118 research outputs found
O K -edge and CuL23-edge XANES study on the concentration and distribution of holes in the (Pb2/3Cu1/3)3Sr2(Y ,Ca)Cu2O8+z superconductive phase
By means of high-resolution O K-edge and Cu L23-edge x-ray absorption near-edge-structure spectroscopy continuous increase of the CuO2-plane hole concentration with increasing Ca-substitution level has been established for the superconductive, oxygen-depleted (z≈0) (Pb2/3Cu1/3)3Sr2(Y1−xCax)Cu2O8+z [(Pb2/3Cu1/3)−3212] phase with a three-layer PbO-Cu-PbO charge-reservoir block. For the O K-edge absorption, a pre-edge peak at ∼528.3 eV is seen, originating from the excitation of the O 1s electron to the O 2p hole state located in the CuO2 plane. With increasing Ca-substitution level, the intensity of this peak continuously increases within the substitution range studied, i.e., 0<~x<~0.5. Consistently, with increasing x, the shoulder on the high-energy side of the main absorption peak at ∼932.0 eV in the Cu L23-edge spectra, i.e., a feature typically assigned to formally trivalent copper, enhances. From the Cu L23-edge spectra it was furthermore confirmed that the charge-reservoir copper remains in the monovalent state, indicating that the holes created through Ca substitution are directed solely into the superconductive CuO2 plane. In terms of increasing the CuO2-plane hole concentration, Ca substitution was found to work more efficiently in (Pb2/3Cu1/3)−3212 as compared to, e.g., the related Bi-2212 phase.Peer reviewe
Layer-specific hole concentrations in Bi2Sr2(Y1-xCax)Cu208+[delta] as probed by XANES spectroscopy and coulometric redox analysis
Induction of holes not only in the superconductive CuO2 plane but also in the Bi2O2+δ charge reservoir of the Bi2Sr2(Y1-xCax)Cu2O8+δ superconductor upon CaII-for-YIII substitution is evidenced by means of two independent techniques, i.e., high-resolution x-ray-absorption near-edge structure (XANES) spectroscopy measurements and coulometric redox titrations. The absolute values derived for the CuO2-plane hole concentration from the Cu L2,3-edge XANES spectra are in good agreement with those obtained from the coulometric redox analysis. The CuO2-plane hole concentration is found to increase from 0.03 to 0.14 concomitantly with the increase in the BiO1+δ/2-layer hole concentration from 0.00 to 0.13 as the Ca-substitution level, x, increases from 0 to 1. The threshold CuO2-plane hole concentration for the appearance of superconductivity is determined at 0.06, while the highest Tc is obtained at the hole concentration of 0.12. In the O K-edge XANES spectrum, the increases in the CuO2-plane and BiO1+δ/2-layer hole concentrations with increasing x are seen as enhancement in the relative intensities of the pre-edge peaks at ∼528.3 and ∼530.5 eV, respectively.Peer reviewe
Layered-specific hole concentrations in Bi2Sr2(Y1-xCax)Cu2O8+d as probed by XANES spectroscopy and coulometric redox analysis
Induction of holes not only in the superconductive CuO2 plane but also in the
Bi2O2+d charge reservoir of the Bi2Sr2(Y1-xCax)Cu2O8+d superconductor upon
CaII-for-YIII substitution is evidenced by means of two independent techniques,
i.e., high-resolution x-ray-absorption near-edge structure (XANES) spectroscopy
measurements and coulometric redox titrations. The absolute values derived for
the CuO2-plane hole concentration from the Cu L2,3-edge XANES spectra are in
good agreement with those obtained from the coulometric redox analysis. The
CuO2-plane hole concentration is found to increase from 0.03 to 0.14
concomitantly with the increase in the BiO1+d/2-layer hole concentration from
0.00 to 0.13 as the Ca-substitution level, x, increases from 0 to 1. The
threshold CuO2-plane hole concentration for the appearance of superconductivity
is determined at 0.06, while the highest Tc is obtained at the hole
concentration of 0.12. In the O K-edge XANES spectrum, the increases in the
CuO2-plane and BiO1+d/2-layer hole concentrations with increasing x are seen as
enhancement in the relative intensities of the pre-edge peaks at ~528.3 and
\~530.5 eV, respectively.Comment: 12 pages, 6 figures, to appear in Phys. Rev.
The complementarity of astrometric and radial velocity exoplanet observations - Determining exoplanet mass with astrometric snapshots
We obtain full information on the orbital parameters by combining radial
velocity and astrometric measurements by means of Bayesian inference. We sample
the parameter probability densities of orbital model parameters with a Markov
chain Monte Carlo (McMC) method in simulated observational scenarios to test
the detectability of planets with orbital periods longer than the observational
timelines. We show that, when fitting model parameters simultaneously to
measurements from both sources, it is possible to extract much more information
from the measurements than when using either source alone. We demonstrate this
by studying the orbit of recently found extra-solar planet HD 154345 b.Comment: 6 pages, 9 figures. Accepted to A&
Mapping the three-body system - decay time and reversibility
In this paper we carry out a quantitative analysis of the three-body systems
and map them as a function of decaying time and intial conguration, look at
this problem as an example of a simple deterministic system, and ask to what
extent the orbits are really predictable. We have investigated the behavior of
about 200 000 general Newtonian three body systems using the simplest initial
conditions. Within our resolution these cover all the possible states where the
objects are initially at rest and have no angular momentum. We have determined
the decay time-scales of the triple systems and show that the distribution of
this parameter is fractal in appearance. Some areas that appear stable on large
scales exhibit very narrow strips of instability and the overall pattern,
dominated by resonances, reminds us of a traditional Maasai warrior shield.
Also an attempt is made to recover the original starting conguration of the
three bodies by backward integration. We find there are instances where the
evolution to the future and to the past lead to different orbits, in spite of
time symmetric initial conditions. This implies that even in simple
deterministic systems there exists an Arrow of Time.Comment: 8 pages, 9 figures. Accepted for publication in MNRAS. Includes
low-resolution figures. High-resolution figures are available as PNG
ROPS: A New Search for Habitable Earths in the Southern Sky
We present the first results from our Red Optical Planet Survey (ROPS) to
search for low mass planets orbiting late type dwarfs (M5.5V - M9V) in their
habitable zones (HZ). Our observations, with the red arm of the MIKE
spectrograph (0.5 - 0.9 microns) at the 6.5 m Magellan Clay telescope at Las
Campanas Observatory indicate that >= 92 per cent of the flux lies beyond 0.7
microns. We use a novel approach that is essentially a hybrid of the
simultaneous iodine and ThAr methods for determining precision radial
velocities. We apply least squares deconvolution to obtain a single high S/N
ratio stellar line for each spectrum and cross correlate against the
simultaneously observed telluric line profile, which we derive in the same way.
Utilising the 0.62 - 0.90 micron region, we have achieved an r.m.s. precision
of 10 m/s for an M5.5V spectral type star with spectral S/N ~160 on 5 minute
timescales. By M8V spectral type, a precision of ~30 m/s at S/N = 25 is
suggested, although more observations are needed. An assessment of our errors
and scatter in the radial velocity points hints at the presence of stellar
radial velocity variations. Of our sample of 7 stars, 2 show radial velocity
signals at 6-sigma and 10-sigma of the cross correlation uncertainties. If the
signals are planetary in origin, our findings are consistent with estimates of
Neptune mass planets that predict a frequency of 13 - 27 per cent for early M
dwarfs.Our current analysis indicates the we can achieve a sensitivity that is
equivalent to the amplitude induced by a 6 M_Earth planet orbiting in the
habitable zone. Based on simulations, we estimate that <10 M_Earth habitable
zone planets will be detected in a new stellar mass regime, with <=20 epochs of
observations.Comment: MNRAS accepted: 14 pages, 8 figures, 3 table
T-cell subpopulations αβ and γδ in cord blood of very preterm infants : The influence of intrauterine infection
Open Access: This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are creditedPreterm infants are very susceptible to infections. Immune response mechanisms in this group of patients and factors that influence cord blood mononuclear cell populations remain poorly understood and are considered insufficient. However, competent immune functions of the cord blood mononuclear cells are also described. The aim of this work was to evaluate the T-cell population (CD3+) with its subpopulations bearing T-cell receptor (TCR) αβ or TCR γδ in the cord blood of preterm infants born before 32 weeks of gestation by mothers with or without an intrauterine infection. Being a pilot study, it also aimed at feasibility check and assessment of an expected effect size. The cord blood samples of 46 infants age were subjected to direct immunofluorescent staining with monoclonal antibodies and then analyzed by flow cytometry. The percentage of CD3+ cells in neonates born by mothers with diagnosis of intrauterine infection was significantly lower than in neonates born by mothers without infection (p = 0.005; Mann-Whitney U test). The number of cells did not differ between groups. Infection present in the mother did not have an influence on the TCR αβ or TCR γδ subpopulations. Our study contributes to a better understanding of preterm infants' immune mechanisms, and sets the stage for further investigations.Peer reviewedFinal Published versio
Pre-natal and post-natal exposure to respiratory infection and atopic diseases development: a historical cohort study
BACKGROUND: According to the hygiene hypothesis, infections in early life protect from allergic diseases. However, in earlier studies surrogate measures of infection rather than clinical infections were associated with decreased frequencies of atopic diseases. Exposure to infection indicating sub-clinical infection rather than clinical infection might protect from atopic diseases. Objective: to investigate whether exposure to acute respiratory infections within pregnancy and the first year of life is associated with atopic conditions at age 5–14 years and to explore when within pregnancy and the first year of life this exposure is most likely to be protective. METHODS: Historical cohort study: Population level data on acute respiratory infections from the routine reporting system of the former German Democratic Republic were linked with individual data from consecutive surveys on atopic diseases in the same region (n = 4672). Statistical analyses included multivariate logistic regression analysis and polynomial distributed lag models. RESULTS: High exposure to acute respiratory infection between pregnancy and age one year was associated with overall reduced odds of asthma, eczema, hay fever, atopic sensitization and total IgE. Exposure in the first 9 months of life showed the most pronounced effect. Adjusted odds ratio's for asthma, hay fever, inhalant sensitization and total IgE were statistical significantly reduced up to around half. CONCLUSION: Exposure to respiratory infection (most likely indicating sub-clinical infection) within pregnancy and the first year of life may be protective in atopic diseases development. The post-natal period thereby seems to be particularly important
Molecular basis for group-specific activation of the virulence regulator PlcR by PapR heptapeptides
The transcriptional regulator PlcR and its cognate cell–cell signalling peptide PapR form a quorum-sensing system that controls the expression of extra-cellular virulence factors in various species of the Bacillus cereus group. PlcR and PapR alleles are clustered into four groups defining four pherotypes. However, the molecular basis for group specificity remains elusive, largely because the biologically relevant PapR form is not known. Here, we show that the in vivo active form of PapR is the C-terminal heptapeptide of the precursor, and not the pentapeptide, as previously suggested. Combining genetic complementation, anisotropy assays and structural analysis we provide a detailed functional and structural explanation for the group specificity of the PlcR–PapR quorum-sensing system. We further show that the C-terminal helix of the PlcR regulatory domain, specifically the 278 residue, in conjunction with the N-terminal residues of the PapR heptapeptide determines this system specificity. Variability in the specificity-encoding regions of plcR and papR genes suggests that selection and evolution of quorum-sensing systems play a major role in adaptation and ecology of Bacilli
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