An evaluation of subjective experiences, effects and overall satisfaction with clozapine treatment in a UK forensic service

Objectives: Patients prescribed clozapine were surveyed to assess (a) the effects, both positive and adverse, and overall satisfaction with clozapine in comparison to previously prescribed antipsychotics and (b) the relative significance of effects experienced, both positive and adverse, in terms of impact on subjective well-being. Methods: A total of 56 male patients prescribed clozapine at a forensic psychiatric hospital were surveyed using a 27-item questionnaire. All patients had been prescribed clozapine for a minimum of 3 months. Respondents were asked to rate effects and satisfaction with clozapine treatment in comparison with previously prescribed antipsychotic medication on a five-point scale. Respondents were also asked to rate effects experienced with clozapine treatment in terms of impact on subjective well-being on a five-point scale. Results: A total of 89% of respondents reported greater satisfaction with clozapine than with previously prescribed antipsychotic medication. A majority of patients reported positive effects in terms of an improvement in their quality of life (68%) and social abilities (52%) with clozapine in comparison with previously prescribed antipsychotics. Nocturnal hypersalivation (84%) and weight gain (57%) were the most common adverse effects. Hedonic responses were assessed for each effect in order to determine the associated subjective experiences. The most positive hedonic responses were for quality of life, mood and alertness. In terms of adverse impact on subjective well-being, nocturnal hypersalivation ranked highest. Conclusions: Patients in a UK forensic sample are largely satisfied with clozapine treatment. The subjective effects of clozapine treatment should be taken into account by clinicians when assessing response. This may provide an opportunity to highlight the positive changes and prioritize management of the most undesirable adverse effects, which is likely to promote compliance and improve longer term treatment outcomes

Steady-state entanglement in a double-well Bose-Einstein condensate through coupling to a superconducting resonator

We consider a two-component Bose-Einstein condensate in a double-well potential, where the atoms are magnetically coupled to a single-mode of the microwave field inside a superconducting resonator. We find that the system has the different dark-state subspaces in the strong- and weak-tunneling regimes, respectively. In the limit of weak tunnel coupling, steady-state entanglement between the two spatially separated condensates can be generated by evolving to a mixture of dark states via the dissipation of the photon field. We show that the entanglement can be faithfully indicated by an entanglement witness. Long-lived entangled states are useful for quantum information processing with atom-chip devices.Comment: 9 pages, 7 figures, minor revisio

A unified approach to realize universal quantum gates in a coupled two-qubit system with fixed always-on coupling

We demonstrate that in a coupled two-qubit system any single-qubit gate can be decomposed into two conditional two-qubit gates and that any conditional two-qubit gate can be implemented by a manipulation analogous to that used for a controlled two-qubit gate. Based on this we present a unified approach to implement universal single-qubit and two-qubit gates in a coupled two-qubit system with fixed always-on coupling. This approach requires neither supplementary circuit or additional physical qubits to control the coupling nor extra hardware to adjust the energy level structure. The feasibility of this approach is demonstrated by numerical simulation of single-qubit gates and creation of two-qubit Bell states in rf-driven inductively coupled two SQUID flux qubits with realistic device parameters and constant always-on coupling.Comment: 4 pages, 3 figure

Coherent control of atomic spin currents in a double well

We propose an experimental feasible method for controlling the atomic currents of a two-component Bose-Einstein condensate in a double well by applying an external field to the atoms in one of the potential wells. We study the ground-state properties of the system and show that the directions of spin currents and net-particle tunneling can be manipulated by adiabatically varying the coupling strength between the atoms and the field. This system can be used for studying spin and tunneling phenomena across a wide range of interaction parameters. In addition, spin-squeezed states can be generated. It is useful for quantum information processing and quantum metrology.Comment: 6 pages, 7 figures, minor revisio

The first operation and results of the Chung-Li VHF radar

The Chung-Li Very High Frequency (VHF) radar is used in the dual-mode operations, applying Doppler beam-swinging as well as the spaced-antenna-drift method. The design of the VHF radar is examined. Results of performance tests are discussed