π½ΠΎ Π΅Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΈΠΉ ΠΏΡ–Π΄Ρ…Ρ–Π΄ Π΄ΠΎ синтСзу 5-ΠΌΠ΅Ρ‚ΠΈΠ»-3-Ρ„Π΅Π½Ρ–Π»-6-(5-Ρ„Π΅Π½Ρ–Π»-1,3,4-оксадіазол-2-Ρ–Π»)Ρ‚Ρ–Ρ”Π½ΠΎ[2,3-d]ΠΏΡ–Ρ€ΠΈΠΌΡ–Π΄ΠΈΠ½-2,4(1H,3H)-Π΄Ρ–ΠΎΠ½Ρƒ ΡˆΠ»ΡΡ…ΠΎΠΌ ΠΏΡ€ΠΎΠΌΠΎΡ‚ΠΎΠ²Π°Π½ΠΎΡ— 1,1’-ΠΊΠ°Ρ€Π±ΠΎΠ½Ρ–Π»Π΄Ρ–Ρ–ΠΌΡ–Π΄Π°Π·ΠΎΠ»ΠΎΠΌ Π²Π·Π°Ρ”ΠΌΠΎΠ΄Ρ–Ρ— 5-ΠΌΠ΅Ρ‚ΠΈΠ»-2,4-діоксо-3-Ρ„Π΅Π½Ρ–Π»-1,2,3,4-Ρ‚Π΅Ρ‚Ρ€Π°Π³Ρ–Π΄Ρ€ΠΎΡ‚Ρ–Ρ”Π½ΠΎ[2,3-d]ΠΏΡ–Ρ€ΠΈΠΌΡ–Π΄ΠΈΠ½-6-ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΎΠ²ΠΎΡ— кислоти Π· Π±Π΅Π½Π·ΠΎΠ³Ρ–Π΄Ρ€Π°Π·ΠΈΠ΄ΠΎΠΌ. ΠŸΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€Π° Ρ‚Π°ΠΊΠΎΠΆ Π²ΠΊΠ»ΡŽΡ‡Π°Ρ” наступну Ρ†ΠΈΠΊΠ»Ρ–Π·Π°Ρ†Ρ–ΡŽ ΠΎΡ‚Ρ€ΠΈΠΌΠ°Π½ΠΎΠ³ΠΎ N’-Π±Π΅Π½Π·ΠΎΡ—Π»-5-ΠΌΠ΅Ρ‚ΠΈΠ»-2,4-діоксо-3-Ρ„Π΅Π½Ρ–Π»-1,2,3,4-Ρ‚Π΅Ρ‚Ρ€Π°-Π³Ρ–Π΄Ρ€ΠΎΡ‚Ρ–Ρ”Π½ΠΎ[2,3-d]ΠΏΡ–Ρ€ΠΈΠΌΡ–Π΄ΠΈΠ½-6-ΠΊΠ°Ρ€Π±ΠΎΠ³Ρ–Π΄Ρ€Π°Π·ΠΈΠ΄Ρƒ кип’ятінням Ρƒ хлорокисі фосфору Ρ‚Π° подальший Π³Ρ–Π΄Ρ€ΠΎΠ»Ρ–Π·Β Π°Ρ‚ΠΎΠΌΠ° Ρ…Π»ΠΎΡ€Ρƒ Ρƒ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ– 2 Ρ‚Ρ–Ρ”Π½ΠΎ[2,3-d]ΠΏΡ–Ρ€ΠΈΠΌΡ–Π΄ΠΈΠ½ΠΎΠ²ΠΎΡ— систСми. ΠΠ»ΠΊΡ–Π»ΡŽΠ²Π°Π½Π½Ρ ΠΎΡ‚Ρ€ΠΈΠΌΠ°Π½ΠΎΠ³ΠΎ Π΄Π²ΠΎΠ»Π°Π½ΠΊΠΎΠ²ΠΎΠ³ΠΎ ансамблю Π³Π΅Ρ‚Π΅Ρ€ΠΎΡ†ΠΈΠΊΠ»Ρ–Π² Π±Π΅Π½Π·ΠΈΠ»Ρ…Π»ΠΎΡ€ΠΈΠ΄Π°ΠΌΠΈ, Ρ…Π»ΠΎΡ€ΠΎΠ°Ρ†Π΅Ρ‚Π°ΠΌΡ–Π΄Π°ΠΌΠΈ Ρ‚Π° 5-(Ρ…Π»ΠΎΡ€ΠΎΠΌΠ΅Ρ‚ΠΈΠ»)-3-Π°Ρ€ΠΈΠ»-1,2,4-оксадіазо-Π»Π°ΠΌΠΈ Π΄ΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΠΎΡ‚Ρ€ΠΈΠΌΠ°Ρ‚ΠΈ 1-Π°Π»ΠΊΡ–Π»-5-ΠΌΠ΅Ρ‚ΠΈΠ»-3-Ρ„Π΅Π½Ρ–Π»-6-(5-Ρ„Π΅Π½Ρ–Π»-1,3,4-оксадіазол-2-Ρ–Π»)Ρ‚Ρ–Ρ”Π½ΠΎ[2,3-d]ΠΏΡ–Ρ€ΠΈΠΌΡ–-Π΄ΠΈΠ½-2,4(1H,3H)-Π΄Ρ–ΠΎΠ½ΠΈ. Π‘Ρ‚Ρ€ΡƒΠΊΡ‚ΡƒΡ€ΠΈ ΠΎΡ‚Ρ€ΠΈΠΌΠ°Π½ΠΈΡ… сполук Π±ΡƒΠ»ΠΈ ΠΏΡ–Π΄Ρ‚Π²Π΅Ρ€Π΄ΠΆΠ΅Π½Ρ– Π½Π° основі Π΄Π°Π½ΠΈΡ… 1Н ЯМР, хроматомас спСктрів Ρ‚Π° Π΅Π»Π΅ΠΌΠ΅Π½Ρ‚Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»Ρ–Π·Ρƒ. Π—Π° Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°ΠΌΠΈ скринінгу ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π΄ΠΈΡ„ΡƒΠ·Ρ–Ρ— Π² Π°Π³Π°Ρ€ (Β«ΠΌΠ΅Ρ‚ΠΎΠ΄ колодязів») встановлСно Π²Ρ–Π΄ΡΡƒΡ‚Π½Ρ–ΡΡ‚ΡŒ Π°Π½Ρ‚ΠΈΠΌΡ–ΠΊΡ€ΠΎΠ±Π½ΠΎΡ— активності Ρƒ 1-Π±Π΅Π½Π·ΠΈΠ»-5-ΠΌΠ΅Ρ‚ΠΈΠ»-3-Ρ„Π΅Π½Ρ–Π»-6-(5-Ρ„Π΅Π½Ρ–Π»-1,3,4-оксадіазол-2-Ρ–Π»)Ρ‚Ρ–Ρ”Π½ΠΎ[2,3-d]ΠΏΡ–Ρ€ΠΈΠΌΡ–Π΄ΠΈΠ½-2,4(1H,3H)-Π΄Ρ–ΠΎΠ½Ρ–Π² Ρ‚Π° 2-[5-ΠΌΠ΅Ρ‚ΠΈΠ»-2,4-діоксо-3-Ρ„Π΅Π½Ρ–Π»-6-(5-Ρ„Π΅Π½Ρ–Π»-1,3,4-оксадіазол-2-Ρ–Π»)-3,4-Π΄ΠΈΠ³Ρ–Π΄Ρ€ΠΎΡ‚Ρ–Ρ”Π½ΠΎ[2,3-d]ΠΏΡ–Ρ€ΠΈΠΌΡ–Π΄ΠΈΠ½-1(2H)-Ρ–Π»]-N-Π°Ρ€ΠΈΠ»Π°Ρ†Π΅Ρ‚Π°ΠΌΡ–Π΄Ρ–Π², Π° Ρ‚Π°ΠΊΠΎΠΆ Π½Π°ΡΠ²Π½Ρ–ΡΡ‚ΡŒ Π°Π½Ρ‚ΠΈΠΌΡ–ΠΊΡ€ΠΎΠ±Π½ΠΎΡ— активності для 1-{[3-Π°Ρ€ΠΈΠ»-1,2,4-оксадіазол-5-Ρ–Π»]ΠΌΠ΅Ρ‚ΠΈΠ»}-5-ΠΌΠ΅Ρ‚ΠΈΠ»-3-Ρ„Π΅Π½Ρ–Π»-6-(5-Ρ„Π΅Π½Ρ–Π»-1,3,4-окса-Π΄Ρ–Π°Π·ΠΎΠ»-2-Ρ–Π»)Ρ‚Ρ–Ρ”Π½ΠΎ[2,3-d]ΠΏΡ–Ρ€ΠΈΠΌΡ–Π΄ΠΈΠ½-2,4(1H,3H)-Π΄Ρ–ΠΎΠ½Ρ–Π². Π”Π°Π½Ρ– Ρ€Π΅Ρ‡ΠΎΠ²ΠΈΠ½ΠΈ виявили Π°Π½Ρ‚ΠΈΠΌΡ–ΠΊΡ€ΠΎΠ±Π½Ρƒ Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ Π΄ΠΎ ΡˆΡ‚Π°ΠΌΡ–Π² Staphylococcus aureus, Escherichia coli Ρ‚Π° Baсillus subtilis Ρ–Π· значСннями Π·ΠΎΠ½ Π·Π°Ρ‚Ρ€ΠΈΠΌΠΊΠΈ росту, близькими Π΄ΠΎ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρ–Π² порівняння ΠΌΠ΅Ρ‚Ρ€ΠΎΠ½Ρ–Π΄Π°Π·ΠΎΠ»Ρƒ Ρ‚Π° стрСптоміцину
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