Inflammatory Activity on Natalizumab Predicts Short-term but not Long-term Disability in Multiple Sclerosis

BACKGROUND: In people with multiple sclerosis treated with interferon-beta or glatiramer acetate, new MRI lesions and relapses during the first year of treatment predict a poor prognosis. OBJECTIVE: To study this association in those receiving natalizumab. METHODS: Data were collected on relapses, new MRI activity, and Modified Rio Score after initiation of natalizumab in an observational cohort of 161 patients with high baseline disability. These were correlated with Expanded Disability Status Scale (EDSS) progression at years 1, 2, 3, and 3-7 after treatment initiation, versus pre-treatment baseline. RESULTS: 46/161 patients had a relapse in the first year and 44/161 had EDSS progression by year 2. Relapses and Modified Rio Score in the first year of treatment predicted EDSS progression at year 1 and 2 after treatment initiation. However, this effect disappeared with longer follow-up. Paradoxically, there was a trend towards inflammatory activity on treatment (first year Modified Rio Score, relapses, and MRI activity) predicting a lower risk of EDSS progression by years 3-7, although this did not reach statistical significance. Those with and without EDSS progression did not differ in baseline age, EDSS, or pre-treatment relapse rate. Relapses in year 0-1 predicted further relapses in years 1-3. CONCLUSIONS: Breakthrough inflammatory activity after natalizumab treatment is predictive of short-term outcome measures of relapses or EDSS progression, but does not predict longer term EDSS progression, in this cohort with high baseline disability

Experiments on a three-core cell for high-speed memories

Includes: magnetic memories, external selection, experimental results, memory criteria, design considerations, preliminary design of plane, reference bibliography, and drawings.The coincident-current magnetic-core memory was suggested in 1949 by Jay W. Forrester as a reliable, random-access storage medium. Development of the first working memory of this type, for the Memory Test Computer at M.I.T., established conclusively the superiority of such a memory over competitive systems and paved the way for others to exploit the new device

Transition phenomena in unstably stratified turbulent flows

We study experimentally and theoretically transition phenomena caused by the external forcing from Rayleigh-Benard convection with the large-scale circulation (LSC) to the limiting regime of unstably stratified turbulent flow without LSC whereby the temperature field behaves like a passive scalar. In the experiments we use the Rayleigh-B\'enard apparatus with an additional source of turbulence produced by two oscillating grids located nearby the side walls of the chamber. When the frequency of the grid oscillations is larger than 2 Hz, the large-scale circulation (LSC) in turbulent convection is destroyed, and the destruction of the LSC is accompanied by a strong change of the mean temperature distribution. However, in all regimes of the unstably stratified turbulent flow the ratio $\big[(\ell_x \nabla_x T)^2 + (\ell_y \nabla_y T)^2 + (\ell_z \nabla_z T)^2\big] /$ varies slightly (even in the range of parameters whereby the behaviour of the temperature field is different from that of the passive scalar). Here $\ell_i$ are the integral scales of turbulence along x, y, z directions, T and \theta are the mean and fluctuating parts of the fluid temperature. At all frequencies of the grid oscillations we have detected the long-term nonlinear oscillations of the mean temperature. The theoretical predictions based on the budget equations for turbulent kinetic energy, turbulent temperature fluctuations and turbulent heat flux, are in agreement with the experimental results.Comment: 14 pages, 14 figures, REVTEX4-1, revised versio

A pattern matching technique for measuring sediment displacement levels

This paper describes a novel technique for obtaining accurate, high (spatial) resolution measurements of sediment redeposition levels. A sequence of different random patterns are projected onto a sediment layer and captured using a high-resolution camera, producing a set of reference images. The same patterns are used to obtain a corresponding sequence of deformed images after a region of the sediment layer has been displaced and redeposited, allowing the use of a high-accuracy pattern matching algorithm to quantify the distribution of the redeposited sediment. A set of experiments using the impact of a vortex ring with a glass ballotini particle layer as the resuspension mechanism are described to test and illustrate the technique. The accuracy of the procedure is assessed using a known crater profile, manufactured to simulate the features of the craters observed in the experiments

Little Earth Experiment: An instrument to model planetary cores

In this paper, we present a new experimental facility, Little Earth Experiment, designed to study the hydrodynamics of liquid planetary cores. The main novelty of this apparatus is that a transparent electrically conducting electrolyte is subject to extremely high magnetic fields (up to 10 T) to produce electromagnetic effects comparable to those produced by moderate magnetic fields in planetary cores. This technique makes it possible to visualise for the first time the coupling between the principal forces in a convection-driven dynamo by means of Particle Image Velocimetry (PIV) in a geometry relevant to planets. We first present the technology that enables us to generate these forces and implement PIV in a high magnetic field environment. We then show that the magnetic field drastically changes the structure of convective plumes in a configuration relevant to the tangent cylinder region of the Earth's core. Published by AIP Publishing

An assessment on the unsteady flow distortion generated by an S-duct intake

Closer integration between the fuselage and the propulsion system is expected for futureaircraft toreducefuel consumption, emissions, weight and drag. The use of embedded or partially embedded propulsion systems may require the use of complex intakes. However, thiscanresult in unsteady flow distortion which can adversely affect the propulsion system efficiency and stability. This works assesses the characteristics of the unsteady flow with a view to the potential flow distortion presented to the compression system.Particle image velocimetry is used to measure the flow distortion generated by an S-shaped intake.The time-resolved tracking of the idealized relative incidence angle revealed that most frequent distortion events exhibited90°exposure sector and upto±5°meanrelativeincidence. The imposition of a thicker boundary at the S-duct inlet increased the probability of distortion events that are characterized by a longer exposure sector and higher relative incidence angles.Because of these characteristics, thedistortion caused by the S-duct intake could induce instabilities that are detrimental for the propulsion system performances and stability. Overall, this work proposes a new method to assess thepossible relativeincidence angle on the compressor rotor taking into account the intake flow unsteadiness

Novel Relapsing Fever Spirochete in Bat Tick

Novel Relapsing Fever Spirochete in Bat Tic