245 research outputs found
A qualitative investigation of consumer experiences of the child directed interaction phase of parentâchild interaction therapy with toddlers
Background: Parentâchild interaction therapy with toddlers (PCIT-T) is an adaptation of standard PCIT, developed to treat young children (12â24 months) with disruptive behaviours. The aim of this study was to gather preliminary qualitative data to gauge parental perceptions about the program. Methods: Semi-structured interviews were conducted with five parents who received the first phase of the program, âchild directed interaction-Toddlerâ (CDI-T) at a community based child behaviour treatment clinic. Interview transcripts were analysed thematically. Results: Participants were initially motivated to seek treatment because of concerns about and difficulties managing child behaviour. All participants reported a range of positive gains as a result of CDI-T including new parenting strategies, improved parental confidence and improved parentâchild relationship quality. Live coaching from behind the one-way mirror, the relationship with the therapist and the home-based practice of skills between sessions were identified as important treatment components. Many participants spoke, however, about the difficulties they experienced with continuing to implement the home practice after program completion. Conclusions: Results suggest that CDI-T is perceived positively by consumers, and highlight a number of key program components
Qualitative evaluation of Australian Caregiver's experiences of parentâchild interaction therapy delivered in a community-based clinic setting
Background: Parentâchild interaction therapy (PCIT) is a short-term, evidence-based parent training program for parents of children aged 2â7 years with disruptive behaviour disorders (DBDs). The evidence-base for the effectiveness of PCIT is extensive but to date most studies have been quantitative in nature and conducted in university research clinics within the United States. Thus, understanding of the effectiveness and acceptability of PCIT in community-based settings in other countries, including Australia, is limited. Objective: This study used a qualitative methodology to explore Australian caregiver's perceptions of a standard PCIT program delivered at a community-based PCIT clinic. Method: Participants were nine mothers and one father who completed the PCIT program at the clinic for treatment of child DBD. Results: Thematic analysis yielded four major themes, namely âParenting challenges before PCITâ; âPositive treatment outcomesâ (sub-themes: improved child behaviour, increased parental confidence, increased insight into the child needs, and improved relationships with partner); âProgram strengthsâ (sub-themes: child-directed interaction, parent-directed interaction, home practice, therapeutic relationship); and âChallenges experienced.â. Conclusions: These findings highlight the benefits of the PCIT program for families who are struggling with DBD in early childhood, and point to the potential positive impacts of disseminating PCIT within clinical settings more widely across Australia
Effects of crack tip geometry on dislocation emission and cleavage: A possible path to enhanced ductility
We present a systematic study of the effect of crack blunting on subsequent
crack propagation and dislocation emission. We show that the stress intensity
factor required to propagate the crack is increased as the crack is blunted by
up to thirteen atomic layers, but only by a relatively modest amount for a
crack with a sharp 60 corner. The effect of the blunting is far less
than would be expected from a smoothly blunted crack; the sharp corners
preserve the stress concentration, reducing the effect of the blunting.
However, for some material parameters blunting changes the preferred
deformation mode from brittle cleavage to dislocation emission. In such
materials, the absorption of preexisting dislocations by the crack tip can
cause the crack tip to be locally arrested, causing a significant increase in
the microscopic toughness of the crack tip. Continuum plasticity models have
shown that even a moderate increase in the microscopic toughness can lead to an
increase in the macroscopic fracture toughness of the material by several
orders of magnitude. We thus propose an atomic-scale mechanism at the crack
tip, that ultimately may lead to a high fracture toughness in some materials
where a sharp crack would seem to be able to propagate in a brittle manner.
Results for blunt cracks loaded in mode II are also presented.Comment: 12 pages, REVTeX using epsfig.sty. 13 PostScript figures. Final
version to appear in Phys. Rev. B. Main changes: Discussion slightly
shortened, one figure remove
Eigenphase preserving two-channel SUSY transformations
We propose a new kind of supersymmetric (SUSY) transformation in the case of
the two-channel scattering problem with equal thresholds, for partial waves of
the same parity. This two-fold transformation is based on two imaginary
factorization energies with opposite signs and with mutually conjugated
factorization solutions. We call it an eigenphase preserving SUSY
transformation as it relates two Hamiltonians, the scattering matrices of which
have identical eigenphase shifts. In contrast to known phase-equivalent
transformations, the mixing parameter is modified by the eigenphase preserving
transformation.Comment: 16 pages, 1 figur
Aging and memory phenomena in magnetic and transport properties of vortex matter: a brief review
There is mounting experimental evidence that strong off-equilibrium
phenomena, such as ``memory'' or ``aging'' effects, play a crucial role in the
physics of vortices in type II superconductors. We give a short review, based
on a recently introduced schematic vortex model, of current progresses in
understanding out of equilibrium vortex behaviours. We develop a unified
description of ``memory'' phenomena in magnetic and transport properties, such
as magnetisation loops and their ``anomalous'' 2nd peak, logarithmic creep,
``anomalous'' finite creep rate in the limit of vanishing temperature,
``memory'' and ``irreversibility'' in I-V characteristics, time dependent
critical currents, ``rejuvenation'' and ``aging'' of the system response.Comment: updated versio
Linear, Deterministic, and Order-Invariant Initialization Methods for the K-Means Clustering Algorithm
Over the past five decades, k-means has become the clustering algorithm of
choice in many application domains primarily due to its simplicity, time/space
efficiency, and invariance to the ordering of the data points. Unfortunately,
the algorithm's sensitivity to the initial selection of the cluster centers
remains to be its most serious drawback. Numerous initialization methods have
been proposed to address this drawback. Many of these methods, however, have
time complexity superlinear in the number of data points, which makes them
impractical for large data sets. On the other hand, linear methods are often
random and/or sensitive to the ordering of the data points. These methods are
generally unreliable in that the quality of their results is unpredictable.
Therefore, it is common practice to perform multiple runs of such methods and
take the output of the run that produces the best results. Such a practice,
however, greatly increases the computational requirements of the otherwise
highly efficient k-means algorithm. In this chapter, we investigate the
empirical performance of six linear, deterministic (non-random), and
order-invariant k-means initialization methods on a large and diverse
collection of data sets from the UCI Machine Learning Repository. The results
demonstrate that two relatively unknown hierarchical initialization methods due
to Su and Dy outperform the remaining four methods with respect to two
objective effectiveness criteria. In addition, a recent method due to Erisoglu
et al. performs surprisingly poorly.Comment: 21 pages, 2 figures, 5 tables, Partitional Clustering Algorithms
(Springer, 2014). arXiv admin note: substantial text overlap with
arXiv:1304.7465, arXiv:1209.196
Parental experience of an early developmental surveillance programme for autism within Australian general practice: A qualitative study
Objectives Implementing support and services early in the life course has been shown to promote positive developmental outcomes for children at high likelihood of developmental conditions including autism. This study examined parents'/caregivers' experiences and perceptions about a digital developmental surveillance pathway for autism, the autism surveillance pathway (ASP), and usual care, the surveillance as usual (SaU) pathway, in the primary healthcare general practice setting. Design This qualitative study involves using a convenience selection process of the full sample of parents/caregivers that participated in the main programme, 'General Practice Surveillance for Autism', a cluster-randomised controlled trial study. All interviews were audio-recorded, transcribed and coded using NVivo V.12 software. An inductive thematic interpretive approach was adopted and data were analysed thematically. Participants Twelve parents/caregivers of children with or without a developmental condition/autism (who participated in the main programme) in South Western Sydney and Melbourne were interviewed. Settings All interviews were completed over the phone. Results There were seven major themes and 20 subthemes that included positive experiences, such as pre-existing patient-doctor relationships and their perceptions on the importance of knowing and accessing early support/services. Barriers or challenges experienced while using the SaU pathway included long waiting periods, poor communication and lack of action plans, complexity associated with navigating the healthcare system and lack of understanding by general practitioners (GPs). Common suggestions for improvement included greater awareness/education for parents/carers and the availability of accessible resources on child development for parents/caregivers. Conclusion The findings support the use of digital screening tools for developmental surveillance, including for autism, using opportunistic contacts in the general practice setting. Trial registration number ANZCTR (ACTRN12619001200178)
Watch me grow integrated (WMG-I): protocol for a cluster randomised controlled trial of a web-based surveillance approach for developmental screening in primary care settings
Introduction The increasing prevalence of developmental disorders in early childhood poses a significant global health burden. Early detection of developmental problems is vital to ensure timely access to early intervention, and universal developmental surveillance is recommended best practice for identifying issues. Despite this, there is currently considerable variation in developmental surveillance and screening between Australian states and territories and low rates of developmental screening uptake by parents. This study aims to evaluate an innovative web-based developmental surveillance programme and a sustainable approach to referral and care pathways, linking primary care general practice (GP) services that fall under federal policy responsibility and state government-funded child health services. Methods and analysis The proposed study describes a longitudinal cluster randomised controlled trial (c-RCT) comparing a â ⏠Watch Me Grow Integrated' (WMG-I) approach for developmental screening, to Surveillance as Usual (SaU) in GPs. Forty practices will be recruited across New South Wales and Queensland, and randomly allocated into either the (1) WMG-I or (2) SaU group. A cohort of 2000 children will be recruited during their 18-month vaccination visit or opportunistic visit to GP. At the end of the c-RCT, a qualitative study using focus groups/interviews will evaluate parent and practitioner views of the WMG-I programme and inform national and state policy recommendations. Ethics and dissemination The South Western Sydney Local Health District (2020/ETH01625), UNSW Sydney (2020/ETH01625) and University of Queensland (2021/HE000667) Human Research Ethics Committees independently reviewed and approved this study. Findings will be reported to the funding bodies, study institutes and partners; families and peer-reviewed conferences/publications
A practical guide to the simultaneous determination of protein structure and dynamics using metainference
Accurate protein structural ensembles can be determined with metainference, a
Bayesian inference method that integrates experimental information with prior
knowledge of the system and deals with all sources of uncertainty and errors as
well as with system heterogeneity. Furthermore, metainference can be
implemented using the metadynamics approach, which enables the computational
study of complex biological systems requiring extensive conformational
sampling. In this chapter, we provide a step-by-step guide to perform and
analyse metadynamic metainference simulations using the ISDB module of the
open-source PLUMED library, as well as a series of practical tips to avoid
common mistakes. Specifically, we will guide the reader in the process of
learning how to model the structural ensemble of a small disordered peptide by
combining state-of-the-art molecular mechanics force fields with nuclear
magnetic resonance data, including chemical shifts, scalar couplings and
residual dipolar couplings.Comment: 49 pages, 9 figure
Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs
Calcitonin gene-related peptide (CGRP) or adrenomedullin (AM) receptors are heteromers of the calcitonin receptor-like receptor (CLR), a class B G protein-coupled receptor, and one of three receptor activity-modifying proteins (RAMPs). How CGRP and AM activate CLR and how this process is modulated by RAMPs is unclear. We have defined how CGRP and AM induce Gs-coupling in CLR-RAMP heteromers by measuring the effect of targeted mutagenesis in the CLR transmembrane domain on cAMP production, modeling the active state conformations of CGRP and AM receptors in complex with the Gs C-terminus and conducting molecular dynamics simulations in an explicitly hydrated lipidic bilayer. The largest effects on receptor signaling were seen with H295A5.40b, I298A5.43b, L302A5.47b, N305A5.50b, L345A6.49b and E348A6.52b, F349A6.53b and H374A7.47b (class B numbering in superscript). Many of these residues are likely to form part of a group in close proximity to the peptide binding site and link to a network of hydrophilic and hydrophobic residues, which undergo rearrangements to facilitate Gs binding. Residues closer to the extracellular loops displayed more pronounced RAMP or ligand-dependent effects. Mutation of H3747.47b to alanine increased AM potency 100-fold in the CGRP receptor. The molecular dynamics simulation showed that TM5 and TM6 pivoted around TM3. The data suggest that hydrophobic interactions are more important for CLR activation than other class B GPCRs, providing new insights into the mechanisms of activation of this class of receptor. Furthermore the data may aid in the understanding of how RAMPs modulate the signaling of other class B GPCRs
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